Prosecution Insights
Prosecution Insights
Technology area: Biotechnology & Pharmaceuticals
128 pending office actions • 27 art units • 91 examiners • 0 of 128 (0%) have an AI response strategy ready • 132 patents granted in the last 365 days
Based on the USPTO statutory response window for each pending office action. 30 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.
Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 30 of the docket's apps have a known mailing date.
Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.
| Bucket | Cases |
|---|---|
| §101 only | 4 (3%) |
| §101 + other | 35 (27%) |
| §103 only | 28 (22%) |
| §102 only | 7 (5%) |
| §112 only | 5 (4%) |
| Double-patenting only | 2 (2%) |
| Double-patenting + other | 10 (8%) |
| Multi-statute (no §101) | 37 (29%) |
How the docket's pending cases split across USPTO tech-center bands.
Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.
| Examiner | Apps on this docket | Allow rate | Interview lift |
|---|---|---|---|
| CROW, ROBERT THOMAS | 6 | 41.7% | +32.7% |
| POHNERT, STEVEN C | 5 | 12.4% | +18.5% |
| RILEY, JEZIA | 3 | 82.9% | +7.3% |
| SCHULTZHAUS, JANNA NICOLE | 3 | 35.1% | +37.0% |
| BAILEY, STEVEN WILLIAM | 3 | 31.6% | +15.2% |
| ELKINS, BLAKE HARRISON | 3 | 100.0% | +0.0% |
| WOITACH, JOSEPH T | 3 | 49.9% | +28.3% |
| YOUNG, BRIAN ELLIS | 2 | 65.8% | +24.8% |
| GZYBOWSKI, MICHAEL STANLEY | 2 | 68.3% | +52.0% |
| WILDER, CYNTHIA B | 2 | 71.0% | +26.6% |
Cases in front of an examiner with an allow rate of 80%+ where the difficulty is Easy or Medium. The top 3 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 18650800 | CONTROLLED POLYNUCLEOTIDE TRANSLOCATION IN NANOPORE SEQUENCING | RILEY, JEZIA | — |
| 18393291 | METHODS OF SEQUENCING USING 3' BLOCKED NUCLEOTIDES | RILEY, JEZIA | — |
| 18569532 | METHODS OF DETECTING METHYLCYTOSINE AND HYDROXYMETHYLCYTOSINE BY SEQUENCING | RILEY, JEZIA | — |
Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 17314513 | GENOME SEQUENCING AND DETECTION TECHNIQUES | AUGER, NOAH ANDREW | 147d overdue |
| 17250814 | METHODS AND SYSTEMS FOR MONITORING ORGAN HEALTH AND DISEASE | BAILEY, STEVEN WILLIAM | 45d overdue |
| 18300343 | SYSTEM AND METHOD FOR SECONDARY ANALYSIS OF NUCLEOTIDE SEQUENCING DATA | LIU, GUOZHEN | 18d overdue |
| 17839387 | QUALITY SCORE CALIBRATION OF BASECALLING SYSTEMS | DARRIGRAND, EMILY ANN | 16d overdue |
| 17830316 | SELF-LEARNED BASE CALLER, TRAINED USING ORGANISM SEQUENCES | PLAYER, ROBERT AUSTIN | 10d overdue |
| 18129565 | MACHINE LEARNING MODELING OF PROBE INTENSITY | RODEN, DONALD THOMAS | 3d overdue |
| 17805138 | SIGNAL-TO-NOISE-RATIO METRIC FOR DETERMINING NUCLEOTIDE-BASE CALLS AND BASE-CALL QUALITY | KALLAL, ROBERT JAMES | 12d |
| 17813852 | METHODS FOR PREPARING SUBSTRATE SURFACE FOR DNA SEQUENCING | RAYMONDA, MATTHEW HAROLD | 27d |
Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 17250814 | METHODS AND SYSTEMS FOR MONITORING ORGAN HEALTH AND DISEASE | BAILEY, STEVEN WILLIAM | 45d overdue |
| 18176761 | FUNCTIONALIZED NANOSTRUCTURES AND FLOW CELL DEPRESSIONS | CROW, ROBERT THOMAS | 24d overdue |
