Prosecution Insights
Last updated: April 19, 2026
Application No. 18/258,418

KCNT1 INHIBITORS AND METHODS OF USE

Non-Final OA §102§112
Filed
Jun 20, 2023
Examiner
HEASLEY, MEGHAN CHRISTINE
Art Unit
1626
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Praxis Precision Medicines Inc.
OA Round
1 (Non-Final)
76%
Grant Probability
Favorable
1-2
OA Rounds
3y 1m
To Grant
99%
With Interview

Examiner Intelligence

Grants 76% — above average
76%
Career Allow Rate
83 granted / 109 resolved
+16.1% vs TC avg
Strong +34% interview lift
Without
With
+33.6%
Interview Lift
resolved cases with interview
Typical timeline
3y 1m
Avg Prosecution
35 currently pending
Career history
144
Total Applications
across all art units

Statute-Specific Performance

§101
1.8%
-38.2% vs TC avg
§103
33.3%
-6.7% vs TC avg
§102
18.4%
-21.6% vs TC avg
§112
27.2%
-12.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 109 resolved cases

Office Action

§102 §112
Detailed Action Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Status of the Claims Claims 1-20 are pending. Claims 4 and 8-20 are withdrawn. Claims 1, 3, and 5 are rejected. Claims 2, 6, and 7 are objected to. Information Disclosure Statements The Information Disclosure Statements (IDS’s) submitted on 6/20/2023, 4/8/2024, and 2/19/2025 were considered by the Examiner. Election/Restrictions Applicant’s election without traverse of Group I and the species: PNG media_image1.png 206 635 media_image1.png Greyscale , in the reply filed on 12/11/2025 is acknowledged. Claims 1-3 and 5-7 embrace Applicant’s elected species and are therefore under examination. As per MPEP 803.02, “Following election, the Markush claim will be examined fully with respect to the elected species and further to the extent necessary to determine patentability.” The elected species is allowable. The examination has been extended to include the 35 USC 102 rejection below over a non-elected species of claims 1 and 3. Claims 2 and 5-7 have been searched in full and are free of the art. However, claim 5 has been rejected below under 35 USC 112(b). Claims 4 and 8-20 are withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a nonelected invention, there being no allowable generic or linking claim. Claim Objections Claim 1 is objected to because of the following informalities: Third line from bottom, Examiner recommends replacing “C1-6alkoxy” with “C1-6alkoxy”. Appropriate correction is required. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claim 5 is rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention. Independent claim 5 recites an “R2” variable in structure of Formula III, without defining R2 in the remainder of the claim. For the purpose of search and examination, Examiner has relied on the instant specification, paragraph [0092], which indicates that the R2 definition is identical (H or C1-4alkyl) in Formula III as to Formula I (instant claim 1). Examiner requires the definition of R2 to be explicitly defined in independent claim 5. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claim(s) 1 and 3 is/are rejected under 35 U.S.C. 102(a)(1) as being anticipated by CAS Registry No. 1436359-23-7 (which entered the STN database on 6/9/2013). Regarding instant claims 1 and 3, CAS Registry No. 1436359-23-7 is drawn to the following structure: PNG media_image2.png 177 441 media_image2.png Greyscale , which is embraced by a compound of instant Formula I: PNG media_image3.png 120 327 media_image3.png Greyscale , and Formula I-a: PNG media_image4.png 137 338 media_image4.png Greyscale , wherein R1 = C2 alkyl; x = 0; R2 = H; R3 = H; R4 = C1 alkyl; X, Y, Z’, Y’ = CH; Z = C; n = 1; R5 = halogen (Cl). Allowable Subject Matter Claims 2, 6, and 7 are objected to as being dependent upon a rejected base claim, but would be allowable if rewritten in independent form including all of the limitations of the base claim and any intervening claims. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to MEGHAN C HEASLEY whose telephone number is (571)270-0785. The examiner can normally be reached Monday - Friday 8:30-4:30 PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Amy Clark can be reached at 571-272-1310. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /MEGHAN C HEASLEY/Examiner, Art Unit 1626 /KAMAL A SAEED/Primary Examiner, Art Unit 1626
Read full office action

Prosecution Timeline

Jun 20, 2023
Application Filed
Jan 16, 2026
Non-Final Rejection — §102, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
76%
Grant Probability
99%
With Interview (+33.6%)
3y 1m
Median Time to Grant
Low
PTA Risk
Based on 109 resolved cases by this examiner. Grant probability derived from career allow rate.

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