Prosecution Insights
Last updated: October 25, 2026

Mbhb - Warf

Technology area: Biotechnology & Pharmaceuticals

24 pending office actions • 2 clients • 22 examiners • 14 art units • 0 of 24 (0%) have an AI response strategy ready • 10 patents granted in the last 365 days

Analysis

This profile covers Biotechnology & Pharmaceuticals and includes 222 career applications. Its resolved allowance rate is 91.74%, with an average of 5.96 office actions per allowance. The data shows a high reported allowance outcome alongside a comparatively extended sequence of office-action activity in matters that reached allowance.

There are 22 pending office actions, creating a current workload that warrants active docket management. The contrast between the allowance rate and the action average is significant for prosecution planning: favorable resolution has been common in the reported record, but it has typically followed repeated examination events. Practitioners can use that pattern when preparing amendment strategies and budgeting response effort for this technology area.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Quality Metrics (n=222 apps, methodology: how we score firms)

91.7%
Allowance Rate
n=222
+1.20σ
Allowance Rate (norm)
n=222
6.0
OAs to Allowance
n=100
+0.25σ
OAs to Allow (norm)
n=100
1480 days
Time to Allowance
n=100
+11.0pp
Interview Lift
n=222
66.1%
RCE Rate
n=222
1.2%
Appeal Rate
n=222

Rejection Performance (% of received rejections ultimately overcome)

72.7%
§101 Overcome
n=33
67.7%
§102 Overcome
n=62
63.7%
§103 Overcome
n=91
68.6%
§112 Overcome
n=102

Specialization & Scale

C12N, A61K, G01N
Top CPC Subclasses
67%
Top-3 CPC Share
n=222
0
Practitioners
n=222
—
Apps / Practitioner
n=222 (min 20)

Portfolio Summary

24
Total Pending OAs
15
Non-Final OAs
8
Final Rejections
1
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 8 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

5
Overdue
0
Due this week
0
Due this month
2
Due in next 60 days
1
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 8 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (5)Due ≤ 60 days (2)Due later (1)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

9
Hard (38%)
10
Medium (42%)
3
Easy (12%)
2
Unknown (8%)

Rejection Statute Mix

BucketCases
§101 + other2 (8%)
§103 only6 (25%)
§112 only2 (8%)
Double-patenting only1 (4%)
Double-patenting + other4 (17%)
Multi-statute (no §101)7 (29%)
No statute on record2 (8%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

22
Life Sciences
92% of docket
0
Information Tech
0% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
1
Mechanical / Eng
4% of docket
1
Business / Other
4% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

240 h
Manual time on pending OAs
48 h
Time saved (low, 20%)
84 h
Time saved (mid, 35%)
2.1 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
SCHUBERG, LAURA J 2 23.6% +37.0%
CANELLA, KAREN A 2 62.3% +32.8%
ABBOTT, KODYE LEE 1 54.5% +71.4%
MOSHER, ERIC PARKER 1 100.0% +0.0%
MARTIN, PAUL C 1 41.8% +21.7%
TAKENAKA, RISA 1 26.1% +100.0%
LARA, CAROLINE MONSERRAT 1 85.7% +16.7%
GONZALES, JOSEPHINE MARIA 1 28.8% +34.6%
WEHBE, ANNE MARIE SABRINA 1 57.3% +43.3%
STOICA, ELLY GERALD 1 66.8% +22.6%

Quick Wins (1)

Cases in front of an examiner with an allow rate of 80%+ where the difficulty is Easy or Medium. The top 1 ordered by deadline are shown.

App #TitleExaminerDue in
18440260 EFFICIENT DIFFERENTIATION OF SECOND HEART FIELD CARDIAC PROGENITOR CELLS AND RIGHT VENTRICLE CARDIOMYOCYTES FROM HUMAN PLURIPOTENT STEM CELLS LARA, CAROLINE MONSERRAT —

Hard Cases (11)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17820488 RETINAL ORGANOID MODEL SYSTEMS HOLLAND, PAUL J 73d overdue
18094221 T CELL SPECIFIC BIOMARKERS FOR PREDICTING GRAFT-VS-HOST DISEASE AND HEMATOPOIETIC MALIGNANCY RELAPSE FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION AND TREATMENT THEREOF GABEL, GAILENE 31d overdue
18463211 REAGENTS AND METHODS FOR PRODUCING ERYTHROMYELOID PROGENITOR CELLS, NK CELLS, AND MEGAKARYOCYTES SCHUBERG, LAURA J 18d overdue
17352873 PLURIPOTENT STEM CELLS OBTAINED BY NON-VIRAL REPORGRAMMING WILSON, MICHAEL C 33d
18302636 COMBINATIONAL IMMUNOTHERAPIES USING CAR-M, CAR-NK, CAR-EOS, AND CAR-N CELLS MELCHIOR, JAMES RYLAND 84d
18982272 Method for the Induction of Arterial-Type of Hemogenic Endothelium from hPSCS ABBOTT, KODYE LEE —
18829184 Methods for In Vivo Tracking of Cells MOSHER, ERIC PARKER —
18819158 Generating Vasculogenic Cell Populations SCHUBERG, LAURA J —

