Prosecution Insights
Last updated: October 04, 2026
Application No. 18/051,549

Difluoromethylene Synthons And Methods Of Use

Final Rejection §102
Filed
Nov 01, 2022
Priority
Nov 02, 2021 — provisional 63/274,591
Examiner
CHICKS, ASHLI ARIANA
Art Unit
1626
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
The Trustees of the University of Pennsylvania
OA Round
3 (Final)
61%
Grant Probability
Moderate
4-5
OA Rounds
0m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 61% of resolved cases
61%
Career Allowance Rate
57 granted / 94 resolved
+0.6% vs TC avg
Strong +50% interview lift
Without
With
+50.3%
Interview Lift
resolved cases with interview
Typical timeline
3y 4m
Avg Prosecution
52 currently pending
Career history
120
Total Applications
across all art units

Statute-Specific Performance

§101
1.5%
-38.5% vs TC avg
§103
30.0%
-10.0% vs TC avg
§102
20.4%
-19.6% vs TC avg
§112
24.0%
-16.0% vs TC avg
Black line = Tech Center average estimate • Based on career data from 94 resolved cases

Office Action

§102
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Status Claims 1 and 3-8 are pending. Claims 5-6 are withdrawn. Claims 1, 3-4 and 7-8 are rejected. Response to Amendment Applicant’s amendments have overcome the previously presented rejections. Additionally, amended claim 3 now embraces the elected species therefore the claim has been rejoined and is currently under examination. Election/Restrictions As per MPEP 803.02, the examiner will determine whether the entire scope of the claims is patentable. Applicant’s elected species appears free of the art. Therefore, according to MPEP 803.02: should the elected species be found allowable, the examination of the Markus-type claim will be extended. If the examination is extended and a non-elected species found not allowable, the Markush-type claim shall be rejected and claims to the non-elected invention held withdrawn from further consideration. The examination of the Markush-type claims has been extended to include the scope of claims 1, 3-4 and 7-8 where the compound is the following: PNG media_image1.png 214 228 media_image1.png Greyscale PNG media_image2.png 48 202 media_image2.png Greyscale ; this species of which are anticipated and not allowable under 35 USC § 102. As a non-elected species has been found not allowable, the Markush-type claims have been rejected and the claims to the nonelected invention are held withdrawn from further consideration. Examination has been limited to claims embracing the elected species which are claims 1, 3-4 and 7-8. Claims 1, 3-4 and 7-8 have been examined to the extent that they are readable on the elected embodiment and the above identified nonelected species. Since the nonelected species has not been found allowable, subject matter not embraced by the elected embodiment or the above identified nonelected species is therefore withdrawn from further consideration. Claims 5-6 are withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Claim Rejections - 35 USC § 102 (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. (a)(2) the claimed invention was described in a patent issued under section 151, or in an application for patent published or deemed published under section 122(b), in which the patent or application, as the case may be, names another inventor and was effectively filed before the effective filing date of the claimed invention. Claim(s) 1, 3-4, and 7-8 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Aoyama et al. J. Chem. Soc., Perkin Trans. 1, 1995, 1905-1912. The prior art discloses compound 18, Ethyl (2R*,3R*)2-(tert-butyldimethylsiloxy)-4,4-difluoro-3-(p-methoxypheny1)pentanoate, on page 1907: PNG media_image1.png 214 228 media_image1.png Greyscale PNG media_image2.png 48 202 media_image2.png Greyscale . The compound reads on claims 1, 3-4 and 7-8, and is embraced by instant formula (I) where R is aryl, Nu is alkyl, and E is alkyl. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to ASHLI A CHICKS whose telephone number is (571)270-0582. The examiner can normally be reached M-Th 7 a.m.- 5 p.m.. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, James H Alstrum-Acevedo can be reached at (571)272-5548. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /A.A.C./Examiner, Art Unit 1626 /MATTHEW P COUGHLIN/Primary Examiner, Art Unit 1626
Read full office action

Prosecution Timeline

Show 1 earlier event
Jan 06, 2023
Response after Non-Final Action
Sep 25, 2025
Non-Final Rejection mailed — §102
Dec 09, 2025
Applicant Interview (Telephonic)
Dec 10, 2025
Examiner Interview Summary
Dec 23, 2025
Response Filed
Apr 08, 2026
Non-Final Rejection mailed — §102
Jun 29, 2026
Response Filed
Oct 01, 2026
Final Rejection mailed — §102 (current)

Precedent Cases

Applications granted by this same examiner with similar technology

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PARP INHIBITOR CONTAINING PIPERAZINE STRUCTURE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
3y 0m to grant Granted Sep 15, 2026
Patent 12715877
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Patent 12679842
HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES
4y 3m to grant Granted Jul 14, 2026
Patent 12662470
HYDROXY AND (HALO)ALKOXY SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS
2y 6m to grant Granted Jun 23, 2026
Patent 12653808
COMPOUNDS FOR TREATING MULTIPLE MYELOMA
5y 0m to grant Granted Jun 16, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

4-5
Expected OA Rounds
61%
Grant Probability
99%
With Interview (+50.3%)
3y 4m (~0m remaining)
Median Time to Grant
High
PTA Risk
Based on 94 resolved cases by this examiner. Grant probability derived from career allowance rate.

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