Prosecution Insights
Last updated: April 19, 2026
Application No. 17/906,893

KCNT1 INHIBITORS AND METHODS OF USE

Non-Final OA §103§112
Filed
Sep 21, 2022
Examiner
ROBINSON, MIKHAIL O'DONNEL
Art Unit
1627
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Praxis Precision Medicines Inc.
OA Round
3 (Non-Final)
57%
Grant Probability
Moderate
3-4
OA Rounds
3y 6m
To Grant
99%
With Interview

Examiner Intelligence

Grants 57% of resolved cases
57%
Career Allow Rate
59 granted / 103 resolved
-2.7% vs TC avg
Strong +48% interview lift
Without
With
+47.7%
Interview Lift
resolved cases with interview
Typical timeline
3y 6m
Avg Prosecution
50 currently pending
Career history
153
Total Applications
across all art units

Statute-Specific Performance

§101
3.8%
-36.2% vs TC avg
§103
41.6%
+1.6% vs TC avg
§102
20.9%
-19.1% vs TC avg
§112
20.3%
-19.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 103 resolved cases

Office Action

§103 §112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Continued Examination Under 37 CFR 1.114 A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on 02/23/2026 has been entered. Response to Arguments Applicant’s arguments, see Pages 2-4, filed 02/23/2026, with respect to the rejection(s) of claim(s) 1-4, 7-15, 19-22, 24-39, 43-47, 51-54, 56, 60 and 62-65 under Kawai et al. (US Patent No. 10538516) have been fully considered and are persuasive. Therefore, the rejection has been withdrawn. However, upon further consideration, a new ground(s) of rejection is made in view of Shomozono et al. (US Patent No. 20050171358). Shomozono teaches compositions comprising compounds which reads to the limitations of claimed invention. Applicant has canceled claims 7-8, 15-16, 25-26, 39-40 and 49-50. Claims 1-6, 9-14, 17-22, 24, 27-38, 41-48, 51-54 and 56-67 is pending. Claims 1-6, 9-14, 17-22, 24, 27-38, 41-48, 51-54 and 56-67 are now evaluated on its merits. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 52 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Regarding claim 52, the structures having a phenyl as R1 is rendered indefinite as claim 52 depends from claim 1 which within its limitations does not include a phenyl. Of particular compounds PNG media_image1.png 77 212 media_image1.png Greyscale , PNG media_image2.png 89 210 media_image2.png Greyscale PNG media_image3.png 88 229 media_image3.png Greyscale . Ultimately, the metes and bounds of the claim is unclear. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. Claims 1-6, 9-14, 17-22, 24, 27-38, 41-48 and 51-53 are rejected under 35 U.S.C. 103 as being unpatentable over Shomozono et al. (US Patent No. 20050171358). Regarding claims 1-6, 9-14, 17-22, 24, 27-38, 41-48 and 51-53, Shomozono teaches a method for preventing plant diseases comprising substituted isoxazole alkylamine derivatives of formula 1 PNG media_image4.png 93 198 media_image4.png Greyscale and a pharmaceutical acceptable carrier (relevant to claims 11, 29 and 53) (para. 0012 and 0421). Of formula 1 Shomozono teaches R1 and R2 as H or a lower alkyl group (relevant to claims 9-10 and 27-29) (para. 0014), Y1 and Y2 as a cycloalkyl, phenyl, heteroaryl or aliphatic hetero ring which may be substituted (para. 0024, 0026). Shomozono additionally teaches formula 3 PNG media_image5.png 89 164 media_image5.png Greyscale with embodiments PNG media_image6.png 110 239 media_image6.png Greyscale (relevant to claims 13-14, 37-38 and 51) (para. 0475), PNG media_image7.png 133 269 media_image7.png Greyscale (relevant to claims 3-4, 24 and 36) (para. 0824), PNG media_image8.png 128 291 media_image8.png Greyscale (relevant to claims 17-18 and 41-42) (para. 0884), PNG media_image9.png 122 303 media_image9.png Greyscale (relevant to claims 19 and 43), Y1 as PNG media_image10.png 94 130 media_image10.png Greyscale (relevant to claims 12 and 30-31) (compound 99), PNG media_image11.png 131 287 media_image11.png Greyscale (relevant to claims 32-33) (para. 0589), PNG media_image12.png 114 297 media_image12.png Greyscale (para. 1015), Y1 as PNG media_image13.png 94 75 media_image13.png Greyscale (relevant to claims 34- 35) (compound 98), Y2 as PNG media_image14.png 76 105 media_image14.png Greyscale (relevant to claim 44) (compound 188). The embodiments of Shomozono reads to the limitations of claims 1-2, 4-6, 20-22 and 45-48. Therefore, it would have been obvious to someone of ordinary skill in the art at the time of filling to have developed compounds PNG media_image15.png 70 214 media_image15.png Greyscale , PNG media_image16.png 99 232 media_image16.png Greyscale One would have been motivated to do so from the teachings of Shomozono of structure PNG media_image5.png 89 164 media_image5.png Greyscale with all its above embodiments. There is a reasonable expectation of developing compounds PNG media_image17.png 109 334 media_image17.png Greyscale and PNG media_image16.png 99 232 media_image16.png Greyscale from the teachings of Shomozono. Allowable Subject Matter Claims 54 and 56-67 are objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to MIKHAIL O'DONNEL ROBINSON whose telephone number is (571)270-0777. The examiner can normally be reached Monday-Friday 7:30am-5:30pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Kortney Klinkel can be reached at 571-270-5239. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. MIKHAIL O'DONNEL. ROBINSON Examiner Art Unit 1627 /MIKHAIL O'DONNEL ROBINSON/ Examiner, Art Unit 1627 /SARAH PIHONAK/ Primary Examiner, Art Unit 1627
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Prosecution Timeline

Sep 21, 2022
Application Filed
May 15, 2025
Non-Final Rejection — §103, §112
Aug 15, 2025
Response Filed
Oct 24, 2025
Final Rejection — §103, §112
Jan 22, 2026
Response after Non-Final Action
Feb 23, 2026
Request for Continued Examination
Feb 26, 2026
Response after Non-Final Action
Mar 17, 2026
Non-Final Rejection — §103, §112 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
57%
Grant Probability
99%
With Interview (+47.7%)
3y 6m
Median Time to Grant
High
PTA Risk
Based on 103 resolved cases by this examiner. Grant probability derived from career allow rate.

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