Prosecution Insights
Last updated: July 17, 2026
Application No. 18/723,545

KETOAMIDE DERIVATIVES AND PHARMACEUTICAL USES THEREOF

Non-Final OA §101§102§112
Filed
Jun 24, 2024
Priority
Mar 01, 2022 — CN 202210199543.5 +1 more
Examiner
SEAMAN, D MARGARET M
Art Unit
Tech Center
Assignee
Westvac Biopharma Co. Ltd.
OA Round
1 (Non-Final)
77%
Grant Probability
Favorable
1-2
OA Rounds
1m
Est. Remaining
85%
With Interview

Examiner Intelligence

Grants 77% — above average
77%
Career Allowance Rate
1068 granted / 1394 resolved
+16.6% vs TC avg
Moderate +8% lift
Without
With
+8.0%
Interview Lift
resolved cases with interview
Fast prosecutor
2y 2m
Avg Prosecution
39 currently pending
Career history
1418
Total Applications
across all art units

Statute-Specific Performance

§101
1.6%
-38.4% vs TC avg
§103
20.2%
-19.8% vs TC avg
§102
17.1%
-22.9% vs TC avg
§112
30.7%
-9.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1394 resolved cases

Office Action

§101 §102 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Priority This application was filed 06/24/2024 which is a 371 of PCT/CN2023/076078 (02/15/2023) which claims foreign priority to China 202210199543.5 (03/01/2022). Claims 1-76 are before the Examiner. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. Claims 71-76 are rejected under 35 U.S.C. 101 because the claimed invention is directed to non-statutory subject matter. The claim(s) does/do not fall within at least one of the four categories of patent eligible subject matter because “Use of” is non-statutory subject matter. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1, 13 and 14 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. For claim 1, after the definition for R4, the paragraphs starts “The substituents of the substituent group are…”. What substituents? Of what group? Is this a new sentence? For claims 13 and 14, these claims have two sentences. The claims are supposed to be one sentence in length. Corrections is required. Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. (a)(2) the claimed invention was described in a patent issued under section 151, or in an application for patent published or deemed published under section 122(b), in which the patent or application, as the case may be, names another inventor and was effectively filed before the effective filing date of the claimed invention. Claims 1-76 are rejected under 35 U.S.C. 102(a)(2) as being anticipated by Powers US Patent 7429560. Powers teaches compounds such as C2 compound AK295 as a pharmaceutical. This anticipates the instant claims. Claims 1-76 are rejected under 35 U.S.C. 102(a)(2) as being anticipated by Kling US Patent 8598211. Kling teaches compounds as pharmaceuticals such as Table A and claim 1. This anticipates the instant claims. Claims 1-76 are rejected under 35 U.S.C. 102(a)(2) as being anticipated by Lynch USPGPub 20150274777. Lynch teaches claim 1 and claim 23 which teaches compounds as pharmaceuticals. This anticipates the instant claims. Claims 1-76 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Lee. Lee teaches compounds such as Figure 1 #2, 2i and 2l. These are compounds and pharmaceuticals. This anticipates the instant claims. Claims 1-76 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Hassan. Hassan teaches Bestatin Analogs on page 2 and Table 1. These are compounds and pharmaceuticals. This anticipates the instant claims. Claims 1-76 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Huang. Huang teaches compounds such as Table 2 page 6 10a-k and Table 3 page 8. These are compounds and pharmaceuticals. This anticipates the instant claims. Claims 1-76 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Bihovsky. Bihovsky teaches compounds such as table 1 8m-8q. These are compounds and pharmaceuticals. This anticipates the instant claims. Claims 1-76 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Cui. Cui teaches compounds such as formula III. These are compounds and pharmaceuticals. This anticipates the instant claims. Claims 1-76 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Peltason. Peltason teaches compounds such as p1871 c). These are compounds and pharmaceuticals. This anticipates the instant claims. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to D MARGARET M SEAMAN whose telephone number is (571)272-0694. The examiner can normally be reached M-F 8am-4pm Eastern. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Andrew Kosar can be reached at 571-272-0913. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /D MARGARET M SEAMAN/Primary Examiner, Art Unit 1625
Read full office action

Prosecution Timeline

Jun 24, 2024
Application Filed
Jun 17, 2026
Non-Final Rejection mailed — §101, §102, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
77%
Grant Probability
85%
With Interview (+8.0%)
2y 2m (~1m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1394 resolved cases by this examiner. Grant probability derived from career allowance rate.

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