Prosecution Insights
Last updated: July 17, 2026
Application No. 18/841,895

ISOQUINOLINONE COMPOUND, AND PREPARATION METHOD AND USE THEREFOR

Non-Final OA §101§102§112
Filed
Aug 27, 2024
Priority
Feb 28, 2022 — CN 202210191835.4 +1 more
Examiner
KENYON, JOHN S
Art Unit
Tech Center
Assignee
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
OA Round
1 (Non-Final)
80%
Grant Probability
Favorable
1-2
OA Rounds
5m
Est. Remaining
98%
With Interview

Examiner Intelligence

Grants 80% — above average
80%
Career Allowance Rate
755 granted / 941 resolved
+20.2% vs TC avg
Strong +18% interview lift
Without
With
+17.5%
Interview Lift
resolved cases with interview
Typical timeline
2y 4m
Avg Prosecution
48 currently pending
Career history
984
Total Applications
across all art units

Statute-Specific Performance

§101
1.8%
-38.2% vs TC avg
§103
20.0%
-20.0% vs TC avg
§102
25.9%
-14.1% vs TC avg
§112
30.3%
-9.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 941 resolved cases

Office Action

§101 §102 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. Current Status of 18/841,895 This Office Action is responsive to the original claims of 27 August 2024. Original claims 1-10 have been examined on the merits. Priority The effective filing date is 27 March 2023. Receipt is acknowledged of certified copies of papers required by 37 CFR 1.55. Information Disclosure Statement The information disclosure statement (IDS) submitted on 27 August 2024, are in compliance with the provisions of 37 CFR 1.97. Accordingly, the information disclosure statement is being considered by the examiner. Claim Objections Claim 1 is objected to as the claim does not end with a period (instead, it ends with a semi-colon). Please revise accordingly. Claim 3 is objected to as the illustrations are highly pixelated and missing commas in between each compound. Please enlarge each illustration and darken all bonds, heteroatoms, and substituents; also, please add commas in between each compound and the article -- or -- in between the last two compounds. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. Claims 4-6 and 10 are rejected under 35 U.S.C. 101 because the claimed invention is directed to non-statutory subject matter. These rejected claims contain “use” claims. “Use” claims are not statutory claims. Statutory claims are only drawn to methods, machines, manufacture, or compositions-of-matter. The rejected claim(s) do not fall within at least one of the four categories of patent eligible subject matter because “use” claims are not methods, machines, manufacture, or compositions-of-matter. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1-10 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. The claims 4-6 and 10 are drawn to “use” claims. The “use” limitations render the metes and bounds of the claims undefined (hence rendering claims 4-6 and 10 indefinite under 35 USC 112(b)). The artisan does not know if the Applicants intend these “use” claims to be method claims, and if so, what the active/verb (“-ing”) steps are to conduct the objectives stated in these rejected claims. Please either cancel the claims or revise the “use” claims into proper method claims containing an objective and “-ing” ending verbs / steps to conduct the stated objective. Claim 1 contains “i.e.” and parentheticals. This renders the metes and bounds of the claim undefined (hence rendering claim 1 indefinite under 35 USC 112(b)): the artisan does not know if the limitations following “i.e.” and/or the limitations within parentheticals are merely exemplary or are required limitations of the claim. Claims 2-10, which refer back to claim 1, are similarly rejected since these claims do not remedy the rationale underpinning the basis for rejecting claim 1. Claim 2 contains “e.g.” and parentheticals. This renders the metes and bounds of the claim undefined (hence rendering claim 2 indefinite under 35 USC 112(b)): the artisan does not know if the limitations following “e.g.” and/or the limitations within parentheticals are merely exemplary or are required limitations of the claim. Claims 7-10, which refer back to claim 2, are similarly rejected since these claims do not remedy the rationale underpinning the basis for rejecting claim 2. Claim 2 contains “preferably”. This renders the metes and bounds of the claim undefined (hence rendering claim 2 indefinite under 35 USC 112(b)): the artisan does not know if the limitations following “preferably” are merely exemplary or are required limitations of the claim. Claims 7-10, which refer back to claim 2, are similarly rejected since these claims do not remedy the rationale underpinning the basis for rejecting claim 2. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 1-2 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS (American Chemical Society. Chemical Abstract Service. RN 137537-53-2. Entered into STN: 22 November 1991). The prior art reference ACS teaches the compound: PNG media_image1.png 222 292 media_image1.png Greyscale (see enclosed ACS prior art reference), wherein: R1 is a C6cycloalkyl; R2 is -C(=O)-NH2 (an “amide”); R3 is phenyl; R4-R7 are each hydrogen (H). This anticipates instant claims 1-2 The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Claims 1 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS 2 (American Chemical Society. Chemical Abstract Service. RN 137537-29-2. Entered into STN: 22 November 1991). The prior art reference ACS 2 teaches the compound: PNG media_image2.png 242 306 media_image2.png Greyscale (see enclosed ACS 2 prior art reference), R1 