Detailed Action Acknowledgments The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA. This action is in reply to the application filed on 12/21/2023 . Claim s 1-24 are currently pending and have been examined. Information Disclosure Statement The Information Disclosure Statements filed 12/21/2023 and 06/27/2025 have been considered. Initialed copies of the Form 1449 are enclosed herewith. Claim Rejections - 35 USC § 101 35 U.S.C. 101 reads as follows: Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title. Claims 1-24 are rejected under 35 U.S.C. 101 because the claimed invention is directed to non- patent eligible subject matter because the claim(s) as a whole, considering all claim elements both individually and in combination, do not amount to significantly more than an abstract idea. Step 1: The claims recite a process, system, apparatus, article of manufacture, and/or a nontransitory storage medium with instructions, each of which are proper statutory categories. Step 2A (prong 1): Claim 1 (representative of claims 9 and 17 ): The claim limitations are grouped as shown immediately following : receiving a request for bioinformatics processing in a bioinformatics pipeline implemented in a cloud computing environment, (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) the cloud computing environment comprising a plurality of monitored availability zones (AZs), each with respective resources, (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) the bioinformatics processing comprising a plurality of steps for deployment and execution in the bioinformatics pipeline; (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) receiving, in conjunction with the request, a definition indicating options for respective resources of varying resource types to use in executing each step of the plurality of steps; (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) orchestrating the deployment and execution of the plurality of steps in the bioinformatics pipeline, the orchestrating comprising: (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) selecting, from the plurality of monitored AZs, an availability zone (AZ) to perform the requested bioinformatics processing; (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) initiating execution of the plurality of steps in the selected AZ, wherein the definition indicates, for a step of the plurality of steps and for a resource type to use in executing the step, a plurality of different resources, of that resource type, that are possible alternatives to each other for selection and use in executing the step, (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) wherein the initiating execution comprises: (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) using the definition to select a resource, from the indicated plurality of different resources, to use in executing the step; (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) initiating execution of the step with a direction to the selected AZ to use the selected resource; (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) monitoring the execution of the plurality of steps in the selected AZ. (Certain Methods Of Organizing Human Activity - business relations or managing personal behavior or relationships or interactions between people including following rules or instructions) dependent claims 6, 14, and 22 overcome the definitions of the independent claims. Step 2A (prong 2): Claim 1 (representative of claims 9 and 17 ): …a computer system …a memory …a processing circuit …a computer readable storage medium These remaining claim limitations are delineated as shown immediately preceding. The abstract idea is not integrated into a practical application. There are no improvements to the functioning of a computer, other technology or technical field, a particular machine is not cited, nothing is transformed to a different state or thing, the abstract idea is not more than a drafting effort designed to monopolize the abstract idea. The claim merely uses a computer as a tool to perform the abstract idea, which is generally linked to a particular field of use, in this case, marketing and advertising. Thus, t hese limitations are recited at a high-level of generality (i.e., as a generic processor and memory performing a generic computer function of processing and storing data) such that it amounts no more than mere instructions to apply the exception using a generic computer component – MPEP 2106.05(f). Further, receiving data, evaluating data and distributing data are data gathering and data outputting, which has no effect on technology and does no more than generally link the use of the judicial exception to a particular technological environment or field of use – see MPEP 2106.05(h). Step 2B: The claim limitations do not provide an Inventive Concept. The claim limitations do not recite additional elements that amount to significantly more that the abstract idea because the additional elements of the system comprising a computer processor, computer readable storage medium with instructions, and a memory configured to store information, each recited at a high level of generality in a computer network which only perform the universal computer functions of