Notice of Pre-AIA or AIA Status
The present application is being examined under the pre-AIA first to invent provisions.
Claim Status
Claims 22-40 are pending and examined. Claims 1-21 have been cancelled.
Specification
The specification is objected to for failing to cite to the patent which has issued from U.S. Application No. 18/363,120.
Appropriate action is advised.
Double Patenting
The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969).
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Claims 22-40 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-5 of U.S. Patent No. 8,759,101 B2 (referred to herein as ‘101). Although the claims at issue are not identical, they are not patentably distinct from each other because instant claims 22-40 are drawn to an expression vector comprising a heterologous promoter operably linked to SEQ ID NO: 1 and encoding the amino acid of SEQ ID NO: 2 and tobacco plants comprising said vector.
Meanwhile, ‘101 claims an isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 1, a polypeptide encoded by said nucleotide sequence, an expression vector comprising said sequence, and tobacco cells and plants comprising said expression vector. SEQ ID NO: 1 from ‘101 has 100% sequence identity to SEQ ID NO: 1 of the instant invention and encodes the polypeptide having SEQ ID NO: 2 of the instant invention (see Attachment).
Therefore, prior to the time of filing of the instant invention it would have been prima facie obvious for one of ordinary skill in the art to arrive at the instant invention because ‘101 claims the identical nucleotide of the instant invention comprised in a vector which may also comprise a heterologous promoter to drive expression of said nucleotide sequence.
Claims 22-40 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-5 of U.S. Patent No. 9,701,978 B2 (referred to herein as ‘978). Although the claims at issue are not identical, they are not patentably distinct from each other because instant claims 22-40 are drawn to an expression vector comprising a heterologous promoter operably linked to SEQ ID NO: 1 and encoding the amino acid of SEQ ID NO: 2 and tobacco plants comprising said vector.
Meanwhile, ‘978 claims a cDNA nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 1, a polypeptide encoded by said nucleotide sequence, an expression vector comprising said sequence, and tobacco cells and plants comprising said expression vector. SEQ ID NO: 1 from ‘978 has 100% sequence identity to SEQ ID NO: 1 of the instant invention and encodes the polypeptide having SEQ ID NO: 2 of the instant invention (see Attachment).
Therefore, prior to the time of filing of the instant invention it would have been prima facie obvious for one of ordinary skill in the art to arrive at the instant invention because ‘978 claims the identical nucleotide of the instant invention comprised in a vector which may also comprise a heterologous promoter to drive expression of said nucleotide sequence.
Conclusion
No claim is allowed.
The closest prior art is Page et al (US 8,624,083 B2), which teaches a nucleic acid sequence having 91% sequence identity to SEQ ID NO: 1 of the instant invention. The polypeptide encoded by said nucleic acid sequence has 89% amino acid sequence identity to the amino acid sequence encoded by SEQ ID NO: 1 of the instant invention (see Attachment A).
Page et al teach the isolation of said nucleic acid sequence, that expression of said nucleic acid sequence led to an increase in nicotine levels, and that said nucleic acid sequence is capable of modulating expression of PMT (col. 25, Example 2; see also col. 26, Example 3; see col. 3, lines 39-67 and col. 4, lines 1-11).
Any inquiry concerning this communication or earlier communications from the examiner should be directed to JASON DEVEAU-ROSEN whose telephone number is (571)272-2828. The examiner can normally be reached 7:30am - 4pm.
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/JASON DEVEAU ROSEN/Primary Examiner, Art Unit 1662
ATTACHMENT
Alignment of SEQ ID NO: 1 from ‘101 with SEQ ID NO: 1 of the instant invention
Patent No. 8759101
GENERAL INFORMATION
APPLICANT: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
APPLICANT: TIMKO, Michael P
APPLICANT: RUSHTON, Paul J
APPLICANT: HAN, Sheng-Cheng
APPLICANT: ZHANG, Hongbo
APPLICANT: BOKOWIEC, Marta T.
