Prosecution Insights
Last updated: October 04, 2026

Macrogenics Inc.

Technology area: Biotechnology & Pharmaceuticals

6 pending office actions • 3 art units • 5 examiners • 0 of 6 (0%) have an AI response strategy ready • 4 patents granted in the last 365 days

Analysis

Macrogenics Inc. is currently managing 6 pending office actions within the Biotechnology & Pharmaceuticals technology area. These actions are distributed among 5 distinct examiners and 3 distinct art units. This distribution indicates that while there is some overlap in the examiners, the prosecution is spread across multiple administrative units. The presence of 5 distinct examiners for 6 pending office actions suggests that most matters are receiving independent reviews, which can lead to a variety of outcomes within the portfolio. This variety requires practitioners to tailor their arguments to the specific preferences of multiple officials to ensure a cohesive strategy across the Biotechnology & Pharmaceuticals sector.

The busiest examiner for this portfolio is MOSELEY II, NELSON B, who is currently responsible for 2 pending office actions. This examiner holds more active matters than any other individual in the data, making their specific tendencies particularly important for the overall success of the portfolio. The involvement of 3 distinct art units indicates that the biotechnology applications cover several specialized technical areas. Practitioners must manage these 6 pending office actions by balancing the specific requirements of the 3 distinct art units and the individual preferences of the 5 distinct examiners involved. This complex distribution necessitates a versatile approach to the company's patent filings.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Portfolio Summary

6
Total Pending OAs
5
Non-Final OAs
1
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 1 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

0
Overdue
0
Due this week
1
Due this month
0
Due in next 60 days
0
Due later

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

2
Hard (33%)
3
Medium (50%)
1
Easy (17%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§103 only1 (17%)
Double-patenting only1 (17%)
Double-patenting + other2 (33%)
Multi-statute (no §101)2 (33%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

5
Life Sciences
83% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
1
Business / Other
17% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

60 h
Manual time on pending OAs
12 h
Time saved (low, 20%)
21 h
Time saved (mid, 35%)
0.5 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
MOSELEY II, NELSON B 2 68.0% +41.5%
NATARAJAN, MEERA 1 62.5% +18.0%
BRISTOL, LYNN ANNE 1 63.4% +39.8%
DUFFY, BRADLEY 1 54.5% +45.8%
YU, MISOOK 1 39.0% +18.1%

Hard Cases (2)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 2 ordered by deadline are shown.

App #TitleExaminerDue in
18577945 PHARMACEUTICAL COMPOSITIONS OF A B7-H3 ANTIBODY AND USE OF THE SAME NATARAJAN, MEERA —
18484921 MULTl-CHAIN POLYPEPTIDE-CONTAINING TRI-SPECIFIC BINDING MOLECULES THAT SPECIFICALLY BIND TO MULTIPLE CANCER ANTIGENS BRISTOL, LYNN ANNE —

Interview Candidates (6)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 6 ordered by deadline are shown.

App #TitleExaminerDue in
18164952 Covalent Diabodies and Uses Thereof DUFFY, BRADLEY 23d
18577945 PHARMACEUTICAL COMPOSITIONS OF A B7-H3 ANTIBODY AND USE OF THE SAME NATARAJAN, MEERA —
18499658 METHODS OF USING BISPECIFIC MOLECULES HAVING IMMUNOREACTIVITY WITH PD-1 AND CTLA-4 MOSELEY II, NELSON B —
18484921 MULTl-CHAIN POLYPEPTIDE-CONTAINING TRI-SPECIFIC BINDING MOLECULES THAT SPECIFICALLY BIND TO MULTIPLE CANCER ANTIGENS BRISTOL, LYNN ANNE —
18321354 Variant CD3-Binding Domains and Their Use in Combination Therapies for the Treatment of Disease MOSELEY II, NELSON B —
18006294 METHODS FOR THE USE OF A PD-1 X CTLA-4 BISPECIFIC MOLECULE YU, MISOOK —

Top Art Units

Art UnitApps
1642 2
1643 2
1641 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18577945 PHARMACEUTICAL COMPOSITIONS OF A B7-H3 ANTIBODY AND USE OF THE SAME NATARAJAN, MEERA — §102§112 Non-Final OA — Pending Jan 09, 2024
18499658 METHODS OF USING BISPECIFIC MOLECULES HAVING IMMUNOREACTIVITY WITH PD-1 AND CTLA-4 MOSELEY II, NELSON B 1642 §112DP Non-Final OA — Pending Nov 01, 2023
18484921 MULTl-CHAIN POLYPEPTIDE-CONTAINING TRI-SPECIFIC BINDING MOLECULES THAT SPECIFICALLY BIND TO MULTIPLE CANCER ANTIGENS BRISTOL, LYNN ANNE 1643 §103§112Other Non-Final OA — Pending Oct 11, 2023
18321354 Variant CD3-Binding Domains and Their Use in Combination Therapies for the Treatment of Disease MOSELEY II, NELSON B 1642 DP Non-Final OA — Pending May 22, 2023
18164952 Covalent Diabodies and Uses Thereof DUFFY, BRADLEY 1643 §103 Final Rejection 23d Pending Feb 06, 2023
18006294 METHODS FOR THE USE OF A PD-1 X CTLA-4 BISPECIFIC MOLECULE YU, MISOOK 1641 §102§103§112DPOther Non-Final OA — Pending Jan 20, 2023

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