Prosecution Insights
Last updated: October 25, 2026
Application No. 18/726,951

1-AMINOBENZO[4,5]IMIDAZO[1,2-A]PYRAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION THEREFOR AND USE THEREOF

Non-Final OA §102§112
Filed
Jul 05, 2024
Priority
Jan 07, 2022 — CN 202210018141.0 +1 more
Examiner
VALENROD, YEVGENY
Art Unit
1628
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Sun Yat-sen University
OA Round
1 (Non-Final)
72%
Grant Probability
Favorable
1-2
OA Rounds
3m
Est. Remaining
98%
With Interview

Examiner Intelligence

Grants 72% — above average
72%
Career Allowance Rate
747 granted / 1030 resolved
+12.5% vs TC avg
Strong +25% interview lift
Without
With
+25.1%
Interview Lift
resolved cases with interview
Typical timeline
2y 6m
Avg Prosecution
43 currently pending
Career history
1081
Total Applications
across all art units

Statute-Specific Performance

§101
2.3%
-37.7% vs TC avg
§103
38.2%
-1.8% vs TC avg
§102
18.2%
-21.8% vs TC avg
§112
21.2%
-18.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1030 resolved cases

Office Action

§102 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Priority Acknowledgment is made of applicant's claim for foreign priority based on an application filed in China on 1/7/2022. It is noted, however, that applicant has not filed a certified copy of the CN202210018141.0 application as required by 37 CFR 1.55. The effective filing date of the current application is 7/7/2022 which is the filing date of PCT/CN2022/104398. Election/Restrictions Applicant’s election without traverse of Group I, claims 1-3, in the reply filed on 7/20/2026 is acknowledged. Upon further review, restriction requirement between groups I and IV is withdrawn. Claims 9-10 and 14-17, directed to an adenosine receptor inhibitor (9, 14-15) and an anti-tumor drug (10, 16-17) are interpreted as composition claims comprising the compound of claims 1-3. Claims 4-8 and 11-13 are withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Election was made without traverse in the reply filed on 7/20/26. Claims 1-3, 9-10 and 14-17 are considered on the merits. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1-3, 9-10 and 14-17 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. The claims are directed to: “A kind of 1-aminobenzo-[4,6]-imidazo[1,2-a]pyrazine-3-formaldehyde compound…” It’s unclear if the claimed compound is limited to the compound of formula (I), or if the term “A kind of” expands the scope of the claim beyond the depicted structure. The meaning of “A kind of” and what limitations the term imposes upon the scope of the claim is unclear. In order to advance examination, Examiner will interpret the claim to be limited to the scope of compound of formula (I). Claims 9-10 and 14-17 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. The claims are directed to an inhibitor or a drug that uses the compound of claim 1, 2 or 3 as the main active ingredient. The limitation of the term “uses” is not clear because the term uses suggests an active step or carrying out of a function. However, the claims are directed to a product, an inhibitor or a drug and no method steps are recited. In order to advance Examination, Examiner will interpret the claims to be directed to a composition comprising compound of claim 1, 2 or 3 with an intended use as an inhibitor or an anti-tumor drug. Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 1-3, 9-10 and 14-17 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by CN110606850A (CN) (the original document and the translation are provided by applicant with IDS) Claim interpretation Claims 9-10 and 14-17 are directed to an adenosine receptor inhibitor or to an anti-tumor drug that uses compound of claim 1, 2 or 3 as the main active ingredient. The claims are interpreted as being directed to a composition with an intended pharmacological use. Since compound of claim 1 is the sole claimed component of the composition, recitation of the compound will be interpreted as meeting all the limitations directed to the composition. Rejection CN discloses compound 31 (paragraph [0181] of the original document) which is the same as compound 14v of claim 3. Compound 31 anticipated claims 1-3: PNG media_image1.png 102 143 media_image1.png Greyscale In the summary of the invention (translation document) CN discloses the disclosed compounds to be inhibitors of adenosine receptor and anti-tumor medicines: PNG media_image2.png 112 578 media_image2.png Greyscale Since the compound itself is the only required component of the composition of claims 9-10 and 14-17, and CN discloses the claimed component, the limitations directed to the composition are met. Conclusion Claims 1-3, 9-10 and 14-17 are rejected Claims 4-8 and 11-13 are withdrawn Any inquiry concerning this communication or earlier communications from the examiner should be directed to YEVGENY VALENROD whose telephone number is (571)272-9049. The examiner can normally be reached Mon-Fri 9am-5pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Amy L Clark can be reached at 571-272-1310. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /YEVGENY VALENROD/Primary Examiner, Art Unit 1628
Read full office action

Prosecution Timeline

Jul 05, 2024
Application Filed
Oct 14, 2026
Non-Final Rejection mailed — §102, §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12767664
SPIROCYCLIC COMPOUND AS KRAS-G12C INHIBITOR
2y 9m to grant Granted Oct 20, 2026
Patent 12746233
REBAMIPIDE FOR USE IN PREVENTION AND/OR TREATMENT OF ARTERIAL STIFFNESS
4y 7m to grant Granted Sep 29, 2026
Patent 12740965
SOTAGLIFLOZIN FOR IMPROVING LEFT ATRIAL FUNCTION
3y 2m to grant Granted Sep 22, 2026
Patent 12735383
LACTATE/KETONE BODY ESTERS
3y 4m to grant Granted Sep 15, 2026
Patent 12728155
COMPOSITIONS AND METHODS FOR INDUCING IMMUNE TOLERANCE
4y 8m to grant Granted Sep 08, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.
Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2
Expected OA Rounds
72%
Grant Probability
98%
With Interview (+25.1%)
2y 6m (~3m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1030 resolved cases by this examiner. Grant probability derived from career allowance rate.

Sign in with your work email

Enter your email to receive a magic link. No password needed.

Personal email addresses (Gmail, Yahoo, etc.) are not accepted.

Free tier: 3 strategy analyses per month