Prosecution Insights
Last updated: October 25, 2026

Fulcrum Therapeutics Inc.

Technology area: Biotechnology & Pharmaceuticals

5 pending office actions • 4 art units • 5 examiners • 0 of 5 (0%) have an AI response strategy ready

Analysis

Fulcrum Therapeutics Inc. has 5 pending office actions in the Biotechnology & Pharmaceuticals technology area. These actions are distributed across 4 distinct art units. The portfolio involves 5 distinct examiners. SEAMAN, D MARGARET M is the busiest examiner with 1 pending office action. Since there are 5 distinct examiners for 5 pending office actions, each examiner is responsible for one case.

This spread across 4 distinct art units indicates that the company's biotech filings are subject to varied examination perspectives. Practitioners should monitor the 4 distinct art units for any diverging trends in biotechnology. Coordinating responses across these 5 distinct examiners will be necessary to maintain a unified prosecution strategy for the 5 pending office actions. The lack of examiner overlap suggests that each application requires a unique approach tailored to the individual examiner.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Portfolio Summary

5
Total Pending OAs
4
Non-Final OAs
1
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 1 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

1
Overdue
0
Due this week
0
Due this month
0
Due in next 60 days
0
Due later

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

3
Hard (60%)
0
Medium (0%)
2
Easy (40%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§112 only2 (40%)
Multi-statute (no §101)3 (60%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

5
Life Sciences
100% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

50 h
Manual time on pending OAs
10 h
Time saved (low, 20%)
18 h
Time saved (mid, 35%)
0.4 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
SEAMAN, D MARGARET M 1 76.6% +8.1%
LEE, ANDREW P 1 48.5% +22.8%
KENYON, JOHN S 1 79.7% +18.2%
HAVLIN, ROBERT H 1 51.3% +28.3%
EBBINGHAUS, BRIANA NOEL 1 59.7% +63.0%

Hard Cases (3)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 3 ordered by deadline are shown.

App #TitleExaminerDue in
18553352 POLYMORPHIC FORMS OF (S)-12-FLUORO-4-(1-METHYL-1H-PYRAZOL-5-YL)-7A,8,13,14-TETRAHYDRO-7H-[1,2,4]TRIAZOLO[4',3':1,6]PYRIDO[3,2-B]BENZOFURO[4,3-FG][1,4]OXAZONINE HAVLIN, ROBERT H 71d overdue
18557694 METHODS OF REGULATING BCL11A EXPRESSION AND TREATMENT OF BCL11A-MEDIATED DISORDERS LEE, ANDREW P —
18553317 MACROCYCLIC AZOLOPYRIDINES KENYON, JOHN S —

Interview Candidates (4)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 4 ordered by deadline are shown.

App #TitleExaminerDue in
18553352 POLYMORPHIC FORMS OF (S)-12-FLUORO-4-(1-METHYL-1H-PYRAZOL-5-YL)-7A,8,13,14-TETRAHYDRO-7H-[1,2,4]TRIAZOLO[4',3':1,6]PYRIDO[3,2-B]BENZOFURO[4,3-FG][1,4]OXAZONINE HAVLIN, ROBERT H 71d overdue
18557694 METHODS OF REGULATING BCL11A EXPRESSION AND TREATMENT OF BCL11A-MEDIATED DISORDERS LEE, ANDREW P —
18553317 MACROCYCLIC AZOLOPYRIDINES KENYON, JOHN S —
17295782 COMPOSITIONS AND METHODS FOR INCREASING FETAL HEMOGLOBIN AND TREATING SICKLE CELL DISEASE EBBINGHAUS, BRIANA NOEL —

Top Art Units

Art UnitApps
1625 2
1691 1
1626 1
1632 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18783250 MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS SEAMAN, D MARGARET M 1625 §112 Non-Final OA — Pending Jul 24, 2024
18557694 METHODS OF REGULATING BCL11A EXPRESSION AND TREATMENT OF BCL11A-MEDIATED DISORDERS LEE, ANDREW P 1691 §102§103§112 Non-Final OA — Pending Oct 27, 2023
18553317 MACROCYCLIC AZOLOPYRIDINES KENYON, JOHN S 1625 §103§112 Non-Final OA — Pending Sep 29, 2023
18553352 POLYMORPHIC FORMS OF (S)-12-FLUORO-4-(1-METHYL-1H-PYRAZOL-5-YL)-7A,8,13,14-TETRAHYDRO-7H-[1,2,4]TRIAZOLO[4',3':1,6]PYRIDO[3,2-B]BENZOFURO[4,3-FG][1,4]OXAZONINE HAVLIN, ROBERT H 1626 §102§103Other Final Rejection 71d overdue Pending Sep 29, 2023
17295782 COMPOSITIONS AND METHODS FOR INCREASING FETAL HEMOGLOBIN AND TREATING SICKLE CELL DISEASE EBBINGHAUS, BRIANA NOEL 1632 §112 Non-Final OA — Pending May 20, 2021

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Frequently Asked Questions

How many pending USPTO office actions does Fulcrum Therapeutics Inc. have?

Fulcrum Therapeutics Inc. has 5 pending office actions as of October 2026, spread across 4 art units and 5 examiners.

Which USPTO examiner handles the most Fulcrum Therapeutics Inc. applications?

D Margaret M Seaman has the most, with 1 of Fulcrum Therapeutics Inc.'s pending office actions.

What technology area are Fulcrum Therapeutics Inc.'s patent applications in?

Mostly Biotechnology & Pharmaceuticals (USPTO Tech Center 1600), based on where its pending office actions are examined.

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