Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
DETAILED ACTION
Continued Examination Under 37 CFR 1.114
A request for continued examination under 37 CFR 1.114, including the fee set forth in 37 CFR 1.17(e), was filed in this application after final rejection. Since this application is eligible for continued examination under 37 CFR 1.114, and the fee set forth in 37 CFR 1.17(e) has been timely paid, the finality of the previous Office action has been withdrawn pursuant to 37 CFR 1.114. Applicant's submission filed on January 8, 2026 has been entered.
RESPONSE TO AMENDMENT
Status of Application/Amendments/claims
3. Applicant’s amendment filed December 22, 2025 and January 8, 2026 is acknowledged. Claims 2-7, 11-14, 19, 21-42 and 46-48 are canceled. Claims 1, 8-10, 15-18, 20, 43-45 and 49 are pending in this application. Claims 43-45 are withdrawn without traverse (filed 04/21/2025) from further consideration pursuant to 37 CFR 1.142(b) as being drawn to nonelected inventions, there being no allowable generic or linking claim. Election was made without traverse in the reply filed on April 21, 2025.
4. Claims 1, 8-10, 15-18, 20 and 49 are under examination with respect to SEQ ID NO:4, SEQ ID NO:3, FGF2 mimetic sequence and SEQ ID NO: 13 in this office action.
5. Applicant’s arguments filed on December 22, 2025 and January 8, 2022 have been fully considered but they are not deemed to be persuasive for the reasons set forth below.
Priority
6. The priority for the claimed supramolecular assembly comprising a.at least one IKVAV peptide amphiphile (IKVAV PA) and b.at least one growth factor mimetic peptide amphiphile (FGF-2 PA), and wherein the IKVAV PA and FGF-2 PA comprise sequences and structures recited in claim 1 is February 23, 2021.
Claim Rejections/Objections Maintained
In view of the amendment filed on December 22, 2025 and January 8, 2026, the following rejections are maintained.
Double Patenting
7. The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969).
A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on nonstatutory double patenting provided the reference application or patent either is shown to be commonly owned with the examined application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. See MPEP § 717.02 for applications subject to examination under the first inventor to file provisions of the AIA as explained in MPEP § 2159. See MPEP § 2146 et seq. for applications not subject to examination under the first inventor to file provisions of the AIA . A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b).
The filing of a terminal disclaimer by itself is not a complete reply to a nonstatutory double patenting (NSDP) rejection. A complete reply requires that the terminal disclaimer be accompanied by a reply requesting reconsideration of the prior Office action. Even where the NSDP rejection is provisional the reply must be complete. See MPEP § 804, subsection I.B.1. For a reply to a non-final Office action, see 37 CFR 1.111(a). For a reply to final Office action, see 37 CFR 1.113(c). A request for reconsideration while not provided for in 37 CFR 1.113(c) may be filed after final for consideration. See MPEP §§ 706.07(e) and 714.13.
The USPTO Internet website contains terminal disclaimer forms which may be used. Please visit www.uspto.gov/patent/patents-forms. The actual filing date of the application in which the form is filed determines what form (e.g., PTO/SB/25, PTO/SB/26, PTO/AIA /25, or PTO/AIA /26) should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to www.uspto.gov/patents/apply/applying-online/eterminal-disclaimer.
Claims 1, 8-10, 15-18, 20 and 49 stand provisionally rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1, 9-10, 12-14, 16-19, 37, 48, 50, 53 and 56-59 of copending Application No. 17425757 in view of Pinto et al. (Tissue Engineering Part A.01 December 2017, Vol. 23 (Supplement 1), abstract Number 421, as in IDS), Stupp et al. (US8748569) and Zamora et al. (US8227411). The reference of Perez is withdrawn. The rejection is maintained for the reasons of record and the reasons set forth below.
