Prosecution Insights
Last updated: August 14, 2026
Application No. 18/775,040

CARBOXYLIC ACID-DERIVED KETO-DIESTERS AND USES THEREOF

Non-Final OA §102§103§DP
Filed
Jul 17, 2024
Priority
Jul 20, 2023 — provisional 63/514,591
Examiner
PHAN, DOAN THI-THUC
Art Unit
1613
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
University of Mississippi
OA Round
1 (Non-Final)
43%
Grant Probability
Moderate
1-2
OA Rounds
1y 1m
Est. Remaining
91%
With Interview

Examiner Intelligence

Grants 43% of resolved cases
43%
Career Allowance Rate
277 granted / 650 resolved
-17.4% vs TC avg
Strong +48% interview lift
Without
With
+48.0%
Interview Lift
resolved cases with interview
Typical timeline
3y 2m
Avg Prosecution
51 currently pending
Career history
744
Total Applications
across all art units

Statute-Specific Performance

§101
0.9%
-39.1% vs TC avg
§103
46.7%
+6.7% vs TC avg
§102
10.5%
-29.5% vs TC avg
§112
25.6%
-14.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 650 resolved cases

Office Action

§102 §103 §DP
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Priority This application has PRO of 63514591 filed 07/20/2023. Accordingly, claims 1-14 are afforded the effective filing date of 07/20/2023. Information Disclosure Statement The information disclosure statement (IDS) submitted on 11/13/2024 has been considered by the examiner and initialed copies of the IDS are included with the mailing of this office action. Election/Restrictions Applicant's election with traverse of Group I, claims 1-4, in the reply filed on 05/14/2026 is acknowledged. Applicant also elected with traverse, the keto-diester of formula III-6 (5-(3-phenylpropanoyl)-2,2-dipropyl-1,3-dioxane-4,6-dione) as disclosed on page 23 of the specification, as the species of compound having formula (VIII). The traversal is on the ground(s) that “the claims of alleged Groups II and III depend directly or indirectly from the claims of alleged Group I. Thus, the compounds of alleged Group I are not distinct from the process of making such compounds as in alleged Group II, or of using such compounds as in alleged Group III.” (Remarks, bottom of page 5 to page 6). This is not found persuasive because as discussed in the Restriction filed 04/13/2026, while the methods of Groups II and III are drawn to a method of making the compound of claim 1 and a method of using the compound of claim 1, respectively, the methods of Groups II and III and the product of Group I remained independent or distinct for the reasons discussed on pages 2-4 of the Restriction, said pages being incorporated herein its entirety. Furthermore, as discussed in the Restriction, in addition to Groups II and III being independent or distinct (as discussed supra), there would also be a serious search and/or examination burden if restriction were not required because of at least the following reason: (C) A different field of search: Where it is necessary to search for one of the inventions in a manner that is not likely to result in finding art pertinent to the other invention(s) (e.g., searching different classes/subclasses or electronic resources, or employing different search queries, a different field of search is shown, even though the two are classified together. The indicated different field of search must in fact be pertinent to the type of subject matter covered by the claims. Patents need not be cited to show different fields of search. Accordingly, for at least the reasons discussed above and in the Restriction filed 04/13/2026, the Restriction for examination purposes as indicated is deemed proper. With respect to the election of species, upon further consideration, the Examiner hereby withdraws the election of species requirement and extend the search to all species of compound having formula (VIII) of claim 1. The requirement is still deemed proper and is therefore made FINAL. Claims 5-14 are withdrawn from further consideration pursuant to 37 CFR 1.142(b), as being drawn to nonelected groups/inventions, there being no allowable generic or linking claim. Applicant timely traversed the restriction (election) requirement in the reply filed on 05/14/2026. Status of the Claims Claims 1-14 are pending in this instant application, of which claims 5-14 are withdrawn at this time being drawn to a nonelected groups/inventions. Claims 1-4 are examined herein on the merits for patentability. Claim Objections Claim 3 is objected to because of the following informalities: please amend “A composition” to “The composition” so that there is proper antecedent basis to composition of claim 2. Appropriate correction is required. