Prosecution Insights
Last updated: October 25, 2026

Whitehead Institute for Biomedical Research

Technology area: Biotechnology & Pharmaceuticals

10 pending office actions • 8 art units • 9 examiners • 0 of 10 (0%) have an AI response strategy ready • 6 patents granted in the last 365 days

Analysis

Whitehead Institute for Biomedical Research currently faces 11 pending office actions, all situated within the Biotechnology & Pharmaceuticals technology area. These matters are distributed across 10 distinct examiners and 9 distinct art units. NOBLE, MARCIA STEPHENS is identified as the busiest examiner, responsible for 2 of the pending cases.

The presence of 10 distinct examiners for the 11 pending office actions suggests that the portfolio is not concentrated under a few individuals. Instead, the institute must navigate the requirements of the 9 distinct art units. This distribution requires a prosecution strategy that can adapt to the different examination cultures present across these units.

With NOBLE, MARCIA STEPHENS handling 2 pending cases, this examiner represents the point of overlap where an individual manages multiple matters. For the remaining pending office actions, the institute deals with many separate examiners. This lack of concentration means that success in any given matter is unlikely to provide direct procedural momentum for others.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Portfolio Summary

10
Total Pending OAs
8
Non-Final OAs
2
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 3 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

2
Overdue
0
Due this week
1
Due this month
0
Due in next 60 days
0
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 3 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (2)Due ≤ 30 days (1)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

4
Hard (40%)
3
Medium (30%)
3
Easy (30%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§103 only3 (30%)
§112 only3 (30%)
Multi-statute (no §101)4 (40%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

10
Life Sciences
100% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

100 h
Manual time on pending OAs
20 h
Time saved (low, 20%)
35 h
Time saved (mid, 35%)
0.9 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
NOBLE, MARCIA STEPHENS 2 67.2% +39.5%
LEE, JAE W 1 65.6% +38.5%
GROOMS, TIFFANY NICOLE 1 57.8% +46.3%
MEAH, MOHAMMAD Y 1 70.7% +42.8%
BUCHANAN, BAILEY CHEYENNE 1 42.9% +57.1%
HUDSON, AMY ROSE 1 74.8% +11.7%
DHAR, MATASHA 1 43.5% +44.8%
PERREIRA, MELISSA JEAN 1 52.1% +25.7%
VISHNYAKOVA, ELENA VLADIMIROVNA 1 68.3% +46.6%

Hard Cases (4)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 4 ordered by deadline are shown.

App #TitleExaminerDue in
18916572 REPROGRAMMING OF SOMATIC CELLS NOBLE, MARCIA STEPHENS —
18773428 METHODS OF EDITING DNA METHYLATION LEE, JAE W —
18386551 CHROMOSOME NEIGHBORHOOD STRUCTURES AND METHODS RELATING THERETO GROOMS, TIFFANY NICOLE —
18038943 MODULATING TRANSCRIPTIONAL CONDENSATES BUCHANAN, BAILEY CHEYENNE —

Interview Candidates (10)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17869611 METHODS FOR LABELING AND TARGETING CELLS HUDSON, AMY ROSE 124d overdue
17318921 THE USE OF CHOLINE SUPPLEMENTATION AS THERAPY FOR APOE4-RELATED DISORDERS VISHNYAKOVA, ELENA VLADIMIROVNA 42d overdue
18350985 ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS MEAH, MOHAMMAD Y 9d
18916572 REPROGRAMMING OF SOMATIC CELLS NOBLE, MARCIA STEPHENS —
18773428 METHODS OF EDITING DNA METHYLATION LEE, JAE W —
18635153 METHODS FOR REPROGRAMMING SOMATIC CELLS NOBLE, MARCIA STEPHENS —
18386551 CHROMOSOME NEIGHBORHOOD STRUCTURES AND METHODS RELATING THERETO GROOMS, TIFFANY NICOLE —
18038943 MODULATING TRANSCRIPTIONAL CONDENSATES BUCHANAN, BAILEY CHEYENNE —

Top Art Units

Art UnitApps
1632 3
1656 1
1637 1
1652 1
1682 1
1636 1
1618 1
1691 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18916572 REPROGRAMMING OF SOMATIC CELLS NOBLE, MARCIA STEPHENS 1632 §103§112 Non-Final OA — Pending Oct 15, 2024
18773428 METHODS OF EDITING DNA METHYLATION LEE, JAE W 1656 §103§112 Non-Final OA — Pending Jul 15, 2024
18635153 METHODS FOR REPROGRAMMING SOMATIC CELLS NOBLE, MARCIA STEPHENS 1632 §112 Non-Final OA — Pending Apr 15, 2024
18386551 CHROMOSOME NEIGHBORHOOD STRUCTURES AND METHODS RELATING THERETO GROOMS, TIFFANY NICOLE 1637 §102§103§112 Non-Final OA — Pending Nov 02, 2023
18350985 ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS MEAH, MOHAMMAD Y 1652 §112 Non-Final OA 9d Pending Jul 12, 2023
18038943 MODULATING TRANSCRIPTIONAL CONDENSATES BUCHANAN, BAILEY CHEYENNE 1682 §102§103§112 Non-Final OA — Pending May 25, 2023
17869611 METHODS FOR LABELING AND TARGETING CELLS HUDSON, AMY ROSE 1636 §112 Final Rejection 124d overdue Pending Jul 20, 2022
17588038 IN VIVO GUIDE RNA LIBRARIES AND METHODS OF MAKING THE SAME DHAR, MATASHA 1632 §103 Non-Final OA — Pending Jan 28, 2022
17611560 METHODS OF CHARACTERIZING AND UTILIZING AGENT-CONDENSATE INTERACTIONS PERREIRA, MELISSA JEAN 1618 §103 Non-Final OA — Pending Nov 15, 2021
17318921 THE USE OF CHOLINE SUPPLEMENTATION AS THERAPY FOR APOE4-RELATED DISORDERS VISHNYAKOVA, ELENA VLADIMIROVNA 1691 §103 Final Rejection 42d overdue Pending May 12, 2021

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Frequently Asked Questions

How many pending USPTO office actions does Whitehead Institute for Biomedical Research have?

Whitehead Institute for Biomedical Research has 10 pending office actions as of October 2026, spread across 8 art units and 9 examiners.

Which USPTO examiner handles the most Whitehead Institute for Biomedical Research applications?

Marcia Stephens Noble has the most, with 2 of Whitehead Institute for Biomedical Research's pending office actions.

What technology area are Whitehead Institute for Biomedical Research's patent applications in?

Mostly Biotechnology & Pharmaceuticals (USPTO Tech Center 1600), based on where its pending office actions are examined.

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