DETAILED ACTION
Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
Claim Rejections - 35 USC § 103
In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status.
The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action:
A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made.
Claims 1, 13, and 17 are rejected under 35 U.S.C. 103 as being unpatentable over “Li et al.,” US 2022/0092739 (hereinafter Li) and “Chen et al.,” US 2021/0161422 (hereinafter Chen).
Regarding to claim 1, Li teaches a method for acquiring a magnetic resonance image dataset of a body part of a subject (MRI [0041], [0044]), the method comprising:
acquiring the magnetic resonance image dataset using an imaging protocol (imaging device configured to scan a subject to acquire image data [0045]),
wherein spatial encoding is performed using phase encoding gradients along at least one phase encoding direction, and frequency encoding gradients along a frequency encoding direction (During the scan, spatial encoding within the slice may be implemented by spatial encoding coils along a phase encoding direction and a frequency encoding direction [0046]), and
wherein k-space is sampled during the imaging protocol by acquiring a plurality of imaging k-space lines oriented along the frequency encoding direction, and having different positions in the at least one phase encoding direction (phase encoding direction correspond to Y direction in the k-space, the frequency encoding direction correspond to X direction in the k-space, and phase and frequency encoding direction may be modified according to the actual needs [0046]),
acquiring or providing a low-resolution magnetic resonance image of the body part (acquire first data associated with the plurality of sample images with relatively low resolution levels [0070]);
acquiring further sets of additional k-space lines within a central region of k-space at intervals throughout the imaging protocol (image processed may only include k-space data in the central region of k space [0101]); and
applying a trained machine learning model (a machine learning algorithm [0095]) to a dataset comprising the low-resolution image in k-space notation and a further set of additional k-space lines (training models using a group of sample images with relatively low resolution levels and a corresponding group of sample images with relatively high resolution levels, training data is k-space data, central region of k space [0141], [0146])
Li does not further disclose further limitations wherein a set of pose parameters is generated, the pose parameters being an estimation of the pose of the subject during the acquisition time of the further set of additional k-space lines.
However, in the analogous field of endeavor in MRI imaging method, Chen teaches an MRI imaging method using MRI image data to estimate a pose of heart ([0007] and [0013]), including limitations wherein a set of pose parameters is generated, the pose parameters being an estimation of the pose of the subject during the acquisition time of the further set of additional k-space lines (low resolution scout images are used to estimate pose of a patient’ heart using a neural network, and AI scout images including compressed sensing where data is undersampled in the K-space, acquired to compare heart pose to those of heart model from initial scouting [0040]-[0041]; Figure 4 shows step 412 and step 414 and using neural network (404 and 418]) to estimate a pose of a heart).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify MRI image data as taught by Li to incorporate teaching of Chen, since using neural network to estimate a pose of a heart using MRI data was well known in the art as taught by Chen. One of ordinary skill in the art could have combined the elements as claimed by Li with no change in their respective functions, implementing neural network of estimating a pose of a subject with existing MRI data of low resolution and k-space lines within a central region of k-space, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to provide automatic adjustment planned image planes to compensate for changes in a pose of a heart throughout an entire scanning process ([0006]), and there was reasonable expectation of success.
Regarding to claim 13, Li and Chen together disclose all limitations of claim 1 as set forth above.
Li further teaches wherein the trained machine learning model comprises a convolutional neural network ( convolutional neural network [0095]).
Regarding to claim 17, Li teaches a computer-implemented method for providing a trained machine learning model (computer instructions including program [0059] and [0129]), the computer-implemented method comprising:
receiving input training data comprising a low-resolution magnetic resonance image of a body part in k-space notation and a set of additional k-space lines from a central region of k- space (training models using a group of sample images with relatively low resolution levels and a corresponding group of sample images with relatively high resolution levels, training data is k-space data, central region of k space [0141], [0146]),
wherein the low resolution image has been derived from an example magnetic resonance image (acquire first data associated with the plurality of sample images with relatively low resolution levels [0070]),
training a machine learning model based on the input training data and the output training data (training module configured to obtain a plurality of processing models by training group of images [0076]); and
providing the trained machine learning model (trained model [0097]).