| 17518135 | SYSTEMS AND METHODS FOR MAKING SEQUENCING LIBRARIES | YOUNG, BRIAN ELLIS | 3d overdue |
| 18069688 | INSTRUMENTS, SYSTEMS, AND METHODS FOR MEASURING LIQUID FLOW THROUGH CHANNELS | GZYBOWSKI, MICHAEL STANLEY | 12d |
| 18885481 | METHODS OF PREPARING LOOP FORK LIBRARIES | YOUNG, BRIAN ELLIS | 15d |
| 17618836 | METHODS FOR SEQUENCING POLYNUCLEOTIDES | WILDER, CYNTHIA B | 19d |
| 18467770 | NANOPARTICLE WITH POLYNUCLEOTIDE BINDING SITE AND METHOD OF MAKING THEREOF | CROW, ROBERT THOMAS | 29d |
| 18343696 | SEQUENCING NANOPARTICLES AND METHODS OF MAKING THE SAME | CROW, ROBERT THOMAS | 34d |
| Art Unit | Apps |
|---|---|
| 1683 | 13 |
| 1682 | 13 |
| 1684 | 9 |
| 1687 | 9 |
| 1681 | 8 |
| 1686 | 6 |
| 1798 | 5 |
| 1796 | 5 |
| 1685 | 5 |
| 2877 | 4 |
| App # | Title | Examiner | Art Unit | Statutes | Status | Due in | AI | Filed |
|---|---|---|---|---|---|---|---|---|
| 18877290 | SEQUENCING SYSTEM WITH CURVED IMAGE PLANE OR OBJECT PLANE | GUNBERG, EDWIN C | 2884 | §102§103 | Non-Final OA | — | Pending | Dec 20, 2024 |
| 18987285 | SEQUENCE DATA PROCESSING, RETENTION, AND RECOVERY | HU, JENSEN | 2169 | §102§103 | Non-Final OA | 35d | Pending | Dec 19, 2024 |
| 18939115 | AUTOFOCUS FUNCTIONALITY IN OPTICAL SAMPLE ANALYSIS | AMARA, MOHAMED K | 2877 | §102§112 | Non-Final OA | — | Pending | Nov 06, 2024 |
| 18921425 | DYNAMIC AUTOFOCUS METHOD AND SYSTEM FOR ASSAY IMAGER | BRYANT, REBECCA CAROLE | 2877 | §103§112 | Non-Final OA | — | Pending | Oct 21, 2024 |
| 18885481 | METHODS OF PREPARING LOOP FORK LIBRARIES | YOUNG, BRIAN ELLIS | 1684 | §103 | Final Rejection | 15d | Pending | Sep 13, 2024 |
| 18818453 | ARTIFICIAL INTELLIGENCE-BASED QUALITY SCORING | BHATNAGAR, ANAND P | — | §101§102 | Non-Final OA | — | Pending | Aug 28, 2024 |
| 18795995 | VALVE ASSEMBLIES AND RELATED SYSTEMS | GZYBOWSKI, MICHAEL STANLEY | 1798 | §103 | Non-Final OA | — | Pending | Aug 06, 2024 |
| 18760831 | Anodized Metal Oxide Substrates Supporting Solid Support Feature Arrays for Patterned Flowcells | WILDER, CYNTHIA B | — | §103 | Non-Final OA | — | Pending | Jul 01, 2024 |
| 18759367 | SYSTEMS AND RELATED REAGENT CARTRIDGE QUEUING METHODS | WRIGHT, PATRICIA KATHRYN | — | §103§112 | Non-Final OA | — | Pending | Jun 28, 2024 |
| 18758066 | PROTECTING FULLY FUNCTIONAL NUCLEOTIDES FROM DEGRADATION | POHNERT, STEVEN C | — | §103§112 | Non-Final OA | — | Pending | Jun 28, 2024 |
| 18725694 | IMAGING SYSTEMS AND RELATED SYSTEMS AND METHODS | PEREZ-GUZMAN, CARLOS GABRIEL | 2877 | §103 | Final Rejection | 60d overdue | Pending | Jun 28, 2024 |
| 18737223 | METHOD FOR POLISHING A SUBSTRATE | ISHAQ, ISHAQ MOHAMED SAID | — | §103§112 | Non-Final OA | — | Pending | Jun 07, 2024 |
| 18736835 | CAPTURING AND AMPLIFYING POLYNUCLEOTIDES, AND REUSING FLOWCELLS, USING SILICA PARTICLES | CHUNDURU, SURYAPRABHA | — | §103§112 | Non-Final OA | — | Pending | Jun 07, 2024 |
| 18732450 | MULTI-VALVE FLUID CARTRIDGE | MUI, CHRISTINE T | — | §102Other | Non-Final OA | — | Pending | Jun 03, 2024 |