Response to Arguments
On p. 5-7 of the response, Applicant acknowledges that i) the ‘569 patent discloses a peptide amphiphile bearing the epitope IKVAV; ii) Zamora teaches FGF analogs; iii) Perez discloses the peptide amphiphile C16V3A3K3GYRSRKYSSWYVALKR. But Applicant argues that i) none of the cited secondary references disclosed or suggest the growth factor mimetic peptide amphiphile recited in claim 1; ii) even if a skilled artisan would combine the cited references, the skilled artisan cannot arrive the claimed supramolecular assembly without impermissible picking and choosing; iii) the claimed supramolecular assembly has remarkable technical effects which are not expected by the cited references or in peptide amphiphile co-assembly disclosed in the Pinto abstract. Applicant further cites p. 37-42 in support of the arguments.
Applicant's arguments have been fully considered but they are not found persuasive. Contrary to Applicant's arguments, the examiner asserts that based on MPEP §804, MPEP §2141, MPEP2141-I, rationales identified by the Court in KSR (KSR International Co. v. Teleflex Inc. (KSR), 550 U.S. 398, 82 USPQ2d 1385 (2007)), MPEP2141-II, the basic factual inquires of Graham v. John Deere Co.(Graham v. John Deere Co., 383 U.S. 1, 148 USPQ 459 (1966)),and MPEP §2141.01-2147.03, the cited references do render the claimed invention unpatentable or obvious because:
i. Applicant cannot show nonobviousness by attacking references individually where the rejections are based on combinations of references. See In re Keller, 642 F.2d 413, 208 USPQ 871 (CCPA 1981); In re Merck & Co., 800 F.2d 1091, 231 USPQ 375 (Fed. Cir. 1986).
It is not necessary that the claimed invention be expressly suggested in any one or all of the references to justify combining their teachings; rather the test is what the combined teachings of the references would have suggested to those of ordinary skill in the art. In re Keller, 642 F.2d 413, 208 USPQ 871 (CCPA 1981). The motivation to combine can arise from the expectation that the prior art elements will perform their expected functions to achieve their expected results when combined for their common known purpose. MPEP. §2144.07. Specific statements in the references themselves which would spell out the claimed invention are not necessary to show obviousness, since questions of obviousness involve not only what references expressly teach, but what they would collectively suggest to one of ordinary skill in the art. See CTS Corp. v. Electro Materials Corp. of America 202 USPQ 22 (DC SNY 1979); and In re Burckel 201 USPQ 67 (CCPA 1979).
Further, in considering the disclosure of a reference, it is proper to take into account not only specific teaching of the reference but also the inferences which one skilled in the art would reasonably be expected to draw therefrom. In re Preda, 401 F.2d 825, 159 USPQ 342, 344 (CCPA 1968).
In this case, claims 1, 9-10, 12-14, 16-19, 37, 48, 50, 53 and 56-59 of Application No. 17425757 (the ‘757 Application) claim a peptide amphiphile (PA), a nanofiber comprising the PA and a pharmaceutical composition or scaffold comprising the nanofiber. The PA of the ‘757 Application comprises:
i) a hydrophobic tail comprising a C8-24 carbon alkyl chain,
ii) a structural peptide segment having a total propensity for forming beta-sheet conformation of 4 or less,
iii) a charged peptide segment comprising EE, EEE or EEEE (SEQ ID NO:5), and
iv) a bioactive peptide, and wherein the structural peptide segment comprises SEQ ID NO:1 (A2G2); and wherein the bioactive peptide includes the bioactive peptide comprising SEQ ID NO:25 (IKVAV) (claim 9), and wherein the PA includes PA comprising C8-24-AAGG-EEEE-G-IKVAV (SEQ ID NO:7) (claim 12).
