Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claims 1-18 are pending in this application.
Election/Restrictions
Applicant’s election without traverse of Group I and a species W = N in the reply filed on 09/29/2026 is acknowledged.
Claim Rejections - 35 USC § 112
The following is a quotation of 35 U.S.C. 112(b):
(b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention.
The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph:
The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention.
Claims 1-5, 7 and 15 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention:
a. Claim 1 and claims dependent thereon are rejected because the phrase “an isotopically labeled compound” is indefinite. What is covered by “an isotopically labelled compound” and what is not? What does an isotopically labeled compound look like? Where are the examples? The examine recommends that applicants delete said phrase.
b. Claim 1 and claims dependent thereon are rejected because the term “polymorph” is indefinite and unclear. What is covered and what is not? What are the different crystalline forms? Where is the x-ray diffraction data for the polymorph? It is recommended that applicants recite x-ray diffraction data or delete said term from the claims.
c. In claim 3, there is no definition for the variables R11 and R12. The phrase “R11 and R12 are.” appears to be incomplete. The claim ends with the word “are”.
Information Disclosure Statement
5. Applicant’s Information Disclosure Statement, filed on 06/05/2026 and 08/16/2024, has been acknowledged. Please refer to Applicant’s copies of the 1449 submitted herewith.
Claim Objections
6. Claim 5 is objected to because of the following informalities: The chemical structures in claim 5 have faded bonds. Note that the previously deleted compounds 561 and 562 were drawn properly compared to compounds 561 and 562 that are added later (see below).
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178
508
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159
467
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Appropriate correction is required.
Conclusion
7. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Kahsay Habte Ph.D. whose telephone number is (571)272-0667. The examiner can normally be reached on 8:30 - 5:00 PM.
Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice.
If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, JEFFREY MURRAY can be reached on 571-272-9023. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300.
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/Kahsay Habte/
Primary Examiner, Art Unit 1624
October 12, 2026
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