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(2) the claimed invention was described in a patent issued under section 151, or in an application for patent published or deemed published under section 122(b), in which the patent or application, as the case may be, names another inventor and was effectively filed before the effective filing date of the claimed invention. Claim(s) 1 and 2 is/are rejected under 35 U.S.C. 102(a)(2) as being anticipated by Heslop-Harrison et al (WO 2024/009078 A1; filing date: 04 July 2023). Regarding claim 1, Heslop-Harrison teaches a compound of formula (I): PNG media_image1.png 166 300 media_image1.png Greyscale , wherein R1a and R1b are independent selected from hydrogen and C1-4 alkyl; X1 and X2 are independently O; R2 and R3 are absent when the oxygen atom to which they are attached forms a carbonyl group with the carbon ring member of ring A; L1 is -CH2-CH2-; and Ar1 is a 6-membered carbocyclic aromatic group (pages 1, 5, and 12-15; claims 1 and 2), which reads on the following structures: PNG media_image2.png 114 160 media_image2.png Greyscale and PNG media_image3.png 138 174 media_image3.png Greyscale , thereby reading on the compound having formula (VIII) as recited in claim 1. Regarding claim 2, Heslop-Harrison teaches a composition comprising the compound of formula (I) and at least one carrier and/or surfactant (pages 14-15). As a result, the aforementioned teachings from Heslop-Harrison are anticipatory to claims 1 and 2 of the instant invention. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. Claim(s) 1-2 is/are rejected under 35 U.S.C. 103 as being unpatentable over Heslop-Harrison et al (WO 2024/009078 A1; filing date: 04 July 2023). Assuming arguendo that the aforementioned teachings from Heslop-Harrison do not anticipate the claimed invention, claim 1 alternatively would have been considered obvious under the meaning of 35 USC 103(a) because Heslop-Harrison teaches a compound of formula (I): PNG media_image1.png 166 300 media_image1.png Greyscale , wherein R1a and R1b are independent selected from hydrogen and C1-4 alkyl; X1 and X2 are independently O; R2 and R3 are absent when the oxygen atom to which they are attached forms a carbonyl group with the carbon ring member of ring A; L1 is -CH2-CH2-; and Ar1 is a 6-membered carbocyclic aromatic group (pages 1, 5, and 12-15; claims 1 and 2). The selections of R1a, R1b, X1, X2, R2, R3, L1, and Ar1 as described above for formula (I) is from a very short list of a handful of members for R1a, R1b, X1, X2, R2, R3, L1, and Ar1 groups and thus, given that the subgenus of formula (I) from Heslop-Harrison is so small that when considered in light of the totality of the circumstance, it would anticipate the claimed species, as one skilled in the art would have envisage each member of the subgenus from formula (I) of Heslop-Harrison. Furthermore, Heslop-Harrison teaches the compound of formula (I) is also used for improving crop quality and weed control (claim 2). Per MPEP §2144.08 (II)(4) (a)-(d), "[w]hen chemical compounds have ‘very close’ structural similarities and similar utilities, without more a prima facie case may be made."). Thus, evidence of similar properties or evidence of any useful properties disclosed in the prior art that would be expected to be shared by the claimed invention weighs in favor of a conclusion that the claimed invention would have been obvious. Dillon, 919 F.2d at 697-98, 16 USPQ2d at 1905; In re Wilder, 563 F.2d 457, 461, 195 USPQ 426, 430 (CCPA 1977); In re Lintner, 458 F.2d 1013, 1016, 173 USPQ 560, 562 (CCPA 1972). Regarding claim 2, Heslop-Harrison teaches a composition comprising the compound of formula (I) and at least one carrier and/or surfactant (pages 14-15). From the teachings of the reference, it is apparent that one of ordinary skill in the art would have had a reasonable expectation of success in producing the claimed invention. Therefore, the invention as a whole was prima facie obvious to one of ordinary skill in the art before the effective filing date of Applicant’s invention, as evidenced by the references, especially in the absence of evidence to the contrary. Claim(s) 1-4 is/are rejected under 35 U.S.C. 103 as being unpatentable over (Heslop-Harrison et al (WO 2024/009078 A1; filing date: 04 July 2023), and further in view of Yuan et al (WO 2022/078494A1; citation and English translation via US 2024/0284912 A1). The compound of claim 1 and the composition of claim 2 are discussed above, said discussion being incorporated herein in its entirety. Regarding claims 3 and 4, Yuan teaches a composition comprising herbicides and other active ingredients such as other herbicides, insecticides, fungicides, bactericides, nematocides, or