TITLE OF INVENTION: COMPOSITIONS AND RELATED METHODS FOR MODULATING ALKALOID
TITLE OF INVENTION: PRODUCTION BY CONTROLLING PMT PROMOTER ACTIVATION MEDIATED BY
TITLE OF INVENTION: TRANSCRIPTIONAL FACTORS ERF AND MYC
FILE REFERENCE: 1021238-001268
CURRENT APPLICATION NUMBER: US/12/676,871
CURRENT FILING DATE: 2010-11-10
PRIOR APPLICATION NUMBER: PCT/US2008/010447
PRIOR FILING DATE: 2008-09-05
PRIOR APPLICATION NUMBER: 60/935,948
PRIOR FILING DATE: 2007-09-07
PRIOR APPLICATION NUMBER: 60/935,947
PRIOR FILING DATE: 2007-09-07
NUMBER OF SEQ ID NOS: 6
SEQ ID NO 1
LENGTH: 2040
TYPE: DNA
ORGANISM: Nicotiana tabacum
FEATURE:
NAME/KEY: CDS
LOCATION: (1)..(2040)
Query Match 100.0%; Score 2040; Length 2040;
Best Local Similarity 100.0%;
Matches 2040; Conservative 0; Mismatches 0; Indels 0; Gaps 0;
Qy 1 ATGACTGATTACAGCTTACCCACCATGAATTTGTGGAATACTAGTGGTACTACCGATGAC 60
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1 ATGACTGATTACAGCTTACCCACCATGAATTTGTGGAATACTAGTGGTACTACCGATGAC 60
Qy 61 AACGTTTCTATGATGGAATCTTTTATGTCTTCTGATCTCACTTCATTTTGGGCTACTTCT 120
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 61 AACGTTTCTATGATGGAATCTTTTATGTCTTCTGATCTCACTTCATTTTGGGCTACTTCT 120
Qy 121 AATTCTACTACTGCTGCTGTTACCTCTAATTCTAATCTTATTCCAGTTAATACCCTAACT 180
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 121 AATTCTACTACTGCTGCTGTTACCTCTAATTCTAATCTTATTCCAGTTAATACCCTAACT 180
Qy 181 GTTCTTCTTCCGTCTTCTTGTGCTTCTACTGTCACAGCTGTGGCTGTCGATGCTTCAAAA 240
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 181 GTTCTTCTTCCGTCTTCTTGTGCTTCTACTGTCACAGCTGTGGCTGTCGATGCTTCAAAA 240
Qy 241 TCCATGTCTTTTTTCAACCAAGAAACTCTTCAGCAGCGTCTTCAAACCCTCATTGATGGT 300
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 241 TCCATGTCTTTTTTCAACCAAGAAACTCTTCAGCAGCGTCTTCAAACCCTCATTGATGGT 300
Qy 301 GCTCGTGAGACGTGGACCTATGCCATCTTTTGGCAGTCATCCGTCGTTGATTTATCGAGT 360
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 301 GCTCGTGAGACGTGGACCTATGCCATCTTTTGGCAGTCATCCGTCGTTGATTTATCGAGT 360
Qy 361 CCGTTTGTGTTGGGCTGGGGAGATGGTTACTACAAAGGTGAAGAAGATAAAGCCAATAGG 420
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 361 CCGTTTGTGTTGGGCTGGGGAGATGGTTACTACAAAGGTGAAGAAGATAAAGCCAATAGG 420
Qy 421 AAATTAGCTGTTTCTTCTCCTGCTTATATTGCTGAGCAAGAACACCGAAAAAAGGTTCTC 480
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 421 AAATTAGCTGTTTCTTCTCCTGCTTATATTGCTGAGCAAGAACACCGAAAAAAGGTTCTC 480
Qy 481 CGGGAGCTGAATTCGTTGATCTCCGGCACGCAAACCGGCACTGATGATGCCGTCGATGAA 540
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 481 CGGGAGCTGAATTCGTTGATCTCCGGCACGCAAACCGGCACTGATGATGCCGTCGATGAA 540
Qy 541 GAAGTTACCGACACTGAATGGTTCTTCCTTATTTCCATGACCCAATCGTTTGTTAACGGA 600
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 541 GAAGTTACCGACACTGAATGGTTCTTCCTTATTTCCATGACCCAATCGTTTGTTAACGGA 600
Qy 601 AGTGGGCTTCCGGGTCAGGCCTTATACAATTCCAGCCCTATTTGGGTCGCCGGAGCAGAG 660
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 601 AGTGGGCTTCCGGGTCAGGCCTTATACAATTCCAGCCCTATTTGGGTCGCCGGAGCAGAG 660
Qy 661 AAATTGGCAGCTTCCCACTGCGAACGGGCTCGGCAGGCCCAGGGATTCGGGCTTCAGACG 720
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 661 AAATTGGCAGCTTCCCACTGCGAACGGGCTCGGCAGGCCCAGGGATTCGGGCTTCAGACG 720
Qy 721 ATGGTTTGTATTCCTTCAGCAAACGGCGTGGTTGAATTGGGCTCCACGGAGTTGATAATC 780
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 721 ATGGTTTGTATTCCTTCAGCAAACGGCGTGGTTGAATTGGGCTCCACGGAGTTGATAATC 780
Qy 781 CAGAGTTGTGATCTCATGAACAAGGTTAGAGTATTGTTTAACTTCAATAATGATTTGGGC 840
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 781 CAGAGTTGTGATCTCATGAACAAGGTTAGAGTATTGTTTAACTTCAATAATGATTTGGGC 840
Qy 841 TCTGGTTCGTGGGCTGTGCAGCCCGAGAGCGATCCGTCCGCTCTTTGGCTCACTGATCCA 900
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 841 TCTGGTTCGTGGGCTGTGCAGCCCGAGAGCGATCCGTCCGCTCTTTGGCTCACTGATCCA 900
Qy 901 TCGTCTGCAGCTGTAGAAGTCCAAGATTTAAATACAGTTAAGGCAAATTCAGTTCCATCA 960
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 901 TCGTCTGCAGCTGTAGAAGTCCAAGATTTAAATACAGTTAAGGCAAATTCAGTTCCATCA 960
Qy 961 AGTAATAGTAGTAAGCAAGTTGTGTTTGATAATGAGAATAATGGTCACAGTTCTGATAAT 1020
