Prosecution Insights
Last updated: October 04, 2026
Application No. 18/843,517

N4-ISOBUTYRYLOXYCYTIDINE ANALOG SYNTHESIS AND COMPOSITION FOR TREATING VIRAL INFECTION COMPRISING ANTI-VIRAL USE THEREOF

Non-Final OA §102
Filed
Sep 03, 2024
Priority
Mar 04, 2022 — RE 10-2022-0028064 +1 more
Examiner
MCINTOSH III, TRAVISS C
Art Unit
Tech Center
Assignee
Dong-A University Research Foundation For Industry-Academy Cooperation
OA Round
1 (Non-Final)
73%
Grant Probability
Favorable
1-2
OA Rounds
4m
Est. Remaining
87%
With Interview

Examiner Intelligence

Grants 73% — above average
73%
Career Allowance Rate
977 granted / 1334 resolved
+13.2% vs TC avg
Moderate +14% lift
Without
With
+14.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 5m
Avg Prosecution
35 currently pending
Career history
1355
Total Applications
across all art units

Statute-Specific Performance

§101
6.1%
-33.9% vs TC avg
§103
16.0%
-24.0% vs TC avg
§102
23.4%
-16.6% vs TC avg
§112
32.0%
-8.0% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1334 resolved cases

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 1-7 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Paymode et al. (Organic Process Research & Development, 2021, vol. 25, pp 1822-1830 (NPL reference 4 from applicant’s IDS filed 9/3/24). Paymode disclose the compound of formula I of claim 1 and compositions comprising the same. See Figure 12-13, page 1827. Likewise, it is noted that this compound is seen to be in a composition in the synthetic processes set forth therein, and thus meet the limitations of the present composition claims. The compositions comprising the same compound claimed herein would be seen to meet the limitations of being used for treating a viral infection such as influenza or dengue virus as claimed herein. Because the compositions could have been used for applicants intended purpose, they properly anticipate the present claims. Allowable Subject Matter Claim 8 is objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. The closest prior art is seen to be Paymode et al. as cited above who discloses the compound of formula I claimed herein and compositions for the same that could have been used for the same purposes herein. However, Paymode uses their compound in a synthetic method of making molnupiravir and thus a skilled artisan would not have found it obvious to use this intermediate in a method of treating a viral infection as set forth in present claim 8. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to TRAVISS C MCINTOSH III whose telephone number is (571)272-0657. The examiner can normally be reached Monday-Friday 9AM-5:30PM EST. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Scarlett Goon can be reached at 571-270-5241. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /TRAVISS C MCINTOSH III/Primary Examiner, Art Unit 1693
Read full office action

Prosecution Timeline

Sep 03, 2024
Application Filed
Sep 24, 2026
Non-Final Rejection mailed — §102 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

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3y 2m to grant Granted Sep 22, 2026
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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
73%
Grant Probability
87%
With Interview (+14.0%)
2y 5m (~4m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1334 resolved cases by this examiner. Grant probability derived from career allowance rate.

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