Prosecution Insights
Last updated: April 19, 2026
Application No. 18/882,678

Method and System for Enhanced Fluorescence Tissue and Cancer Margin Imaging

Non-Final OA §102
Filed
Sep 11, 2024
Examiner
VARGAS, DIXOMARA
Art Unit
3798
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
Cytoveris Inc.
OA Round
1 (Non-Final)
93%
Grant Probability
Favorable
1-2
OA Rounds
2y 11m
To Grant
99%
With Interview

Examiner Intelligence

Grants 93% — above average
93%
Career Allow Rate
924 granted / 998 resolved
+22.6% vs TC avg
Moderate +8% lift
Without
With
+8.4%
Interview Lift
resolved cases with interview
Typical timeline
2y 11m
Avg Prosecution
25 currently pending
Career history
1023
Total Applications
across all art units

Statute-Specific Performance

§101
15.5%
-24.5% vs TC avg
§103
22.4%
-17.6% vs TC avg
§102
40.2%
+0.2% vs TC avg
§112
16.0%
-24.0% vs TC avg
Black line = Tech Center average estimate • Based on career data from 998 resolved cases

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Information Disclosure Statement The information disclosure statement filed 02/21/25 fails to comply with 37 CFR 1.98(a)(2), which requires a legible copy of each cited foreign patent document; each non-patent literature publication or that portion which caused it to be listed; and all other information or that portion which caused it to be listed. It has been placed in the application file, but the information referred to therein has not been considered. Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 1 and 3 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Kim et al. (US 2013/0006116 A1). With respect to claim 1, Kim discloses a system for analyzing a tissue, comprising: an excitation light unit configured to selectively produce a plurality of excitation lights (see Figures 3 and 4 showing excitation lights #2 - #5 and #2’-#7’ respectively), each said excitation light centered on a wavelength distinct from the centered wavelength of the other said excitation lights (see paragraph 0047 showing the different fluorescence excitation sources with different fluorescence excitation wavelengths considered as the claimed light centered on a wavelength distinct from the centered wavelength of the other), wherein the plurality of excitation lights includes a plurality of first excitation lights configured to produce an autofluorescence emission from one or more biomolecules of interest present within the tissue (see paragraph 0114), and a diffuse reflectance signal from the tissue (see paragraphs 0011 and 0047-0053), and a second excitation light is configured to produce a fluorescence emission from a fluorescent agent administered to the tissue (see paragraph 0131); a photodetector configured to detect the autofluorescence emission and the diffuse reflectance resulting from the plurality of first excitation lights directed to the tissue and produce first signals representative of the autofluorescence emission and the diffuse reflectance, and configured to detect the fluorescence emission signal resulting from the second excitation light directed to the tissue and produce second signals representative of the fluorescence emission (see detector #3 and #3’ in figures 3 and 4 respectively; see paragraph 0047); and a system controller in communication with the excitation light unit, the photodetector, and a non-transitory memory storing instructions, which instructions when executed cause the system controller to: control the excitation light unit to sequentially produce the first excitation light and the second excitation light (see paragraph 0053); receive and process the first signals to produce a first image representative of the first signals, and receive and process the second signals to produce a second image representative of the second signals (see paragraphs 0053 and 0111; see Figure 20 showing the images); and analyze the tissue using the first image and the second image to identify the presence of diseased tissue within the tissue (see paragraphs 0113-0115 and 0120-0124). With respect to claim 3, Kim discloses a method of analyzing a tissue, comprising: administering a fluorescent agent to the tissue (see paragraph 0131); producing a first excitation lights (see Figures 3 and 4 showing excitation lights #2 - #5 and #2’-#7’ respectively) light centered on a first wavelength (see paragraph 0047 showing the different fluorescence excitation sources with different fluorescence excitation wavelengths considered as the claimed light centered on a wavelength distinct from the centered wavelength of the other), wherein the first excitation light is configured to produce an autofluorescence emission from one or more biomolecules of interest present within the tissue (see paragraph 0114), and a diffuse reflectance signal from the tissue (see paragraphs 0011 and 0047-0053); producing a second excitation light centered on a second wavelength, wherein the second excitation light is configured to produce a fluorescence emission from the fluorescent agent administered to the tissue (see paragraph 0131); using a photodetector to detect the autofluorescence emissions, the diffuse reflectance signals and produce first signals representative of the autofluorescence emission and the diffuse reflectance; using the photodetector to detect the fluorescence emissions and produce second signals representative of the fluorescence emission (see detector #3 and #3’ in figures 3 and 4 respectively; see paragraph 0047); producing a first image using the first signals; producing a second image using the second signals (see paragraphs 0053 and 0111; see Figure 20 showing the images); and analyzing the tissue using the first image and the second image to identify the presence of diseased tissue within the tissue (see paragraphs 0113-0115 and 0120-0124). Allowable Subject Matter Claim 2 is objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. Conclusion The prior art made of record and not relied upon is considered pertinent to applicant's disclosure. The additional prior art cited in the PTO 892 not relied upon discloses light devices that emit fluorescent light to produce images of a tissue. Any inquiry concerning this communication or earlier communications from the examiner should be directed to DIXOMARA VARGAS whose telephone number is (571)272-2252. The examiner can normally be reached Monday-Friday 8am-5pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Raymond Keith can be reached at 571-270-1790. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /DIXOMARA VARGAS/ Primary Examiner, Art Unit 3798
Read full office action

Prosecution Timeline

Sep 11, 2024
Application Filed
Oct 07, 2025
Non-Final Rejection — §102 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
93%
Grant Probability
99%
With Interview (+8.4%)
2y 11m
Median Time to Grant
Low
PTA Risk
Based on 998 resolved cases by this examiner. Grant probability derived from career allow rate.

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