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 961 AGTAATAGTAGTAAGCAAGTTGTGTTTGATAATGAGAATAATGGTCACAGTTCTGATAAT 1020
Qy 1021 CAGCAACAGCAGCATTCTAAGCATGAAACACAAGGATTTTTCACAAGGGAGTTGAATTTT 1080
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1021 CAGCAACAGCAGCATTCTAAGCATGAAACACAAGGATTTTTCACAAGGGAGTTGAATTTT 1080
Qy 1081 TCAGAATTTGGGTTTGATGGAAGTAGTAATAATAGGAATGGGAATTCATCACTTTCTTGC 1140
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1081 TCAGAATTTGGGTTTGATGGAAGTAGTAATAATAGGAATGGGAATTCATCACTTTCTTGC 1140
Qy 1141 AAGCCAGAGTCGGGGGAAATCTTGAATTTTGGTGATAGTACTAAGAAAAGTGCAAATGGG 1200
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1141 AAGCCAGAGTCGGGGGAAATCTTGAATTTTGGTGATAGTACTAAGAAAAGTGCAAATGGG 1200
Qy 1201 AACTTATTTTCGGGTCAGTCCCATTTTGGGGCAGGGGAGGAGAATAAGAACAAGAAAAGG 1260
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1201 AACTTATTTTCGGGTCAGTCCCATTTTGGGGCAGGGGAGGAGAATAAGAACAAGAAAAGG 1260
Qy 1261 TCACCTGCTTCCAGAGGAAGCAATGAAGAAGGAATGCTTTCATTTGTTTCGGGTACAATC 1320
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1261 TCACCTGCTTCCAGAGGAAGCAATGAAGAAGGAATGCTTTCATTTGTTTCGGGTACAATC 1320
Qy 1321 TTGCCTGCAGCTTCTGGTGCGATGAAGTCAAGTGGAGGTGTAGGTGAAGACTCTGATCAT 1380
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1321 TTGCCTGCAGCTTCTGGTGCGATGAAGTCAAGTGGAGGTGTAGGTGAAGACTCTGATCAT 1380
Qy 1381 TCGGATCTTGAGGCCTCAGTGGTGAAAGAAGCTGAAAGTAGTAGAGTTGTAGAACCCGAA 1440
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1381 TCGGATCTTGAGGCCTCAGTGGTGAAAGAAGCTGAAAGTAGTAGAGTTGTAGAACCCGAA 1440
Qy 1441 AAGAGGCCAAAGAAGCGAGGAAGGAAGCCAGCAAATGGACGGGAGGAACCTTTGAATCAC 1500
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1441 AAGAGGCCAAAGAAGCGAGGAAGGAAGCCAGCAAATGGACGGGAGGAACCTTTGAATCAC 1500
Qy 1501 GTCGAAGCAGAGAGGCAAAGGAGAGAGAAATTAAACCAAAGGTTCTACGCATTAAGAGCT 1560
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1501 GTCGAAGCAGAGAGGCAAAGGAGAGAGAAATTAAACCAAAGGTTCTACGCATTAAGAGCT 1560
Qy 1561 GTTGTTCCGAATGTGTCCAAGATGGACAAGGCATCACTGCTTGGAGATGCAATTTCATAT 1620
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1561 GTTGTTCCGAATGTGTCCAAGATGGACAAGGCATCACTGCTTGGAGATGCAATTTCATAT 1620
Qy 1621 ATTAATGAGCTGAAGTTGAAGCTTCAAAATACAGAAACAGATAGAGAAGAATTGAAGAGC 1680
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1621 ATTAATGAGCTGAAGTTGAAGCTTCAAAATACAGAAACAGATAGAGAAGAATTGAAGAGC 1680
Qy 1681 CAAATAGAAGATTTAAAGAAAGAATTAGTTAGTAAAGACTCAAGGCGCCCTGGTCCTCCA 1740
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1681 CAAATAGAAGATTTAAAGAAAGAATTAGTTAGTAAAGACTCAAGGCGCCCTGGTCCTCCA 1740
Qy 1741 CCATCAAATCATGATCACAAGATGTCTAGCCATACTGGAAGCAAGATTGTAGACGTGGAT 1800
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1741 CCATCAAATCATGATCACAAGATGTCTAGCCATACTGGAAGCAAGATTGTAGACGTGGAT 1800
Qy 1801 ATAGATGTTAAGATAATTGGATGGGATGCGATGATTCGTATACAATGTAATAAAAAGAAT 1860
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1801 ATAGATGTTAAGATAATTGGATGGGATGCGATGATTCGTATACAATGTAATAAAAAGAAT 1860
Qy 1861 CATCCAGCTGCAAGGTTAATGGTAGCCCTCAAGGAGTTAGATCTAGATGTGCACCATGCC 1920
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1861 CATCCAGCTGCAAGGTTAATGGTAGCCCTCAAGGAGTTAGATCTAGATGTGCACCATGCC 1920
Qy 1921 AGTGTTTCAGTGGTGAACGATTTGATGATCCAACAAGCCACTGTGAAAATGGGTAGCAGA 1980
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1921 AGTGTTTCAGTGGTGAACGATTTGATGATCCAACAAGCCACTGTGAAAATGGGTAGCAGA 1980
Qy 1981 CTTTACACGGAAGAGCAACTTAGGATAGCATTGACATCCAGAGTTGCTGAAACACGCTAA 2040
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1981 CTTTACACGGAAGAGCAACTTAGGATAGCATTGACATCCAGAGTTGCTGAAACACGCTAA 2040
Alignment of SEQ ID NO: 1 from ‘978 with SEQ ID NO: 1 of the instant invention
Result Query Filing
No. Score Match Length ID Date Dups Description
------------------------------------------------------------------------------------
1 2040 100.0 2040 US-12-676-871-1 2010-11-10 5
US-14-311-684B-1 2014-06-23
Alignment of SEQ ID NO: 1 from Page et al with SEQ ID NO: 1 of the instant invention
US-13-464-212-1
; Sequence 1, Application US/13464212
; Patent No. 8624083
; GENERAL INFORMATION
; APPLICANT: NATIONAL RESEARCH COUNCIL OF CANADA
; APPLICANT:PAGE, JONATHAN
; APPLICANT:TODD, ANDREA T.
