Prosecution Insights
Last updated: April 19, 2026
Application No. 18/268,575

STRUCTURE-BASED DESIGN AND DISCOVERY OF LONG-ACTING COCAINE HYDROLASE MUTANTS WITH IMPROVED BINDING AFFINITY TO NEONATAL FC RECEPTOR FOR TREATMENT OF SUBSTANCE USE DISORDERS AND ORGANOPHOSPHORUS TOXICITY

Non-Final OA §102§103§112§DP
Filed
Jun 20, 2023
Examiner
REDDIG, PETER J
Art Unit
1646
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
OA Round
1 (Non-Final)
58%
Grant Probability
Moderate
1-2
OA Rounds
3y 6m
To Grant
98%
With Interview

Examiner Intelligence

Grants 58% of resolved cases
58%
Career Allow Rate
582 granted / 1008 resolved
-2.3% vs TC avg
Strong +40% interview lift
Without
With
+40.2%
Interview Lift
resolved cases with interview
Typical timeline
3y 6m
Avg Prosecution
58 currently pending
Career history
1066
Total Applications
across all art units

Statute-Specific Performance

§101
6.4%
-33.6% vs TC avg
§103
25.8%
-14.2% vs TC avg
§102
21.7%
-18.3% vs TC avg
§112
27.2%
-12.8% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1008 resolved cases

