Technology area: Biotechnology & Pharmaceuticals
54 pending office actions • 33 art units • 46 examiners • 0 of 54 (0%) have an AI response strategy ready • 49 patents granted in the last 365 days
The University of North Carolina at Chapel Hill has 50 pending office actions in Biotechnology & Pharmaceuticals. The matters involve 42 distinct examiners and 29 distinct art units, showing that the portfolio is distributed across multiple examination teams and technical groupings.
ARMSTRONG, SUSANNAH SIPPLE is the busiest examiner, with 3 pending matters. Because the leading examiner accounts for only a small part of the listed activity, a uniform prosecution playbook may need to accommodate varied examiner practices. Coordination of claim language, disclosure support, and response positions can help preserve consistency across the portfolio.
Based on the USPTO statutory response window for each pending office action. 15 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.
Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 15 of the docket's apps have a known mailing date.
Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.
| Bucket | Cases |
|---|---|
| §101 + other | 2 (4%) |
| §103 only | 14 (26%) |
| §102 only | 1 (2%) |
| §112 only | 6 (11%) |
| Double-patenting only | 1 (2%) |
| Double-patenting + other | 9 (17%) |
| Multi-statute (no §101) | 21 (39%) |
How the docket's pending cases split across USPTO tech-center bands.
Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.
| Examiner | Apps on this docket | Allow rate | Interview lift |
|---|---|---|---|
| ARMSTRONG, SUSANNAH SIPPLE | 3 | 30.0% | +53.1% |
| NGUYEN, QUANG | 3 | 37.9% | +52.6% |
| CHOI, YOUNHEE JEON | 2 | 71.6% | +48.2% |
| MUI, CHRISTINE T | 2 | 78.4% | +19.8% |
| DONOHUE, SEAN R | 2 | 41.4% | +21.0% |
| SCHUBERG, LAURA J | 2 | 23.6% | +37.0% |
| RODZIWICZ, AARON M | 1 | 70.4% | +18.3% |
| KIKNADZE, IRAKLI | 1 | 89.1% | +7.9% |
| AL-AWADI, DANAH J | 1 | 54.6% | +13.2% |
| KANG, TAE-SIK | 1 | 58.5% | +27.7% |
Cases in front of an examiner with an allow rate of 80%+ where the difficulty is Easy or Medium. The top 1 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 19123661 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR INTRA-OPERATIVE ASSESSMENT OF TISSUE SPECIMEN MAMMOGRAPHY IMAGES TO PREDICT TUMOR MARGIN STATUS | KIKNADZE, IRAKLI | — |
Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 16761876 | METHODS AND COMPOSITIONS FOR CIRCULAR RNA MOLECULES | NGUYEN, QUANG | 103d overdue |
| 18034669 | DUAL TARGETING CHIMERIC ANTIGEN RECEPTORS | HUYNH, PHUONG N | 66d overdue |
| 16006460 | PATCH GRAFT COMPOSITIONS FOR CELL ENGRAFTMENT | SCHUBERG, LAURA J | 60d overdue |
| 17867135 | PATCH GRAFT COMPOSITIONS FOR CELL ENGRAFTMENT | SCHUBERG, LAURA J | 44d overdue |