; TITLE OF INVENTION: NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING
; TITLE OF INVENTION:ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM
; FILE REFERENCE: 045952-0175
; CURRENT APPLICATION NUMBER: US/13/464,212
; CURRENT FILING DATE: 2012-07-19
; PRIOR APPLICATION NUMBER: PCT/IB2008/003131
; PRIOR FILING DATE: 2008-05-23
; PRIOR APPLICATION NUMBER: 60/924,675
; PRIOR FILING DATE: 2007-05-25
; NUMBER OF SEQ ID NOS: 21
; SOFTWARE: PatentIn version 3.5
; SEQ ID NO 1
; LENGTH: 2313
; TYPE: DNA
; ORGANISM: Nicotiana benthamiana
US-13-464-212-1
Query Match 91.8%; Score 1871.8; DB 17; Length 2313;
Best Local Similarity 95.1%;
Matches 1943; Conservative 0; Mismatches 97; Indels 3; Gaps 1;
Qy 1 ATGACTGATTACAGCTTACCCACCATGAATTTGTGGAATACTAGTGGTACTACCGATGAC 60
|||||||||||||| |||||||||||||||||||||||| ||||||||| ||||||||||
Db 124 ATGACTGATTACAGATTACCCACCATGAATTTGTGGAATGCTAGTGGTAGTACCGATGAC 183
Qy 61 AACGTTTCTATGATGGAATCTTTTATGTCTTCTGATCTCACTTCATTTTGGGCTACTTCT 120
|||||||||||||||||| |||| || |||||||||||||| |||||||| |||||||||
Db 184 AACGTTTCTATGATGGAAGCTTTGATATCTTCTGATCTCACCTCATTTTGTGCTACTTCT 243
Qy 121 AATTCTACTACTGCTGCTGTTACCTCTAATTCTAATCTTATTCCAGTTAATACCCTAACT 180
|||||| || |||||||| |||| |||||||||||| ||||||||||||||||| |||
Db 244 AATTCTTCTGCTGCTGCTATTACTGCTAATTCTAATCATATTCCAGTTAATACCCGAACG 303
Qy 181 GTTCTTCTTCCGTCTTCTTGTGCTTCTACTGTCACAGCTGTGGCTGTCGATGCTTCAAAA 240
|||||||||||||||||||||||||||||||||||||||||| |||||||||||||||||
Db 304 GTTCTTCTTCCGTCTTCTTGTGCTTCTACTGTCACAGCTGTGCCTGTCGATGCTTCAAAA 363
Qy 241 TCCATGTCTTTTTTCAACCAAGAAACTCTTCAGCAGCGTCTTCAAACCCTCATTGATGGT 300
|| ||||||| ||||||||||||||||||||| |||||||| ||||||||||||||||||
Db 364 TCGATGTCTTATTTCAACCAAGAAACTCTTCAACAGCGTCTCCAAACCCTCATTGATGGT 423
Qy 301 GCTCGTGAGACGTGGACCTATGCCATCTTTTGGCAGTCATCCGTCGTTGATTTATCGAGT 360
|||||||| ||||||||||| ||||| ||||||||||||||||| ||||||||| |||||
Db 424 GCTCGTGAAACGTGGACCTACGCCATATTTTGGCAGTCATCCGTTGTTGATTTAACGAGT 483
Qy 361 CCGTTTGTGTTGGGCTGGGGAGATGGTTACTACAAAGGTGAAGAAGATAAAGCCAATAGG 420
||| || |||||| ||||||||||||||||||||||||||||||||||||||||||||||
Db 484 CCGATTTTGTTGGTCTGGGGAGATGGTTACTACAAAGGTGAAGAAGATAAAGCCAATAGG 543
Qy 421 AAATTAGCTGTTTCTTCTCCTGCTTATATTGCTGAGCAAGAACACCGAAAAAAGGTTCTC 480
||||||||||||||||||||||||||||| ||||||||||||||||| ||||||||||||
Db 544 AAATTAGCTGTTTCTTCTCCTGCTTATATAGCTGAGCAAGAACACCGGAAAAAGGTTCTC 603
Qy 481 CGGGAGCTGAATTCGTTGATCTCCGGCACGCAAACCGGCACTGATGATGCCGTCGATGAA 540
|| ||||||||||||||||||||||||||||||||||||||| |||||||||||||||||
Db 604 CGTGAGCTGAATTCGTTGATCTCCGGCACGCAAACCGGCACTAATGATGCCGTCGATGAA 663
Qy 541 GAAGTTACCGACACTGAATGGTTCTTCCTTATTTCCATGACCCAATCGTTTGTTAACGGA 600
||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||||
Db 664 GAAGTTACCGACACTGAATGGTTCTTCCTTATTTCCATGACCCCATCGTTTGTTAACGGA 723
Qy 601 AGTGGGCTTCCGGGTCAGGCCTTATACAATTCCAGCCCTATTTGGGTCGCCGGAGCAGAG 660
|||||||||||||||||||||||||||||||||||||||||||||||| ||||||||||
Db 724 AGTGGGCTTCCGGGTCAGGCCTTATACAATTCCAGCCCTATTTGGGTCTTCGGAGCAGAG 783
Qy 661 AAATTGGCAGCTTCCCACTGCGAACGGGCTCGGCAGGCCCAGGGATTCGGGCTTCAGACG 720
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 784 AAATTGGCAGCTTCCCACTGCGAACGGGCTCGGCAGGCCCAGGGATTCGGGCTTCAGACA 843