| 18664102 | DIGITAL MICROFLUIDIC SYSTEM FOR SINGLE-CELL ISOLATION AND CHARACTERIZATION OF ANALYTES | TSUI, YUNG-SHENG M | — | §102§112DP | Non-Final OA | — | Pending | May 14, 2024 |
| 18650800 | CONTROLLED POLYNUCLEOTIDE TRANSLOCATION IN NANOPORE SEQUENCING | RILEY, JEZIA | — | §102 | Non-Final OA | — | Pending | Apr 30, 2024 |
| 18633966 | CAPTURING AND AMPLIFYING POLYNUCLEOTIDES | CHUNDURU, SURYAPRABHA | — | §102§112 | Non-Final OA | — | Pending | Apr 12, 2024 |
| 18618263 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING | CROW, ROBERT THOMAS | — | §103§112 | Non-Final OA | — | Pending | Mar 27, 2024 |
| 18420482 | INFERRING MICROORGANISM OF ORIGIN FOR ANTIMICROBIAL RESISTANCE MARKERS IN TARGETED METAGENOMICS | MYERS, CARLA J | 1671 | §101§112 | Non-Final OA | — | Pending | Jan 23, 2024 |
| 18414085 | CONCURRENT SEQUENCING OF FORWARD AND REVERSE COMPLEMENT STRANDS ON SEPARATE POLYNUCLEOTIDES FOR METHYLATION DETECTION | BELLAH, JEFFREY LAWRENCE | 1683 | §102§103§112DP | Non-Final OA | — | Pending | Jan 16, 2024 |
| 18403902 | MULTI-OMIC ANALYSIS IN MONODISPERSE DROPLETS | KAPUSHOC, STEPHEN THOMAS | 1683 | §102§103DP | Non-Final OA | — | Pending | Jan 04, 2024 |
| 18575265 | DNA ORIGAMI STRUCTURE AND PROTEIN NANOPORE CONSTRUCT | STAVROU, CONSTANTINA E | 1632 | §102§103 | Non-Final OA | — | Pending | Dec 28, 2023 |
| 18575242 | ANALOG CIRCUIT TO COMPENSATE BIAS OFFSET IN AMPLIFIER ARRAY | SALMON, KATHERINE D | 1682 | §102§103§112 | Non-Final OA | — | Pending | Dec 28, 2023 |
| 18392826 | DETECTION OF ANALYTES USING TARGETED EPIGENETIC ASSAYS, PROXIMITY-INDUCED TAGMENTATION, STRAND INVASION, RESTRICTION, OR LIGATION | SWITZER, JULIET CAROLINE | 1682 | §112 | Non-Final OA | — | Pending | Dec 21, 2023 |
| 18393291 | METHODS OF SEQUENCING USING 3' BLOCKED NUCLEOTIDES | RILEY, JEZIA | 1681 | DP | Non-Final OA | — | Pending | Dec 21, 2023 |
| 18389877 | MULTI-SURFACE BIOLOGICAL SAMPLE IMAGING SYSTEM AND METHOD | CROW, ROBERT THOMAS | 1683 | §103§112 | Non-Final OA | — | Pending | Dec 20, 2023 |
| 18572189 | IMAGING SYSTEMS AND RELATED METHODS | PHILLIPS, RUFUS L | 2877 | §103 | Final Rejection | 76d | Pending | Dec 20, 2023 |
| 18390578 | PALLADIUM CATALYST COMPOSITIONS AND METHODS FOR SEQUENCING BY SYNTHESIS | BELLAH, JEFFREY LAWRENCE | 1683 | §103 | Non-Final OA | — | Pending | Dec 20, 2023 |
| 18545638 | CLOUD COMPUTING ENVIRONMENT FOR BIOLOGICAL DATA | LE, THANH T | 2495 | §103§112 | Non-Final OA | — | Pending | Dec 19, 2023 |
| 18542447 | FLOW CELLS | KASS, BENJAMIN JOSEPH | — | §102§103§112 | Non-Final OA | — | Pending | Dec 15, 2023 |
| 18542470 | FLOW CELLS | BOWERS, NATHAN ANDREW | — | §103§112 | Non-Final OA | — | Pending | Dec 15, 2023 |
| 18571069 | APTAMER DYNAMIC RANGE COMPRESSION AND DETECTION TECHNIQUES | PHAM, KHAI QUYNH TIEN | 1682 | §103§112 | Non-Final OA | — | Pending | Dec 15, 2023 |
| 18538441 | Reusable Flow Cells Having Primer Binding Sites Comprising Reactive Sulfur Moieties and Methods of Using the Same, and Reagents for Use Therewith | KOVACH, KARA NICOLE | 1681 | §103DP | Non-Final OA | — | Pending | Dec 13, 2023 |
