Prosecution Insights
Last updated: April 19, 2026
Application No. 17/570,530

Covalent Diabodies and Uses Thereof

Non-Final OA §112
Filed
Jan 07, 2022
Examiner
DUFFY, BRADLEY
Art Unit
1643
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Macrogenics Inc.
OA Round
3 (Non-Final)
54%
Grant Probability
Moderate
3-4
OA Rounds
3y 8m
To Grant
99%
With Interview

Examiner Intelligence

Grants 54% of resolved cases
54%
Career Allow Rate
396 granted / 729 resolved
-5.7% vs TC avg
Strong +45% interview lift
Without
With
+45.4%
Interview Lift
resolved cases with interview
Typical timeline
3y 8m
Avg Prosecution
47 currently pending
Career history
776
Total Applications
across all art units

Statute-Specific Performance

§101
3.2%
-36.8% vs TC avg
§103
27.9%
-12.1% vs TC avg
§102
19.7%
-20.3% vs TC avg
§112
29.8%
-10.2% vs TC avg
Black line = Tech Center average estimate • Based on career data from 729 resolved cases

Office Action

§112
Notice of Pre-AIA or AIA Status The present application is being examined under the pre-AIA first to invent provisions. DETAILED ACTION Continued Examination Under 37 CFR 1.114 A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on January 27, 2026, has been entered. Claims 46-61 are pending in the application and are under examination. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (B) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 61 is rejected under 35 U.S.C. 112, second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which applicant regards as the invention. The claim is indefinite in the recitation of parentheses, such as “chronic myelocytic (granulocytic) leukemia”, “angiosarcoma (hemangiosarcoma)”, “fungaling (polypoid)”, “squamous cell carcinoma (epidermoid carcinoma)”, “classic (typical) testicular cancer”, and “transitional cell cancer (renal pelvis and/or uterer)” because it is unclear whether the limitations in parentheses are part of the claimed invention or merely a preference or something else. See MPEP § 2173.05(d). Examples and preferences in a claim may lead to confusion over the intended scope of the claim. The description of examples or preferences is properly set forth in the specification rather than the claims. Conclusion Claims 47-60 are allowed. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Brad Duffy whose telephone number is (571) 272-9935. The examiner works a flexible schedule. If attempts to reach the examiner by telephone are unsuccessful, the examiner's supervisor, Julie Wu can be reached on (571) 272-5205. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative or access to the automated information system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. Respectfully, Brad Duffy 571-272-9935 /Brad Duffy/ Primary Examiner, Art Unit 1643 March 11, 2026
Read full office action

Prosecution Timeline

Jan 07, 2022
Application Filed
Apr 25, 2025
Non-Final Rejection — §112
Aug 06, 2025
Response Filed
Nov 24, 2025
Final Rejection — §112
Jan 27, 2026
Response after Non-Final Action
Feb 27, 2026
Request for Continued Examination
Mar 05, 2026
Response after Non-Final Action
Mar 11, 2026
Non-Final Rejection — §112 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12600789
MODIFIED ANTIBODY CONSTANT REGION
2y 5m to grant Granted Apr 14, 2026
Patent 12590164
PRODUCTIVITY-ENHANCED ANTIBODY AND METHOD FOR PRODUCING SAME
2y 5m to grant Granted Mar 31, 2026
Patent 12570751
BINDING AGENTS BINDING TO PD-L1 AND CD137 AND USE THEREOF
2y 5m to grant Granted Mar 10, 2026
Patent 12570718
PD-1-CD28 FUSION PROTEINS AND THEIR USE IN MEDICINE
2y 5m to grant Granted Mar 10, 2026
Patent 12565536
METHOD FOR GENERATING AVID-BINDING MULTISPECIFIC ANTIBODIES
2y 5m to grant Granted Mar 03, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
54%
Grant Probability
99%
With Interview (+45.4%)
3y 8m
Median Time to Grant
High
PTA Risk
Based on 729 resolved cases by this examiner. Grant probability derived from career allow rate.

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