Office Action

§102 §103 §112 §DP
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . 1. The Election filed February 27, 2026 in response to the Office Action of December 29, 2025 is acknowledged and has been entered. Applicant's election with traverse of Group I, claims 1-4 and 8-12 is acknowledged and the species of SEQ ID NOs: 5, 6, and 16. Applicant argues that as reflected in the Listing of the Claims, independent claims 1 and 13 have each been amended to recite, in pertinent part: "wherein the BChE mutant is selected from the group consisting of SEQ ID NO: 4 and SEQ ID NO: 5." U.S. Pat. No. 10,772,940 ("Zhan") was not asserted to teach, nor actually teaches, a butyrylcholinesterase (BChE) fusion protein including a BChE mutant consistent with that recited in currently amended independent claims 1 and 13. The claimed subject matter of currently amended independent claims 1 and 13 thus recite a technical feature that makes a contribution over the prior art. Groups I and II thus possess unity of invention for at least this reason. Applicant argues that therefore, applicant traverses the current restriction requirement and respectfully submits all pending claims warrant present examination. Applicant’s arguments have been considered and have been found persuasive. The restriction requirement between inventions of Groups 1 and 2, as set forth in the Office action mailed on December 29, 2025, is hereby withdrawn and claims 13-16 and 20 are hereby rejoined and fully examined for patentability under 37 CFR 1.104. In view of the withdrawal of the restriction requirement, applicant(s) are advised that if any claim presented in a divisional application is anticipated by, or includes all the limitations of, a claim that is allowable in the present application, such claim may be subject to provisional statutory and/or nonstatutory double patenting rejections over the claims of the instant application. Once the restriction requirement is withdrawn, the provisions of 35 U.S.C. 121 are no longer applicable. See In re Ziegler, 443 F.2d 1211, 1215, 170 USPQ 129, 131-32 (CCPA 1971). See also MPEP § 804.01. 2. Claims 1-4, 8-16 and 20 are pending and under consideration. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(d): (d) REFERENCE IN DEPENDENT FORMS.—Subject to subsection (e), a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. The following is a quotation of pre-AIA 35 U.S.C. 112, fourth paragraph: Subject to the following paragraph [i.e., the fifth paragraph of pre-AIA 35 U.S.C. 112], a claim in dependent form shall contain a reference to a claim previously set forth and then specify a further limitation of the subject matter claimed. A claim in dependent form shall be construed to incorporate by reference all the limitations of the claim to which it refers. 3. Claims 4 and 16 are rejected under 35 U.S.C. 112(d) or pre-AIA 35 U.S.C. 112, 4th paragraph, as being of improper dependent form for failing to further limit the subject matter of the claim upon which it depends, or for failing to include all the limitations of the claim upon which it depends. Claims 4 and 16 are drawn to the method of claim 1 or 13, wherein the butyrylcholinesterase fusion protein is a sequence selected from the group consisting of SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, and SEQ ID NO: 16. The BChE mutants of SEQ ID NO: 4 and 5 are not comprised by SEQ ID NOs: 11-16 of claims 4 and 16. See Appendix. Thus, claims 4 and 16 fail to include all the limitations of the claim(s) upon which it depends. Applicant may cancel the claim(s), amend the claim(s) to place the claim(s) in proper dependent form, rewrite the claim(s) in independent form, or present a sufficient showing that the dependent claim(s) complies with the statutory requirements. Claim Rejections - 35 USC § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. (a)(2) the claimed invention was described in a patent issued under section 151, or in an application for patent published or deemed published under section 122(b), in which the patent or application, as the case may be, names another inventor and was effectively filed before the effective filing date of the claimed invention. 4. Claim 4 is rejected under 35 U.S.C. 102(a)(1)/(a)(2) as being anticipated by US Pat. No. 10,772,940 (Zhan et al. Sep. 15, 2020, IDS), “Zhan”. Zhan teaches treating cocaine-induced conditions comprising administering a butyrylcholinestrase (BChE) polypeptide fusion comprising a second polypeptide and/or pharmaceutical compositions thereof to an individual. See abstract and column 4-lines 10-20. Zhan teaches cocaine-induced conditions include overdose and cocaine addiction. See paragraph bridging columns 13 and 14. Zhan teaches the BChE fusion polypeptide SEQ ID NO: 152 which comprises the claimed SEQ ID NO: 11. See col. 11-lines 62-64 and Appendix. Zhan teaches the BChE fusion polypeptide SEQ ID NO: 166 which comprises the claimed SEQ ID NO: 12. See col. 11-lines 38-40 and Appendix . Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. 5. Claim 16 is rejected under 35 U.S.C. 103 as being unpatentable over US Pat. No. 10,772,940 (Zhan et al. Sep. 15, 2020, IDS), “Zhan”.as applied to claim 4 above, and further in view of WO 2015/168284 (Bassan et al. Nov. 5, 2015, IDS), “Bassan” . Zhan teaches as set forth above, but does not teach treating organophosphorus poisoning in a subject. Zhan also teaches that the BChE fusion polypeptides have a longer half-life than the BChE polypeptide alone. See col. 13-lines 45-55 and col. 23-lines 10-25 and Fig. 1. Bassan teaches treating a mammal poisoned with a neurotoxin, like an organophosphorus toxin, by administering BChE fused to human serum albumins (HAS), SEQ ID NO: 1 for detoxification. See abstract, p. 4, p. 8-line 20 to p. 9-line 21, Example 2, Table 3 and claims 1-24. It would have been prima facie obvious at the time the invention was filed given that the level of skill in the art was high to combine the teachings of Zhan and Bassan and use the BChE fusion polypeptides of Zhan, like SEQ ID NOs: 152 and 166, in the method Bassan to treat a mammal poisoned with a neurotoxin, like an organophosphorus toxin, by administering the BChE fusion polypeptides of Zhan because Bassan teaches BChE can be used to effectively treat organophosphorus poisoning and Zhan teaches BChE fusion proteins with increased half-life. Thus, one would have been motivated to use the BChE fusion polypeptides of Zhan, like SEQ ID NOs: 152 and 166, to increase the efficacy of organophosphorus detoxification by using the BChE fusion polypeptides with increased half-lives. Conclusion 6. Claims 4 and 16 are rejected. 