Prosecution Insights
Last updated: April 19, 2026
Application No. 18/924,434

METHOD AND SYSTEM USING ULTRASOUND REFLECTIONS OF MAIN PORTAL VEIN TO PREDICT LIVER CANCER

Non-Final OA §102
Filed
Oct 23, 2024
Examiner
REMALY, MARK DONALD
Art Unit
3797
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
Regents Of The University Of Minnesota
OA Round
1 (Non-Final)
69%
Grant Probability
Favorable
1-2
OA Rounds
3y 7m
To Grant
85%
With Interview

Examiner Intelligence

Grants 69% — above average
69%
Career Allow Rate
492 granted / 709 resolved
-0.6% vs TC avg
Strong +16% interview lift
Without
With
+15.8%
Interview Lift
resolved cases with interview
Typical timeline
3y 7m
Avg Prosecution
24 currently pending
Career history
733
Total Applications
across all art units

Statute-Specific Performance

§101
6.8%
-33.2% vs TC avg
§103
37.8%
-2.2% vs TC avg
§102
23.6%
-16.4% vs TC avg
§112
28.5%
-11.5% vs TC avg
Black line = Tech Center average estimate • Based on career data from 709 resolved cases

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Election/Restrictions Claims 1-7 and 15-20 are withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected method, there being no allowable generic or linking claim. Election was made without traverse in the reply filed on 12/03/2025. Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 8-14 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Mammone (US 2013/0023767 A1). Regarding claim 8, Mammone (‘767) teach a sonography system comprising: a transducer, receiving sound signals from a living body and converting the sound signals into electrical signals (“probe 100 is shown to include an ultrasound transducer 102” see [0041]; and Fig. 1); a transform module for transforming the electrical signal into frequency intensity values (“These reflection coefficients may be put into a frequency domain vector and an inverse Fourier transform may be used to transform into the time/distance domain” see [0050]); a neural network receiving a representation of the frequency intensity values as input and outputting an indication of whether the living body has liver cancer (“automatically determine probabilities of what the regions of interest actually are (e.g., malignant cancer, benign cancer, unknown tissue). The classifiers 1622 may include neural network(s)” see [0090]); and a display for displaying whether the living body has liver cancer (“The resulting aggregation or summation may be displayed as a composite A-scan 1628” see [0090]). Regarding claim 9, Mammone (‘767) teach the sonography system of claim 8 wherein the representation of the frequency intensity values comprises an image and wherein the sonography system further comprises a processor that converts the frequency intensity values into the image (see [0089]-[0090]). Regarding claim 10, Mammone (‘767) teach the sonography system of claim 9 wherein the image comprises a graph of frequency intensities over time (see [0089]-[0090], [0096]). Regarding claim 11, Mammone (‘767) teach the sonography system of claim 10 wherein the image uses brightness to indicate intensity (see [0089]-[0090], [0096]). Regarding claim 12, Mammone (‘767) teach the sonography system of claim 1 wherein the received sound signals comprise reflected ultrasound signals (see [0041]-[0042]). Regarding claim 13, Mammone (‘767) teach the sonography system of claim 12 wherein the reflected ultrasound signals are reflected from a main portal vein (see [0087]). Regarding claim 14, Mammone (‘767) teach the sonography system of claim 13 wherein the reflected ultrasound signals are not reflected from the liver (see [0087]). Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to MARK REMALY whose telephone number is (571)270-1491. The examiner can normally be reached Mon - Fri 9:00 - 6:00. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Christopher Koharski can be reached at (571) 272-7230. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /MARK D REMALY/Primary Examiner, Art Unit 3797
Read full office action

Prosecution Timeline

Oct 23, 2024
Application Filed
Jan 10, 2026
Non-Final Rejection — §102 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
69%
Grant Probability
85%
With Interview (+15.8%)
3y 7m
Median Time to Grant
Low
PTA Risk
Based on 709 resolved cases by this examiner. Grant probability derived from career allow rate.

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