| 16428138 | Methods and Compositions for Treating Dystroglycanopathy Disorders | SINGH, ANOOP KUMAR | 44d overdue |
| 19100114 | INTRAVASCULAR DUAL FREQUENCY SONOTHROMBOLYSIS MEDIATED WITH MICROBUBBLES/NANODROPLETS | CHOI, YOUNHEE JEON | 43d overdue |
| 19169745 | FUNCTIONALIZED AROMATIC PHOSPHONIC ACIDS FOR DISPLAY AND SOLAR CELL APPLICATIONS | KANG, TAE-SIK | 33d |
| 18558919 | COMPOSITIONS AND METHODS RELATED TO THE TREATMENT OF OCULAR DISEASES IN EQUINES | NGUYEN, QUANG | 46d |
Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 16761876 | METHODS AND COMPOSITIONS FOR CIRCULAR RNA MOLECULES | NGUYEN, QUANG | 103d overdue |
| 16006460 | PATCH GRAFT COMPOSITIONS FOR CELL ENGRAFTMENT | SCHUBERG, LAURA J | 60d overdue |
| 17867135 | PATCH GRAFT COMPOSITIONS FOR CELL ENGRAFTMENT | SCHUBERG, LAURA J | 44d overdue |
| 19100114 | INTRAVASCULAR DUAL FREQUENCY SONOTHROMBOLYSIS MEDIATED WITH MICROBUBBLES/NANODROPLETS | CHOI, YOUNHEE JEON | 43d overdue |
| 19169745 | FUNCTIONALIZED AROMATIC PHOSPHONIC ACIDS FOR DISPLAY AND SOLAR CELL APPLICATIONS | KANG, TAE-SIK | 33d |
| 18720482 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR USING TRAINED MACHINE LEARNING MODEL INCLUDING AN ATTENTION MODULE TO ESTIMATE GESTATIONAL AGE FROM ULTRASOUND IMAGE DATA | CHOI, YOUNHEE JEON | 41d |
| 18558919 | COMPOSITIONS AND METHODS RELATED TO THE TREATMENT OF OCULAR DISEASES IN EQUINES | NGUYEN, QUANG | 46d |
| 17176561 | FLOW CELLS UTILIZING SURFACE-ATTACHED STRUCTURES, AND RELATED SYSTEMS AND METHODS | MUI, CHRISTINE T | 76d |
| Art Unit | Apps |
|---|---|
| 1631 | 6 |
| 1615 | 3 |
| 1616 | 3 |
| 1672 | 3 |
| 3797 | 2 |
| 1626 | 2 |
| 1797 | 2 |
| 1618 | 2 |
| 1619 | 2 |
| 1637 | 2 |
| App # | Title | Examiner | Art Unit | Statutes | Status | Due in | AI | Filed |
|---|---|---|---|---|---|---|---|---|
| 19397315 | Ephemeral Substrates for Oyster Aquaculture | RODZIWICZ, AARON M | 3642 | §103 | Non-Final OA | — | Pending | Nov 21, 2025 |
| 19123661 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR INTRA-OPERATIVE ASSESSMENT OF TISSUE SPECIMEN MAMMOGRAPHY IMAGES TO PREDICT TUMOR MARGIN STATUS | KIKNADZE, IRAKLI | 2884 | §103 | Non-Final OA | — | Pending | Apr 23, 2025 |
| 19120162 | IMPLANTABLE SCAFFOLDS AND METHODS OF USE | AL-AWADI, DANAH J | 1615 | §103§112 | Non-Final OA | — | Pending | Apr 10, 2025 |
| 19169745 | FUNCTIONALIZED AROMATIC PHOSPHONIC ACIDS FOR DISPLAY AND SOLAR CELL APPLICATIONS | KANG, TAE-SIK | 1728 | §102§103 | Final Rejection | 33d | Pending | Apr 03, 2025 |
| 19096901 | BASSINET | ORTIZ, ADAM C | 3673 | §103 | Non-Final OA | — | Pending | Apr 01, 2025 |
| 19100114 | INTRAVASCULAR DUAL FREQUENCY SONOTHROMBOLYSIS MEDIATED WITH MICROBUBBLES/NANODROPLETS | CHOI, YOUNHEE JEON | 3797 | §103§112 | Final Rejection | 43d overdue | Pending | Jan 30, 2025 |
