Prosecution Insights
Last updated: April 19, 2026
Application No. 18/330,874

INHIBITORS OF THE INTERACTION BETWEEN TRIP8B AND HCN CHANNELS AND USES THEREOF FOR TREATING NEUROLOGICAL DISEASES AND DISORDERS

Non-Final OA §102§112
Filed
Jun 07, 2023
Examiner
SAWYER, JENNIFER C
Art Unit
1691
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Northwestern University
OA Round
1 (Non-Final)
69%
Grant Probability
Favorable
1-2
OA Rounds
2y 9m
To Grant
58%
With Interview

Examiner Intelligence

Grants 69% — above average
69%
Career Allow Rate
375 granted / 545 resolved
+8.8% vs TC avg
Minimal -11% lift
Without
With
+-10.6%
Interview Lift
resolved cases with interview
Typical timeline
2y 9m
Avg Prosecution
45 currently pending
Career history
590
Total Applications
across all art units

Statute-Specific Performance

§101
0.2%
-39.8% vs TC avg
§103
43.9%
+3.9% vs TC avg
§102
19.4%
-20.6% vs TC avg
§112
24.7%
-15.3% vs TC avg
Black line = Tech Center average estimate • Based on career data from 545 resolved cases

Office Action

§102 §112
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Detailed Action This office action is in response to applicant’s communication filed on 11/20/25. Claims 1-21 are pending in this application. Applicant’s election without traverse of Group I, claims 1-16 in the reply filed on 11/20/2025 is acknowledged. Thus Claims 17-21 are withdrawn from further consideration being drawn to the nonelected invention. Applicant’s election of the following compound is acknowledged herewith: PNG media_image1.png 140 240 media_image1.png Greyscale Applicant’s elected species has been found allowable. Since applicant’s species has been found allowable, the next species to be searched is the following compound 27 from Becker et al. (US 3954442, pub date May 4, 1976). See the 102 rejection over Becker et al. below. PNG media_image2.png 182 490 media_image2.png Greyscale Compound 27 reads on applicant’s compound in claim 1 when: X = 4-chlorophenyl m = 1 R2 = R3 = R4 = H R1 = methyl W = -C(O)- Y = -NH-(Alk)n-Z n = 0 Z = 4-chlorophenyl Thus, additionally, claims 4-5, 10-12 and 15, along with claims 17-21, are hereby withdrawn from consideration being non-readable on the species as shown herein. Accordingly, the claims have been searched solely to the extent of the species as shown herein. The search has not been extended to determine the patentability of the other species encompassed by the claims. “If prior art is then found that anticipates or renders obvious the Markush-type claim with respect to a nonelected species, the Markush-type claim shall be rejected and claims to the nonelected species held withdrawn from further consideration. The prior art search, however, will not be extended unnecessarily to cover all nonelected species.” (MPEP 803.02) As a result, claims 1-3, 6-9, 13-14 and 16 are being examined in this Office Action. Priority The applicant claims benefit as follows: PNG media_image3.png 54 394 media_image3.png Greyscale Objections Claim 1 is objected to because of the following informalities: Claim 1 recites “hetrocycle“ twice. The examiner believes the correct spelling is “heterocycle“. Appropriate correction is required. Claim Rejections - 35 USC § 112 The following is a quotation of 35 U.S.C. 112(b): (b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. Claims 1-3, 6-9, 13-14 and 16 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112, second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor regards as the invention. Claim 1 recites the connection “W-Y” and the definition of W includes “-C(O)-“, while the definition of Y includes “carboxyl”. This would give a connectivity of two carbonyls attached to each other: -C(O)-C(O)-OH. This is improbable based on applicant’s specification and examples. Claim 1 also recites X can be halogen when m = 1. This would result in a connectivity of a halogen attached to an oxygen atom: -O-X. This is improbable based on applicant’s specification and examples. The remaining claims are rejected as depending from a rejected claim. Appropriate correction is required. Furthermore, as a courtesy, even though claim 15 has been withdrawn, the examiner notes that claim 15 recites the following compounds: PNG media_image4.png 172 602 media_image4.png Greyscale These compounds do not read on claim 1. For the first compound Y is a hydroxyl group. However, a hydroxyl group is not included in the definition of Y. For the second compound X is -C(O)H. However, this group is not included in the definition of X. Additionally, the -OH group does not read on applicant’s -O-CR1-W-Y group. Additionally, claim 15 is replete with other compounds that do not read on claim 1. Claim Rejections – 35 USC 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of the AIA 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale or otherwise available to the public before the effective filing date of the claimed invention. (a)(2) the claimed invention was described in a patent issued under section 151, or in an application for patent published or deemed published under section 122(b), in which the patent or application, as the case may be, names another inventor and was effectively filed before the effective filing date of the claimed invention. This application currently names joint inventors. In considering patentability of the claims the examiner presumes that the subject matter of the various claims was commonly owned as of the effective filing date of the claimed invention(s) absent any evidence to the contrary. Applicant is advised of the obligation under 37 CFR 1.56 to point out the inventor and effective filing dates of each claim that was not commonly owned as of the effective filing date of the later invention in order for the examiner to consider the applicability of 35 U.S.C. 102(b)(2)(C) for any potential 35 U.S.C. 102(a)(2) prior art against the later invention. Claims 1-3, 6-9, 13-14 and 16 are rejected under AIA 35 U.S.C. 102(a)(1) and/or 102(a)(2) as being anticipated by Becker et al. (US 3954442, pub date May 4, 1976). Becker et al. teaches the following herbicidal compound 27 and compositions in water or solvent. (column 3, lines 23-45; column 4, lines 32-45, Example 1, column 11; see compound 27 in Table, column 7 and 8, 3rd compound from the bottom) PNG media_image2.png 182 490 media_image2.png Greyscale Compound 27 reads on applicant’s compound in claim 1 when: X = 4-chlorophenyl m = 1 R2 = R3 = R4 = H R1 = methyl W = -C(O)- Y = -NH-(Alk)n-Z n = 0 Z = 4-chlorophenyl Therefore these claims are fully met. Conclusion Claims 1-3, 6-9, 13-14 and 16 are rejected Any inquiry concerning this communication or earlier communications from the examiner should be directed to Jennifer Cho Sawyer whose telephone number is (571) 270 1690. The examiner can normally be reached on Monday-Friday 9 AM - 6 PM PST. If attempts to reach the examiner by telephone are unsuccessful, the examiner's supervisor, Renee Claytor can be reached on (571) 272-8394. The fax phone number for the organization where this application or proceeding is assigned is 571-274-1690. Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://pair-direct.uspto.gov. Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative or access to the automated information system, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. Jennifer Cho Sawyer Patent Examiner Art Unit: 1691 /RENEE CLAYTOR/Supervisory Patent Examiner, Art Unit 1691
Read full office action

Prosecution Timeline

Jun 07, 2023
Application Filed
Feb 21, 2026
Non-Final Rejection — §102, §112 (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
69%
Grant Probability
58%
With Interview (-10.6%)
2y 9m
Median Time to Grant
Low
PTA Risk
Based on 545 resolved cases by this examiner. Grant probability derived from career allow rate.

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