Qy 721 ATGGTTTGTATTCCTTCAGCAAACGGCGTGGTTGAATTGGGCTCCACGGAGTTGATAATC 780
|||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||
Db 844 ATGGTTTGTATTCCTTCAGCAAACGGCGTGGTTGAATTGGGCTCCACGGAGTTGATTATT 903
Qy 781 CAGAGTTGTGATCTCATGAACAAGGTTAGAGTATTGTTTAACTTCAATAATGATTTGGGC 840
||||||| |||| |||| ||||||||||||||||||||||||||||||||||||||||||
Db 904 CAGAGTTCTGATATCATCAACAAGGTTAGAGTATTGTTTAACTTCAATAATGATTTGGGC 963
Qy 841 TCTGGTTCGTGGGCTGTGCAGCCCGAGAGCGATCCGTCCGCTCTTTGGCTCACTGATCCA 900
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 964 TCTGGTTCGTGGGCTGTGCAGCCCGAGAGCGATCCGTCCGCTCTTTGGCTCACTGATCCA 1023
Qy 901 TCGTCTGCAGCTGTAGAAGTCCAAGATTTAAATACAGTTAAGGCAAATTCAGTTCCATCA 960
||| ||||||||||| || ||||||||||||||||| ||||||||||||||||| ||
Db 1024 TCGCCTGCAGCTGTACCTGTGAAAGATTTAAATACAGTTGAGGCAAATTCAGTTCCACCA 1083
Qy 961 AGTAATAGTAGTAAGCAAGTTGTGTTTGATAATGAGAATAATGGTCACAGTTCTGATAAT 1020
|||||||||||||||||| |||||||||||||||||||||||||||| |||| |||||||
Db 1084 AGTAATAGTAGTAAGCAACTTGTGTTTGATAATGAGAATAATGGTCAAAGTTGTGATAAT 1143
Qy 1021 CAGCAACAGCAGCATTCTAAGCATGAAACACAAGGATTTTTCACAAGGGAGTTGAATTTT 1080
||||||||||| |||||| |||| |||||||||||||||||||||||||||||||||||
Db 1144 CAGCAACAGCACCATTCTCAGCAACAAACACAAGGATTTTTCACAAGGGAGTTGAATTTT 1203
Qy 1081 TCAGAATTTGGGTTTGATGGAAGTAGTAATAATAGGAATGGGAATTCATCACTTTCTTGC 1140
|||||||| |||||||||||| ||| ||||| ||||||||| ||||||||| ||||||||
Db 1204 TCAGAATTCGGGTTTGATGGATGTAATAATATTAGGAATGGTAATTCATCAGTTTCTTGC 1263
Qy 1141 AAGCCAGAGTCGGGGGAAATCTTGAATTTTGGTGATAGTACTAAGAAAAGTGCAAATGGG 1200
|||||||||||||||||||||||||||||| ||||||| ||||||||||||||||||||
Db 1264 AAGCCAGAGTCGGGGGAAATCTTGAATTTTTGTGATAGCCCTAAGAAAAGTGCAAATGGG 1323
Qy 1201 AACTTATTTTCGGGTCAGTCCCATTTTGGGGCAGGGGAGGAGAATAAGAACAAGAAAAGG 1260
|||||||||||| |||||||||||||||||||||||||||||||||||||||||||||||
Db 1324 AACTTATTTTCGTGTCAGTCCCATTTTGGGGCAGGGGAGGAGAATAAGAACAAGAAAAGG 1383
Qy 1261 TCACCTGCTTCCAGAGGAAGCAATGAAGAAGGAATGCTTTCATTTGTTTCGGGTACAATC 1320
||| |||||||||||||||||||||||||||||||||||||||||||||| |||||||||
Db 1384 TCAGCTGCTTCCAGAGGAAGCAATGAAGAAGGAATGCTTTCATTTGTTTCAGGTACAATC 1443
Qy 1321 TTGCCTGCAGCTTCTGGTGCGATGAAGTCAAGTGGAGGTGTAGGTGAAG---ACTCTGAT 1377
||||||||||||||||||||||||||||||| |||| | || | ||||| |||||||
Db 1444 TTGCCTGCAGCTTCTGGTGCGATGAAGTCAATTGGATGCGTCGCTGAAGGCTCCTCTGAT 1503
Qy 1378 CATTCGGATCTTGAGGCCTCAGTGGTGAAAGAAGCTGAAAGTAGTAGAGTTGTAGAACCC 1437
||||| ||||||||||||||| ||||||||||||||||||||||||||||||||||||||
Db 1504 CATTCAGATCTTGAGGCCTCACTGGTGAAAGAAGCTGAAAGTAGTAGAGTTGTAGAACCC 1563
Qy 1438 GAAAAGAGGCCAAAGAAGCGAGGAAGGAAGCCAGCAAATGGACGGGAGGAACCTTTGAAT 1497
|||||||||||||||||||||||||||||||||||||||||||| |||||||||||||||
Db 1564 GAAAAGAGGCCAAAGAAGCGAGGAAGGAAGCCAGCAAATGGACGTGAGGAACCTTTGAAT 1623
Qy 1498 CACGTCGAAGCAGAGAGGCAAAGGAGAGAGAAATTAAACCAAAGGTTCTACGCATTAAGA 1557
||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||||
Db 1624 CACGTCGAAGCAGAGAGGCAAAGGAGAGAGAAATTAAACCAAAGGTTCTACGCTTTAAGA 1683
Qy 1558 GCTGTTGTTCCGAATGTGTCCAAGATGGACAAGGCATCACTGCTTGGAGATGCAATTTCA 1617
||||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||
Db 1684 GCTGTTGTTCCGAATGTGTCCAAAATGGACAAGGCATCACTGCTTGGAGATGCAATTTCA 1743