| 18538262 | ALTERED CYTIDINE DEAMINASES AND METHODS OF USE | HUTSON, RICHARD G | 1652 | §103 | Final Rejection | 53d | Pending | Dec 13, 2023 |
| 18569532 | METHODS OF DETECTING METHYLCYTOSINE AND HYDROXYMETHYLCYTOSINE BY SEQUENCING | RILEY, JEZIA | 1681 | §102 | Non-Final OA | — | Pending | Dec 12, 2023 |
| 18535492 | AUTOMATED VOLUMETRIC REAGENT DELIVERY TESTING | WHATLEY, BENJAMIN R | — | §101§102§103§112DPOther | Non-Final OA | — | Pending | Dec 11, 2023 |
| 18568366 | DETECTING METHYLCYTOSINE USING A MODIFIED BASE OPPOSITE TO THE METHYLCYTOSINE | SALMON, KATHERINE D | 1682 | §102§103 | Final Rejection | — | Pending | Dec 08, 2023 |
| 18534113 | FLOW CELLS AND SEQUENCING KITS | JONES, CHRISTINE MICHELLE | 1682 | §103§112DP | Final Rejection | 4d overdue | Pending | Dec 08, 2023 |
| 18568756 | PERIODATE COMPOSITIONS AND METHODS FOR CHEMICAL CLEAVAGE OF SURFACE-BOUND POLYNUCLEOTIDES | MARTIN, KEVIN STEPHEN | 1681 | §112Other | Non-Final OA | — | Pending | Dec 08, 2023 |
| 18567989 | ORTHOGONAL HYBRIDIZATION | PARISI, JESSICA DANIELLE | 1682 | §102§103§112 | Non-Final OA | — | Pending | Dec 07, 2023 |
| 18530865 | NUCLEOSIDES AND NUCLEOTIDES WITH 3' BLOCKING GROUPS AND CLEAVABLE LINKERS | CRAIGO, BAHAR ALAWI | 1699 | §112 | Non-Final OA | — | Pending | Dec 06, 2023 |
| 18530025 | ETCH-FREE PHOTORESIST PATTERNING IN MULTI-DEPTH NANOWELLS | GORDON, BRIAN R | — | §102§103§112 | Non-Final OA | — | Pending | Dec 05, 2023 |
| 18566369 | IDENTIFYING NUCLEOTIDES USING CHANGES IN IMPEDANCE BETWEEN ELECTRODES | GRAY, JESSICA | 1682 | §101§103§112 | Non-Final OA | — | Pending | Dec 01, 2023 |
| 18523636 | FLOW CELLS WITH PASSIVATION COMPONENTS | ALABI, OYELEYE A | — | §102§103 | Non-Final OA | — | Pending | Nov 29, 2023 |
| 18515013 | REVERSIBLY CROSS-LINKED HYDROGELS, AND METHODS OF USING THE SAME FOR CLUSTER AMPLIFICATION | YU, TIAN NMN | 1681 | §102§103DPOther | Final Rejection | — | Pending | Nov 20, 2023 |
| 18562095 | OLIGO-MODIFIED NUCLEOTIDE ANALOGUES FOR NUCLEIC ACID PREPARATION | VANHORN, ABIGAIL LOUISE | — | §102§103§112 | Non-Final OA | — | Pending | Nov 17, 2023 |
| 18507414 | DESIGNING PROBES FOR DEPLETING ABUNDANT TRANSCRIPTS | POHNERT, STEVEN C | 1683 | §101§103§112 | Non-Final OA | — | Pending | Nov 13, 2023 |
| 18505624 | SPATIALLY DISTINGUISHED, MULTIPLEX NUCLEIC ACID ANALYSIS OF BIOLOGICAL SPECIMENS | SHI, TINGCHEN | 1796 | §103 | Final Rejection | 3d overdue | Pending | Nov 09, 2023 |
| 18484268 | DETECTING AND CORRECTING METHYLATION VALUES FROM METHYLATION SEQUENCING ASSAYS | ZEMAN, MARY K | — | §101§103 | Non-Final OA | — | Pending | Oct 10, 2023 |
| 18477346 | COPY NUMBER VARIATION (CNV) BREAKPOINT DETECTION | BICKHAM, DAWN MARIE | — | §101§102§103§112 | Non-Final OA | — | Pending | Sep 28, 2023 |
| 18476232 | MACHINE-LEARNING MODEL FOR REFINING STRUCTURAL VARIANT CALLS | LEMMA, SAMSON B | 2498 | §103 | Final Rejection | — | Pending | Sep 27, 2023 |
| 18476151 | NUCLEIC ACID SEQUENCING COMPONENTS INCLUDING A GLYCOLIPID BI-LAYER | POHNERT, STEVEN C | 1683 | §102§103§112DP | Non-Final OA | — | Pending | Sep 27, 2023 |