Li does not further teach receiving output training data comprising the set of pose parameters and the set of additional k-space lines has been derived from the same example magnetic resonance image after the image has been rotated, translated, or rotated and translated by a set of pose parameters.
However, in the analogous field of endeavor in MRI imaging method, Chen teaches an MRI imaging method using MRI image data to estimate a pose of heart using a neural network ([0007] and [0013]), and the set of additional k-space lines has been derived from the same example magnetic resonance image after the image has been rotated, translated by a set of pose parameters (low resolution scout images are used to estimate pose of a patient’ heart using a neural network, and AI scout images including compressed sensing where data is undersampled in the K-space, acquired to compare heart pose to those of heart model from initial scouting [0040]-[0041]; Figure 4 shows step 412 and step 414 and using neural network (404 and 418]) to estimate a pose of a heart, reposition the imaging planes to correspond to the current location and pose of the patient’s heart and cause MRI scanner to use repositioned imaging planes to perform an acquisition scan and generate an image [0016]).
The examiner further notes that repositioning image plane involve any adjustment in imaging plane, would include either rotation or translation as claimed.
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify MRI image data as taught by Li to incorporate teaching of Chen, since using neural network to estimate a pose of a heart using MRI data was well known in the art as taught by Chen. One of ordinary skill in the art could have combined the elements as claimed by Li with no change in their respective functions, implementing neural network of estimating a pose of a subject with existing MRI data of low resolution and k-space lines within a central region of k-space, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to provide automatic adjustment planned image planes to compensate for changes in a pose of a heart throughout an entire scanning process ([0006]), and there was reasonable expectation of success.
Claims 2-8 are rejected under 35 U.S.C. 103 as being unpatentable over Li and Chen as applied to claim 1 above, and further in view of “Splitthoff et al.,” US 2022/0342018 (hereinafter Splitthoff).
Regarding to claims 2, Li and Chen together teach all limitations of claim 1 as set forth above.
Li and Chen do not further explicitly disclose a reference image and its details.
However, in the analogous field of endeavor in MRI imaging method, Splitthoff teaches an MRI imaging method further comprising
Of claim 2, acquiring a reference set of additional k-space lines within a central region of k-space (motion free reference data is k-space data around the center [0030]).
Of claim 4, wherein the pose parameters are used for prospective, retrospective, or prospective and retrospective motion correction of the magnetic resonance image dataset (retrospective and prospective correction [0026]), for notifying an operator, for triggering further actions, or for notifying the operator and for triggering the further actions (generating a warning for physicians and operator so that the operator may elect or to redo the scan [0040]).
Of claim 6, wherein the pose parameters are used to adapt a field-of-view of the magnetic resonance image dataset during the imaging protocol (field-of-view [0033]).
Of claim 7, wherein the pose parameters are used for retrospective motion correction of the magnetic resonance image dataset (retrospective motion correction [0026]).
Of claim 8, wherein the pose parameters are further processed and, when the pose parameters indicate that subject motion has been above a certain threshold, the method further comprises triggering alerting a user supervising during the image acquisition, aborting or restarting the acquisition of the magnetic resonance image dataset, re-acquiring the magnetic resonance data affected by the subject motion, or any combination thereof (motion assessment generated by neural network to provide motion assessment to the operator, and motion score is compared to a threshold score that quantifies the extent of motion, indicating serious motion, a warning may be provided to the operator so that the operator may elect to redo the scan or the portion of the scan [0040]).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify MRI imaging method as taught by Li and Chen to incorporate teaching of Splitthoff , since using reference data and motion correction adjustment based on motion assessment was well known in the art as taught by Splitthoff. One of ordinary skill in the art could have combined the elements as claimed by Li and Chen with no change in their respective functions, implementing motion correction and further actions based on motion, using a reference data, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to prospective and retrospective motion correction ([0026]), and to make sure the region of interest is included in the field of view, or to check the exposure techniques ([0030]), and there was reasonable expectation of success.
Regarding to claim 3, Li, Chen and Splitthoff together teach all limitations of claim 2 as set forth above.