7. Claims 1-3, 8-15 and 20 are allowed. 8. Any inquiry concerning this communication or earlier communications from the examiner should be directed to PETER J REDDIG whose telephone number is (571)272-9031. The examiner can normally be reached M-F 8:30-5:30 Eastern Time. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Greg Emch can be reached at 571-272-8149. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /PETER J REDDIG/Primary Examiner, Art Unit 1646 APPENDIX Alignment of SEQ ID NO: 4 with SEQ ID NO: 11 Title: US-18-268-575-4 Perfect score: 3110 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-11.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2843 91.4 762 1 US-18-268-575-11 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-11 Query Match 91.4%; Score 2843; DB 1; Length 762; Best Local Similarity 99.6%; Matches 529; Conservative 1; Mismatches 1; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||| ||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVVE 531 Alignment of SEQ ID NO: 4 with SEQ ID NO: 12 Title: US-18-268-575-4 Perfect score: 3110 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-12.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2843 91.4 762 1 US-18-268-575-12 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-12 Query Match 91.4%; Score 2843; DB 1; Length 762; Best Local Similarity 99.6%; Matches 529; Conservative 1; Mismatches 1; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||| ||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVVE 531 Alignment of SEQ ID NO: 4 with SEQ ID NO: 13 Title: US-18-268-575-4 Perfect score: 3110 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-13.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2851 91.7 762 1 US-18-268-575-13 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-13 Query Match 91.7%; Score 2851; DB 1; Length 762; Best Local Similarity 99.8%; Matches 530; Conservative 1; Mismatches 0; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||||||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVVE 531 Alignment of SEQ ID NO: 4 with SEQ ID NO: 14 Title: US-18-268-575-4 Perfect score: 3110 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-14.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2843 91.4 762 1 US-18-268-575-14 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-14 Query Match 91.4%; Score 2843; DB 1; Length 762; Best Local Similarity 99.6%; Matches 529; Conservative 1; Mismatches 1; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||||||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVVE 531 Alignment of SEQ ID NO: 4 with SEQ ID NO: 15 Title: US-18-268-575-4 Perfect score: 3110 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-15.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2843 91.4 762 1 US-18-268-575-15 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-15 Query Match 91.4%; Score 2843; DB 1; Length 762; Best Local Similarity 99.6%; Matches 529; Conservative 1; Mismatches 1; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||||||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVVE 531 Alignment of SEQ ID NO: 4 with SEQ ID NO: 16 Title: US-18-268-575-4 Perfect score: 3110 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-16.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2843 91.4 762 1 US-18-268-575-16 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-16 Query Match 91.4%; Score 2843; DB 1; Length 762; Best Local Similarity 99.6%; Matches 529; Conservative 1; Mismatches 1; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||||||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVVE 531 Alignment of SEQ ID NO: 5 with SEQ ID NO: 11 Title: US-18-268-575-5 Perfect score: 3107 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-11.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2835 91.2 762 1 US-18-268-575-11 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-11 Query Match 91.2%; Score 2835; DB 1; Length 762; Best Local Similarity 99.4%; Matches 528; Conservative 1; Mismatches 2; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||| ||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVVE 531 Alignment of SEQ ID NO: 5 with SEQ ID NO: 12 Title: US-18-268-575-5 Perfect score: 3107 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-12.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2835 91.2 762 1 US-18-268-575-12 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-12 Query Match 91.2%; Score 2835; DB 1; Length 762; Best Local Similarity 99.4%; Matches 528; Conservative 1; Mismatches 2; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||| ||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVVE 531 Alignment of SEQ ID NO: 5 with SEQ ID NO: 13 Title: US-18-268-575-5 Perfect score: 3107 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-13.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2843 91.5 762 1 US-18-268-575-13 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-13 Query Match 91.5%; Score 2843; DB 1; Length 762; Best Local Similarity 99.6%; Matches 529; Conservative 1; Mismatches 1; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||||||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVVE 531 Alignment of SEQ ID NO: 5 with SEQ ID NO: 14 Title: US-18-268-575-5 Perfect score: 3107 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-14.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2848 91.7 762 1 US-18-268-575-14 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-14 Query Match 91.7%; Score 2848; DB 1; Length 762; Best Local Similarity 99.8%; Matches 530; Conservative 1; Mismatches 0; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||||||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVVE 531 Alignment of SEQ ID NO: 5 with SEQ ID NO: 15 Title: US-18-268-575-5 Perfect score: 3107 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-15.