| 18476031 | MESOPHILIC COMPOSITIONS FOR NUCLEIC ACID AMPLIFICATION | POHNERT, STEVEN C | 1683 | §101§102§103§112DP | Non-Final OA | — | Pending | Sep 27, 2023 |
| 18473564 | Compositions and Methods for Assessing DNA Damage in a Library and Normalizing Amplicon Size Bias | PHAM, KHAI QUYNH TIEN | — | §102§103§112 | Non-Final OA | — | Pending | Sep 25, 2023 |
| 18473971 | Resynthesis Kits and Methods | BROWN, MINDY G | 1683 | §102§103 | Non-Final OA | — | Pending | Sep 25, 2023 |
| 18369587 | SYSTEMS AND METHODS INCLUDING A ROTARY VALVE FOR AT LEAST ONE OF SAMPLE PREPARATION OR SAMPLE ANALYSIS | KWAK, DEAN P | 1798 | §102Other | Non-Final OA | — | Pending | Sep 18, 2023 |
| 18467770 | NANOPARTICLE WITH POLYNUCLEOTIDE BINDING SITE AND METHOD OF MAKING THEREOF | CROW, ROBERT THOMAS | 1683 | §103 | Final Rejection | 29d | Pending | Sep 15, 2023 |
| 18367308 | Reusable Flow Cells Having Signal Intensity Retention, Methods of Retaining Signal Intensity in Reusable Flow Cells and Reagents and Kits Therefor | BERKELEY, EMILY R | 1796 | §102 | Non-Final OA | — | Pending | Sep 12, 2023 |
| 18243594 | COMPUTE SCHEDULING FOR SEQUENCING ANALYSIS | CLOW, LORI A | — | §101§102§103§112 | Non-Final OA | — | Pending | Sep 07, 2023 |
| 18455090 | FLOW CELLS | HUANG, MICKEY NMN | 1758 | §112 | Non-Final OA | — | Pending | Aug 24, 2023 |
| 18359502 | RAPID SINGLE-CELL MULTIOMICS PROCESSING USING AN EXECUTABLE FILE | SCHULTZHAUS, JANNA NICOLE | — | §103 | Final Rejection | — | Pending | Jul 26, 2023 |
| 18357829 | NUCLEIC ACID SEQUENCE ANALYSIS AND CONFIGURABLE REPORT GENERATION | ANDERSON-FEARS, KEENAN NEIL | — | §101§102§103DP | Non-Final OA | — | Pending | Jul 24, 2023 |
| 18216859 | IN-TIP MAGNETIC-BASED MAGNETIC BEAD PROCESSING | MUI, CHRISTINE T | 1797 | §102§103 | Non-Final OA | — | Pending | Jun 30, 2023 |
| 18343842 | HYDRATION AND HOMOGENIZATION OF LYOPHILIZED REAGENTS | SEIFU, LESSANEWORK T | — | §103§112 | Non-Final OA | — | Pending | Jun 29, 2023 |
| 18215794 | IN-SITU FLUIDIC INSPECTION | SHI, TINGCHEN | 1796 | §103 | Final Rejection | 5d overdue | Pending | Jun 28, 2023 |
| 18215641 | NON-CONTACT DISPENSERS AND RELATED SYSTEMS AND METHODS | LYLE, SOPHIA YUAN | 1796 | §102§103 | Final Rejection | 34d | Pending | Jun 28, 2023 |
| 18343696 | SEQUENCING NANOPARTICLES AND METHODS OF MAKING THE SAME | CROW, ROBERT THOMAS | 1683 | §103 | Final Rejection | 34d | Pending | Jun 28, 2023 |
| 18342463 | GENERATING AND IMPLEMENTING A STRUCTURAL VARIATION GRAPH GENOME | BAILEY, STEVEN WILLIAM | — | §101§102§103 | Non-Final OA | — | Pending | Jun 27, 2023 |
| 18340795 | SPLIT-READ ALIGNMENT BY INTELLIGENTLY IDENTIFYING AND SCORING CANDIDATE SPLIT GROUPS | ELKINS, BLAKE HARRISON | — | §101§102§103DP | Non-Final OA | — | Pending | Jun 23, 2023 |
| 18307482 | MACHINE-LEARNING MODELS FOR SELECTING OLIGONUCLEOTIDE PROBES FOR ARRAY TECHNOLOGIES | SANFORD, DIANA PATRICIA | — | §101§103§112 | Final Rejection | — | Pending | Apr 26, 2023 |
| 18301595 | TARGETED CALLING OF OVERLAPPING COPY NUMBER VARIANTS | BICKHAM, DAWN MARIE | — | §101§102 | Non-Final OA | — | Pending | Apr 17, 2023 |