Splitthoff further discloses wherein acquiring the reference set of additional k-space lines within the central region of k-space comprises acquiring the reference set of additional k-space lines within the central region of k-space at a beginning of the imaging protocol (motion free reference may be acquired during a scout scan or may be identified from a previous scan [0030]).
Regarding to claim 5, Li and Chen together teach all limitations of claim 1 as set forth above.
Li further teach wherein the trained machine learning model is applied to a dataset comprising the low-resolution image in k-space notation, and a further set of additional k-space lines (training models using a group of sample images with relatively low resolution levels and a corresponding group of sample images with relatively high resolution levels, training data is k-space data, central region of k space [0141], [0146]).
Li and Chen do not further disclose reference k-space lines.
However, In the analogous field of endeavor in MRI imaging method, Splitthoff teaches acquiring a reference set of additional k-space lines within a central region of k-space (motion free reference data is k-space data around the center [0030]), and a neural network with training data including a reference data ([0048]).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify MRI imaging method as taught by Li and Chen to incorporate teaching of Splitthoff , since motion correction using a reference k-space data was well known in the art as taught by Splitthoff. One of ordinary skill in the art could have combined the elements as claimed by Li and Chen with no change in their respective functions, implementing motion correction using a reference data, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to estimate baseline, to make sure the region of interest is included in the field of view, or to check the exposure techniques ([0030]), and there was reasonable expectation of success.
Claims 9 and 12 are rejected under 35 U.S.C. 103 as being unpatentable over Li and Chen as applied to claim 1 above, and further in view of “Polak et al.,” US 2022/0326330 (hereinafter Polak).
Regarding to claims 9 and 12, Li and Chen together teach all limitations of claim 1 as set forth above.
Li and Chen do not further teach timing of acquisition and using a multi-channel coil array as claimed.
However, in the analogous field of endeavor in MRI imaging method, Polak teaches an MRI imaging with following details:
Of claim 9, wherein the low-resolution image has a different magnetic resonance contrast than the further sets of additional k-space lines, and is acquired in a calibration imaging scan performed before the imaging protocol (low resolution scout image acquired with same or different imaging protocol than high resolution image data set, having slightly differing contrast to the imaging protocol [0025]).
Of claim 12, wherein the magnetic resonance image dataset is acquired using a multi-channel coil array (imaging protocol uses a 3D parallel imaging technique where image data set is acquired using a multi-channel coil array [0028]), and wherein the low-resolution image in k-space notation and the further set of additional k-space lines are pre-processed by removing a peripheral region of k-space, by reducing a number of channels, or by removing the peripheral region of k-space and by reducing the number of channels (sub-sampling [0039] and coil compression that multi-channel k-space data was compressed to a lower number of coils [0078]).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify MRI imaging acquisition as taught by Li to incorporate teaching of Polak, since multi-channel array and different contrast for low/high resolution image was well known in the art as taught by Polak. One of ordinary skill in the art could have combined the elements as claimed by Li and Chen with no change in their respective functions, configuring multi-channel array for MRI acquisition and imaging low resolution image with different contrast, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to (1) provide scout image (low resolution) with different imaging protocol from high resolution image ([0025]), and to (2) reduce computational footprint of the motion optimization ([0078]), and there was reasonable expectation of success.
Claims 10-11 are rejected under 35 U.S.C. 103 as being unpatentable over Li and Chen as applied to claim 1 above, and further in view of “Polak et al.,” US 2022/0326330 (hereinafter Polak), “Daniel et al.,” US 2019/0355157 (hereinafter Daniel), and “Splitthoff et al.,” US 2022/0342018 (hereinafter Splitthoff).
Regarding to claim 10, Li and Chen together teach all limitations of claim 1 as set forth above.
Li and Chen do not further teach echo trains and acquisition details of k-space line data as claimed.