| 18869126 | NOVEL HEPATOSELECTIVE POLYADENYLATING POLYMERASES INHIBITORS AND THEIR METHOD OF USE | JACKSON, SHAWQUIA | 1626 | §112 | Non-Final OA | — | Pending | Nov 25, 2024 |
| 18853592 | ADAPTIVE PATCHES FOR DYNAMIC ORGANS | ARMSTRONG, SUSANNAH SIPPLE | 1616 | §102§103§112 | Non-Final OA | — | Pending | Oct 02, 2024 |
| 18884822 | COMPOSITIONS AND METHODS FOR INHIBITING PATHOGEN INFECTION | FOLEY, SHANON A | 1671 | DP | Non-Final OA | — | Pending | Sep 13, 2024 |
| 18836156 | COMPOSITIONS AND METHODS FOR ENHANCED DRUG LOADING OF LONG-ACTING IN SITU FORMING IMPLANTS AND USES THEREOF | ARMSTRONG, SUSANNAH SIPPLE | 1616 | §102§103DP | Non-Final OA | — | Pending | Aug 06, 2024 |
| 18763211 | ULTRASOUND TRANSDUCER AND ARRAY FOR INTRAVASCULAR THROMBOLYSIS | HOLWERDA, KATHLEEN SONNETT | 3771 | §102§103 | Final Rejection | — | Pending | Jul 03, 2024 |
| 18720482 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR USING TRAINED MACHINE LEARNING MODEL INCLUDING AN ATTENTION MODULE TO ESTIMATE GESTATIONAL AGE FROM ULTRASOUND IMAGE DATA | CHOI, YOUNHEE JEON | 3797 | §112 | Final Rejection | 41d | Pending | Jun 14, 2024 |
| 18674521 | ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES | OLSON, ANDREA STEFFEL | 1693 | §102§103§112Other | Non-Final OA | — | Pending | May 24, 2024 |
| 18672675 | SYSTEMS AND METHODS FOR NUCLEIC ACID PURIFICATION USING FLOW CELLS WITH ACTUATED SURFACE-ATTACHED STRUCTURES | MUI, CHRISTINE T | 1797 | §103Other | Final Rejection | — | Pending | May 23, 2024 |
| 18706869 | COMPOSITIONS AND METHODS FOR TREATING CANCER VIA PTP1B INHIBITION | CHICKS, ASHLI ARIANA | 1626 | §103 | Non-Final OA | — | Pending | May 02, 2024 |
| 18696032 | METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES FOR VACCINE AND DIAGNOSTIC DEVELOPMENT | CHEN, STACY BROWN | 1672 | §112 | Non-Final OA | — | Pending | Mar 27, 2024 |
| 18691748 | MODIFIED PROTEIN DISULFIDE ISOMERASE AND USES THEREOF | NOAKES, SUZANNE MARIE | 1656 | §102§112 | Final Rejection | 50d | Pending | Mar 13, 2024 |
| 18689948 | TARGETED NANODROPLET AND MICROBUBBLE COMPOSITIONS AND METHODS FOR ENRICHMENT, LYSIS, AND EXTRACTION OF MICROBIAL CELLS | WILLIAMS, EMMALEE RAE | 1653 | §103§112 | Non-Final OA | — | Pending | Mar 07, 2024 |
| 18690230 | IODIDE NANOPARTICLES AND COMPOSITIONS OF METHODS OF USE THEREOF | DONOHUE, SEAN R | 1618 | §102§103Other | Non-Final OA | — | Pending | Mar 07, 2024 |
| 18591127 | Methods, Systems and Devices for Post-Fabrication Drug Loading | HELM, CARALYNNE E | 1615 | §103§112 | Non-Final OA | — | Pending | Feb 29, 2024 |
| 18688256 | METHODS AND COMPOSITIONS FOR INHIBITING FIBROSIS AND SCARRING | CHERNYSHEV, OLGA N | 1675 | §102§112 | Non-Final OA | — | Pending | Feb 29, 2024 |
