Prosecution Insights
Last updated: October 25, 2026

The Scripps Research Institute

Technology area: Biotechnology & Pharmaceuticals

21 pending office actions • 18 art units • 21 examiners • 0 of 21 (0%) have an AI response strategy ready • 24 patents granted in the last 365 days

Analysis

The Scripps Research Institute has 21 pending office actions in Biotechnology & Pharmaceuticals. The matters involve 21 examiners across 18 art units, showing a highly distributed docket with several matters sharing technical examination groups but not examiners.

DRISCOLL, LORA E BARNHART is the busiest examiner, with 1 pending office action. No examiner accounts for multiple actions in the available data, so prosecution management should emphasize technology and art-unit organization, along with file-specific review of each examiner’s position.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Portfolio Summary

21
Total Pending OAs
16
Non-Final OAs
5
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 6 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

3
Overdue
0
Due this week
0
Due this month
0
Due in next 60 days
3
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 6 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (3)Due later (3)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

11
Hard (52%)
8
Medium (38%)
2
Easy (10%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§101 + other2 (10%)
§103 only2 (10%)
§102 only3 (14%)
§112 only1 (5%)
Double-patenting only1 (5%)
Double-patenting + other3 (14%)
Multi-statute (no §101)9 (43%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

18
Life Sciences
86% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
3
Business / Other
14% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

210 h
Manual time on pending OAs
42 h
Time saved (low, 20%)
74 h
Time saved (mid, 35%)
1.8 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
DRISCOLL, LORA E BARNHART 1 31.8% +20.8%
HASTINGS, ALISON AZAR 1 62.5% +42.1%
TSAY, MARSHA M 1 45.5% +52.8%
GRIZER, CASSANDRA SENN 1 70.0% +48.0%
SCHMIDT, IZABELA MARIA 1 65.7% +42.7%
BUCCINI, MICHELLE CALLAHAN 1 — —
JONES, CHRISTINE MICHELLE 1 0.0% +0.0%
NEAGU, IRINA 1 46.7% +57.2%
LEE, ANDREW P 1 48.5% +22.8%
CHANDRAKUMAR, NIZAL S 1 72.7% +18.2%

Hard Cases (11)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18327110 ENGINEERED CELLS AND METHODS OF USE KELLY, ROBERT M 2d overdue
17923171 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 SCHACHERMEYER, SAMANTHA LYNN 65d
18388023 METHODS FOR MITIGATING AND PREVENTING PROTEOSTASIS-BASED INJURIES LEE, ANDREW P 83d
18859759 MOLECULAR EDITING OF MULTIPLE C-H BONDS LEVERAGING RECOGNITION OF DISTANCE, GEOMETRY AND CHIRALITY HASTINGS, ALISON AZAR —
18821631 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HIV INFECTION GRIZER, CASSANDRA SENN —
18423804 Methods, Systems, and Compositions for Diagnosing Transplant Rejection JONES, CHRISTINE MICHELLE —
18517049 PHARMACOLOGICAL DEPLETION OF HEME FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME NEAGU, IRINA —
18548635 HETEROBIFUNCTIONAL COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION AND METHODS FOR THEIR USE CHANDRAKUMAR, NIZAL S —

Interview Candidates (8)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18388023 METHODS FOR MITIGATING AND PREVENTING PROTEOSTASIS-BASED INJURIES LEE, ANDREW P 83d
19083131 REENGINEERING MRNA PRIMARY STRUCTURE FOR ENHANCED PROTEIN PRODUCTION DRISCOLL, LORA E BARNHART —
18859759 MOLECULAR EDITING OF MULTIPLE C-H BONDS LEVERAGING RECOGNITION OF DISTANCE, GEOMETRY AND CHIRALITY HASTINGS, ALISON AZAR —
18917399 NUCLEOSIDE TRIPHOSPHATE TRANSPORTER AND USES THEREOF TSAY, MARSHA M —
18821631 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HIV INFECTION GRIZER, CASSANDRA SENN —
18627081 NOVEL KAPPA OPIOID LIGANDS SCHMIDT, IZABELA MARIA —
18517049 PHARMACOLOGICAL DEPLETION OF HEME FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME NEAGU, IRINA —
18548635 HETEROBIFUNCTIONAL COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION AND METHODS FOR THEIR USE CHANDRAKUMAR, NIZAL S —