| 18300343 | SYSTEM AND METHOD FOR SECONDARY ANALYSIS OF NUCLEOTIDE SEQUENCING DATA | LIU, GUOZHEN | 1686 | §101 | Final Rejection | 18d overdue | Pending | Apr 13, 2023 |
| 18129565 | MACHINE LEARNING MODELING OF PROBE INTENSITY | RODEN, DONALD THOMAS | 2128 | §101§103 | Final Rejection | 3d overdue | Pending | Mar 31, 2023 |
| 18193206 | COPY NUMBER VARIANT CALLING FOR LPA KIV-2 REPEAT | SCHULTZHAUS, JANNA NICOLE | — | §101§102§103§112 | Non-Final OA | — | Pending | Mar 30, 2023 |
| 18193512 | METHODS FOR INSERTING NANOPORES INTO POLYMERIC MEMBRANES USING CHAOTROPIC SOLVENTS | PEPITONE, MICHAEL F | 1765 | §102§103§112 | Non-Final OA | — | Pending | Mar 30, 2023 |
| 18193517 | NANOPORE DEVICES INCLUDING BARRIERS USING POLYMERS WITH END GROUPS, AND METHODS OF MAKING THE SAME | CHIU, TAK LIANG | 1777 | §103 | Final Rejection | 63d | Pending | Mar 30, 2023 |
| 18192291 | NUCLEOSIDES AND NUCLEOTIDES WITH 3' VINYL BLOCKING GROUP | CREWS, JARET JAMES | 1691 | §103 | Final Rejection | — | Pending | Mar 29, 2023 |
| 18190809 | SYSTEMS AND METHODS OF SEQUENCING POLYNUCLEOTIDES | GIAMMONA, FRANCESCA FILIPPA | 1681 | §103 | Non-Final OA | — | Pending | Mar 27, 2023 |
| 18189842 | SEQUENCE-TO-SEQUENCE BASE CALLING | FRUMKIN, JESSE P | — | §101§102 | Non-Final OA | — | Pending | Mar 24, 2023 |
| 18176761 | FUNCTIONALIZED NANOSTRUCTURES AND FLOW CELL DEPRESSIONS | CROW, ROBERT THOMAS | 1683 | §103 | Final Rejection | 24d overdue | Pending | Mar 01, 2023 |
| 18174468 | CALIBRATION SEQUENCES FOR NUCLEOTIDE SEQUENCING | LEVERETT, MARY CHANG | — | §101§103§112 | Non-Final OA | — | Pending | Feb 24, 2023 |
| 18164341 | Microfluidic Droplet Generators | CROW, ROBERT THOMAS | 1683 | §103Other | Non-Final OA | 34d | Pending | Feb 03, 2023 |
| 18156846 | LIGHT ENERGY FLUORESCENCE EXCITATION | XU, XIAOYUN | 1797 | §103§112 | Final Rejection | 33d | Pending | Jan 19, 2023 |
| 18151128 | Beads as Transposome Carriers | BEIL, RANDI LYNN | 1684 | §103§112 | Non-Final OA | — | Pending | Jan 06, 2023 |
| 18069688 | INSTRUMENTS, SYSTEMS, AND METHODS FOR MEASURING LIQUID FLOW THROUGH CHANNELS | GZYBOWSKI, MICHAEL STANLEY | 1798 | §103 | Final Rejection | 12d | Pending | Dec 21, 2022 |
| 18009545 | DRY REAGENT CUP ASSEMBLIES AND METHODS | HANDY, DWAYNE K | 1798 | §103 | Final Rejection | 10d overdue | Pending | Dec 09, 2022 |
| 18008953 | COMPOSITIONS AND METHODS FOR SEQUENCING USING AT LEAST ELECTRICAL CHARACTERISTICS | KENNEDY, SARAH JANE | 1682 | §103 | Final Rejection | 32d overdue | Pending | Dec 07, 2022 |
| 18000666 | SELECTING APTAMERS USING SEQUENCING | GIAMMONA, FRANCESCA FILIPPA | 1681 | §103§112 | Non-Final OA | — | Pending | Dec 02, 2022 |
| 18059326 | GENERATING CLUSTER-SPECIFIC-SIGNAL CORRECTIONS FOR DETERMINING NUCLEOTIDE-BASE CALLS | ELKINS, BLAKE HARRISON | 1687 | §101§103§112DP | Non-Final OA | — | Pending | Nov 28, 2022 |
| 18055550 | PROTEIN STRUCTURE-BASED PROTEIN LANGUAGE MODELS | SMITH, JENNIFER JOY | 1685 | §101§103DP | Non-Final OA | — | Pending | Nov 15, 2022 |
