Prosecution Insights
Last updated: October 01, 2026
Application No. 18/787,216

INHIBITORS OF MUTANT IDH1 AND IDH2

Non-Final OA §112
Filed
Jul 29, 2024
Priority
Jul 31, 2023 — provisional 63/516,613
Examiner
ROBINSON, MIKHAIL O'DONNEL
Art Unit
Tech Center
Assignee
Board of Regents of the University of Texas System
OA Round
1 (Non-Final)
59%
Grant Probability
Moderate
1-2
OA Rounds
1y 2m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 59% of resolved cases
59%
Career Allowance Rate
77 granted / 130 resolved
-0.8% vs TC avg
Strong +42% interview lift
Without
With
+42.1%
Interview Lift
resolved cases with interview
Typical timeline
3y 4m
Avg Prosecution
47 currently pending
Career history
163
Total Applications
across all art units

Statute-Specific Performance

§101
5.3%
-34.7% vs TC avg
§103
41.0%
+1.0% vs TC avg
§102
21.4%
-18.6% vs TC avg
§112
22.2%
-17.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 130 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 30 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Regarding claim 30, the position of Ra of Formula IC and IIC renders the claim indefinite because it is unclear whether the position of Ra in Formula IC and IIC falls within the scope of claim 1. As claim 30 depends from claim 1, which teaches the above position as Q with the limitations of O, CRcRd and =CRc. The limitations of Ra per claim 1 is relevant to embodiment Z and not Q. Ultimately, the metes and bounds of the claim is unclear. Allowable Subject Matter Claims 1-5, 10, 16-20, 23, 31-32, 35 and 42-45 are free of the arts. Closest prior art is of Bauer et al. (WO 2018111707 A1). Bauer teaches a pharmaceutical composition for the treatment of IDH1 or IDH2 mutant cancer comprising administration of Formula I: PNG media_image1.png 278 538 media_image1.png Greyscale (Pg. 2) and a pharmaceutically acceptable carrier (Pg. 3, lines 19-21). The teachings of Bauer differ from claimed invention of R1 and R2 not connected as per claim 1 of claimed invention. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to MIKHAIL O'DONNEL ROBINSON whose telephone number is (571)270-0777. The examiner can normally be reached Monday-Friday 7:30am-5:30pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Kortney Klinkel can be reached at 571-270-5239. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. MIKHAIL O'DONNEL. ROBINSON Examiner Art Unit 1627 /MIKHAIL O'DONNEL ROBINSON/Examiner, Art Unit 1627 /SARAH PIHONAK/Primary Examiner, Art Unit 1627
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Prosecution Timeline

Jul 29, 2024
Application Filed
Jul 02, 2026
Non-Final Rejection mailed — §112 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
59%
Grant Probability
99%
With Interview (+42.1%)
3y 4m (~1y 2m remaining)
Median Time to Grant
Low
PTA Risk
Based on 130 resolved cases by this examiner. Grant probability derived from career allowance rate.

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