Prosecution Insights
Last updated: September 17, 2026
Application No. 18/726,801

CRYSTAL OF 4’-SUBSTITUTED NUCLEOSIDE, PREPARATION METHOD THEREFOR, COMPOSITION CONTAINING THE SAME, AND USE THEREOF

Non-Final OA §112
Filed
Jul 04, 2024
Priority
Jan 17, 2022 — CN 202210049924.5 +1 more
Examiner
BERRY, LAYLA D
Art Unit
Tech Center
Assignee
Henan Genuine Biotech Co. Ltd.
OA Round
1 (Non-Final)
66%
Grant Probability
Favorable
1-2
OA Rounds
7m
Est. Remaining
75%
With Interview

Examiner Intelligence

Grants 66% — above average
66%
Career Allowance Rate
960 granted / 1455 resolved
+6.0% vs TC avg
Moderate +9% lift
Without
With
+9.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 9m
Avg Prosecution
53 currently pending
Career history
1481
Total Applications
across all art units

Statute-Specific Performance

§101
3.9%
-36.1% vs TC avg
§103
34.2%
-5.8% vs TC avg
§102
19.6%
-20.4% vs TC avg
§112
25.1%
-14.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1455 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . CONTINUING DATA This application is a 371 of PCT/CN2023/072478 01/17/2023 FOREIGN APPLICATIONS CHINA 202210049924.5 01/17/2022 Claims 1-6 and 8-10 are pending. Claim Objections Claim 2 does not end with a period. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1-6 and 8-10 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 1 recites peaks that are “allowed to vary within an error range.” The specification does not define “error range” and does not provide any examples of an error range. It is impossible to determine the metes and bounds of the claim without a definition of the error range. Claims 2-6 and 8-10 depend from claim 1 and incorporate the same limitation by reference. Claims 3 and 5 recite “lower paraffin hydrocarbons.” “Lower” is a relative term. The specification states that lower paraffin hydrocarbons include but not limited to pentane, hexane, octane, nonane, decane, or the like, which is a range of 5-10 carbons. It is unclear which hydrocarbons meet the limitation “lower.” Claim 5 recites “lower paraffin hydrocarbons, which may include but not limited to pentane, hexane, °octane, nonane, or decane or the like.” The limitation is indefinite because “lower” is not defined, nor is “or the like.” It is unclear which hydrocarbons are included and which ones are not. A broad range or limitation together with a narrow range or limitation that falls within the broad range or limitation (in the same claim) may be considered indefinite if the resulting claim does not clearly set forth the metes and bounds of the patent protection desired. See MPEP § 2173.05(c). In the present instance, claim 3 recites the broad recitation “25°C to 120°C,” and the claim also recites “preferably 40°C to 60°C,” which is the narrower statement of the range/limitation. Claim 3 recites the broad recitation “1 to 24 h,” followed by the narrower limitation “preferably 3 to 5 h.” Claim 4 recites the broad recitation “2 to 72 h,” followed by the narrower limitation “preferably 20 to 60 h, more preferably 48 h.” Claim 4 recites the broad limitation “120°C to 150°C,” followed by the narrower limitation “preferably 140°C to 145°C, more preferably 141°C.” Claim 5 recites the broad limitation “40°C to 70°C,” followed by the narrower limitation “preferably 50°C.” Claim 5 recites the broad recitation “1 to 4 h,” followed by the narrower limitation “preferably 60 to 70 minutes.” Claim 5 recites the broad recitation “40°C to 80°C,” followed by the narrower limitation “preferably 50°C.” The claim(s) are considered indefinite because there is a question or doubt as to whether the feature introduced by such narrower language is (a) merely exemplary of the remainder of the claim, and therefore not required, or (b) a required feature of the claims. Conclusion No claims are allowed. The closest prior art is CN109893536 A (cited on IDS). US 20230151048A1 (Chang) is used as an English equivalent. Chang teaches the same compound 3 which is shown in the current claims. See page 5. Chang provides diffraction peaks on pages 5-6 which do not include the peaks recited in the current claims, and which are not within a reasonable error range. Chang also does not prepare the crystal in the same way as the current crystal was prepared. See paragraphs [0047]-[0048]. Any inquiry concerning this communication or earlier communications from the examiner should be directed to LAYLA D BERRY whose telephone number is (571)272-9572. The examiner can normally be reached 7:00-3:00 CST, M-F. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Scarlett Goon can be reached at 571-270-5241. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /LAYLA D BERRY/Primary Examiner, Art Unit 1693
Read full office action

Prosecution Timeline

Jul 04, 2024
Application Filed
Aug 20, 2026
Non-Final Rejection mailed — §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
66%
Grant Probability
75%
With Interview (+9.0%)
2y 9m (~7m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1455 resolved cases by this examiner. Grant probability derived from career allowance rate.

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