The PA recited in claims of the ‘757 Application teaches a PA basic structure comprises C8-24-A2G2-EEEE-G-a bioactive peptide including IKVAV (instant SEQ ID NO:1). The PA recited in claims of the ‘757 Application comprises the claimed hydrophobic segment (i.e.C8-24)-the claimed structural peptide segment (i.e.A2G2 (instant SEQ ID NO:4))-the claimed charged peptide (i.e.-EEEE- (instant SEQ ID NO:11)0-G-a bioactive peptide including IKVAV (instant SEQ ID NO:1). Thus, the PA recited in the claims of the ‘757 Application meets the limitation “a. at least one IKVAV peptide amphiphile comprising a hydrophobic…and a bioactive peptide comprising the amino acid sequence IKVAV (SEQ ID NO:1)” and the basic structure of item b. recited in instant claim 1 except the limitation “FGF-2 mimetic sequence comprising the sequence YRSRKYSSWYVALKR (SEQ ID NO:2)” or a structural peptide segment comprising V2A2 (SEQ ID NO:3) recited in claim 1.
While the claims of the ‘757 Application do not recite that the limitation “b. at least one growth factor mimetic peptide amphiphile…. wherein the growth factor mimetic sequence is FGF-2 mimetic sequence comprising the sequence..(SEQ ID NO:2)” recited in instant claim 1 or “FGF-2-PA comprising instant SEQ ID NO:13” recited in claims 17 and 18, Pinto, Stupp and Zamora teach these limitations and provide motivation and an expectation of success in generating a supramolecular assembly comprising at least two PA including at least one IKVAV-PA and at least one growth factor-memetic PA that is FGF-2 mimetic PA as instantly claimed because:
i. Pinto teaches self-assembled nanostructures comprising an FGF-2 mimetic PA co-assembled with a known IKVAV-PA to form nanofibers for promoting vascularization, nerve regeneration, functional recovery and limiting the damage in an experimental mouse model of spinal cord injury (SCI) (see Abstract 421, p. S105-S106).
ii. Stupp (US8748569) teaches self-assembly PA molecules/compounds for promoting axonal or neurite outgrowth and treatment of different neurodegenerative diseases or neuronal damage in spinal cord due to traumatic injury, and wherein the PA molecules/compounds include a basic structure of C6-C22/C15-V2A2-E4-G-IKVAV (SEQ ID NO. 1) or C6-C22/C15-V2A2-E4-G-growth factor (see col. 9, lines 61-col. 10, lines 16). Stupp teaches that the self-assembly PA molecules/compounds comprise four segments:
(1) a hydrophobic segment including C6-C22 or C15 acyl group;
(2) a structural peptide or beta-sheet-forming peptide segment comprising 3-10 non-polar amino acid residues including V, A, G or V2A2;
(3) a charged peptide segment comprising the formula of (E)x(G)y, wherein x is 2-6 and y is 1-6, including (E)2-G or (E)4-G (instant SEQ ID NO:11) and
(4) a signaling epitope comprising the peptide IKVAV (SEQ ID NO. 1) or a growth factor (see col.31-32, claims 1-5; col. 2, lines 4-63; col. 4, line 31-col.6, line 5; col. 8, line 32-col.11, line 61).
iii. Zamora (US8227411) teaches an FGF-2 analog comprising the amino acid sequence of SEQ ID NO:7 (YRSRKYSSWYVALKR), which is 100% identical to instant SEQ ID NO:2 (see the sequence alignment; col. 4, line 30).
A person of ordinary skill in the art would have recognized that selecting and applying the known FGF-2 mimetic sequence comprising instant SEQ ID NO:2 or the known FGF2-PA comprising instant SEQ ID NO:13 (V2A2-E4-G-SEQ ID NO:2) and the known technique disclosed by Pinto, Stupp and Zamora to the nanofiber comprising the PA and a pharmaceutical composition or scaffold recited in claims of the ‘757 Application would have yielded the predictable result of generating the claimed supramolecular assembly comprising at least one IKVAV-PA and at least one growth factor mimetic PA including FGF2-PA comprising instant SEQ ID NO:13, and resulted in an improved product.