accessing, receiving, storing, and processing data, transmitting and presenting information. Taking the elements both individually and as an ordered combination, the function performed by the computer at each step of the process is purely orthodox. Using a computer to obtain and display data are some of the most basic functions of a computer. As shown, the individual limitations claimed are some of the most rudimentary functions of a computer. The technical solution described in this invention does not alter hardware structure or its routine, does not transform the character of the information being processed, does not identify a novel source or type of data, does not advance the functionality of a computer as a tool, and does not incorporate specific rules enabling the computer to accomplish innovative utilities. In summary, the individual step and/or component does no more than require a general computer to perform standard computer functions. As discussed above with respect to integration of the abstract idea into a practical application, the additional element of a computer devices amounts to no more than mere instructions to apply the exception using a generic computer component - requiring the use of software to tailor information and provide it to the user on a generic computer, Intellectual Ventures I LLC v. Capital One Bank (USA), 792 F.3d 1363, 1370-71, 115 USPQ2d 1636, 1642 (Fed. Cir. 2015); CONCLUSION The prior art made of record and not relied upon is considered pertinent to applicant's disclosure. Non-Patent Literature: Konstantinos Krampis et al. “ A Review of Cloud Computing Bioinformatics Solutions for Next- Gen Sequencing Data Analysis and Research .” ( June 2, 2015 ). Retrieved online 03/19/2026 . Krampis-and-Wultsch-2015-A-Review-of-Cloud-Computing-Bioinformatics-Solutions-for-Next-Gen-Sequencing-Data-Analysis-and-Research.pdf Somak Roy, MD . “ Next-Generation Sequencing Bioinformatics Pipelines A guide to practical implementation for clinical laboratories .” ( Mar 01, 2020 ). Retrieved online 03/19/2026. https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwj1osGu3qyTAxXtEVkFHd08F0oQFnoECBgQAQ&url=https%3A%2F%2Fmyadlm.org%2Fcln%2Farticles%2F2020%2Fmarch%2Fnext-generation-sequencing-bioinformatics-pipelines&usg=AOvVaw0Fgl98NRSdmeaI92OCfgw0&opi=89978449 Sofia M. Vignolo et al. “ A cloud-based bioinformatic analytic infrastructure and Data Management Core for the Expanded Program on Immunization Consortium .” ( 22 September 2020 ). Retrieved online 03/19/2026. https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwj1osGu3qyTAxXtEVkFHd08F0oQFnoECBcQAQ&url=https%3A%2F%2Fwww.cambridge.org%2Fcore%2Fjournals%2Fjournal-of-clinical-and-translational-science%2Farticle%2Fcloudbased-bioinformatic-analytic-infrastructure-and-data-management-core-for-the-expanded-program-on-immunization-consortium%2F13BDAEBFCF13A5170324DDBAB07263E6&usg=AOvVaw0SzmKlY1q_hlFcBOI57foO&opi=89978449 Foreign Art: BIANCHINI et al. “ Method Of Autoscaling In Datacenter, Involves Determining Whether To Scale-down Selected Component Based On Datacenter Metrics After Sending Instruction To Server Computer To Scale-up Component, And Sending Instruction To Server Computer To Scale-down Selected Component .” ( WO 2023 / 229719 A1 ). CHEN et al. “ Method For Managing Resources In A Distributed Resource Management System, Involves Receiving Resource Request By Processor In Distributed Resource Management System, Where Class Identifier Is Provided For Identifying Additional Resource .” ( WO 2017 / 088794 A1 ) MAGGIARI et al. “ Method Of Deployment Of Virtualized Service On Cloud Infrastructure, Involves Selecting First Computing System From First Subset Of Computing Systems And Links Of First Subset Of Links Based On Associated Costs .” ( WO 2021 / 094812 A1 ) Any inquiry of a general nature or relating to the status of this application or concerning this communication or earlier communications from the Examiner should be directed to James A. Reagan ( james.reagan@uspto.gov ) whose telephone number is 571.272.6710. The Examiner can normally be reached Monday through Friday from 9 AM to 5 PM. If attempts to reach the examiner by telephone are unsuccessful, the Examiner’s supervisor, John Hayes, can be reached at 571.272.670 8 . Information regarding the status of an application may be obtained from the Patent Application Information Retrieval (PAIR) system. Status information for published applications may be obtained from either Private PAIR or Public PAIR. Status information for unpublished applications is available through Private PAIR only. For more information about the PAIR system, see http://portal.uspto.gov/external/portal/pair . Should you have questions on access to the Private PAIR system, contact the Electronic Business Center (EBC) at 866.217.9197 (toll-free). Any response to this action should be mailed to: Commissioner for Patents PO Box 1450 Alexandria, Virginia 22313-1450 or faxed to 571-273-8300 . Hand delivered responses should be brought to the United States Patent and Trademark Office Customer Service Window : Randolph Building 401 Dulany Street Alexandria, VA 22314. /JAMES A REAGAN/ Primary Examiner, Art Unit 3697 james.reagan@uspto.gov 571.272.6710 (Office) 571.273.6710 (Desktop Fax)