is a C6cycloalkyl; R2 is cyano; R3 is phenyl; R4-R7 are each hydrogen (H). This anticipates instant claim 1. The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Claims 1 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS 3 (American Chemical Society. Chemical Abstract Service. RN 212501-79-6. Entered into STN: 11 October 1998). The prior art reference ACS 3 teaches the compound: PNG media_image3.png 248 408 media_image3.png Greyscale (see enclosed ACS 3 prior art reference), wherein: R1 is an amino-substituted phenyl; R2 is carboxyl; R3 is tri-methoxy substituted phenyl; and R4-R7 are each hydrogen (H). This anticipates instant claim 1. The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Claims 1 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS 4 (American Chemical Society. Chemical Abstract Service. RN 212501-75-2. Entered into STN: 11 October 1998). The prior art reference ACS 4 teaches the compound: PNG media_image4.png 252 354 media_image4.png Greyscale (see enclosed ACS 4 prior art reference), wherein: R1 is an phenyl; R2 is carboxyl; R3 is tri-methoxy substituted phenyl; and R4-R7 are each hydrogen (H). This anticipates instant claim 1. The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Claims 1 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS 5 (American Chemical Society. Chemical Abstract Service. RN 212490-70-5. Entered into STN: 11 October 1998). The prior art reference ACS 5 teaches the compound: PNG media_image5.png 302 410 media_image5.png Greyscale (see enclosed ACS 5 prior art reference), wherein: R1 is an phenyl; R2 is amide; R3 is di-methoxy substituted and a bromo-substituted phenyl; and R4 and R7 are each hydrogen (H); R5 and R6 are each methoxy. This anticipates instant claim 1. The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Claims 1 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS 6 (American Chemical Society. Chemical Abstract Service. RN 849636-21-1. Entered into STN: 2 May 2005). The prior art reference ACS 6 teaches the compound: PNG media_image6.png 252 294 media_image6.png Greyscale (see enclosed ACS 6 prior art reference), wherein: R1 is a C3cycloalkyl; R2 is cyano; R3 is fluorine-substituted phenyl; and R4 is bromine; R5 is hydroxyl; and R6 and R7 are each hydrogen (H). This anticipates instant claim 1. The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Claim(s) 1 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS 7 (American Chemical Society. Chemical Abstract Service. RN 849634-65-7. Entered into STN: 2 May 2005). The prior art reference ACS 7 teaches the compound: PNG media_image7.png 252 360 media_image7.png Greyscale (see enclosed ACS 7 prior art reference), wherein: R1 is a C3cycloalkyl; R2 is cyano; R3 is fluorine-substituted phenyl; and R4 is H; R5 is C3alkoxy; and R6 and R7 are each hydrogen (H). This anticipates instant claim 1. The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Claims 1 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS 8 (American Chemical Society. Chemical Abstract Service. RN 849634-63-5. Entered into STN: 2 May 2005). The prior art reference ACS 8 teaches the compound: PNG media_image8.png 252 344 media_image8.png Greyscale (see enclosed ACS 8 prior art reference), wherein: R1 is a C3cycloalkyl; R2 is cyano; R3 is fluorine-substituted phenyl; and R4 is H; R5 is C2alkoxy; and R6 and R7 are each hydrogen (H). This anticipates instant claim 1. The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Claims 1 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS 9 (American Chemical Society. Chemical Abstract Service. RN 849634-60-2. Entered into STN: 2 May 2005). The prior art reference ACS 9 teaches the compound: PNG media_image9.png 294 400 media_image9.png Greyscale (see enclosed ACS 9 prior art reference), wherein: R1 is a C3cycloalkyl; R2 is cyano; R3 is fluorine-substituted phenyl; and R4 is H; R5 is C2trifluoromethoxy; and R6 and R7 are each hydrogen (H). This anticipates instant claim 1. The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Claims 1 and 4-6 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by: ACS 10 (American Chemical Society. Chemical Abstract Service. RN 849634-59-9. Entered into STN: 2 May 2005). The prior art reference ACS 10 teaches the compound: PNG media_image10.png 240 294 media_image10.png Greyscale (see enclosed ACS 10 prior art reference), wherein: R1 is a C3cycloalkyl; R2 is cyano; R3 is fluorine-substituted phenyl; and R4 is H; R5 is hydroxy; and R6 and R7 are each hydrogen (H). This anticipates instant claim 1. The “use” claims 4-6 constitute intended use limitations. Nothing precludes the use as claimed. Conclusion No claims are presently allowable as written. Any inquiry concerning this communication or earlier communications from the examiner should be directed to JOHN S KENYON whose telephone number is (571)270-1567. The examiner can normally be reached Monday-Friday 10a-6p. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Andrew D Kosar can be reached at (571) 272-0913. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JOHN S KENYON/Primary Patent Examiner, Art Unit 1625
Read full office action

Prosecution Timeline

Aug 27, 2024
Application Filed
Jun 26, 2026
Non-Final Rejection mailed — §101, §102, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
80%
Grant Probability
98%
With Interview (+17.5%)
2y 4m (~5m remaining)
Median Time to Grant
Low
PTA Risk
Based on 941 resolved cases by this examiner. Grant probability derived from career allowance rate.

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