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2848 91.7 762 1 US-18-268-575-15 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-15 Query Match 91.7%; Score 2848; DB 1; Length 762; Best Local Similarity 99.8%; Matches 530; Conservative 1; Mismatches 0; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||||||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVVE 531 Alignment of SEQ ID NO: 5 with SEQ ID NO: 16 Title: US-18-268-575-5 Perfect score: 3107 Sequence: 1 EDDIIIATKNGKVRGMNLTV..........MDWKNQFNDYTSKKESCVGL 574 Scoring table: BLOSUM62 Gapop 10.0 , Gapext 0.5 Searched: 1 seqs, 762 residues Total number of hits satisfying chosen parameters: 1 Minimum DB seq length: 0 Maximum DB seq length: inf Post-processing: Minimum Match 0% Maximum Match 100% Listing first 1 summaries Database : US-18-268-575-16.pep:* SUMMARIES % Result Query No. Score Match Length DB ID Description ---------------------------------------------------------------------------- 1 2848 91.7 762 1 US-18-268-575-16 STRUCTURE-BASED DE ALIGNMENTS RESULT 1 US-18-268-575-16 Query Match 91.7%; Score 2848; DB 1; Length 762; Best Local Similarity 99.8%; Matches 530; Conservative 1; Mismatches 0; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTALGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVLE 531 |||||||||||||||||||||||||||||||||||||||||||||||||:| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWGSFFPKVVE 531 Alignment of SEQ ID NO: 11 with SEQ ID NO: 152 of Zhan US-14-102-977B-152 Sequence 152, US/14102977B Patent No. 10772940 GENERAL INFORMATION APPLICANT: University of Kentucky Research Foundation APPLICANT: Zhan, Chang-Guo TITLE OF INVENTION: COCAINE HYDROLASE-FC FUSION PROTEINS FOR COCAINE AND METHODS FOR TITLE OF INVENTION: UTILIZING THE SAME FILE REFERENCE: 13177N/1852US CURRENT APPLICATION NUMBER: US/14/102,977B CURRENT FILING DATE: 2013-12-11 NUMBER OF SEQ ID NOS: 182 SEQ ID NO 152 LENGTH: 762 TYPE: PRT ORGANISM: Artificial Sequence FEATURE: OTHER INFORMATION: Synthesized Query Match 100.0%; Score 4111; Length 762; Best Local Similarity 100.0%; Matches 762; Conservative 0; Mismatches 0; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVVEPKSCDKTHT 540 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVVEPKSCDKTHT 540 Qy 541 CPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVH 600 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 541 CPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVH 600 Qy 601 NAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE 660 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 601 NAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE 660 Qy 661 PQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFF 720 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 661 PQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFF 720 Qy 721 LYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 762 |||||||||||||||||||||||||||||||||||||||||| Db 721 LYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 762 Alignment of SEQ ID NO: 12 with SEQ ID NO: 166 of Zhan US-14-102-977B-166 Sequence 166, US/14102977B Patent No. 10772940 GENERAL INFORMATION APPLICANT: University of Kentucky Research Foundation APPLICANT: Zhan, Chang-Guo TITLE OF INVENTION: COCAINE HYDROLASE-FC FUSION PROTEINS FOR COCAINE AND METHODS FOR TITLE OF INVENTION: UTILIZING THE SAME FILE REFERENCE: 13177N/1852US CURRENT APPLICATION NUMBER: US/14/102,977B CURRENT FILING DATE: 2013-12-11 NUMBER OF SEQ ID NOS: 182 SEQ ID NO 166 LENGTH: 762 TYPE: PRT ORGANISM: Artificial Sequence FEATURE: OTHER INFORMATION: Synthesized Query Match 100.0%; Score 4113; Length 762; Best Local Similarity 100.0%; Matches 762; Conservative 0; Mismatches 0; Indels 0; Gaps 0; Qy 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 1 EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATK 60 Qy 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 61 YANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQT 120 Qy 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 121 GTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQK 180 Qy 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 181 NIAAFGGNPKSVTLFGESSGAASVSLHLLSPGSHSLFTRAILQSGSANAPWAVTSLYEAR 240 Qy 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 241 NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLGVNFGPTVDGDFLT 300 Qy 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 301 DMPDILLELGQFKKTQILVGVNKDEGTWFLVGGAPGFSKDNNSIITRKEFQEGLKIFFPG 360 Qy 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 361 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYY 420 Qy 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 421 FEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP 480 Qy 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVVEPKSCDKTHT 540 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 481 NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVVEPKSCDKTHT 540 Qy 541 CPPCPAPELLGGPSVFLFPPKPKDTLYISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVH 600 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 541 CPPCPAPELLGGPSVFLFPPKPKDTLYISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVH 600 Qy 601 NAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE 660 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 601 NAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE 660 Qy 661 PQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFF 720 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Db 661 PQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFF 720 Qy 721 LYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 762 |||||||||||||||||||||||||||||||||||||||||| Db 721 LYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 762
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Prosecution Timeline

Jun 20, 2023
Application Filed
Mar 17, 2026
Non-Final Rejection — §102, §103, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
58%
Grant Probability
98%
With Interview (+40.2%)
3y 6m
Median Time to Grant
Low
PTA Risk
Based on 1008 resolved cases by this examiner. Grant probability derived from career allow rate.

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