Using and including the known FGF-2 mimetic sequence comprising instant SEQ ID NO:2 or the known FGF2-PA comprising instant SEQ ID NO:13 (V2A2-E4-G-SEQ ID NO:2) in the composition comprising PAs, or nanofibers or nanostructures or supramolecular structures of the ‘757 Application would generate the claimed supramolecular assembly comprising the claimed IKVAV-PA and at least one growth factor mimetic PA including FGF-2-PA having instant SEQ ID NO:13, and expand application of the composition of the ‘757 Application in therapeutic purposes and treatment of a nervous system injury, and would increase patient’s satisfaction with treatment of nervous injury including trauma using a composition comprising PAs and nanofibers, nanostructures or supramolecular structures because Pinto teaches self-assembled nanostructures comprising an FGF-2 mimetic PA co-assembled with a known IKVAV-PA to form nanofibers for promoting vascularization, nerve regeneration, functional recovery and limit the damage in an experimental mouse model of spinal cord injury (SCI), the claims of the ‘757 Application and Stupp teach self-assembled PAs including PAs comprising C8-24-V2A2-E4-G-growth factor mimetic sequence for promoting neurite outgrowth or cell survival of motor neurons; and Zamora teaches an FGF-2 analog comprising instant SEQ ID NO:2 and FGF2-PA nanoribbons comprising instant SEQ ID NO:13 for repair of damaged tissue caused by trauma.
Thus, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to select and apply the known FGF-2-PA comprising instant SEQ ID NO:2 or the known FGF2-PA comprising instant SEQ ID NO:13, the known supramolecular assembly comprising self-assembly of IKVAV-PA and growth factor-memetic PA, and the known technique of generating supramolecular assembly disclosed by Pinto, Stupp and Zamora to the nanofiber or scaffold or pharmaceutical composition of the ‘757 Application, and yield the predictable result of generating a supramolecular assembly comprising at least one IKVAV-PA having the recited structures and sequences and at least one growth factor-memetic PA including FGF2-PA having the recited structures and sequences for therapeutic purposes and for treatment of a nervous system injury.
ii. In response to Applicant’s arguments related to unexpected results, note that evidence of unexpected results must be weighed against evidence supporting prima facie obviousness in making a final determination of the obviousness of the claimed invention. In re May, 574 F.2d 1082, 197 USPQ 601 (CCPA 1978). See MPEP 716.02(c)-I.
Any differences between the claimed invention and the prior art may be expected to result in some differences in properties. The issue is whether the properties differ to such an extent that the difference is really unexpected. See: MPEP §716.02.
In this case, the effect of self-assembled nanostructures comprising an FGF-2 mimetic PA co-assembled with a known IKVAV-PA to form nanofibers for promoting vascularization, nerve regeneration, functional recovery and limiting the damage in an experimental mouse model of spinal cord injury (SCI) is known as taught by Pinto. The twofold greater than the co-assembly of IKVAV-PA and FGF2-PA1 (with a structural peptide segment V2A2) than the co-assembly of IKVAV-PA and FGF2-PA2 (with a structural peptide segment A2G2) is not really unexpected because “A greater than expected result is an evidentiary factor pertinent to the legal conclusion of obviousness ... of the claims at issue.” In re Corkill, 711 F.2d 1496, 226 USPQ 1005 (Fed. Cir. 1985). See MPEP 716.02(a)-I.
Note that “The selection of a known material based on its suitability for its intended use supported a prima facie obviousness determination in Sinclair & Carroll Co. v. Interchemical Corp., 325 U.S. 327, 65 USPQ 297 (1945).” See MPEP 2144.07.