However, in the analogous field of endeavor in MRI imaging method, Polak teaches
wherein the imaging protocol comprises acquiring a plurality of echo trains, each echo train of the plurality of echo trains comprising a plurality of echoes (echo train including several echoes [0014]), wherein one k-space line is sampled during one echo (one k-space line acquired during one echo [0014]), and wherein at least one further set of additional k-space lines is acquired in at least some echo trains of the plurality of echo trains (Figure 2 shows additional k-space lines acquired in echo trains [0061]).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify k-space data acquisition as taught by Li and Chen to incorporate teaching of Polak, since acquiring echo trains and sampling k-pace line during echo train was well known in the art as taught by Polak. One of ordinary skill in the art could have combined the elements as claimed by Li with no change in their respective functions, configuring acquisition of k-space line to be in echo train, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to provide a fast imaging protocol ([0014]), and there was reasonable expectation of success.
Polak is silent in wherein at least one further set of additional k-space lines is acquired in at least some echo trains of the plurality of echo trains, preferably at the beginning of the echo train.
However, in MRI imaging method, Daniel teaches acquiring central k-space earlier in the echo train ([0043]). Thus, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify k-space line acquisition in echo train as taught by Polak to incorporate teaching of Daniel, since k-space line acquisition in earlier part of the echo train was well known in the art as taught by Daniel. One of ordinary skill in the art could have combined the elements as claimed by Polak with no change in their respective functions, acquiring k-space line at earlier part of the echo train, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to avoid the estimation of the low- resolution phase from the central k-space data ([0043]), and there was reasonable expectation of success.
Polak does not further disclose wherein the pose parameters estimated from a further set of additional k-space lines is used to adapt a field-of-view of the magnetic resonance image dataset in the same echo train in which the further set of additional k-space lines is acquired, or in the next echo train.
However, in the analogous field of endeavor in MRI imaging method, Splitthoff teaches that based on scout can, position of the slices, protocol parameters such as field-of-view can be modified to optimize for particular patient’s anatomy, in acquiring MR data as k-space data in a series of echo trains ([0033]).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify adjusting imaging parameters as taught by Li and Chen to incorporate teaching of Splitthoff, since adjusting field of view was well known in the art as taught by Splitthoff. One of ordinary skill in the art could have combined the elements as claimed by Li and Chen with no change in their respective functions, using a pose of a patient’s anatomy to provide adjustment for further imaging as disclosed by Chen to include a field of view adjustment in MR data acquisition as k-space data in echo train as taught by Splitthoff, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to provide a field of view optimization for particular patient’s anatomy ([0033]), and there was reasonable expectation of success.
Regarding to claim 11, Li, Chen, Polak, Daniel and Splitthoff together and collectively teach all limitations of claim 10 as set forth above.
Daniel further teaches wherein the at least one further set of additional k-space lines is acquired in the at least some echo trains at the beginning of the echo train ([0043]).
Claim 14 is rejected under 35 U.S.C. 103 as being unpatentable over Li and Chen as applied to claim 13 above, and further in view of “Braun et al.,” US 2019/0128989 (hereinafter Braun).
Regarding to claim 14, Li and Chen together teach all limitations of claim 13 as set forth above.
Li and Chen disclose convolutional neural network but does not specifically disclose it is a DenseNet.
However, in the analogous field of endeavor in MRI imaging method, Braun teaches correcting motion artifacts in MRI image data, using machine learning algorithm of convolutional network, a DenseNet ([0037]).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify convolutional neural network as taught by Li to incorporate teaching of Braun, since DenseNet was well known in the art as taught by Braun. One of ordinary skill in the art could have combined the elements as claimed by Li with no change in their respective functions, configuring convolutional neural network to implement DenseNet, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to provide neural network with feed-forward connection of algorithms ([0037]), and there was reasonable expectation of success.
Claims 15-16 and 18 are rejected under 35 U.S.C. 103 as being unpatentable over “Li et al.,” US 2022/0092739 (hereinafter Li) and “Chen et al.,” US 2021/0161422 (hereinafter Chen), and “Polak et al.,” US 2022/0326330 (hereinafter Polak).