Qy 1618 TATATTAATGAGCTGAAGTTGAAGCTTCAAAATACAGAAACAGATAGAGAAGAATTGAAG 1677
||||||||||||||||||||||||||||||||||||||||||||||| ||| | ||||||
Db 1744 TATATTAATGAGCTGAAGTTGAAGCTTCAAAATACAGAAACAGATAGGGAAAACTTGAAG 1803
Qy 1678 AGCCAAATAGAAGATTTAAAGAAAGAATTAGTTAGTAAAGACTCAAGGCGCCCTGGTCCT 1737
||||||||||||||||| ||||||||||||| ||||||||||||||||||||||||||||
Db 1804 AGCCAAATAGAAGATTTGAAGAAAGAATTAGCTAGTAAAGACTCAAGGCGCCCTGGTCCT 1863
Qy 1738 CCACCATCAAATCATGATCACAAGATGTCTAGCCATACTGGAAGCAAGATTGTAGACGTG 1797
|||||| ||||||| |||||||||||||||||||||||||| |||||| ||||||| |||
Db 1864 CCACCACCAAATCAAGATCACAAGATGTCTAGCCATACTGGGAGCAAGGTTGTAGATGTG 1923
Qy 1798 GATATAGATGTTAAGATAATTGGATGGGATGCGATGATTCGTATACAATGTAATAAAAAG 1857
||||||||||||||| ||||||||||||||||||||||| || ||||||||||||||||
Db 1924 GATATAGATGTTAAGGTAATTGGATGGGATGCGATGATTAGTGTACAATGTAATAAAAAT 1983
Qy 1858 AATCATCCAGCTGCAAGGTTAATGGTAGCCCTCAAGGAGTTAGATCTAGATGTGCACCAT 1917
|| || ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 1984 AACCACCCAGCTGCAAGGTTAATGGTAGCCCTCAAGGAGTTAGATCTAGATGTGCACCAT 2043
Qy 1918 GCCAGTGTTTCAGTGGTGAACGATTTGATGATCCAACAAGCCACTGTGAAAATGGGTAGC 1977
|||||||||||||||||||||||||||||||||||||||||||| |||||||||||||||
Db 2044 GCCAGTGTTTCAGTGGTGAACGATTTGATGATCCAACAAGCCACAGTGAAAATGGGTAGC 2103
Qy 1978 AGACTTTACACGGAAGAGCAACTTAGGATAGCATTGACATCCAGAGTTGCTGAAACACGC 2037
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 2104 AGACTTTACACGGAAGAGCAACTTAGGATAGCATTGACATCCAGAGTTGCTGAAACACGC 2163
Qy 2038 TAA 2040
|||
Db 2164 TAA 2166
Alignment of the polypeptide encoded by the nucleic acid sequence of SEQ ID NO: 1 from Page et al with SEQ ID NO: 1 of the instant invention
US-13-464-212-3
; Sequence 3, Application US/13464212
; Patent No. 8624083
; GENERAL INFORMATION
; APPLICANT: NATIONAL RESEARCH COUNCIL OF CANADA
; APPLICANT:PAGE, JONATHAN
; APPLICANT:TODD, ANDREA T.
; TITLE OF INVENTION: NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING
; TITLE OF INVENTION:ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM
; FILE REFERENCE: 045952-0175
; CURRENT APPLICATION NUMBER: US/13/464,212
; CURRENT FILING DATE: 2012-07-19
; PRIOR APPLICATION NUMBER: PCT/IB2008/003131
; PRIOR FILING DATE: 2008-05-23
; PRIOR APPLICATION NUMBER: 60/924,675
; PRIOR FILING DATE: 2007-05-25
; NUMBER OF SEQ ID NOS: 21
; SOFTWARE: PatentIn version 3.5
; SEQ ID NO 3
; LENGTH: 680
; TYPE: PRT
; ORGANISM: Nicotiana benthamiana
US-13-464-212-3
Alignment Scores:
Length: 680
Score: 3159.50 Matches: 620
Percent Similarity: 94.6% Conservative: 23
Best Local Similarity: 91.2% Mismatches: 36
Query Match: 88.8% Indels: 1
DB: 5 Gaps: 1
US-14-311-684-1 (1-2040) x US-13-464-212-3 (1-680)
Qy 1 ATGACTGATTACAGCTTACCCACCATGAATTTGTGGAATACTAGTGGTACTACCGATGAC 60
|||||||||||| |||||||||||||||||||||||| ||||||:::|||||||||
Db 1 MetThrAspTyrArgLeuProThrMetAsnLeuTrpAsnAlaSerGlySerThrAspAsp 20
Qy 61 AACGTTTCTATGATGGAATCTTTTATGTCTTCTGATCTCACTTCATTTTGGGCTACTTCT 120
||||||||||||||||||::: :::||||||||||||||||||||| |||||||||
Db 21 AsnValSerMetMetGluAlaLeuIleSerSerAspLeuThrSerPheCysAlaThrSer 40
Qy 121 AATTCTACTACTGCTGCTGTTACCTCTAATTCTAATCTTATTCCAGTTAATACCCTAACT 180
||||||::: ||||||:::|||:::||||||||| ||||||||||||||| |||