In this case, Pinto teaches self-assembled nanostructures comprising an FGF-2 mimetic PA co-assembled with a known IKVAV-PA to form nanofibers for promoting vascularization, nerve regeneration, functional recovery and limit the damage in an experimental mouse model of spinal cord injury (SCI), the claims of the ‘757 Application and Stupp teach self-assembled PAs including PAs comprising C8-24-V2A2-E4-G-growth factor mimetic sequence for promoting neurite outgrowth or cell survival of motor neurons; and Zamora teaches an FGF-2 analog comprising instant SEQ ID NO:2 and FGF2-PA nanoribbons comprising instant SEQ ID NO:13 for repair of damaged tissue caused by trauma. Thus, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to select and apply the known FGF-2-PA comprising instant SEQ ID NO:2 or the known FGF2-PA comprising instant SEQ ID NO:13, the known supramolecular assembly comprising self-assembly of IKVAV-PA and growth factor-memetic PA, and the known technique of generating supramolecular assembly disclosed by Pinto, Stupp and Zamora to the nanofiber or scaffold or pharmaceutical composition of the ‘757 Application, and yield the predictable result of generating a supramolecular assembly comprising at least one IKVAV-PA having the recited structures and sequences and at least one growth factor-memetic PA including FGF2-PA having the recited structures and sequences for therapeutic purposes and for treatment of a nervous system injury.
Accordingly, the provisional rejection of claims 1, 8-10, 15-18, 20 and 49 on the ground of nonstatutory double patenting as being unpatentable over claims 1, 9-10, 12-14, 16-19, 37, 48, 50, 53 and 56-59 of copending Application No. 17425757 in view of Pinto, Stupp and Zamora is maintained.
Double Patenting
8. Claims 1, 8-10, 15-18, 20 and 49 stand provisionally rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-18 and 30-35 of copending Application No. 19147007 (the ‘007 Application) in view of Pinto et al. (2017), Stupp et al. (US8748569), and Zamora et al. (US8227411). The rejection is maintained for the reasons of record and the reasons set forth below.
Response to Arguments
On p. 7-8 of the response, Applicant argues that the instant application has an earlier effecting date than the ‘007 Application because the filing date of the ‘007 Application is January 16, 2024. Applicant argues that the rejection should be withdrawn in view of MPEP 804(I)(B)(b)(i) because the rejection is the only rejection remaining.
Applicant's arguments have been fully considered but they are not found persuasive. Contrary to Applicant's arguments, the double patenting rejection over the ‘007 Application is the only one rejection for the reasons set forth above.
Based on MPEP §804, MPEP §2141, MPEP2141-I, rationales identified by the Court in KSR (KSR International Co. v. Teleflex Inc. (KSR), 550 U.S. 398, 82 USPQ2d 1385 (2007)), MPEP2141-II, the basic factual inquires of Graham v. John Deere Co.(Graham v. John Deere Co., 383 U.S. 1, 148 USPQ 459 (1966)),and MPEP §2141.01-2147.03, the cited references do render the claimed invention unpatentable or obvious because:
i. Claims 2-18 and 30-35 of Application No. 19147007 (the ‘007 Application) claim a composition comprising peptide amphiphiles (PA) self-assembled into a supramolecular nanofiber, wherein the PAs comprises
a) a hydrophobic non-peptide segment comprising an acyl chain including C6-C20;
b) a structural peptide segment comprising a beta-sheet forming peptide segment including A2G2 (SEQ ID NO:4) and V2A2 (SEQ ID NO:3);
c) a charged peptide segment which is a glutamate and/or aspartate-rich segment including EE, EEE or EEEE; and
d) a bioactive peptide including a IKVAV and a FGF2 mimetic peptide (claims 16-17) or a composition comprising a first PA and a second PA (claim 31), which relate to the limitations recited in instant claims.
