Prosecution Insights
Last updated: September 17, 2026
Application No. 18/720,402

PHENYLETHYLIDENEHYDRAZINE DIMERS AND METHODS OF USING SAME

Final Rejection §102
Filed
Jun 14, 2024
Priority
Dec 16, 2021 — provisional 63/290,634 +1 more
Examiner
RAHMANI, NILOOFAR
Art Unit
Tech Center
Assignee
Neurawell Therapeutics
OA Round
2 (Final)
78%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
74%
With Interview

Examiner Intelligence

Grants 78% — above average
78%
Career Allowance Rate
884 granted / 1140 resolved
+17.5% vs TC avg
Minimal -3% lift
Without
With
+-3.1%
Interview Lift
resolved cases with interview
Fast prosecutor
1y 11m
Avg Prosecution
47 currently pending
Career history
1157
Total Applications
across all art units

Statute-Specific Performance

§101
2.7%
-37.3% vs TC avg
§103
13.8%
-26.2% vs TC avg
§102
28.4%
-11.6% vs TC avg
§112
38.6%
-1.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1140 resolved cases

Office Action

§102
DETAILED ACTION 1. Claims 1-3, 5-6, 10-13, 15, 23, 25-26, 28-29, 36-38, 54 are pending in the instant application. 2. The rejection of claim 37 under 35 U.S.C. 112, second paragraph is withdrawn in view of applicant’s amendment and argument in paper dated on 08/12/2026. 3. The rejection of claims 36-38, 54 under 35 U.S.C. 112, first paragraph is withdrawn in view of applicant’s amendment and argument in paper dated on 08/12/2026. 4. The rejection of claims 1-3, 5-6, 10-13, 15, 23, 25-26, 28-29, 36-38, 54 under 35 U.S.C. 102(a)(1) over Filler et al., Journal of the Chemical Society [section] C: organic (1971), (11), 2062-8 is maintained for reason of record. Applicants argue that Filler discloses various reactions of polyfluoroaromatic compounds. Neither does Filler disclose combining hydrazine dimers with pharmaceutically acceptable carriers or using hydrazine dimers to treat psychological disorders. It is Examiners position that Filler discloses the instant claimed compound as follows: PNG media_image1.png 276 490 media_image1.png Greyscale . The above compound can be used as antidepressant drugs and treat psychological disorder. Therefore, the above compound can be in pharmaceutical composition form. Therefore, using the above compound as a pharmaceutical composition is inherently there. 5. The rejection of claims 1-3, 5-6, 10-13, 15, 23, 25-26, 28-29 under 35 U.S.C. 102(a)(1) and 102(a)(2) over Arashi et al., US 3959343 is maintained for reason of record. Applicants argue that Arashi discloses a “process for producing hydrazonitriles” using ketazines such as RN 18300-79-3 as intermediates in the manufacture of azonitriles for use as polymerization initiators and blowing agents. It is Examiners position that Arashi discloses the instant claimed compound as follows: PNG media_image2.png 154 314 media_image2.png Greyscale . The above compound can be used as a pharmaceutical composition form. Therefore, using the above compound as a pharmaceutical composition is inherently there. 6. The rejection of claims 1-3, 5-6, 10-13, 15, 23, 25-26, 28-29 under 35 U.S.C. 102(a)(1) over Toyota et al., Heteroatom Chemistry (2001), 12(5), 418-423 is maintained for reason of record. Applicants argue that Toyota is directed to NMR studies. As such, Toyota does not disclose the recited claim limitations of a “therapeutically effective amount,” and “a pharmaceutically acceptable carrier,” or treatment o “a psychological disorder.” It is Examiners position that Filler discloses the instant claimed compound as follows: PNG media_image3.png 226 424 media_image3.png Greyscale . The above compound can be used in pharmaceutical composition form. Therefore, using the above compound as a pharmaceutical composition is inherently there. 7. The rejection of claims 1-3, 5-6, 10-13, 15, 23, 25-26, 28-29 under 35 U.S.C. 102(a)(1) over Xu et al., Acta Crystallographica, section E: structure reports online (2009), 65(12), m1559-m1560 is maintained for reason of record. Applicants argue that Xu is directed to spectroscopic studies. It is Examiners position that Filler discloses the instant claimed compound as follows: PNG media_image3.png 226 424 media_image3.png Greyscale . The above compound can be used in pharmaceutical composition form. Therefore, using the above compound as a pharmaceutical composition is inherently there. 8. The rejection of claims 1-3, 5-6, 10-13, 15, 23, 25-26, 28-29 under 35 U.S.C. 102(a)(1) over Nodzewska et al., Science of synthesis, knowledge updates (2012), (3), 445-463 is maintained for reason of record. Applicants argue that Nodzewska discloses methods of azine synthesis. It is Examiners position that Filler discloses the instant claimed compound as follows: PNG media_image4.png 156 448 media_image4.png Greyscale . The above compound can be used in pharmaceutical composition form. Therefore, using the above compound as a pharmaceutical composition is inherently there. THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicants are reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for replying to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any extension fee pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the date of this final action. 9. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Niloofar Rahmani whose telephone number is 571-272-4329. The examiner can normally be reached on Monday through Friday from 8:30 am to 5:00 pm. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Renee Claytor, can be reached on 571-272-8394. The fax phone number for the organization where this application or proceeding is assigned is 703-872-9306. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). /NILOOFAR RAHMANI/ Primary Examiner, Art Unit 1691 08/25/2026
Read full office action

Prosecution Timeline

Jun 14, 2024
Application Filed
May 14, 2026
Non-Final Rejection mailed — §102
Aug 12, 2026
Response Filed
Aug 28, 2026
Final Rejection mailed — §102 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
78%
Grant Probability
74%
With Interview (-3.1%)
1y 11m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1140 resolved cases by this examiner. Grant probability derived from career allowance rate.

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