mixtures thereof, and agricultural carriers, wherein the composition is used for providing a greater spectrum of weed control (Abstract; [0011], [0063], [0073], [0078], and [0089]). It would have been obvious to one of ordinary skill in the art to include other active ingredients such as other herbicides, insecticides, fungicides, bactericides, nematocides, or mixtures thereof in the composition of Heslop-Harrison, and produce the claimed invention. One of ordinary skill in the art would have been motivated to do so because the compound in the composition of Heslop-Harrison is used for improving crop quality and weed control (Heslop-Harrison: claim 2) and the composition of Yuan is also used for weed control (Yuan: [0063] and [0078]). Thus, an ordinary artisan seeking to provide a greater spectrum of weed control would have looked to include other active ingredients such as other herbicides, insecticides, fungicides, bactericides, nematocides, or mixtures thereof, in the composition of Heslop-Harrison, per guidance from Yuan, and achieve Applicant’s claimed invention with reasonable expectation of success. From the teachings of the references, it is apparent that one of ordinary skill in the art would have had a reasonable expectation of success in producing the claimed invention. Therefore, the invention as a whole was prima facie obvious to one of ordinary skill in the art before the effective filing date of Applicant’s invention, as evidenced by the references, especially in the absence of evidence to the contrary. Double Patenting The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on nonstatutory double patenting provided the reference application or patent either is shown to be commonly owned with the examined application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP § 2146 et seq. for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b). The filing of a terminal disclaimer by itself is not a complete reply to a nonstatutory double patenting (NSDP) rejection. A complete reply requires that the terminal disclaimer be accompanied by a reply requesting reconsideration of the prior Office action. Even where the NSDP rejection is provisional the reply must be complete. See MPEP § 804, subsection I.B.1. For a reply to a non-final Office action, see 37 CFR 1.111(a). For a reply to final Office action, see 37 CFR 1.113(c). A request for reconsideration while not provided for in 37 CFR 1.113(c) may be filed after final for consideration. See MPEP §§ 706.07(e) and 714.13. The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/patent/patents-forms. The actual filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to www.uspto.gov/patents/apply/applying-online/eterminal-disclaimer. Claims 1-4 are provisionally rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-4 of copending Application No. 19424296 (reference application). Although the claims at issue are not identical, they are not patentably distinct from each other because the claims in copending Application ‘296 significantly overlap with the subject matter of the instant claims, i.e., a compound having the following formula: PNG media_image4.png 160 170 media_image4.png Greyscale or a herbicidally-effective salt thereof; wherein n is independently 0, 1, 2, 3, 4, or 5; R1 and R2 are independently H or alkyl group; R4 is independently an alkyl chain having 1 carbon atom; and R3 is independently PNG media_image5.png 372 550 media_image5.png Greyscale PNG media_image6.png 22 184 media_image6.png Greyscale Consequently, the ordinary artisan would have recognized the obvious variation of the instant claimed subject matter over copending Application No. 19424296. This is a provisional nonstatutory double patenting rejection because the patentably indistinct claims have not in fact been patented. Conclusion No claim is allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to DOAN THI-THUC PHAN whose telephone number is (571)270-3288. The examiner can normally be reached 8-5 EST Monday-Friday. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Brian Kwon can be reached at 571-272-0581. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /DOAN T PHAN/ Primary Examiner, Art Unit 1613
Read full office action

Prosecution Timeline

Jul 17, 2024
Application Filed
Aug 06, 2026
Non-Final Rejection mailed — §102, §103, §DP (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
43%
Grant Probability
91%
With Interview (+48.0%)
3y 2m (~1y 1m remaining)
Median Time to Grant
Low
PTA Risk
Based on 650 resolved cases by this examiner. Grant probability derived from career allowance rate.

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