| 18438385 | BIFUNCTIONAL CHEMICAL EPIGENENTIC MODIFIERS AND METHODS OF USE | COPPINS, JANET L | 1628 | §112DP | Final Rejection | 52d overdue | Pending | Feb 09, 2024 |
| 18578434 | LABELED COMPOUNDS AND CALCIUM SENSING RECEPTOR LIGANDS FOR IMAGING AND USES THEREOF | DONOHUE, SEAN R | 1618 | §103§112 | Non-Final OA | — | Pending | Jan 11, 2024 |
| 18409276 | METHODS AND COMPOSITIONS FOR ACTIVATION OF T CELLS USING NANOPARTICLES CONJUGATED WITH MULTIPLE LIGANDS FOR BINDING RECEPTORS ON T CELLS | GODDARD, LAURA B | 1642 | §102§103DP | Non-Final OA | — | Pending | Jan 10, 2024 |
| 18391998 | POLYMERIC IMPLANTS WITH HIGH DRUG LOADING AND LONG-ACTING DRUG RELEASE AND METHODS OF MAKING THE SAME | MITCHELL, EDWIN COLEMAN | 1619 | §103§112DP | Final Rejection | 96d overdue | Pending | Dec 21, 2023 |
| 18572427 | DETECTION OF A TARGET VIRUS VIA SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) USING A PEPTIDE-MODIFIED NANOSTRUCTURED METAL | KINSEY WHITE, NICOLE ERIN | 1672 | §103§112 | Non-Final OA | — | Pending | Dec 20, 2023 |
| 18571985 | INVERTED CHIMERIC siRNA MOLECULES AND METHODS OF USE THEREOF | POLIAKOVA-GEORGAN, EKATERINA | 1637 | §102§103DP | Final Rejection | — | Pending | Dec 19, 2023 |
| 16963023 | METHODS AND COMPOSITIONS FOR INHIBITION OF INNATE IMMUNE RESPONSE ASSOCIATED WITH AAV TRANSDUCTION | CORDAS, EMILY ANN | 1632 | §112 | Non-Final OA | — | Pending | Dec 15, 2023 |
| 18388359 | METHOD FOR EMULSIFICATION USING IONIC FLUX | NILAND, PATRICK DENNIS | 1763 | §102 | Non-Final OA | — | Pending | Nov 09, 2023 |
| 18558919 | COMPOSITIONS AND METHODS RELATED TO THE TREATMENT OF OCULAR DISEASES IN EQUINES | NGUYEN, QUANG | 1631 | §102§103§112 | Final Rejection | 46d | Pending | Nov 03, 2023 |
| 18553312 | METHODS FOR ASSESSING PROLIFERATION AND ANTI-FOLATE THERAPEUTIC RESPONSE | VANN-OJUEKAIYE, KENDRA RAYCHELL | 1682 | §101§103§112DP | Non-Final OA | — | Pending | Sep 29, 2023 |
| 18239036 | PATCH GRAFT COMPOSITIONS FOR CELL ENGRAFTMENT | PARK, HAEJIN S | 1614 | §103Other | Final Rejection | — | Pending | Aug 28, 2023 |
| 18264136 | PROTEIN M ANALOGS AND FUSION PROTEINS AND THEIR USE FOR INHIBITING ANTIBODY FUNCTION | GANGLE, BRIAN J | 1645 | §102§112 | Non-Final OA | — | Pending | Aug 03, 2023 |
| 18334530 | METHODS AND COMPOSITIONS FOR CIRCULAR RNA MOLECULES | NGUYEN, QUANG | 1631 | §103Other | Final Rejection | — | Pending | Jun 14, 2023 |
| 18265797 | METHOD FOR MEASUREMENT IN BIOSENSORS | CONSTANTINE, CHARLES Z | 1657 | §103§112DP | Non-Final OA | — | Pending | Jun 07, 2023 |
| 18039387 | ENGINEERED CELLS FUNCTIONALIZED WITH IMMUNE CHECKPOINT MOLECULES AND USES THEREOF | KIM, TAEYOON | 1631 | §103 | Final Rejection | — | Pending | May 30, 2023 |
| 18322823 | D-beta-HYDROXYBUTYRATE DEHYDROGENASES (BHBDhs) AND THEIR USE FOR KETONE MONITORING | SINGH, SATYENDRA K | 1657 | §103 | Non-Final OA | — | Pending | May 24, 2023 |
