Prosecution Insights
Last updated: April 19, 2026
Application No. 17/242,559

Immune CB1 Activation for Obesity Therapy

Non-Final OA §112
Filed
Apr 28, 2021
Examiner
SKOKO III, JOHN JOSEPH
Art Unit
1643
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
UNIVERSITY OF SOUTH CAROLINA
OA Round
7 (Non-Final)
52%
Grant Probability
Moderate
7-8
OA Rounds
3y 7m
To Grant
99%
With Interview

Examiner Intelligence

Grants 52% of resolved cases
52%
Career Allow Rate
53 granted / 102 resolved
-8.0% vs TC avg
Strong +60% interview lift
Without
With
+59.9%
Interview Lift
resolved cases with interview
Typical timeline
3y 7m
Avg Prosecution
37 currently pending
Career history
139
Total Applications
across all art units

Statute-Specific Performance

§101
2.6%
-37.4% vs TC avg
§103
32.2%
-7.8% vs TC avg
§102
11.6%
-28.4% vs TC avg
§112
25.0%
-15.0% vs TC avg
Black line = Tech Center average estimate • Based on career data from 102 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . DETAILED ACTION Claims 1-3, 6-7, 9-11, 14-15, and 17-18 are pending. Rejections Withdrawn The objections of claims 1-3, 6-11, and 14-16 are withdrawn in view of claim amendment. The rejection of instant claims 8 and 16 under 35 USC § 112(d) are withdrawn in view of claim amendment. Claim interpretation The methods of claims 1 and 9 recite, “selectively targeting immune-specific cannabinoid receptor CB1 in immune cells via delivery of an agonist to the immune cells and selectively activating immune-specific cannabinoid receptor CB1 in the immune cells via the agonist” which is interpreted as activating only cannabinoid receptor CB1 on immune cells with a CB1 agonist wherein the non-immune cells are not activated with the CB1 agonist and other receptors that include CB2 are also not activated by the CB1 agonist. The methods of claims 17 and 18 recite, “selectively targeting hematopoietic-specific cannabinoid receptor CB1 in hematopoietic cells via delivery of an agonist to the hematopoietic cells and selectively activating hematopoietic-specific cannabinoid receptor CB1 in the hematopoietic cells via the agonist” which is interpreted as activating only cannabinoid receptor CB1 on hematopoietic cells with a CB1 agonist wherein the non-hematopoietic cells are not activated with the CB1 agonist and other receptors that include CB2 are also not activated by the CB1 agonist. Claim Rejections U.S.C. §112(d) The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. Claims 2-3, 6-7, 10-11, and 14-15 are rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. Claims 2-3, 6-7, 10-11, and 14-15 recite outcomes of the claimed methods of claim 1 and 9, but do not have active method steps that further narrow the claimed methods. The claimed methods of claims 1 and 9 have been shown to demonstrate the effects recited in claims 2-3, 6-7, 10-11, and 14-15, but there are no further steps that individually vary the effects recited in claims 2-3, 6-7, 10-11, and 14-15. Thus, claims 2-3, 6-7, 10-11, and 14-15 do not further narrow claims 1 and 9. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. Conclusion Claims 2-3, 6-7, 10-11, and 14-15 are rejected. Claims 1, 9, and 17-18 have allowable subject matter. Any inquiry concerning this communication or earlier communications from the examiner should be directed to JOHN J SKOKO III whose telephone number is (571)272-1107. The examiner can normally be reached M-F 8:30 - 5:00. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Julie Z Wu can be reached at (571)272-5205. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /J.J.S./ Examiner, Art Unit 1643 /Karen A. Canella/ Primary Examiner, Art Unit 1643
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Prosecution Timeline

Apr 28, 2021
Application Filed
Nov 15, 2022
Non-Final Rejection — §112
Dec 21, 2022
Response Filed
Jan 25, 2023
Non-Final Rejection — §112
Jul 31, 2023
Response Filed
Oct 13, 2023
Final Rejection — §112
Apr 22, 2024
Request for Continued Examination
Apr 24, 2024
Response after Non-Final Action
May 03, 2024
Non-Final Rejection — §112
Nov 11, 2024
Response Filed
Jan 07, 2025
Final Rejection — §112
May 14, 2025
Examiner Interview Summary
May 14, 2025
Applicant Interview (Telephonic)
Jul 15, 2025
Request for Continued Examination
Jul 17, 2025
Response after Non-Final Action
Aug 21, 2025
Non-Final Rejection — §112
Nov 26, 2025
Response Filed
Feb 21, 2026
Non-Final Rejection — §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

7-8
Expected OA Rounds
52%
Grant Probability
99%
With Interview (+59.9%)
3y 7m
Median Time to Grant
High
PTA Risk
Based on 102 resolved cases by this examiner. Grant probability derived from career allow rate.

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