Regarding to claim 15, Li teaches a method for generating a motion-corrected magnetic resonance image dataset of an object (motion artifact [0185]), the method comprising:
receiving k-space data acquired using an acquisition method (k-space data generated [0007]), the acquisition method comprising:
acquiring a magnetic resonance image dataset using an imaging protocol (imaging device configured to scan a subject to acquire image data [0045]), wherein spatial encoding is performed using phase encoding gradients along at least one phase encoding direction, and frequency encoding gradients along a frequency encoding direction (During the scan, spatial encoding within the slice may be implemented by spatial encoding coils along a phase encoding direction and a frequency encoding direction [0046]), and
wherein k-space is sampled during the imaging protocol by acquiring a plurality of imaging k-space lines oriented along the frequency encoding direction, and having different positions in the at least one phase encoding direction (phase encoding direction correspond to Y direction in the k-space, the frequency encoding direction correspond to X direction in the k-space, and phase and frequency encoding direction may be modified according to the actual needs [0046]),
acquiring or providing a low-resolution magnetic resonance image of a body part (acquire first data associated with the plurality of sample images with relatively low resolution levels [0070]);
acquiring further sets of additional k-space lines within a central region of k-space at intervals throughout the imaging protocol (image processed may only include k-space data in the central region of k space [0101]); and
applying a trained machine learning model (a machine learning algorithm [0095]) to a dataset comprising the low-resolution image in k-space notation and a further set of additional k-space lines (training models using a group of sample images with relatively low resolution levels and a corresponding group of sample images with relatively high resolution levels, training data is k-space data, central region of k space [0141], [0146])
Li does not teach estimating a pose from by machine learning model.
However, in the analogous field of endeavor in MRI imaging method, Chen teaches an MRI imaging method using MRI image data to estimate a pose of heart ([0007] and [0013]), including limitations wherein a set of pose parameters is generated, the pose parameters being an estimation of the pose of the subject during the acquisition time of the further set of additional k-space lines (low resolution scout images are used to estimate pose of a patient’ heart using a neural network, and AI scout images including compressed sensing where data is undersampled in the K-space, acquired to compare heart pose to those of heart model from initial scouting [0040]-[0041]; Figure 4 shows step 412 and step 414 and using neural network (404 and 418]) to estimate a pose of a heart).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify MRI image data as taught by Li to incorporate teaching of Chen, since using neural network to estimate a pose of a heart using MRI data was well known in the art as taught by Chen. One of ordinary skill in the art could have combined the elements as claimed by Li with no change in their respective functions, implementing neural network of estimating a pose of a subject with existing MRI data of low resolution and k-space lines within a central region of k-space, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to provide automatic adjustment planned image planes to compensate for changes in a pose of a heart throughout an entire scanning process ([0006]), and there was reasonable expectation of success.
Li and Chen do not further teach motion-corrected image dataset, forward model, and encoding matrix as well as further details.
However, in the analogous field of endeavor in ultrasound imaging method, Polka teaches following limitations:
receiving estimated pose parameters for each further set of additional k-space lines ( k-space data used to estimate motion [0091]);
estimating the motion-corrected magnetic resonance image dataset ( motion-corrected image data set [0029]), the estimating of the motion-corrected magnetic resonance image dataset comprising minimizing the data consistency error between the k-space data acquired in the imaging protocol and a forward model described by an encoding matrix (minimizing data consistency error of the forward model [0072]),
wherein the encoding matrix includes the pose parameters for each further set of additional k-space lines and Fourier encoding (encoding matrix includes the effects of rigid-body motion for each shot, Fourier encoding [0031] and [0039]).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify MRI image data as taught by Li to incorporate teaching of Polak, since estimating motion of k-space data, minimizing error to forward model, and encoding matrix was well known in the art as taught by Polak. One of ordinary skill in the art could have combined the elements as claimed by Li with no change in their respective functions, estimating motion correction of MRI datasets using encoding matrix and forward model, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to estimate motion corrected image dataset ([0031]), and there was reasonable expectation of success.
Regarding to claim 16, Li, Chen, and Polka together teach all limitation of claim 15 as set forth above.
Polka further teaches wherein the encoding matrix further includes subsampling, coil sensitivities of a multi-channel coil array, or a combination thereof ( multi-channel k-space data acquired using a multi-channel coil array [0030]).