| 18034669 | DUAL TARGETING CHIMERIC ANTIGEN RECEPTORS | HUYNH, PHUONG N | 1641 | §102§103§112 | Final Rejection | 66d overdue | Pending | Apr 28, 2023 |
| 17997791 | MODIFIED ADENO-ASSOCIATED VIRUS VECTORS THAT EVADE NEUTRALIZING ANTIBODIES AND USES THEREOF | CORNELIUS, CLAIRE ADRIENNE | 1672 | §101§102§103§112 | Final Rejection | — | Pending | Nov 02, 2022 |
| 17801705 | EUTECTIC BASED ANESTHETIC COMPOSITIONS AND APPLICATIONS THEREOF | ARMSTRONG, SUSANNAH SIPPLE | 1616 | §103§112 | Non-Final OA | — | Pending | Aug 23, 2022 |
| 17821371 | Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design and Nitric Oxide Release | WHEELER, THURMAN MICHAEL | 1619 | §103§112 | Final Rejection | — | Pending | Aug 22, 2022 |
| 17759757 | NANOMATERIALS FOR TARGETED TREATMENT AND IMAGING OF ANEURYSMAL MICROENVIRONMENT | FISCHER, JOSEPH | 1658 | §103§112 | Non-Final OA | — | Pending | Jul 29, 2022 |
| 17867135 | PATCH GRAFT COMPOSITIONS FOR CELL ENGRAFTMENT | SCHUBERG, LAURA J | 1631 | §103§112DP | Final Rejection | 44d overdue | Pending | Jul 18, 2022 |
| 17775222 | REACTIVE POLYAMIDEIMIDE OLIGOMERS, METHODS, AND ARTICLES | QIAO, HUIHONG | 1700 | §103DP | Non-Final OA | — | Pending | May 06, 2022 |
| 17769917 | METHODS AND COMPOSITIONS FOR CANCER TREATMENT USING NANOPARTICLES CONJUGATED WITH MULTIPLE LIGANDS FOR BINDING RECEPTORS ON NK CELLS | CANELLA, KAREN A | 1643 | §112 | Final Rejection | 28d | Pending | Apr 18, 2022 |
| 17621303 | IN SITU RECRUITMENT, REPROGRAMMING, AND RELEASE OF CAR-T CELLS | NATARAJAN, MEERA | 1643 | §103 | Non-Final OA | — | Pending | Dec 21, 2021 |
| 17398982 | PATCH GRAFT COMPOSITIONS FOR CELL ENGRAFTMENT | HUHN, RICHARD A | 1764 | §112 | Non-Final OA | 69d | Pending | Aug 10, 2021 |
| 17424109 | SALT NANOPARTICLES AND COMPOSITIONS AND METHODS OF USE THEREOF | NGUYEN, NGOC-ANH THI | 1615 | §103 | Non-Final OA | — | Pending | Jul 19, 2021 |
| 17336180 | BIOMARKERS FOR PREDICTING RISK OF ACUTE ISCHEMIC STROKE AND METHODS OF USE THEREOF | SWITZER, JULIET CAROLINE | 1682 | §103 | Final Rejection | — | Pending | Jun 01, 2021 |
| 17176561 | FLOW CELLS UTILIZING SURFACE-ATTACHED STRUCTURES, AND RELATED SYSTEMS AND METHODS | MUI, CHRISTINE T | 1797 | §103 | Final Rejection | 76d | Pending | Feb 16, 2021 |
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Start Free TrialThe University of North Carolina at Chapel Hill has 54 pending office actions as of October 2026, spread across 33 art units and 46 examiners.
Susannah Sipple Armstrong has the most, with 3 of The University of North Carolina at Chapel Hill's pending office actions.
Mostly Biotechnology & Pharmaceuticals (USPTO Tech Center 1600), based on where its pending office actions are examined.