While the claims of the ‘007 Application do not recite that the limitation “b. at least one growth factor mimetic peptide amphiphile…. wherein the growth factor mimetic sequence is FGF-2 mimetic sequence comprising the sequence..(SEQ ID NO:2)” recited in instant claim 1, “FGF-2-PA comprising instant SEQ ID NO:13” in claims 17 and 18, Pinto, Stupp and Zamora teach these limitations and provide motivation and an expectation of success in generating a supramolecular assembly comprising at least two PA including at least one IKVAV-PA and at least one growth factor-memetic PA that comprises instant SEQ ID NO:2 or wherein the FGF-2 mimetic PA comprises instant SEQ ID NO:13 for the reasons set forth above. Thus, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to select and apply the known FGF-2-PA comprising instant SEQ ID NO:2 or the known FGF2-PA comprising instant SEQ ID NO:13, the known supramolecular assembly comprising self-assembly of IKVAV-PA and growth factor-memetic PA, and the known technique of generating supramolecular assembly disclosed by Pinto, Stupp and Zamora to the nanofiber/scaffold/pharmaceutical composition of the ‘007 Application, and yield the predictable result of generating a supramolecular assembly comprising at least one IKVAV-PA having the recited structures and sequences and at least one growth factor-memetic PA including FGF2-PA having the recited structures and sequences for therapeutic purposes and for treatment of a nervous system injury.
Accordingly, the provisional rejection of claims 1, 8-10, 15-18, 20 and 49 on the ground of nonstatutory double patenting as being unpatentable over claims 1-18 and 30-35 of copending Application No. 19147007 in view of Pinto, Stupp and Zamora is maintained.
New Grounds of Rejection Necessitated by the Amendment
The following rejections are new grounds of rejections necessitated by the amendment filed on December 22, 2025 and January 8, 2026.
Double Patenting
9. Claims 1, 8-10, 15-18, 20 and 49 are provisionally rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-59 of copending Application No. 19448840 (the ‘840 Application) in view of Pinto et al. (2017), Stupp et al. (US8748569), and Zamora et al. (US8227411).
Claims 1-59 of Application No. 19448840 (the ‘840 Application) claim a peptide amphiphile (PA), comprising a hydrophobic tail, a structural peptide segment having a total propensity for forming b-sheet conformations of 4 or less, a charged peptide segment, and a bioactive peptide, wherein the hydrophobic tail includes a C8-C24 carbon alkyl chain (claim 2), the structural peptide includes A2G2 (claim 6) and the bioactive peptide includes IKVAV (claim 9), and wherein the PA includes including IKVAV(G)E4A2G2-C8-24 (claim 12), a nanofiber comprising the claimed PA or a pharmaceutical composition or a scaffold comprising the claimed PA or the claimed nanofiber, or a system comprising the claimed scaffold, and methods of using the claimed PA, nanofiber or pharmaceutical composition for treating nervous system injury or culturing cells.
While the claims of the ‘840 Application do not recite that the limitation “b. at least one growth factor mimetic peptide amphiphile…. wherein the growth factor mimetic sequence is FGF-2 mimetic sequence comprising the sequence..(SEQ ID NO:2)” recited in instant claim 1 or “FGF-2-PA comprising instant SEQ ID NO:13” recited in claims 17 and 18, Pinto, Stupp and Zamora teach these limitations and provide motivation and an expectation of success in generating a supramolecular assembly comprising at least two PA including at least one IKVAV-PA and at least one growth factor-memetic PA that is FGF-2 mimetic PA for the reasons set forth above. Thus, it would have been obvious to one of ordinary skill in the art before the effective filing date of the claimed invention to select and apply the known FGF-2-PA comprising instant SEQ ID NO:2 or the known FGF2-PA comprising instant SEQ ID NO:13, the known supramolecular assembly comprising self-assembly of IKVAV-PA and growth factor-memetic PA, and the known technique of generating supramolecular assembly disclosed by Pinto, Stupp and Zamora to the nanofiber or scaffold or pharmaceutical composition of the ‘840 Application, and yield the predictable result of generating a supramolecular assembly comprising at least one IKVAV-PA having the recited structures and sequences and at least one growth factor-memetic PA including FGF2-PA having the recited structures and sequences for therapeutic purposes and for treatment of a nervous system injury.