Interview Candidates (11)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
18463211 REAGENTS AND METHODS FOR PRODUCING ERYTHROMYELOID PROGENITOR CELLS, NK CELLS, AND MEGAKARYOCYTES SCHUBERG, LAURA J 18d overdue
18982272 Method for the Induction of Arterial-Type of Hemogenic Endothelium from hPSCS ABBOTT, KODYE LEE —
18819158 Generating Vasculogenic Cell Populations SCHUBERG, LAURA J —
18770187 Generation of Adipocytes from Bovine Embryonic Stem Cell Lines MARTIN, PAUL C —
18613041 REAGENTS AND METHODS FOR PROMOTING ARTERIAL ENDOTHELIUM DIFFERENTIATION AND NITRIC OXIDE PRODUCTION TAKENAKA, RISA —
18440260 EFFICIENT DIFFERENTIATION OF SECOND HEART FIELD CARDIAC PROGENITOR CELLS AND RIGHT VENTRICLE CARDIOMYOCYTES FROM HUMAN PLURIPOTENT STEM CELLS LARA, CAROLINE MONSERRAT —
18451617 GENERATION OF THERAPEUTIC CELLS USING EXTRACELLULAR COMPONENTS OF TARGET ORGANS GONZALES, JOSEPHINE MARIA —
18351246 Macrophage Cell Therapy to Treat Orthopedic Injury WEHBE, ANNE MARIE SABRINA —

Client Portfolio (2 clients)

