Prosecution Insights
Last updated: October 25, 2026

Cozen O'Connor (Alnylam)

Technology areas: Biotechnology & Pharmaceuticals • Chemistry & Materials

9 pending office actions • 5 clients • 9 examiners • 8 art units • 0 of 9 (0%) have an AI response strategy ready

Analysis

COZEN O'CONNOR (Alnylam) is associated with Biotechnology & Pharmaceuticals. It has 9 pending office actions and 19456 career applications, showing a focused active client docket supported by a broad historical application record.

The resolved allowance rate is 85.66%, and the average is 3.35 office actions per allowance. Resolved matters commonly achieve allowance, but the examination process may require multiple responses. For practitioners, the profile supports disciplined monitoring of the active matters while highlighting the need to review biotechnology-specific claim and prior-art issues individually.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Quality Metrics (n=19456 apps, methodology: how we score firms)

85.7%
Allowance Rate
n=19456
+0.54σ
Allowance Rate (norm)
n=19456
3.4
OAs to Allowance
n=12817
-0.03σ
OAs to Allow (norm)
n=12817
1067 days
Time to Allowance
n=12817
+4.9pp
Interview Lift
n=19456
24.9%
RCE Rate
n=19456
2.2%
Appeal Rate
n=19456

Rejection Performance (% of received rejections ultimately overcome)

77.7%
§101 Overcome
n=1370
78.5%
§102 Overcome
n=5625
80.2%
§103 Overcome
n=8950
82.4%
§112 Overcome
n=5891

Specialization & Scale

H04W, H04L, G06F
Top CPC Subclasses
11%
Top-3 CPC Share
n=19456
0
Practitioners
n=19456
—
Apps / Practitioner
n=19456 (min 20)

Portfolio Summary

9
Total Pending OAs
5
Non-Final OAs
4
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 2 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

1
Overdue
0
Due this week
0
Due this month
0
Due in next 60 days
1
Due later

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

5
Hard (56%)
4
Medium (44%)
0
Easy (0%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§101 + other1 (11%)
§103 only3 (33%)
Double-patenting + other1 (11%)
Multi-statute (no §101)4 (44%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

8
Life Sciences
89% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
1
Mechanical / Eng
11% of docket
0
Business / Other
0% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

90 h
Manual time on pending OAs
18 h
Time saved (low, 20%)
31 h
Time saved (mid, 35%)
0.8 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
CHONG, JASON Y 1 73.3% +18.1%
OLSON, ANDREA STEFFEL 1 62.4% -11.9%
CHO, DAVID H 1 31.9% +67.0%
ZAHORIK, AMANDA MARY 1 58.3% +49.3%
MONTGOMERY, STEPHEN EDWARD 1 — —
OGLES, MATTHEW ERIC 1 50.0% +58.4%
BRETZ, COREY LANE 1 0.0% +0.0%
NGUYEN, KHANH TUAN 1 74.5% +18.7%
TRAN, CHRISTINA L 1 51.6% +49.8%

Hard Cases (5)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 5 ordered by deadline are shown.

App #TitleExaminerDue in
18510470 CORTICAL RECORDING AND SIGNAL PROCESSING METHODS AND DEVICES OGLES, MATTHEW ERIC 74d overdue
18259887 2'-MODIFIED NUCLEOSIDE BASED OLIGONUCLEOTIDE PRODRUGS BRETZ, COREY LANE 69d
18897206 PROCESS AND APPARATUS FOR CHEMICALLY TREATING A CARBON-CONTAINING FEEDSTOCK CHONG, JASON Y —
18734491 METHODS OF TREATING CANCERS OVEREXPRESSING CARM1 WITH EZH2 INHIBITORS AND A PARP INHIBITOR OLSON, ANDREA STEFFEL —
18394838 PROCESSES FOR PRODUCING AND REPROCESSING A RECYCLABLE ETHYLENE-VINYL ESTER POLYMER MONTGOMERY, STEPHEN EDWARD —

Interview Candidates (6)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 6 ordered by deadline are shown.

