Prosecution Insights
Last updated: October 25, 2026
Application No. 18/927,395

MODULAR BIOMATERIAL PLATFORM LOCAL, INJECTABLE DELIVERY OF A DRUG AND METHODS OF MAKING AND USING SAME

Non-Final OA §112
Filed
Oct 25, 2024
Priority
Oct 27, 2023 — provisional 63/546,082 +1 more
Examiner
MI, QIUWEN
Art Unit
Tech Center
Assignee
Duke University
OA Round
1 (Non-Final)
68%
Grant Probability
Favorable
1-2
OA Rounds
6m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 68% — above average
68%
Career Allowance Rate
1100 granted / 1609 resolved
+8.4% vs TC avg
Strong +50% interview lift
Without
With
+50.0%
Interview Lift
resolved cases with interview
Typical timeline
2y 6m
Avg Prosecution
26 currently pending
Career history
1643
Total Applications
across all art units

Statute-Specific Performance

§101
10.1%
-29.9% vs TC avg
§103
44.1%
+4.1% vs TC avg
§102
22.5%
-17.5% vs TC avg
§112
18.9%
-21.1% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1609 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Claims 1-20 are pending. Claims 1-20 are examined on the merits. Claim Rejections –35 USC § 112, 2nd The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 1-20 are rejected under 35 U.S.C. 112, second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which applicant regards as the invention. Claim 1 recites parenthetical expression "(D-microgels)" at line 9; “(L-microgels)” at line 10; “(D-microgel assembly)” at line 11; and “(L-microgel assembly)” at line 12. The metes and bounds of Claim 1 are rendered vague and indefinite by the parenthetical recitation of because it is unclear as to whether the limitation is part of the instantly claimed subject matter. Claim 17 is rejected for the same reason. Claim 16 recites “D-beads and L-beads” at line 4, it is not clear what they stand for, there is no mentioning about “D-beads and L-beads” in the prior claims, Applicant should at least have some brief description about the definition of “D-beads and L-beads”. Claim 19 recites “The method according to claim 17, wherein the number of alloreactive CD45R+ B cells and/or allorcactive CD3+ T cells is reduced”, but there is no antecedent basis about that recitation. Therefore, the metes and bounds of claims are rendered vague and indefinite. The lack of clarity renders the claims very confusing and ambiguous since the resulting claims do not clearly set forth the metes and bounds of the patent protection desired. All other cited claims depend directly or indirectly from rejected claims and are, therefore, also, rejected under U.S.C. 112, second paragraph for the reasons set forth above. Conclusion No claim is allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to QIUWEN MI whose telephone number is (571)272-5984. The examiner can normally be reached on Monday-Friday 9:00 am to 5:00 pm. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Anand Desai can be reached on 571-272-0947. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative or access to the automated information system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /Qiuwen Mi/ Primary Examiner, Art Unit 1655
Read full office action

Prosecution Timeline

Oct 25, 2024
Application Filed
Oct 05, 2026
Non-Final Rejection mailed — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12766092
COSMETIC COMPOSITIONS COMPRISING A CACTUS FLOWER EXTRACT COMPLEX
2y 7m to grant Granted Oct 20, 2026
Patent 12758486
Personal Care Compositions
3y 2m to grant Granted Oct 13, 2026
Patent 12751912
IMPROVEMENTS IN OR RELATING TO EXTRACTS
3y 5m to grant Granted Oct 06, 2026
Patent 12751932
COMPOSITIONS COMPRISING CURCUMINOIDS FOR USE IN THE TREATMENT OF MUSCLE SORENESS
2y 9m to grant Granted Oct 06, 2026
Patent 12746195
BERTHOLLETIA EXCELSA EXTRACT AND USE THEREOF
3y 1m to grant Granted Sep 29, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
68%
Grant Probability
99%
With Interview (+50.0%)
2y 6m (~6m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1609 resolved cases by this examiner. Grant probability derived from career allowance rate.

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