Prosecution Insights
Last updated: May 29, 2026
Application No. 18/760,074

METHOD OF USING MULTIPARAMETRIC IMAGING DATA TO DIAGNOSE DISEASE STATES AND TO MONITOR THEIR PROGRESSION

Non-Final OA §112
Filed
Jul 01, 2024
Priority
Feb 03, 2021 — provisional 63/145,118 +1 more
Examiner
PENG, BO JOSEPH
Art Unit
3797
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
UNIVERSITY OF ROCHESTER
OA Round
2 (Non-Final)
70%
Grant Probability
Favorable
2-3
OA Rounds
1y 8m
Est. Remaining
83%
With Interview

Examiner Intelligence

Grants 70% — above average
70%
Career Allowance Rate
528 granted / 759 resolved
At TC average
Moderate +13% lift
Without
With
+13.1%
Interview Lift
resolved cases with interview
Typical timeline
3y 7m
Avg Prosecution
28 currently pending
Career history
793
Total Applications
across all art units

Statute-Specific Performance

§101
2.2%
-37.8% vs TC avg
§103
78.9%
+38.9% vs TC avg
§102
3.8%
-36.2% vs TC avg
§112
6.2%
-33.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 759 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 22, 27-28 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. In re claim 22, “a function of time is first mentioned in “ b… the modality parameters as a function of time,” so it is unclear what the metes and bounds of a function of time in: a) the measured parameters as function of time in f, b) the parameter as a function of time in h. Are all the “function of time” the same? Or different? Or anything else? It is unclear what the metes and bounds of “the parameter” in h are. There are the modality parameters, measured parameters and live parameters. So what is the parameter referring to? Is “trajectories taken from the training set of images” in g the same as “trajectories taken from the training set of images” of e? If they are the same, then the one in g should have “the” in the front. In g, “the trajectories from the living subject” lacks antecedent basis. In h, it is unclear what the metes and bounds of “each trajectory” are. Which trajectory is being colored? It is unclear what the parameter is referring to. What are the metes and bounds of “relates”? In re claim 27, it is still unclear what the “preexisting trajectories” are. The “preexisting trajectories” lack antecedent basis. It seems that claim 27 is same the claim 22’s e. In re claim 28, claim 22 already recites every limitation of claim 28, then claim 28 is not further limiting. The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. Claims 27-28 arerejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. As shown above in the rejection of 112(b), claims 27 and claim 28 are reciting the same limitation of claim 22. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. Response to Arguments Applicant’s amendments have not resolved any previous 112 rejection. At the same time, Applicant has now included some dependent claims with previous 112 rejection into the independent claim. Such amendment has introduced new 112 rejections as shown above. Due to many unclearness of these claim limitations, proper art searches cannot be provided until some of these 112 rejections are fully resolved. Conclusion Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to BO JOSEPH PENG whose telephone number is (571)270-1792. The examiner can normally be reached Monday thru Friday: 8:00 AM-5:00 PM EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, KEITH M RAYMOND can be reached at (571)270-1790. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BO JOSEPH PENG/Primary Examiner, Art Unit 3798
Read full office action

Prosecution Timeline

Jul 01, 2024
Application Filed
Jul 01, 2025
Non-Final Rejection mailed — §112
Sep 19, 2025
Response Filed
Dec 19, 2025
Final Rejection mailed — §112
Jan 29, 2026
Response after Non-Final Action

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

2-3
Expected OA Rounds
70%
Grant Probability
83%
With Interview (+13.1%)
3y 7m (~1y 8m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 759 resolved cases by this examiner. Grant probability derived from career allowance rate.

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