App #TitleExaminerDue in
18510470 CORTICAL RECORDING AND SIGNAL PROCESSING METHODS AND DEVICES OGLES, MATTHEW ERIC 74d overdue
18897206 PROCESS AND APPARATUS FOR CHEMICALLY TREATING A CARBON-CONTAINING FEEDSTOCK CHONG, JASON Y —
18613537 3'-OH RNA-CONTAINING OLIGONUCLEOTIDE DEPROTECTION CHO, DAVID H —
18577377 BIS-RNAI COMPOUNDS FOR CNS DELIVERY ZAHORIK, AMANDA MARY —
18142234 INORGANIC SOLID PARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF NGUYEN, KHANH TUAN —
18015202 Circular siRNAs TRAN, CHRISTINA L —

Client Portfolio (5 clients)

Top Art Units

Art UnitApps
16932
17721
16361
17651
37911
16351
17611
16371

Pending Office Actions

App #TitleClientExaminerArt UnitStatutesStatusDue inAIFiled
18897206 PROCESS AND APPARATUS FOR CHEMICALLY TREATING A CARBON-CONTAINING FEEDSTOCK Braskem America, Inc. CHONG, JASON Y 1772 §102§103§112 Non-Final OA — Pending Sep 26, 2024
18734491 METHODS OF TREATING CANCERS OVEREXPRESSING CARM1 WITH EZH2 INHIBITORS AND A PARP INHIBITOR The Wistar Institut Of Anatomy And Biology OLSON, ANDREA STEFFEL 1693 §103§112Other Non-Final OA — Pending Jun 05, 2024
18613537 3'-OH RNA-CONTAINING OLIGONUCLEOTIDE DEPROTECTION Alnylam Pharmaceuticals, Inc. CHO, DAVID H 1693 §102§103§112DP Non-Final OA — Pending Mar 22, 2024
18577377 BIS-RNAI COMPOUNDS FOR CNS DELIVERY Alnylam Pharmaceuticals, Inc. ZAHORIK, AMANDA MARY 1636 §103 Non-Final OA — Pending Jan 08, 2024
18394838 PROCESSES FOR PRODUCING AND REPROCESSING A RECYCLABLE ETHYLENE-VINYL ESTER POLYMER Case Western Reserve University MONTGOMERY, STEPHEN EDWARD 1765 §103§112 Non-Final OA — Pending Dec 22, 2023
18510470 CORTICAL RECORDING AND SIGNAL PROCESSING METHODS AND DEVICES Thomas Jefferson University OGLES, MATTHEW ERIC 3791 §101§112 Final Rejection 74d overdue Pending Nov 15, 2023
18259887 2'-MODIFIED NUCLEOSIDE BASED OLIGONUCLEOTIDE PRODRUGS Alnylam Pharmaceuticals, Inc. BRETZ, COREY LANE 1635 §103§112 Final Rejection 69d Pending Jun 29, 2023
18142234 INORGANIC SOLID PARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF Braskem America, Inc. NGUYEN, KHANH TUAN 1761 §103 Final Rejection — Pending May 02, 2023
18015202 Circular siRNAs Alnylam Pharmaceuticals, Inc. TRAN, CHRISTINA L 1637 §103 Final Rejection — Pending Jan 09, 2023

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Frequently Asked Questions

What is Cozen O'Connor (Alnylam)'s patent allowance rate?

85.7% of resolved applications prosecuted by Cozen O'Connor (Alnylam) were allowed, across 19,456 applications in USPTO records.

How many office actions does Cozen O'Connor (Alnylam) average before allowance?

3.35 office actions per allowed application on average.

How many pending office actions does Cozen O'Connor (Alnylam) have?

9 pending office actions as of October 2026, for 5 clients, before 9 examiners in 8 art units.

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