Prosecution Insights
Last updated: April 19, 2026
Application No. 17/702,638

ELECTROCHEMICAL POLYNUCLEOTIDE SYNTHESIS

Non-Final OA §102§103§112
Filed
Mar 23, 2022
Examiner
HASKE, WOJCIECH
Art Unit
1794
Tech Center
1700 — Chemical & Materials Engineering
Assignee
Twist Bioscience Corporation
OA Round
1 (Non-Final)
73%
Grant Probability
Favorable
1-2
OA Rounds
2y 6m
To Grant
91%
With Interview

Examiner Intelligence

Grants 73% — above average
73%
Career Allow Rate
417 granted / 571 resolved
+8.0% vs TC avg
Strong +18% interview lift
Without
With
+17.6%
Interview Lift
resolved cases with interview
Typical timeline
2y 6m
Avg Prosecution
39 currently pending
Career history
610
Total Applications
across all art units

Statute-Specific Performance

§101
1.1%
-38.9% vs TC avg
§103
45.9%
+5.9% vs TC avg
§102
27.0%
-13.0% vs TC avg
§112
17.1%
-22.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 571 resolved cases

Office Action

§102 §103 §112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Election/Restrictions Applicant’s election of Group 1 in the reply filed on 07/01/2025 is acknowledged. Because applicant did not distinctly and specifically point out the supposed errors in the restriction requirement, the election has been treated as an election without traverse (MPEP § 818.01(a)). Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 41 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 41 recites method steps in the product claim, therefore it is not clear what is product structure or composition further limited by the claim. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 1, 2, 10, 11, 14, 15, 37-39 and 41 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Southern et al. (US 20040238369 A1). Considering claims 1, 2, 10, 11, 37, 39 and 41, Southern discloses a composition for electrochemical acid generation comprising: a first redox compound (benzoquinone) [0050]; a second redox compound (hydroquinone) [0050]; an organic salt (tetrabutylammonium hexafluorophosphate) [0064]; and at least one solvent (acetonitrile) [0063], wherein the redox potential between the first redox compound and the second redox compound is less than 2 volts in the solvent [0113], and wherein application of a voltage to the composition results in electrochemical acid generation [0058]. Considering claims 14 and 38, Southern discloses the concentration of tetrabutylammonium hexafluorophosphate is 25 mM [0113]. Considering claim 15, Southern discloses the composition does not comprise an amine base [0113]. Claim(s) 1, 2, 10, 11, 37, 39 and 41 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Maurer et al. (US 10006131 B1). Considering claims 1, 2, 10, 11, 37, 39 and 41, Maurer discloses a composition for electrochemical acid generation comprising: a first redox compound (reducible chemical) (col. 23, lines 4-43); a second redox compound (acid source) (col. 21, lines 4-41); an organic salt (tetrabutylammonium hexafluorophosphate) (col. 16, lines 15-33); and at least one solvent (col. 4, lines 4-14), wherein the redox potential between the first redox compound and the second redox compound is less than 2 volts in the solvent (col. 4, line 47), and wherein application of a voltage to the composition results in electrochemical acid generation (col. 4, liens 25-29). Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. Claim(s) 4-7 and 42-45 is/are rejected under 35 U.S.C. 103 as being unpatentable over Southern et al. (US 20040238369 A1). Considering claims 4-7 and 42-45, Southern teaches the substituents R3, R4, R5 and R6 may be a halogen [0052], where halogen includes chlorine [0047], with the purpose of altering the precise potential at which oxidation or reduction occurs [0056]. It would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to have chloring as the substituents in the first and the second redox compound, because Southern teaches the substituents R3, R4, R5 and R6 may be selected for the group comprising hydrogen, chlorine or fluorine, with the purpose of altering the precise potential at which oxidation or reduction occurs. Claim(s) 12 and 40 is/are rejected under 35 U.S.C. 103 as being unpatentable over Maurer et al. (US 10006131 B1). Considering claims 12 and 40, Maurer discloses the concentration of the first redox compound is from 0.001 mM to 200 mM (col. 23, lines 4-6), which overlaps the claimed range of 0.1 to 2 M, and the concentration of the second redox compound is from 0.1 mM to 2 M (col. 21, lines 4-10), which overlaps the claimed range of 0.1 to 2 M. It would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to have the recited range because a prima facie case of obviousness exists in the case where the claimed ranges “overlap or lie inside ranges disclosed by the prior art”. In re Wertheim, 541 F.2d 257, 191 USPQ 90 (CCPA 1976); In re Woodruff, 919 F.2d 1575, 16 USPQ2d 1934 (Fed. Cir. 1990). Furthermore, "[ A ] prior art reference that discloses a range encompassing a somewhat narrower claimed range is sufficient to establish a prima facie case of obviousness." In re Peterson, 315 F.3d 1325, 1330, 65 USPQ2d 1379, 1382-83 (Fed. Cir. 2003). See MPEP 2144.05. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to Wojciech Haske whose telephone number is (571)272-5666. The examiner can normally be reached M-F: 9:30 am - 6:00 pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, James Lin can be reached at 571-272-8902. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /WOJCIECH HASKE/Examiner, Art Unit 1794
Read full office action

Prosecution Timeline

Mar 23, 2022
Application Filed
Oct 10, 2025
Non-Final Rejection — §102, §103, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
73%
Grant Probability
91%
With Interview (+17.6%)
2y 6m
Median Time to Grant
Low
PTA Risk
Based on 571 resolved cases by this examiner. Grant probability derived from career allow rate.

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