Last updated: August 14, 2026

Application No. 19/429,999

COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES AND USES THEREOF

Final Rejection

Filed

Dec 22, 2025

Priority

Dec 15, 2017 — provisional 62/599,547 +7 more

Examiner

CHONG, KIMBERLY

Art Unit

1636

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

Flagship Pioneering Inc.

OA Round

2 (Final)

Interview Optional

— +12.8% interview lift. Interview already conducted in this application's prosecution history. This examiner has a 72% grant rate with +12.8% interview lift. Since an interview has already been tried, recommend written response with narrowed claims based on precedent claim evolution patterns.

Based on 1493 resolved cases, 2023–2026

Examiner Intelligence

CHONG, KIMBERLY View full profile →

Grants 72% — above average

Career Allowance Rate

1081 granted / 1493 resolved

+12.4% vs TC avg

Moderate +13% lift

Without

With

+12.8%

Interview Lift

resolved cases with interview

Typical timeline

2y 6m

Avg Prosecution

62 currently pending

Career history

1554

Total Applications

across all art units

Statute-Specific Performance

§101

3.8%

-36.2% vs TC avg

§103

31.2%

-8.8% vs TC avg

§102

17.3%

-22.7% vs TC avg

§112

33.2%

-6.8% vs TC avg

Black line = Tech Center average estimate • Based on career data from 1493 resolved cases

Prosecution Timeline

Dec 22, 2025

Application Filed

Apr 15, 2026

Non-Final Rejection mailed

Jul 02, 2026

Interview Requested

Jul 14, 2026

Examiner Interview Summary

Jul 15, 2026

Response Filed

Aug 05, 2026

Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

16/966,503

Patent 12697386

NUCLEIC ACID ANTIBODY CONSTRUCTS FOR USE AGAINST EBOLA VIRUS

6y 0m to grant Granted Aug 04, 2026

19/054,315

Patent 12673108

CELL-PENETRATING PEPTIDE CONJUGATES AND METHODS OF THEIR USE

1y 4m to grant Granted Jul 07, 2026

18/903,985

Patent 12668799

NON-LIPOSOMAL SYSTEMS FOR NUCLEIC ACID DELIVERY

1y 9m to grant Granted Jun 30, 2026

17/635,190

Patent 12662672

A Method Of Promoting Survival And/Or Function Of A Motor Neuron And Related Agents, Uses And Methods

4y 4m to grant Granted Jun 23, 2026

18/362,190

Patent 12662669

RAAV-BASED COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS

2y 10m to grant Granted Jun 23, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

3-4

Expected OA Rounds

72%

Grant Probability

85%

With Interview (+12.8%)

2y 6m (~1y 10m remaining)

Median Time to Grant

Moderate

PTA Risk

Based on 1493 resolved cases by this examiner. Grant probability derived from career allowance rate.