Db 41 AsnSerSerAlaAlaAlaIleThrAlaAsnSerAsnHisIleProValAsnThrArgThr 60
Qy 181 GTTCTTCTTCCGTCTTCTTGTGCTTCTACTGTCACAGCTGTGGCTGTCGATGCTTCAAAA 240
|||||||||||||||||||||||||||||||||||||||||| |||||||||||||||
Db 61 ValLeuLeuProSerSerCysAlaSerThrValThrAlaValProValAspAlaSerLys 80
Qy 241 TCCATGTCTTTTTTCAACCAAGAAACTCTTCAGCAGCGTCTTCAAACCCTCATTGATGGT 300
|||||||||:::||||||||||||||||||||||||||||||||||||||||||||||||
Db 81 SerMetSerTyrPheAsnGlnGluThrLeuGlnGlnArgLeuGlnThrLeuIleAspGly 100
Qy 301 GCTCGTGAGACGTGGACCTATGCCATCTTTTGGCAGTCATCCGTCGTTGATTTATCGAGT 360
||||||||||||||||||||||||||||||||||||||||||||||||||||||:::|||
Db 101 AlaArgGluThrTrpThrTyrAlaIlePheTrpGlnSerSerValValAspLeuThrSer 120
Qy 361 CCGTTTGTGTTGGGCTGGGGAGATGGTTACTACAAAGGTGAAGAAGATAAAGCCAATAGG 420
||| :::||| |||||||||||||||||||||||||||||||||||||||||||||
Db 121 ProIleLeuLeuValTrpGlyAspGlyTyrTyrLysGlyGluGluAspLysAlaAsnArg 140
Qy 421 AAATTAGCTGTTTCTTCTCCTGCTTATATTGCTGAGCAAGAACACCGAAAAAAGGTTCTC 480
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 141 LysLeuAlaValSerSerProAlaTyrIleAlaGluGlnGluHisArgLysLysValLeu 160
Qy 481 CGGGAGCTGAATTCGTTGATCTCCGGCACGCAAACCGGCACTGATGATGCCGTCGATGAA 540
||||||||||||||||||||||||||||||||||||||||||:::|||||||||||||||
Db 161 ArgGluLeuAsnSerLeuIleSerGlyThrGlnThrGlyThrAsnAspAlaValAspGlu 180
Qy 541 GAAGTTACCGACACTGAATGGTTCTTCCTTATTTCCATGACCCAATCGTTTGTTAACGGA 600
|||||||||||||||||||||||||||||||||||||||||| |||||||||||||||
Db 181 GluValThrAspThrGluTrpPhePheLeuIleSerMetThrProSerPheValAsnGly 200
Qy 601 AGTGGGCTTCCGGGTCAGGCCTTATACAATTCCAGCCCTATTTGGGTCGCCGGAGCAGAG 660
|||||||||||||||||||||||||||||||||||||||||||||||| |||||||||
Db 201 SerGlyLeuProGlyGlnAlaLeuTyrAsnSerSerProIleTrpValPheGlyAlaGlu 220
Qy 661 AAATTGGCAGCTTCCCACTGCGAACGGGCTCGGCAGGCCCAGGGATTCGGGCTTCAGACG 720
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 221 LysLeuAlaAlaSerHisCysGluArgAlaArgGlnAlaGlnGlyPheGlyLeuGlnThr 240
Qy 721 ATGGTTTGTATTCCTTCAGCAAACGGCGTGGTTGAATTGGGCTCCACGGAGTTGATAATC 780
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 241 MetValCysIleProSerAlaAsnGlyValValGluLeuGlySerThrGluLeuIleIle 260
Qy 781 CAGAGTTGTGATCTCATGAACAAGGTTAGAGTATTGTTTAACTTCAATAATGATTTGGGC 840
|||||| |||::::::||||||||||||||||||||||||||||||||||||||||||
Db 261 GlnSerSerAspIleIleAsnLysValArgValLeuPheAsnPheAsnAsnAspLeuGly 280
Qy 841 TCTGGTTCGTGGGCTGTGCAGCCCGAGAGCGATCCGTCCGCTCTTTGGCTCACTGATCCA 900
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 281 SerGlySerTrpAlaValGlnProGluSerAspProSerAlaLeuTrpLeuThrAspPro 300
Qy 901 TCGTCTGCAGCTGTAGAAGTCCAAGATTTAAATACAGTTAAGGCAAATTCAGTTCCATCA 960
||| ||||||||| |||:::|||||||||||||||:::|||||||||||||||
Db 301 SerProAlaAlaValProValLysAspLeuAsnThrValGluAlaAsnSerValProPro 320
Qy 961 AGTAATAGTAGTAAGCAAGTTGTGTTTGATAATGAGAATAATGGTCACAGTTCTGATAAT 1020
||||||||||||||||||:::|||||||||||||||||||||||| ||| ||||||
Db 321 SerAsnSerSerLysGlnLeuValPheAspAsnGluAsnAsnGlyGlnSerCysAspAsn 340
Qy 1021 CAGCAACAGCAGCATTCTAAGCATGAAACACAAGGATTTTTCACAAGGGAGTTGAATTTT 1080
||||||||| ||||||::: :::|||||||||||||||||||||||||||||||||
Db 341 GlnGlnGlnHisHisSerGlnGlnGlnThrGlnGlyPhePheThrArgGluLeuAsnPhe 360
Qy 1081 TCAGAATTTGGGTTTGATGGAAGTAGTAATAATAGGAATGGGAATTCATCACTTTCTTGC 1140
