Prosecution Insights
Last updated: July 17, 2026
Application No. 18/154,209

Compositions and Methods for Treating Cancer with Anti-CD123 Immunotherapy

Non-Final OA §112
Filed
Jan 13, 2023
Priority
Mar 02, 2022 — continuation of 11/590,169
Examiner
WHITEMAN, BRIAN A
Art Unit
1636
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Lentigen Technology Inc.
OA Round
2 (Non-Final)
68%
Grant Probability
Favorable
2-3
OA Rounds
0m
Est. Remaining
85%
With Interview

Examiner Intelligence

Grants 68% — above average
68%
Career Allowance Rate
792 granted / 1159 resolved
+8.3% vs TC avg
Strong +17% interview lift
Without
With
+16.7%
Interview Lift
resolved cases with interview
Typical timeline
2y 8m
Avg Prosecution
51 currently pending
Career history
1197
Total Applications
across all art units

Statute-Specific Performance

§101
1.8%
-38.2% vs TC avg
§103
43.0%
+3.0% vs TC avg
§102
15.2%
-24.8% vs TC avg
§112
11.6%
-28.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1159 resolved cases

Office Action

§112
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Drawings The drawings were received on 4/15/26. These drawings are acceptable. Specification The amendment to the specification filed on 4/15/26 has been entered. The rejections or objections have been overcome by the amendment filed on 4/15/26. See the reasons for allowance at the end of the office action mailed on 4/15/26. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 4, 5, 24 and 33 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Claim 4 recites the limitation "the transmembrane domain" in line 3. There is insufficient antecedent basis for this limitation in the claim. Claim 3 depends on claim 1 and claim 1 recites at least one transmembrane domain. Claim 5 recites the limitation "a transmembrane domain" in lines 2-3. There is insufficient antecedent basis for this limitation in the claim. Claim 3 depends on claim 1 and claim 1 recites at least one transmembrane domain. Claim 24 recites the limitation “a nucleic acid molecule of claim 1" in line 1. There is insufficient antecedent basis for this limitation in the claim. Claim 1 recites: An isolated nucleic acid molecule. Claim 33 recites the limitation “a nucleic acid molecule of claim 1" in lines 2-3. There is insufficient antecedent basis for this limitation in the claim. Claim 1 recites: An isolated nucleic acid molecule. Conclusion Claims 1, 6-8, 10, 12-14, 25, 28-29, 32, 36, and 45-46 are in condition for allowance. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Brian Whiteman whose telephone number is (571)272-0764. The examiner can normally be reached on Monday thru Friday; 6:00 AM to 3:00PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Neil Hammell can be reached at (571)-270-5919. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative or access to the automated information system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /BRIAN WHITEMAN/ Primary Examiner, Art Unit 1636
Read full office action

Prosecution Timeline

Jan 13, 2023
Application Filed
Jan 15, 2026
Non-Final Rejection mailed — §112
Apr 15, 2026
Response Filed
May 27, 2026
Examiner Interview (Telephonic)
Jun 01, 2026
Non-Final Rejection mailed — §112 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

2-3
Expected OA Rounds
68%
Grant Probability
85%
With Interview (+16.7%)
2y 8m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1159 resolved cases by this examiner. Grant probability derived from career allowance rate.

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