Prosecution Insights
Last updated: October 25, 2026

Merus N V

Technology area: Biotechnology & Pharmaceuticals

18 pending office actions • 8 art units • 15 examiners • 0 of 18 (0%) have an AI response strategy ready • 4 patents granted in the last 365 days

Analysis

Merus N V has 17 pending office actions in Biotechnology & Pharmaceuticals. The matters are distributed across 14 examiners and 8 art units, showing substantial examiner diversity alongside repeated art-unit activity. The art-unit concentration provides an opportunity to track recurring technical treatment, but the examiner distribution requires individualized prosecution management.

WEHBE, ANNE MARIE SABRINA is the busiest examiner, handling 2 pending matters. The leading examiner assignment is limited relative to the full portfolio, so it should inform coordination without becoming the sole basis for prosecution planning.

A centralized review of claim language, technical disclosures, and prior-art positions can support consistency across related matters. Responses should still be tailored to the particular examiner and art unit, especially where biotechnology claims raise distinct issues across the examination tracks.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Portfolio Summary

18
Total Pending OAs
9
Non-Final OAs
9
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 8 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

1
Overdue
1
Due this week
4
Due this month
0
Due in next 60 days
2
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 8 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (1)Due ≤ 7 days (1)Due ≤ 30 days (4)Due later (2)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

8
Hard (44%)
6
Medium (33%)
4
Easy (22%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§101 + other1 (6%)
§103 only2 (11%)
§102 only1 (6%)
§112 only4 (22%)
Double-patenting + other3 (17%)
Multi-statute (no §101)7 (39%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

18
Life Sciences
100% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

180 h
Manual time on pending OAs
36 h
Time saved (low, 20%)
63 h
Time saved (mid, 35%)
1.6 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
WEHBE, ANNE MARIE SABRINA 2 57.3% +43.3%
BRISTOL, LYNN ANNE 2 63.4% +39.8%
ALSOMAIRY, SARAH ABDOALATIF 2 57.4% +30.7%
CHASE, CAROL ANN 1 41.9% +84.9%
HOPPE, EMMA RUTH 1 40.0% +58.3%
DONOGHUE, BRITTNEY ERIN 1 58.7% +47.4%
LI, RUIXIANG 1 59.5% +18.7%
NICKOL, GARY B 1 46.6% +33.3%
GODDARD, LAURA B 1 50.8% +13.6%
DUNN, MCKENZIE A 1 54.2% +57.3%

Hard Cases (8)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17431044 COMBINATIONS OF BINDING MOIETIES THAT BIND EGFR, HER2 AND HER3 ALSOMAIRY, SARAH ABDOALATIF 30d overdue
18084797 BINDING DOMAINS AGAINST CANCER-ASSOCIATED MUC1 XIAO, YAN 69d
18398935 PROMISCUOUS CD3 BINDING MOLECULES CHASE, CAROL ANN —
18566982 NEW NRG1 FUSIONS, FUSION JUNCTIONS AND METHODS FOR DETECTING THEM HOPPE, EMMA RUTH —
18460482 ANTIBODY PRODUCING NON-HUMAN ANIMALS WEHBE, ANNE MARIE SABRINA —
18449460 ERBB-2 AND ERBB3 BINDING BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT OF CELLS THAT HAVE AN NRG1 FUSION GENE LI, RUIXIANG —
18190607 METHOD FOR DETECTING EXPRESSION OR CLUSTERING OF CELL SURFACE MOIETIES DUNN, MCKENZIE A —
17431041 PRODUCING COMPOSITIONS COMPRISING TWO OR MORE ANTIBODIES FAUST, AMBER KATHLEEN —

Interview Candidates (13)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17431044 COMBINATIONS OF BINDING MOIETIES THAT BIND EGFR, HER2 AND HER3 ALSOMAIRY, SARAH ABDOALATIF 30d overdue
18251832 MEANS AND METHODS FOR TREATING SUBJECTS WITH ERBB3 MUTATION POSITIVE CANCER GODDARD, LAURA B 6d
17926283 METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES BRISTOL, LYNN ANNE 27d
17755196 MEANS AND METHODS FOR TREATING SUBJECTS WITH HER2 AND HER3 POSITIVE CANCER BRISTOL, LYNN ANNE 70d
18398935 PROMISCUOUS CD3 BINDING MOLECULES CHASE, CAROL ANN —
18566982 NEW NRG1 FUSIONS, FUSION JUNCTIONS AND METHODS FOR DETECTING THEM HOPPE, EMMA RUTH —
18553114 NOVEL MULTISPECIFIC ANTIBODIES DONOGHUE, BRITTNEY ERIN —
18464173 ANTIBODY PRODUCING NON-HUMAN ANIMALS WEHBE, ANNE MARIE SABRINA —