Conclusion
10. NO CLAIM IS ALLOWED.
11. The prior art made of record and not relied upon is considered pertinent to applicant's disclosure.
US8748569 teaches peptide amphiphiles (PAs) comprising at least one IKVAV PA wherein the PAs including a PA comprising instant SEQ ID NO:12 (see the sequence alignment below).
SEQ ID NO:12
US-13-442-210B-7
Sequence 7, US/13442210B
Patent No. 8748569
GENERAL INFORMATION
APPLICANT: Stupp, Samuel I.
APPLICANT: Goldberger, Joshua E.
APPLICANT: Berns, Eric J.
TITLE OF INVENTION: PEPTIDE AMPHIPHILES AND METHODS TO ELECTROSTATICALLY CONTROL
TITLE OF INVENTION: BIOACTIVITY OF THE IKVAV PEPTIDE EPITOPE
FILE REFERENCE: NWEST-32590/US-2/ORD
CURRENT APPLICATION NUMBER: US/13/442,210B
CURRENT FILING DATE: 2012-04-09
PRIOR APPLICATION NUMBER: US 61/473,593
PRIOR FILING DATE: 2011-04-08
NUMBER OF SEQ ID NOS: 19
SEQ ID NO 7
LENGTH: 14
TYPE: PRT
ORGANISM: Artificial Sequence
FEATURE:
OTHER INFORMATION: Synthetic
Query Match 70.1%; Score 47; Length 14;
Best Local Similarity 100.0%;
Matches 10; Conservative 0; Mismatches 0; Indels 0; Gaps 0;
Qy 5 EEEEGIKVAV 14
||||||||||
Db 5 EEEEGIKVAV 14
US8227411 teaches an FGF-2 analog comprising the amino acid sequence of SEQ ID NO:7, which is 100% identical to instant SEQ ID NO:2 (see the sequence alignment below; col. 4, line 30).
SEQ ID NO:2
Sequence 7, US/11361565B
Patent No. 8227411
GENERAL INFORMATION
APPLICANT: BioSurface Engineering Technologies, Inc.
APPLICANT: Brookhaven National Laboratory
APPLICANT: Zamora, Paul O.
APPLICANT: Pena, Louis A.
APPLICANT: Lin, Xinhua
APPLICANT: Takahashi, Kazuyuki
TITLE OF INVENTION: FGF Growth Factor Analogs
FILE REFERENCE: 30817-Util-860
CURRENT APPLICATION NUMBER: US/11/361,565B
CURRENT FILING DATE: 2006-02-23
PRIOR APPLICATION NUMBER: 60/656,860
PRIOR FILING DATE: 2005-02-25
PRIOR APPLICATION NUMBER: 10/644,703
PRIOR FILING DATE: 2003-08-19
PRIOR APPLICATION NUMBER: 10/224,268
PRIOR FILING DATE: 2003-08-20
PRIOR APPLICATION NUMBER: 11/064,039
PRIOR FILING DATE: 2005-02-22
PRIOR APPLICATION NUMBER: 11/065,970
PRIOR FILING DATE: 2005-02-24
NUMBER OF SEQ ID NOS: 49
SEQ ID NO 7
LENGTH: 15
TYPE: PRT
ORGANISM: Artificial
FEATURE:
OTHER INFORMATION: Synthetic FGF-2 analog
Query Match 100.0%; Score 15; Length 15;
Best Local Similarity 100.0%;
Matches 15; Conservative 0; Mismatches 0; Indels 0; Gaps 0;
Qy 1 YRSRKYSSWYVALKR 15
|||||||||||||||
Db 1 YRSRKYSSWYVALKR 15
12. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Chang-Yu Wang whose telephone number is (571)272-4521. The examiner can normally be reached on Monday-Thursday, 7:00am-5:30pm EST.
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Chang-Yu Wang
February 7, 2026
/CHANG-YU WANG/Primary Examiner, Art Unit 1675