Prosecution Insights
Last updated: August 14, 2026
Application No. 17/906,893

KCNT1 INHIBITORS AND METHODS OF USE

Final Rejection §103
Filed
Sep 21, 2022
Priority
Mar 23, 2020 — provisional 62/993,359 +1 more
Examiner
ROBINSON, MIKHAIL O'DONNEL
Art Unit
1627
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Praxis Precision Medicines Inc.
OA Round
4 (Final)
59%
Grant Probability
Moderate
5-6
OA Rounds
0m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 59% of resolved cases
59%
Career Allowance Rate
73 granted / 124 resolved
-1.1% vs TC avg
Strong +42% interview lift
Without
With
+41.5%
Interview Lift
resolved cases with interview
Typical timeline
3y 4m
Avg Prosecution
46 currently pending
Career history
160
Total Applications
across all art units

Statute-Specific Performance

§101
5.3%
-34.7% vs TC avg
§103
40.9%
+0.9% vs TC avg
§102
21.9%
-18.1% vs TC avg
§112
22.1%
-17.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 124 resolved cases

Office Action

§103
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Response to Arguments Applicant's arguments filed 06/15/2026 have been fully considered but they are not persuasive. Applicant argues (Pages 3-4) prior art of Shimozono fails to teach in any of the examples containing both a 6-membered heteroaryl or a 5-7 membered heterocyclyl for the position corresponding to Ring A and a 5-6 membered heteroaryl, 5-8 membered carbocyclyl, or 5-10 membered heterocyclyl for the position corresponding to R1. Moreover, in each of Shimozono's compounds for which Ring A corresponds to either a 6- membered heteroaryl or a 5-7 membered heterocyclyl, the position corresponding to R1 is a phenyl. Applicants argument is moot to the teaching of Shimozono which falls within the scope of claimed invention additionally as to the examples of Shimozono “disclosed examples and preferred embodiments do not constitute a teaching away from a broader disclosure or nonpreferred embodiments. In re Susi, 440 F.2d 442, 169 USPQ 423 (CCPA 1971)” as per MPEP 2123 II. As applicants arguments are rendered moot the previous rejection of record over Shimozono is maintained. Applicant has overcome the 112b rejection of claim 52 by the cancelation of the claim. Applicant has canceled claim 52 and added claim 68, no new matter was added. Claims 1-6, 9-14, 17-22, 24, 27-38, 41-48, 51, 53-54 and 56-68 is pending. Claims 1-6, 9-14, 17-22, 24, 27-38, 41-48, 51, 53-54 and 56-68 are now evaluated on its merits. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. Claims 1-6, 9-14, 17-22, 24, 27-38, 41-48, 51, 53 and 68 are rejected under 35 U.S.C. 103 as being unpatentable over Shomozono et al. (US Patent No. 20050171358). Regarding claims 1-6, 9-14, 17-22, 24, 27-38, 41-48, 51, 53 and 68, Shomozono teaches a method for preventing plant diseases comprising substituted isoxazole alkylamine derivatives of formula 1 PNG media_image1.png 93 198 media_image1.png Greyscale and a pharmaceutical acceptable carrier (relevant to claims 11, 29 and 53) (para. 0012 and 0421). Of formula 1 Shomozono teaches R1 and R2 as H or a lower alkyl group (relevant to claims 9-10 and 27-29) (para. 0014), Y1 and Y2 as a cycloalkyl, phenyl, heteroaryl or aliphatic hetero ring which may be substituted (para. 0024, 0026). Shomozono additionally teaches formula 3 PNG media_image2.png 89 164 media_image2.png Greyscale with embodiments PNG media_image3.png 110 239 media_image3.png Greyscale (relevant to claims 13-14, 37-38 and 51) (para. 0475), PNG media_image4.png 133 269 media_image4.png Greyscale (relevant to claims 3-4, 24 and 36) (para. 0824), PNG media_image5.png 128 291 media_image5.png Greyscale (relevant to claims 17-18 and 41-42) (para. 0884), PNG media_image6.png 122 303 media_image6.png Greyscale (relevant to claims 19 and 43), Y1 as PNG media_image7.png 94 130 media_image7.png Greyscale (relevant to claims 12 and 30-31) (compound 99), PNG media_image8.png 131 287 media_image8.png Greyscale (relevant to claims 32-33) (para. 0589), PNG media_image9.png 114 297 media_image9.png Greyscale (para. 1015), Y1 as PNG media_image10.png 94 75 media_image10.png Greyscale (relevant to claims 34- 35) (compound 98), Y2 as PNG media_image11.png 76 105 media_image11.png Greyscale (relevant to claim 44) (compound 188). The embodiments of Shomozono reads to the limitations of claims 1-2, 4-6, 20-22 and 45-48. Shomozono additionally teaches Y2 as PNG media_image12.png 52 114 media_image12.png Greyscale wherein the cycloalkyl is substituted (Table 2). Therefore, it would have been obvious to someone of ordinary skill in the art at the time of filling to have developed compounds PNG media_image13.png 70 214 media_image13.png Greyscale , PNG media_image14.png 71 210 media_image14.png Greyscale PNG media_image15.png 81 217 media_image15.png Greyscale PNG media_image16.png 76 211 media_image16.png Greyscale . One would have been motivated to do so from the teachings of Shomozono of structure PNG media_image2.png 89 164 media_image2.png Greyscale wherein Y1 is a heteroaryl substituted with CF3, R1 is H, R2 is a methyl and Y2 is an aliphatic heterocyclic or cycloalkyl. There is a reasonable expectation of developing compounds PNG media_image17.png 109 334 media_image17.png Greyscale , PNG media_image15.png 81 217 media_image15.png Greyscale PNG media_image14.png 71 210 media_image14.png Greyscale and PNG media_image16.png 76 211 media_image16.png Greyscale from the teachings of Shomozono. Allowable Subject Matter Claims 54 and 56-67 are objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. Conclusion THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to MIKHAIL O'DONNEL ROBINSON whose telephone number is (571)270-0777. The examiner can normally be reached Monday-Friday 7:30am-5:30pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Kortney Klinkel can be reached at 571-270-5239. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. MIKHAIL O'DONNEL. ROBINSON Examiner Art Unit 1627 /MIKHAIL O'DONNEL ROBINSON/ Examiner, Art Unit 1627 /SARAH PIHONAK/ Primary Examiner, Art Unit 1627
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Prosecution Timeline

Show 2 earlier events
Aug 15, 2025
Response Filed
Oct 28, 2025
Final Rejection mailed — §103
Jan 22, 2026
Response after Non-Final Action
Feb 23, 2026
Request for Continued Examination
Feb 26, 2026
Response after Non-Final Action
Mar 19, 2026
Non-Final Rejection mailed — §103
Jun 15, 2026
Response Filed
Jul 24, 2026
Final Rejection mailed — §103 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

5-6
Expected OA Rounds
59%
Grant Probability
99%
With Interview (+41.5%)
3y 4m (~0m remaining)
Median Time to Grant
High
PTA Risk
Based on 124 resolved cases by this examiner. Grant probability derived from career allowance rate.

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