Top Art Units

Art UnitApps
1643 5
1646 3
1642 3
1634 2
1674 2
1683 1
1675 1
1678 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18398935 PROMISCUOUS CD3 BINDING MOLECULES CHASE, CAROL ANN 1646 §102§112 Non-Final OA — Pending Dec 28, 2023
18566982 NEW NRG1 FUSIONS, FUSION JUNCTIONS AND METHODS FOR DETECTING THEM HOPPE, EMMA RUTH 1683 §101§102§112DP Non-Final OA — Pending Dec 04, 2023
18553114 NOVEL MULTISPECIFIC ANTIBODIES DONOGHUE, BRITTNEY ERIN 1675 §112 Non-Final OA — Pending Sep 28, 2023
18464173 ANTIBODY PRODUCING NON-HUMAN ANIMALS WEHBE, ANNE MARIE SABRINA 1634 §102 Final Rejection — Pending Sep 08, 2023
18460482 ANTIBODY PRODUCING NON-HUMAN ANIMALS WEHBE, ANNE MARIE SABRINA 1634 §102§103§112Other Final Rejection — Pending Sep 01, 2023
18449460 ERBB-2 AND ERBB3 BINDING BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT OF CELLS THAT HAVE AN NRG1 FUSION GENE LI, RUIXIANG 1674 §103§112 Non-Final OA — Pending Aug 14, 2023
18257804 MULTISPECIFIC ANTIBODIES FOR THE TREATMENT OF CANCER NICKOL, GARY B 1643 §103 Final Rejection — Pending Jun 15, 2023
18251832 MEANS AND METHODS FOR TREATING SUBJECTS WITH ERBB3 MUTATION POSITIVE CANCER GODDARD, LAURA B 1642 §102§103§112DP Final Rejection 6d Pending May 04, 2023
18190607 METHOD FOR DETECTING EXPRESSION OR CLUSTERING OF CELL SURFACE MOIETIES DUNN, MCKENZIE A 1678 §102§103§112 Final Rejection — Pending Mar 27, 2023
18084797 BINDING DOMAINS AGAINST CANCER-ASSOCIATED MUC1 XIAO, YAN 1642 §102§112Other Final Rejection 69d Pending Dec 20, 2022
18062871 BINDING MOLECULES THAT MODULATE A BIOLOGICAL ACTIVITY EXPRESSED BY A CELL MOSELEY II, NELSON B 1642 §112 Final Rejection 22d Pending Dec 07, 2022
17926283 METHODS AND MEANS FOR THE PRODUCTION OF IG-LIKE MOLECULES BRISTOL, LYNN ANNE 1643 §112 Non-Final OA 27d Pending Nov 18, 2022
17921042 TREATMENT OF CANCERS WITH AN ANTIBODY THAT BINDS LGR5 AND EGFR SHUPE, ELIZABETH A 1643 §103DP Non-Final OA 29d Pending Oct 24, 2022
17759728 MEANS AND METHOD FOR MODULATING IMMUNE CELL ENGAGING EFFECTS ALSOMAIRY, SARAH ABDOALATIF 1646 §103 Final Rejection — Pending Jul 29, 2022
17755196 MEANS AND METHODS FOR TREATING SUBJECTS WITH HER2 AND HER3 POSITIVE CANCER BRISTOL, LYNN ANNE 1643 §112 Non-Final OA 70d Pending Apr 22, 2022
17632181 TREATMENT OF CANCER WITH A COMBINATION OF AN ANTIBODY THAT BINDS LGR5 AND EGFR AND A TOPOISOMERASE I INHIBITOR MIDDLETON, DANAYA L 1674 §103§112DP Non-Final OA 28d Pending Feb 01, 2022
17431044 COMBINATIONS OF BINDING MOIETIES THAT BIND EGFR, HER2 AND HER3 ALSOMAIRY, SARAH ABDOALATIF 1646 §103§112 Final Rejection 30d overdue Pending Aug 13, 2021
17431041 PRODUCING COMPOSITIONS COMPRISING TWO OR MORE ANTIBODIES FAUST, AMBER KATHLEEN 1643 §102§103§112 Non-Final OA — Pending Aug 13, 2021

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Frequently Asked Questions

How many pending USPTO office actions does Merus N V have?

Merus N V has 18 pending office actions as of October 2026, spread across 8 art units and 15 examiners.

Which USPTO examiner handles the most Merus N V applications?

Anne Marie Sabrina Wehbe has the most, with 2 of Merus N V's pending office actions.

What technology area are Merus N V's patent applications in?

Mostly Biotechnology & Pharmaceuticals (USPTO Tech Center 1600), based on where its pending office actions are examined.

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