| 18051966 | METHODS AND COMPOSITIONS FOR PREPARING NUCLEIC ACID LIBRARIES | BOESEN, CHRISTIAN C | 1684 | §102 | Non-Final OA | — | Pending | Nov 02, 2022 |
| 17978130 | SEQUENCING KITS | ZHANG, KAIJIANG | 1684 | §102§103 | Non-Final OA | — | Pending | Oct 31, 2022 |
| 17997633 | GENOME SEQUENCING AND DETECTION TECHNIQUES | ELKINS, BLAKE HARRISON | 1687 | §101§103§112DP | Non-Final OA | — | Pending | Oct 31, 2022 |
| 17921936 | COMPOSITIONS AND METHODS FOR SEQUENCING USING POLYMER BRIDGES | SITTON, JEHANNE SOUAYA | 1682 | §102§103DP | Non-Final OA | — | Pending | Oct 27, 2022 |
| 17968766 | COVARIATE CORRECTION INCLUDING DRUG USE FROM TEMPORAL DATA | REYES, REGINALD R | 3684 | §101 | Final Rejection | — | Pending | Oct 18, 2022 |
| 17935476 | FACILITATING SECURE EXECUTION OF EXTERNAL WORKFLOWS FOR GENOMIC SEQUENCING DIAGNOSTICS | GRAFF, SHARON LEVINE | 1687 | §101§103 | Non-Final OA | — | Pending | Sep 26, 2022 |
| 17935497 | AUTOMATICALLY SWITCHING VARIANT ANALYSIS MODEL VERSIONS FOR GENOMIC ANALYSIS APPLICATIONS | GRAFF, SHARON LEVINE | 1687 | §101§103 | Non-Final OA | — | Pending | Sep 26, 2022 |
| 17953293 | COMBINED AND TRANSFER LEARNING OF A VARIANT PATHOGENICITY PREDICTOR USING GAPPED AND NON-GAPPED PROTEIN SAMPLES | MOHANTA, PRAMOD KUMAR | 1686 | §103 | Non-Final OA | — | Pending | Sep 26, 2022 |
| 17953286 | PREDICTING VARIANT PATHOGENICITY FROM EVOLUTIONARY CONSERVATION USING THREE-DIMENSIONAL (3D) PROTEIN STRUCTURE VOXELS | ASIAMAH, ABENA ASANTEWAA | 1685 | §101DP | Non-Final OA | — | Pending | Sep 26, 2022 |
| 17821410 | AUTOMATICALLY IDENTIFYING FAILURE SOURCES IN NUCLEOTIDE SEQUENCING FROM BASE-CALL-ERROR PATTERNS | PLAYER, ROBERT AUSTIN | 1686 | §103§112 | Final Rejection | — | Pending | Aug 22, 2022 |
| 17813852 | METHODS FOR PREPARING SUBSTRATE SURFACE FOR DNA SEQUENCING | RAYMONDA, MATTHEW HAROLD | 1684 | §103§112 | Non-Final OA | 27d | Pending | Jul 20, 2022 |
| 17864655 | PRE-TEMPLATED INSTANT PARTITIONING OF DNA-ENCODED LIBRARIES | FLINDERS, JEREMY C | 1684 | §103 | Non-Final OA | — | Pending | Jul 14, 2022 |
| 17790077 | FLOW CELL ASSEMBLIES AND RELATED REAGENT SELECTOR VALVES | KASS, BENJAMIN JOSEPH | 1798 | §103 | Final Rejection | — | Pending | Jun 29, 2022 |
| 17839387 | QUALITY SCORE CALIBRATION OF BASECALLING SYSTEMS | DARRIGRAND, EMILY ANN | 1686 | §101§103 | Final Rejection | 16d overdue | Pending | Jun 13, 2022 |
| 17837642 | DETERMINING PATHOGENIC RFC1 EXPANSIONS FROM SEQUENCING DATA | BEVERIDGE, CONNOR HAMMOND | 1687 | §103 | Non-Final OA | — | Pending | Jun 10, 2022 |
| 17833394 | METHODS AND SYSTEMS FOR IDENTIFYING RECOMBINANT VARIANTS | SMITH, EMILIE ALINE | 1686 | §101§112 | Non-Final OA | — | Pending | Jun 06, 2022 |
| 17805138 | SIGNAL-TO-NOISE-RATIO METRIC FOR DETERMINING NUCLEOTIDE-BASE CALLS AND BASE-CALL QUALITY | KALLAL, ROBERT JAMES | 1685 | §101 | Final Rejection | 12d | Pending | Jun 02, 2022 |
| 17830316 | SELF-LEARNED BASE CALLER, TRAINED USING ORGANISM SEQUENCES | PLAYER, ROBERT AUSTIN | 1686 | §101§103§112Other | Non-Final OA | 10d overdue | Pending | Jun 01, 2022 |
| 17747569 | TEMPLATE PARTICLES WITH MICROPORES AND NANOPORES | WRIGHT, SARAH C | 1619 | §103§112 | Non-Final OA | — | Pending | May 18, 2022 |