Top Art Units

Art UnitApps
1699 2
3991 1
1656 1
1621 1
1675 1
1682 1
1629 1
1691 1
1625 1
1624 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
19083131 REENGINEERING MRNA PRIMARY STRUCTURE FOR ENHANCED PROTEIN PRODUCTION DRISCOLL, LORA E BARNHART 3991 §112DPOther Non-Final OA — Pending Mar 18, 2025
18859759 MOLECULAR EDITING OF MULTIPLE C-H BONDS LEVERAGING RECOGNITION OF DISTANCE, GEOMETRY AND CHIRALITY HASTINGS, ALISON AZAR — §102§112Other Non-Final OA — Pending Oct 24, 2024
18917399 NUCLEOSIDE TRIPHOSPHATE TRANSPORTER AND USES THEREOF TSAY, MARSHA M 1656 §102§103§112DP Non-Final OA — Pending Oct 16, 2024
18821631 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HIV INFECTION GRIZER, CASSANDRA SENN — §102§103§112 Non-Final OA — Pending Aug 30, 2024
18627081 NOVEL KAPPA OPIOID LIGANDS SCHMIDT, IZABELA MARIA 1621 DP Non-Final OA — Pending Apr 04, 2024
18554340 NOVEL THERAPIES WITH ENGINEERED EFFECTOR CELLS BUCCINI, MICHELLE CALLAHAN 1675 §102§103§112DP Non-Final OA — Pending Jan 31, 2024
18423804 Methods, Systems, and Compositions for Diagnosing Transplant Rejection JONES, CHRISTINE MICHELLE 1682 §101§103§112DP Non-Final OA — Pending Jan 26, 2024
18517049 PHARMACOLOGICAL DEPLETION OF HEME FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME NEAGU, IRINA 1629 §102§103 Non-Final OA — Pending Nov 22, 2023
18388023 METHODS FOR MITIGATING AND PREVENTING PROTEOSTASIS-BASED INJURIES LEE, ANDREW P 1691 §102§103 Non-Final OA 83d Pending Nov 08, 2023
18548635 HETEROBIFUNCTIONAL COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION AND METHODS FOR THEIR USE CHANDRAKUMAR, NIZAL S 1625 §103§112 Final Rejection — Pending Sep 01, 2023
18546217 SMALL MOLECULE ACTIVATORS OF YAP TRANSCRIPTIONAL ACTIVITY FOR REGENERATIVE ORGAN REPAIR BRAUN, MADELINE E 1624 §103§112 Non-Final OA — Pending Aug 11, 2023
18257808 IMMUNOGENIC COMPOSITIONS BOESEN, AGNIESZKA 1672 §102 Final Rejection 70d Pending Jun 15, 2023
18327110 ENGINEERED CELLS AND METHODS OF USE KELLY, ROBERT M 1638 §102§112Other Non-Final OA 2d overdue Pending Jun 01, 2023
18305292 COILED COIL IMMUNOGLOBULIN FUSION PROTEINS AND COMPOSITIONS THEREOF NATARAJAN, MEERA 1643 §102 Non-Final OA — Pending Apr 21, 2023
18044260 SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS JARRELL, NOBLE E 1699 §101§102§112 Non-Final OA — Pending Mar 07, 2023
17923171 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 SCHACHERMEYER, SAMANTHA LYNN 1693 §102§103 Non-Final OA 65d Pending Nov 03, 2022
17918448 GUANIDINE-MODIFIED C-TERMINUS VANCOMYCIN COMPOUNDS, COMPOSITIONS AND METHODS REYNOLDS, FRED H 1658 §103Other Final Rejection 30d overdue Pending Oct 12, 2022
17617989 METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY CONDITIONS LOCKARD, JON MCCLELLAND 1647 §112 Non-Final OA — Pending Sep 29, 2022
17826660 SULFUR (VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF OTTON, ALICIA L 1699 §102 Final Rejection — Pending May 27, 2022
17716848 COMPOSITIONS AND METHODS FOR IN VIVO SYNTHESIS OF UNNATURAL POLYPEPTIDES SHIN, DANA H 1635 §103Other Final Rejection 8d overdue Pending Apr 08, 2022
17263490 ENGINERRED ANTIBODIES TO HIV ENV SIFFORD, JEFFREY MARK 1671 §103§112 Non-Final OA — Pending Jan 26, 2021

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Frequently Asked Questions

How many pending USPTO office actions does The Scripps Research Institute have?

The Scripps Research Institute has 21 pending office actions as of October 2026, spread across 18 art units and 21 examiners.

Which USPTO examiner handles the most The Scripps Research Institute applications?

Lora E Barnhart Driscoll has the most, with 1 of The Scripps Research Institute's pending office actions.

What technology area are The Scripps Research Institute's patent applications in?

Mostly Biotechnology & Pharmaceuticals (USPTO Tech Center 1600), based on where its pending office actions are examined.

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