||||||||||||||||||||| :::||| ||||||||||||||||||:::||||||
Db 361 SerGluPheGlyPheAspGlyCysAsnAsnIleArgAsnGlyAsnSerSerValSerCys 380
Qy 1141 AAGCCAGAGTCGGGGGAAATCTTGAATTTTGGTGATAGTACTAAGAAAAGTGCAAATGGG 1200
|||||||||||||||||||||||||||||| |||||| ||||||||||||||||||
Db 381 LysProGluSerGlyGluIleLeuAsnPheCysAspSerProLysLysSerAlaAsnGly 400
Qy 1201 AACTTATTTTCGGGTCAGTCCCATTTTGGGGCAGGGGAGGAGAATAAGAACAAGAAAAGG 1260
|||||||||||| |||||||||||||||||||||||||||||||||||||||||||||
Db 401 AsnLeuPheSerCysGlnSerHisPheGlyAlaGlyGluGluAsnLysAsnLysLysArg 420
Qy 1261 TCACCTGCTTCCAGAGGAAGCAATGAAGAAGGAATGCTTTCATTTGTTTCGGGTACAATC 1320
||| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 421 SerAlaAlaSerArgGlySerAsnGluGluGlyMetLeuSerPheValSerGlyThrIle 440
Qy 1321 TTGCCTGCAGCTTCTGGTGCGATGAAGTCAAGTGGAGGTGTAGGTGAA---GACTCTGAT 1377
|||||||||||||||||||||||||||||| ||| ||| ||| ||||||
Db 441 LeuProAlaAlaSerGlyAlaMetLysSerIleGlyCysValAlaGluGlySerSerAsp 460
Qy 1378 CATTCGGATCTTGAGGCCTCAGTGGTGAAAGAAGCTGAAAGTAGTAGAGTTGTAGAACCC 1437
|||||||||||||||||||||:::||||||||||||||||||||||||||||||||||||
Db 461 HisSerAspLeuGluAlaSerLeuValLysGluAlaGluSerSerArgValValGluPro 480
Qy 1438 GAAAAGAGGCCAAAGAAGCGAGGAAGGAAGCCAGCAAATGGACGGGAGGAACCTTTGAAT 1497
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 481 GluLysArgProLysLysArgGlyArgLysProAlaAsnGlyArgGluGluProLeuAsn 500
Qy 1498 CACGTCGAAGCAGAGAGGCAAAGGAGAGAGAAATTAAACCAAAGGTTCTACGCATTAAGA 1557
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 501 HisValGluAlaGluArgGlnArgArgGluLysLeuAsnGlnArgPheTyrAlaLeuArg 520
Qy 1558 GCTGTTGTTCCGAATGTGTCCAAGATGGACAAGGCATCACTGCTTGGAGATGCAATTTCA 1617
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 521 AlaValValProAsnValSerLysMetAspLysAlaSerLeuLeuGlyAspAlaIleSer 540
Qy 1618 TATATTAATGAGCTGAAGTTGAAGCTTCAAAATACAGAAACAGATAGAGAAGAATTGAAG 1677
||||||||||||||||||||||||||||||||||||||||||||||||||| ||||||
Db 541 TyrIleAsnGluLeuLysLeuLysLeuGlnAsnThrGluThrAspArgGluAsnLeuLys 560
Qy 1678 AGCCAAATAGAAGATTTAAAGAAAGAATTAGTTAGTAAAGACTCAAGGCGCCCTGGTCCT 1737
|||||||||||||||||||||||||||||| |||||||||||||||||||||||||||
Db 561 SerGlnIleGluAspLeuLysLysGluLeuAlaSerLysAspSerArgArgProGlyPro 580
Qy 1738 CCACCATCAAATCATGATCACAAGATGTCTAGCCATACTGGAAGCAAGATTGTAGACGTG 1797
|||||| ||| |||||||||||||||||||||||||||||||||:::|||||||||
Db 581 ProProProAsnGlnAspHisLysMetSerSerHisThrGlySerLysValValAspVal 600
Qy 1798 GATATAGATGTTAAGATAATTGGATGGGATGCGATGATTCGTATACAATGTAATAAAAAG 1857
|||||||||||||||:::||||||||||||||||||||| :::||||||||||||
Db 601 AspIleAspValLysValIleGlyTrpAspAlaMetIleSerValGlnCysAsnLysAsn 620
Qy 1858 AATCATCCAGCTGCAAGGTTAATGGTAGCCCTCAAGGAGTTAGATCTAGATGTGCACCAT 1917
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 621 AsnHisProAlaAlaArgLeuMetValAlaLeuLysGluLeuAspLeuAspValHisHis 640
Qy 1918 GCCAGTGTTTCAGTGGTGAACGATTTGATGATCCAACAAGCCACTGTGAAAATGGGTAGC 1977
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 641 AlaSerValSerValValAsnAspLeuMetIleGlnGlnAlaThrValLysMetGlySer 660
Qy 1978 AGACTTTACACGGAAGAGCAACTTAGGATAGCATTGACATCCAGAGTTGCTGAAACACGC 2037
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Db 661 ArgLeuTyrThrGluGluGlnLeuArgIleAlaLeuThrSerArgValAlaGluThrArg 680