Prosecution Insights
Last updated: October 02, 2026
Application No. 18/911,076

ANOMALY DETECTION IN MEDICAL IMAGING DATA

Non-Final OA §DP
Filed
Oct 09, 2024
Priority
Mar 16, 2021 — provisional 63/161,864 +1 more
Examiner
NGUYEN, TUAN HOANG
Art Unit
Tech Center
Assignee
Genentech Inc.
OA Round
1 (Non-Final)
90%
Grant Probability
Favorable
1-2
OA Rounds
3m
Est. Remaining
94%
With Interview

Examiner Intelligence

Grants 90% — above average
90%
Career Allowance Rate
1399 granted / 1546 resolved
+30.5% vs TC avg
Minimal +4% lift
Without
With
+4.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 3m
Avg Prosecution
23 currently pending
Career history
1553
Total Applications
across all art units

Statute-Specific Performance

§101
7.9%
-32.1% vs TC avg
§103
59.0%
+19.0% vs TC avg
§102
12.4%
-27.6% vs TC avg
§112
10.7%
-29.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1546 resolved cases

Office Action

§DP
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Information Disclosure Statement 1. The information disclosure statement (IDS) submitted on 12/12/2024 has been considered by Examiner and made of record in the application file. Double Patenting 2. The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the claims at issue are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); and In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321 (c) or 1.321(d) may be used to overcome an actual or provisional rejection based on a nonstatutory double patenting ground provided the reference application or patent either is shown to be commonly owned with this application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP §§ 706.02(l)(1) - 706.02(l)(3) for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321 (b). The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/forms/. The filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based e Terminal Disclaimer may be filled out completely online using web-screens. An e Terminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about e Terminal Disclaimers, refer to http://www.uspto.gov/patents/process/file/efs/guidance/eTD-info-l.jsp. 3. Claims 1, 15 and 18 are rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1, 15 and 18 of U.S. Patent No. 12,283,365 in view of Annen et al. (U.S PAT. 12,143,407 hereinafter, “Annen”). Although the conflicting claims are not identical, they are not patentably distinct from each other because all the claimed limitations are transparently found in the U.S. Patent No. 12,283,365 with obvious wording variations as shown in the following table. U.S. Patent No. 12,283,365 U.S Application No. 18/911,076 1. A method for anomaly detection, comprising: receiving, by an image processing system, an image of a tissue sample; generating, by the image processing system, a set of tiles of the image of the tissue sample; inputting, by the image processing system, the set of tiles into an anomaly detection model, the anomaly detection model comprising: a generator model comprising functional skip-connections; and a Markovian discriminator model; wherein the anomaly detection model was trained to isolate a feature space of normal tissue samples; computing, by the image processing system, anomaly scores for the set of tiles; and generating, by the image processing system and based on the anomaly scores for the set of tiles, an assessment for the image of the tissue sample, wherein the assessment identifies the image of the tissue sample as including abnormal tissue. 1. A method for anomaly detection, comprising: receiving, by an image processing system, an image of a tissue sample; generating, by the image processing system, a set of tiles of the image of the tissue sample; inputting, by the image processing system, the set of tiles into an anomaly detection model, the anomaly detection model comprising: a deep learning neural network; and/or a UNet-based generator network; wherein the anomaly detection model is trained to isolate a feature space of normal tissue samples; computing, by the image processing system, anomaly scores for the set of tiles; and generating, by the image processing system and based on the anomaly scores for the set of tiles, an assessment for the image of the tissue sample, wherein the assessment identifies the image of the tissue sample as including abnormal tissue. Consider claims 1, 15 and 18, U.S. Patent No. 12,283,365 does not explicitly disclose the anomaly detection model comprising: a deep learning neural network; and/or a UNet-based generator network. Annen teaches in the same field of endeavor the anomaly detection model comprising: a deep learning neural network; and/or a UNet-based generator network (col. 23, lines 20-35). It would have been obvious to one of ordinary skill in the art at the time the invention was made to modify U.S. Patent No. 12,283,365 in view of Annen to incorporate the anomaly detection model comprising: a deep learning neural network; and/or a UNet-based generator network to provide leverage machine learning to detect anomalies and ransomware on data backups with little or no impact on production systems. U.S. Patent No. 12,283,365 Application No. 18/911,076 2-5, 7, 6, 8-10, 13, 11, 12, 14, 16-17 2-5, 6, 7, 8-10, 11, 12, 13, 14,16-17 and 19-20. and 19-20. Conclusion 4. Any response to this action should be mailed to: Mail Stop_________ (Explanation, e.g., Amendment or After-final, etc.) Commissioner for Patents P.O. Box 1450 Alexandria, VA 22313-1450 Facsimile responses should be faxed to: (571) 273-8300 Hand-delivered responses should be brought to: Customer Service Window Randolph Building 401 Dulany Street Alexandria, VA 22313 Any inquiry concerning this communication or earlier communications from the examiner should be directed to Tuan H. Nguyen whose telephone number is (571) 272-8329. The examiner can normally be reached on 8:00Am - 5:00Pm. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Pan Yuwen can be reached on (571) 272-7855. The fax phone number for the organization where this application or proceeding is assigned is (571) 273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). /TUAN H NGUYEN/Primary Examiner, Art Unit 2649
Read full office action

Prosecution Timeline

Oct 09, 2024
Application Filed
Sep 01, 2026
Non-Final Rejection mailed — §DP (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
90%
Grant Probability
94%
With Interview (+4.0%)
2y 3m (~3m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1546 resolved cases by this examiner. Grant probability derived from career allowance rate.

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