Prosecution Insights
Last updated: October 02, 2026
Application No. 19/577,281

METHODS FOR FORMING ENCLOSURES AND PERFORMING ASSAYS ON A CELL WITHIN AN ENCLOSURE

Non-Final OA §112
Filed
Mar 24, 2026
Priority
Jan 08, 2021 — provisional 63/135,463 +11 more
Examiner
HORLICK, KENNETH R
Art Unit
1681
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Cellanome Inc.
OA Round
1 (Non-Final)
79%
Grant Probability
Favorable
1-2
OA Rounds
1y 11m
Est. Remaining
94%
With Interview

Examiner Intelligence

Grants 79% — above average
79%
Career Allowance Rate
828 granted / 1049 resolved
+18.9% vs TC avg
Strong +15% interview lift
Without
With
+15.3%
Interview Lift
resolved cases with interview
Typical timeline
2y 5m
Avg Prosecution
32 currently pending
Career history
1073
Total Applications
across all art units

Statute-Specific Performance

§101
7.9%
-32.1% vs TC avg
§103
28.7%
-11.3% vs TC avg
§102
9.7%
-30.3% vs TC avg
§112
34.7%
-5.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1049 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status 1. The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . OBJECTIONS 2. Claims 1-17 are objected to because of the following informality: independent claim 1 recites in step (f) ‘form’ instead of ‘from’. Correction is required. 3. Claim 16 is further objected to because it lacks a period at the end. Correction is required. NON-PRIOR ART REJECTION 4. The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 29 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. This claim is indefinite because it does not comprise a complete sentence; it would appear that the language ‘wherein’ was inadvertently omitted. Correction is required. ALLOWABLE SUBJECT MATTER 5. Claims 1-31 are free of the prior art, but they are objected to, and claim 29 is rejected for another reason. The closest prior art is Varadarajan et al. (US 2021/0018503), which discloses integrating functional and molecular profiling of cells in a fluidic device, wherein the functional assay is performed on a cell within an enclosure. This document does not teach or suggest releasing nucleic acid from the enclosed cell and capturing it in the same enclosure, as is required by independent claims 1 and 18. Rather, Varadarajan discloses performing a functional assay such as imaging on an enclosed cell, isolating the cell from the enclosure, and then releasing nucleic acids from the relocated cell in a separate container. CONCLUSION 6. No claims are allowable. 7. Any inquiry concerning this communication or earlier communications from the examiner should be directed to KENNETH R HORLICK whose telephone number is (571)272-0784. The examiner can normally be reached Mon. - Thurs. 8:30 - 6:30. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Gary Benzion can be reached at 571-272-0782. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. 08/25/26 /KENNETH R HORLICK/ Primary Examiner, Art Unit 1681
Read full office action

Prosecution Timeline

Mar 24, 2026
Application Filed
Aug 27, 2026
Non-Final Rejection mailed — §112
Sep 25, 2026
Response Filed

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12747466
ANALYSIS OF NUCLEIC ACIDS ASSOCIATED WITH EXTRACELLULAR VESICLES
3y 4m to grant Granted Sep 29, 2026
Patent 12735751
SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION
11m to grant Granted Sep 15, 2026
Patent 12729401
CHIMERIC AMPLICON ARRAY SEQUENCING
3y 9m to grant Granted Sep 08, 2026
Patent 12729402
METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES
1y 5m to grant Granted Sep 08, 2026
Patent 12716094
Methods of Producing Ribosomal Ribonucleic Acid Complexes
3y 7m to grant Granted Aug 25, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
79%
Grant Probability
94%
With Interview (+15.3%)
2y 5m (~1y 11m remaining)
Median Time to Grant
Low
PTA Risk
Based on 1049 resolved cases by this examiner. Grant probability derived from career allowance rate.

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