Prosecution Insights
Last updated: October 23, 2026
Application No. 18/319,864

ENGINEERED THERMOPHILIC REVERSE TRANSCRIPTASE

Final Rejection §DOUBLEPATENT
Filed
May 18, 2023
Priority
May 18, 2022 — provisional 63/343,451
Examiner
FRONDA, CHRISTIAN L
Art Unit
1652
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
10x Genomics Inc.
OA Round
2 (Final)
82%
Grant Probability
Favorable
3-4
OA Rounds
0m
Est. Remaining
97%
With Interview

Examiner Intelligence

Grants 82% — above average
82%
Career Allowance Rate
1131 granted / 1371 resolved
+22.5% vs TC avg
Moderate +14% lift
Without
With
+14.3%
Interview Lift
resolved cases with interview
Typical timeline
2y 5m
Avg Prosecution
45 currently pending
Career history
1410
Total Applications
across all art units

Statute-Specific Performance

§101
5.2%
-34.8% vs TC avg
§103
25.7%
-14.3% vs TC avg
§102
7.8%
-32.2% vs TC avg
§112
38.6%
-1.4% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1371 resolved cases

Office Action

§DOUBLEPATENT
DETAILED ACTION The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claims 1, 2, 5, 6, 8-10, 13-17, 22-25 are pending in the instant application. Claims 13-17 are withdrawn from further consideration pursuant to 37 CFR 1.142(b), as being drawn to a nonelected invention. Claims 1, 2, 5, 6, 8-10, 22-25 are pending in the instant application. In view of the amendment and arguments filed 08/10/2026, the previous rejection(s) of the claims 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph; 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph; 35 U.S.C. 103 have been. ` Double Patenting The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory obviousness-type double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); and In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on a nonstatutory double patenting ground provided the conflicting application or patent either is shown to be commonly owned with this application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. Effective January 1, 1994, a registered attorney or agent of record may sign a terminal disclaimer. A terminal disclaimer signed by the assignee must fully comply with 37 CFR 3.73(b). Claims 1, 2, 5, 6, 8-10, 22-25 are provisionally rejected on the ground of nonstatutory double patenting as being unpatentable over claims 1-3, 5-7, 10, 19, 21-23, 26-32, 34, 37, 41, 50 of Application Serial No. 19249939. Applicant’s statement filed 08/10/2026 to hold he rejection be held in abeyance has been acknowledged. However, until a terminal disclaimer is filed the claims are rejected for the reasons stated below. Although the conflicting claims are not identical, they are not patentably distinct from each other for the following reasons. The claims and/or specification of the copending application teach the claimed engineered nucleic acid processing enzyme comprising: the recited (a) a first domain; and (b) a second domain conjugated to the first domain. Thus, the teachings anticipate the claimed invention. This is a provisional nonstatutory double patenting rejection because the patentably indistinct claims have not in fact been patented. Conclusion No claim is allowed. THIS ACTION IS MADE FINAL Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any extension fee pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Christian L Fronda whose telephone number is (571)272 0929. The examiner can normally be reached Monday-Thursday and alternate Fridays between 9:00AM-5:00PM. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Robert Mondesi can be reached on (408)918-7584. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /CHRISTIAN L FRONDA/Primary Examiner, Art Unit 1652
Read full office action

Prosecution Timeline

May 18, 2023
Application Filed
Feb 12, 2026
Non-Final Rejection mailed — §DOUBLEPATENT
Aug 10, 2026
Response Filed
Oct 15, 2026
Final Rejection mailed — §DOUBLEPATENT (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12767965
METHODS FOR THE BIOTECHNOLOGICAL PRODUCTION OF ALDEHYDE MIXTURES
4y 1m to grant Granted Oct 20, 2026
Patent 12760284
STABLE SYNTHETIC PHYTASE VARIANTS
3y 5m to grant Granted Oct 13, 2026
Patent 12742189
RECOMBINANT HOST CELLS WITH IMPROVED PRODUCTION OF TETRAKETIDE DERIVATIVES
5y 2m to grant Granted Sep 22, 2026
Patent 12742150
METHOD FOR PRESERVING FERMENTATION BROTH OF ENGINEERED STRAIN OF D-PSICOSE-3-EPIMERASE
3y 0m to grant Granted Sep 22, 2026
Patent 12735682
Modified glutamate dehydrogenase and the use thereof
3y 8m to grant Granted Sep 15, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
82%
Grant Probability
97%
With Interview (+14.3%)
2y 5m (~0m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1371 resolved cases by this examiner. Grant probability derived from career allowance rate.

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