Prosecution Insights
Last updated: July 17, 2026
Application No. 18/729,020

LIPIDIC COMPOUNDS, AND USES THEREOF

Non-Final OA §102§112
Filed
Jul 15, 2024
Priority
Jan 17, 2022 — EU 22305043.6 +1 more
Examiner
PIPIC, ALMA
Art Unit
1617
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Sanofi S.A.
OA Round
1 (Non-Final)
54%
Grant Probability
Moderate
1-2
OA Rounds
1y 1m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 54% of resolved cases
54%
Career Allowance Rate
385 granted / 710 resolved
-5.8% vs TC avg
Strong +56% interview lift
Without
With
+55.7%
Interview Lift
resolved cases with interview
Typical timeline
3y 1m
Avg Prosecution
55 currently pending
Career history
763
Total Applications
across all art units

Statute-Specific Performance

§101
0.2%
-39.8% vs TC avg
§103
64.9%
+24.9% vs TC avg
§102
3.4%
-36.6% vs TC avg
§112
5.7%
-34.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 710 resolved cases

Office Action

§102 §112
-DETAILED ACTION- Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Applicants’ response dated May 19, 2026 is acknowledged. Priority This application is a 371 of PCT/EP2023/050891 filed on 01/16/2023, which claims foreign priority in EP22305043.6 filed on 01/17/2022. Claim Status Claims 1, 3-10, 12-17, 32, and 33 are pending. Claims 2, 11, 13-16, and 18-31 were cancelled. Claims 32 and 33 were newly added. Claims 6, 9, 14-16 and 32 are withdrawn. Claims 1, 3-5, 7, 8, 10, 12, 13, 17, and 33 are examined. Election/Restriction Applicant’s election without traverse of Group I (Claims 1, 3-10, 12-17, 32, and 33), drawn to a compound of Formula I in the reply filed on May 19, 2026, is acknowledged. Applicant’s election without traverse of Compound VII as a species of the compound of Formula I, is acknowledged. Claims 1, 3-5, 7, 8, 10, 12, 13, 17, and 33 read on the elected species. The requirement is still deemed proper and is therefore made FINAL. Accordingly, claims 6, 9,14-16, and 32 are withdrawn from further consideration pursuant to 37 CFR 1.142(b), as being withdrawn to a non-elected invention, and non-elected species of the invention, there being no allowable generic or linking claims. Response to the restriction requirement of February 19, 2026 was timely filed. Claims 1, 3-5, 7, 8, 10, 12, 13, 17, and 33 are examined on the merits. The elected compound was searched and no applicable prior art was found. In accordance with MPEP 804, the examiner has moved on and examined remaining species of compounds of formula (I) in claim 17 and no applicable prior art was found. The examiner has selected the compound of formula (I) in which R1 is linear saturated C12 hydrocarbon, Z is –(CH2CH2O)4-, B is -O-, X is oxygen, n is 2, and A is 6-membered saturated heterocyclic radical comprising 4 carbon atoms and 2 nitrogen atoms, and substituted with C1 alkyl, which is encompassed by claims 1, 4, 5, 7, 8, 10, 12, and 13, and an action on this species follows. Claim Rejections – 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. Claims 1, 3-5, 7, 8, 10, 12, 13, and 17 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. In claim 1, the chemical structure of the compound of formula I is indefinite because the carbon atom C in “CX” is not balanced as drawn. In view of dependent claims, it is apparent that applicant intended for the carbon atom in -CX- moiety to be double bonded to X and single bonded to the B variable and single bonded to the methylene moiety. The correct notation for carbon double bonded to X is -C(X)-. Appropriate correction is required. The chemical structure NR2R3-Alk-Y- is indefinite when Y is a nitrogen atom because it does not have a balanced valance. Nitrogen requires three covalent bonds to be balanced and the nitrogen atom in the claimed structure has only two covalent bonds and requires a third covalent bond complete its valance. Claim 3 recites a group of chemical structures from which the R1 variable is selected. The claim is indefinite because none of the structures indicate a point of attachment of the R1 variable to Z. Claims 4, 5, 7, 8, 10, 12, 13, and 17 are rejected as indefinite because the claims depend from an indefinite base claim and contain indefinite limitations. Claim Rejections – 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 1, 4, 5, 7, 8, 10, 12, and 13 are rejected under 35 U.S.C. 102(a) as being anticipated by Acosta (WO 2014/105764 A1 Published July 3, 2014 – of record in IDS dated 04/30/2025). The claims encompass a compound of formula (I) in which R1 is linear saturated C12 hydrocarbon, Z is –(CH2CH2O)4-, B is -O-, X is oxygen, n is 2, and A is 6-membered saturated heterocyclic radical comprising 4 carbon atoms and 2 nitrogen atoms, and substituted with C1 alkyl. Acosta discloses a compound of the formula: PNG media_image1.png 129 712 media_image1.png Greyscale (Example 1 paragraphs 00192-00193). Claims 1 is anticipated by Acosta because the claimed genus encompasses Acosta’s compound when R1 is linear saturated C12 hydrocarbon, Z is –(CH2CH2O)4-, B is -O-, X is oxygen, n is 2, and A is 6-membered saturated heterocyclic radical comprising 4 carbon atoms and 2 nitrogen atoms, and substituted with C1 alkyl. Claim 4 is anticipated when m is 4, r is 0, and q is 0. Claim 5 is anticipated when B is oxygen. Claim 7 is anticipated when X is oxygen. Claim 8 is anticipated when n is 2. Claim 10 is anticipated when A is 6-membered saturated heterocyclic radical comprising 4 carbon atoms and 2 nitrogen atoms, and substituted with C1 alkyl. Claim 12 is anticipated when R4 is C1 alkyl, p is 0 (R12 is absent), R5, R6, R8, and R9 are each -CH2-, and R7 is N. Claim 13 is anticipated when r 0 and m is 4. Conclusion Claim 33 is allowed. Claims 1, 3-5, 7, 8, 10, 12, 13, and 17 are rejected. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Alma - Pipic whose telephone number is (571)270-7459. The examiner can normally be reached M-F 9:00am-5:00pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Michael Hartley can be reached on 571-272-0616. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /ALMA PIPIC/Primary Examiner, Art Unit 1617
Read full office action

Prosecution Timeline

Jul 15, 2024
Application Filed
Jun 10, 2026
Non-Final Rejection mailed — §102, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
54%
Grant Probability
99%
With Interview (+55.7%)
3y 1m (~1y 1m remaining)
Median Time to Grant
Low
PTA Risk
Based on 710 resolved cases by this examiner. Grant probability derived from career allowance rate.

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