Regarding to claim 18, Li teaches a magnetic resonance imaging apparatus comprising:
a processor configured to acquire a magnetic resonance image dataset of a body part of a subject (processor process data obtained from the imaging device [0059]), the acquisition comprising:
acquisition of the magnetic resonance image dataset using an imaging protocol (imaging device configured to scan a subject to acquire image data [0045]),
wherein spatial encoding is performed using phase encoding gradients along at least one phase encoding direction, and frequency encoding gradients along a frequency encoding direction (During the scan, spatial encoding within the slice may be implemented by spatial encoding coils along a phase encoding direction and a frequency encoding direction [0046]), and
wherein k-space is sampled during the imaging protocol by acquiring a plurality of imaging k- space lines oriented along the frequency encoding direction, and having different positions in the at least one phase encoding direction (phase encoding direction correspond to Y direction in the k-space, the frequency encoding direction correspond to X direction in the k-space, and phase and frequency encoding direction may be modified according to the actual needs [0046]),
acquisition or provision of a low-resolution magnetic resonance image of the body part (acquire first data associated with the plurality of sample images with relatively low resolution levels [0070]);
acquisition of further sets of additional k-space lines within a central region of k- space at intervals throughout the imaging protocol (image processed may only include k-space data in the central region of k space [0101]); and
application of a trained machine learning model to a dataset comprising the low- resolution image in k-space notation and a further set of additional k-space lines (training models using a group of sample images with relatively low resolution levels and a corresponding group of sample images with relatively high resolution levels, training data is k-space data, central region of k space [0141], [0146]),
Li does not teach estimating a pose from by machine learning model.
However, in the analogous field of endeavor in MRI imaging method, Chen teaches an MRI imaging method using MRI image data to estimate a pose of heart ([0007] and [0013]), including limitations wherein a set of pose parameters is generated, the pose parameters being an estimation of the pose of the subject during the acquisition time of the further set of additional k-space lines (low resolution scout images are used to estimate pose of a patient’ heart using a neural network, and AI scout images including compressed sensing where data is undersampled in the K-space, acquired to compare heart pose to those of heart model from initial scouting [0040]-[0041]; Figure 4 shows step 412 and step 414 and using neural network (404 and 418]) to estimate a pose of a heart).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify MRI image data as taught by Li to incorporate teaching of Chen, since using neural network to estimate a pose of a heart using MRI data was well known in the art as taught by Chen. One of ordinary skill in the art could have combined the elements as claimed by Li with no change in their respective functions, implementing neural network of estimating a pose of a subject with existing MRI data of low resolution and k-space lines within a central region of k-space, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to provide automatic adjustment planned image planes to compensate for changes in a pose of a heart throughout an entire scanning process ([0006]), and there was reasonable expectation of success.
Li and Chen do not further teach following limitations:
a radio frequency (RF) controller configured to drive an RF-coil comprising a multi- channel coil array;
a gradient controller configured to control gradient coils; and
a control unit configured to control the radio frequency controller and the gradient controller to execute the imaging protocol.
However, in the analogous field of endeavor in ultrasound imaging method, Polka teaches following limitations:
a radio frequency (RF) controller configured to drive an RF-coil comprising a multi- channel coil array (radio frequency controller configured to drive an RF- coil comprising a multi-channel coil-array [0036]);
a gradient controller configured to control gradient coils (a gradient controller configured to control gradient coils [0036]); and
a control unit configured to control the radio frequency controller and the gradient controller to execute the imaging protocol (a control unit configured to control the radio frequency controller and the gradient controller to execute the imaging protocol [0036]).
Therefore, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to modify MR imaging apparatus as taught by Li to incorporate teaching of Polak, since controller controlling RF coil and gradient coil for multi-channel coil array was well known in the art as taught by Polak. One of ordinary skill in the art could have combined the elements as claimed by Li with no change in their respective functions, configuring its MRI apparatus to acquire image using a multi-channel coil array and its controller, and the combination would have yielded nothing more than predictable results to one of ordinary skill in the art before the effective filing date of the claimed invention. The motivation would have been to provide a multi-shot imaging protocol ([0036]), and there was reasonable expectation of success.
Conclusion
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/PATRICIA J PARK/Primary Examiner, Art Unit 3798
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