| 17747603 | MULTI-OMIC ANALYSIS OF EXTRACELLULAR VESICLES IN MONODISPERSE DROPLETS | GRAY, JESSICA | 1682 | §103DP | Final Rejection | 23d | Pending | May 18, 2022 |
| 17747599 | PRE-TEMPLATED INSTANT PARTITIONS FOR SCREENING | BEIL, RANDI LYNN | 1684 | §103§112 | Non-Final OA | — | Pending | May 18, 2022 |
| 17665849 | DISTINGUISHING METHYLATION LEVELS IN COMPLEX BIOLOGICAL SAMPLES | LIN, JERRY | 1685 | §101§112 | Final Rejection | — | Pending | Feb 07, 2022 |
| 17592895 | LINEAR FOURIER FIDUCIAL | KRCHA, MATTHEW D | 1796 | §102 | Final Rejection | — | Pending | Feb 04, 2022 |
| 17618836 | METHODS FOR SEQUENCING POLYNUCLEOTIDES | WILDER, CYNTHIA B | 1681 | §103 | Final Rejection | 19d | Pending | Dec 13, 2021 |
| 17547297 | METHODS AND SYSTEMS FOR VISUALIZING SHORT READS IN REPETITIVE REGIONS OF THE GENOME | WOITACH, JOSEPH T | 1687 | §101§103 | Final Rejection | — | Pending | Dec 10, 2021 |
| 17538812 | SYSTEM AND METHOD FOR DETECTION OF GENETIC ALTERATIONS | LAFAVE, ELIZABETH ROSE | 1684 | §101§103 | Non-Final OA | — | Pending | Nov 30, 2021 |
| 17518135 | SYSTEMS AND METHODS FOR MAKING SEQUENCING LIBRARIES | YOUNG, BRIAN ELLIS | 1684 | §103 | Final Rejection | 3d overdue | Pending | Nov 03, 2021 |
| 17511353 | DETECTING MATERIALS IN A MIXTURE USING OLIGONUCLEOTIDES | SISSON, BRADLEY L | 1682 | §112 | Final Rejection | 22d | Pending | Oct 26, 2021 |
| 17472038 | COMPOSITIONS AND METHODS FOR DETECTING AN ABASIC SITE | POHNERT, STEVEN C | 1683 | §103§112 | Non-Final OA | — | Pending | Sep 10, 2021 |
| 17400165 | SAMPLE ANALYZER FOR ANALYZING NUCLEIC ACID SEQUENCING DATA | WOITACH, JOSEPH T | — | §101 | Non-Final OA | — | Pending | Aug 12, 2021 |
| 17348212 | METHODS AND SYSTEMS FOR ANALYZING IMAGE DATA | WOITACH, JOSEPH T | — | §101§103Other | Non-Final OA | — | Pending | Jun 15, 2021 |
| 17332904 | Machine Learning-Based Analysis of Process Indicators to Predict Sample Reevaluation Success | BAILEY, STEVEN WILLIAM | 1687 | §101§103§112 | Non-Final OA | — | Pending | May 27, 2021 |
| 17324363 | APPARATUS WITH A SENSOR HAVING AN ACTIVE SURFACE | KRCHA, MATTHEW D | 1700 | §103 | Non-Final OA | — | Pending | May 19, 2021 |
| 17314513 | GENOME SEQUENCING AND DETECTION TECHNIQUES | AUGER, NOAH ANDREW | 1687 | §101§112 | Final Rejection | 147d overdue | Pending | May 07, 2021 |
| 17281157 | TARGET CAPTURE AND BARCODING IN MONODISPERSE DROPLETS | TURPIN, ZACHARY MARK | 1682 | DP | Non-Final OA | — | Pending | Mar 29, 2021 |
| 17250814 | METHODS AND SYSTEMS FOR MONITORING ORGAN HEALTH AND DISEASE | BAILEY, STEVEN WILLIAM | 1687 | §101§103 | Final Rejection | 45d overdue | Pending | Mar 05, 2021 |
| 17026069 | METHODS AND COMPOSITIONS FOR IDENTIFYING LIGANDS ON ARRAYS USING INDEXES AND BARCODES | MYERS, CARLA J | 1682 | §112DP | Non-Final OA | — | Pending | Sep 18, 2020 |
| 16333933 | SOMATIC COPY NUMBER VARIATION DETECTION | SCHULTZHAUS, JANNA NICOLE | 1685 | §101§112 | Final Rejection | — | Pending | Mar 15, 2019 |
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