Top Art Units

Art UnitApps
16314
16323
16533
16332
16432
16121
16341
16181
16441
37741

Pending Office Actions

App #TitleClientExaminerArt UnitStatutesStatusDue inAIFiled
18982272 Method for the Induction of Arterial-Type of Hemogenic Endothelium from hPSCS Wisconsin Alumni Research Foundation ABBOTT, KODYE LEE 1632 §103§112Other Non-Final OA — Pending Dec 16, 2024
18829184 Methods for In Vivo Tracking of Cells Wisconsin Alumni Research Foundation MOSHER, ERIC PARKER 1612 §103§112 Non-Final OA — Pending Sep 09, 2024
18819158 Generating Vasculogenic Cell Populations Wisconsin Alumni Research Foundation SCHUBERG, LAURA J 1631 §103§112DP Non-Final OA — Pending Aug 29, 2024
18770187 Generation of Adipocytes from Bovine Embryonic Stem Cell Lines Wisconsin Alumni Research Foundation MARTIN, PAUL C §103§112 Non-Final OA — Pending Jul 11, 2024
18613041 REAGENTS AND METHODS FOR PROMOTING ARTERIAL ENDOTHELIUM DIFFERENTIATION AND NITRIC OXIDE PRODUCTION Wisconsin Alumni Research Foundation TAKENAKA, RISA 1653 §102§103§112 Non-Final OA — Pending Mar 21, 2024
18440260 EFFICIENT DIFFERENTIATION OF SECOND HEART FIELD CARDIAC PROGENITOR CELLS AND RIGHT VENTRICLE CARDIOMYOCYTES FROM HUMAN PLURIPOTENT STEM CELLS Wisconsin Alumni Research Foundation LARA, CAROLINE MONSERRAT 1633 §102§112DP Non-Final OA — Pending Feb 13, 2024
18463211 REAGENTS AND METHODS FOR PRODUCING ERYTHROMYELOID PROGENITOR CELLS, NK CELLS, AND MEGAKARYOCYTES Wisconsin Alumni Research Foundation SCHUBERG, LAURA J 1631 §102§112 Final Rejection 18d overdue Pending Sep 07, 2023
18451617 GENERATION OF THERAPEUTIC CELLS USING EXTRACELLULAR COMPONENTS OF TARGET ORGANS Wisconsin Alumni Research Foundation GONZALES, JOSEPHINE MARIA 1631 §103 Non-Final OA — Pending Aug 17, 2023
18351246 Macrophage Cell Therapy to Treat Orthopedic Injury Wisconsin Alumni Research Foundation WEHBE, ANNE MARIE SABRINA 1634 §112 Non-Final OA — Pending Jul 12, 2023
18345385 Targeted Radiotherapy Chelates for In Situ Immune Modulated Cancer Vaccination Wisconsin Alumni Research Foundation CANELLA, KAREN A 1643 DP Non-Final OA — Pending Jun 30, 2023
18332457 Fibroblast Activation ImmunoPET for Detection of Fibrosis Activity Wisconsin Alumni Research Foundation STOICA, ELLY GERALD 1618 §103§112DP Non-Final OA — Pending Jun 09, 2023
18310510 GENERATING ARTERIAL ENDOTHELIAL CELL POPULATIONS Wisconsin Alumni Research Foundation NGUYEN, NGHI V 1653 §103 Final Rejection 5d overdue Pending May 01, 2023
18302636 COMBINATIONAL IMMUNOTHERAPIES USING CAR-M, CAR-NK, CAR-EOS, AND CAR-N CELLS Wisconsin Alumni Research Foundation MELCHIOR, JAMES RYLAND 1644 §103§112 Non-Final OA 84d Pending Apr 18, 2023
18297417 GENERATING ALLOGENIC ENDOTHELIAL CELL-SEEDED VASCULAR GRAFTS AND METHODS OF USE THEREOF Wisconsin Alumni Research Foundation BLANCO, JAVIER G 3774 §103 Final Rejection 39d Pending Apr 07, 2023
18182850 Using Targeted Radiotherapy (TRT) to Drive Anti-Tumor Immune Response to Immunotherapies Wisconsin Alumni Research Foundation CANELLA, KAREN A 1643 Other Non-Final OA — Pending Mar 13, 2023
18094221 T CELL SPECIFIC BIOMARKERS FOR PREDICTING GRAFT-VS-HOST DISEASE AND HEMATOPOIETIC MALIGNANCY RELAPSE FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION AND TREATMENT THEREOF Wisconsin Alumni Research Foundation GABEL, GAILENE 1678 §101§103 Final Rejection 31d overdue Pending Jan 06, 2023
17973020 Simplified Compositions and Methods for Generating Neural Stem Cells from Human Pluripotent Stem Cells Wisconsin Alumni Research Foundation DUTT, ADITI 1675 §112DP Non-Final OA — Pending Oct 25, 2022
17963806 DERIVATION OF HEPATOCYTES AND HEMATOPOIETIC PROGENITORS FROM HUMAN EMBRYONIC STEM CELLS Wisconsin Alumni Research Foundation PARAS JR, PETER 1632 Other Final Rejection — Pending Oct 11, 2022
17820488 RETINAL ORGANOID MODEL SYSTEMS Wisconsin Alumni Research Foundation HOLLAND, PAUL J 1656 §101§103 Final Rejection 73d overdue Pending Aug 17, 2022
17863363 LPS Priming of Stromal Cells to Generate LPS-Specific Exosome Educated Macrophages Wisconsin Alumni Research Foundation FOX, ALLISON M 1633 §112Other Final Rejection 37d overdue Pending Jul 12, 2022
17545416 METHODS FOR CONTROLLED INDUCTION OF BIOENGINEERED NEUROEPITHELIAL TISSUES AND 3-D NEUROEPITHELIAL TUBES Wisconsin Alumni Research Foundation STAVROU, CONSTANTINA E 1632 §103 Non-Final OA — Pending Dec 08, 2021
17352873 PLURIPOTENT STEM CELLS OBTAINED BY NON-VIRAL REPORGRAMMING Wisconsin Alumni Resarch Foundation WILSON, MICHAEL C 1638 §103§112 Non-Final OA 33d Pending Jun 21, 2021
17343647 COMPOSITIONS AND METHODS FOR PRECISE PATTERNING OF POSTERIOR NEUROECTODERM FROM HUMAN PLURIPOTENT STEM CELLS Wisconsin Alumni Research Foundation WILLIAMS, EMMALEE RAE 1653 §103 Final Rejection — Pending Jun 09, 2021
17117062 IN VITRO EXPANSION OF DOPAMINERGIC SUBTYPE NEURONAL PROGENITORS DERIVED FROM PLURIPOTENT STEM CELLS Wisconsin Alumni Research Foundation MIANO, JOSEPH PAUL 1631 §103 Non-Final OA — Pending Dec 09, 2020

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Frequently Asked Questions

What is Mbhb - Warf's patent allowance rate?

91.7% of resolved applications prosecuted by Mbhb - Warf were allowed, across 222 applications in USPTO records.

How many office actions does Mbhb - Warf average before allowance?

5.96 office actions per allowed application on average.

How many pending office actions does Mbhb - Warf have?

24 pending office actions as of October 2026, for 2 clients, before 22 examiners in 14 art units.

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