Prosecution Insights
Last updated: April 19, 2026
Application No. 18/454,285

OPTOELECTROFLUIDIC DEVICE FOR MASSIVE PARALLEL TRAPPING AND ENHANCED SPECTROSCOPY OF SINGLE NANOSCALE OBJECTS

Non-Final OA §101§102§DP
Filed
Aug 23, 2023
Examiner
CHOI, JAMES J
Art Unit
2878
Tech Center
2800 — Semiconductors & Electrical Systems
Assignee
VANDERBILT UNIVERSITY
OA Round
1 (Non-Final)
67%
Grant Probability
Favorable
1-2
OA Rounds
3y 0m
To Grant
99%
With Interview

Examiner Intelligence

Grants 67% — above average
67%
Career Allow Rate
250 granted / 374 resolved
-1.2% vs TC avg
Strong +47% interview lift
Without
With
+47.1%
Interview Lift
resolved cases with interview
Typical timeline
3y 0m
Avg Prosecution
63 currently pending
Career history
437
Total Applications
across all art units

Statute-Specific Performance

§101
1.2%
-38.8% vs TC avg
§103
63.6%
+23.6% vs TC avg
§102
14.7%
-25.3% vs TC avg
§112
17.8%
-22.2% vs TC avg
Black line = Tech Center average estimate • Based on career data from 374 resolved cases

Office Action

§101 §102 §DP
DETAILED ACTION The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Election/Restrictions Applicant's election of Group I in the reply filed on 12/4/25 is acknowledged. Because applicant did not distinctly and specifically point out the supposed errors in the restriction requirement, the election has been treated as an election without traverse (MPEP § 818.01(a)). Status of the Application Claim(s) 1-20 is/are pending. Claim(s) 6-9, 15-19 is/are withdrawn. Claim(s) 1-5, 10-14, 20 is/are rejected. Information Disclosure Statement Priority document 63/400321 filed 8/23/22 appears to be a combination of two documents. First, figures (page 1-5 of the document) appear to be the same images eventually reproduced in Chuchuan Hong & Justus C. Ndukaife, Scalable trapping of single nanosized extracellular vesicles using plasmonics, Nature Communications volume 14, (Aug. 9, 2023). However pages 6-35 of the priority document appear to be excerpts from a larger PowerPoint presentation. Examiner was unable to locate this document in the IDS or through a database search. To assist in efficient examination, examiner respectfully requests that this entire presentation be shared, including the date(s) it was disseminated and/or presented. The Examiner would like to note the latest Information Disclosure Statement (IDS) submittals are extremely long. By an initial estimate, it includes 1242 pages of NPL documents alone. Some of them (e.g. page 261 of the Jackson E&M textbook) are presented without context. The Examiner has considered all of the references submitted as part of the Information Disclosure Statements, based upon the time and resource constraints set forth by office examination procedures, but has not found most of them to be particularly relevant. If Applicant is aware of particularly pertinent material in the references, he/she should so state in a response to this Office action. Applicant is reminded of section 2004, paragraph 13, of the MPEP: It is desirable to avoid the submission of long lists of documents if it can be avoided. Eliminate clearly irrelevant and marginally pertinent cumulative information. If a long list is submitted, highlight those documents which have been specifically brought to applicant’s attention and/or are known to be of most significance. See Penn Yan Boats, Inc. v. Sea Lark Boats, Inc., 359 F. Supp. 948, 175 USPQ 260 (S.D. Fla. 1972), aff ’d, 479 F.2d 1338, 178 USPQ 577 (5th Cir. 1973), cert. denied, 414 U.S. 874 (1974). But cf. Molins PLC v. Textron Inc., 48 F.3d 1172, 33 USPQ2d 1823 (Fed. Cir. 1995). Double Patenting The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory obviousness-type double patenting rejection is appropriate where the conflicting claims are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); and In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on a nonstatutory double patenting ground provided the conflicting application or patent either is shown to be commonly owned with this application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. Effective January 1, 1994, a registered attorney or agent of record may sign a terminal disclaimer. A terminal disclaimer signed by the assignee must fully comply with 37 CFR 3.73(b). Claims 1-5, 10-14, 20 is/are rejected on the ground of nonstatutory obviousness-type double patenting as being unpatentable over claims 1, 8-10, 12-15 of US 11823807 B2 (hereinafter patent 807). Although the conflicting claims are not identical, they are not patentably distinct from each other because the different configurations of nanohole arrays would have been obvious variations of each other as a routine skill in the art to obtain a desired size for the trapping region. Claims 1-5, 10-14, 20 is/are rejected on the ground of nonstatutory obviousness-type double patenting as being unpatentable over claim(s) 12-14, 19 of US 10656311 B2 (hereinafter patent 311). Although the conflicting claims are not identical, they are not patentably distinct from each other because the different configurations of nanohole arrays would have been obvious variations of each other as a routine skill in the art to obtain a desired size for the trapping region. Claim Rejections – 35 U.S.C. § 101 35 U.S.C. 101 reads as follows: PNG media_image1.png 113 742 media_image1.png Greyscale Claim(s) 1-5, 10-14, 20 is/are rejected under 35 U.S.C. § 101. The claimed invention is directed to non-statutory subject matter. The claim(s) does/do not fall within at least one of the four categories of patent eligible subject matter because under their broadest reasonable interpretation, the claim(s) can be directed to naturally occurring phenomenon, as discussed in the § 102 rejection in view of Hu, as discussed below. Claim Rejections – 35 U.S.C. § 102 The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – PNG media_image2.png 281 1244 media_image2.png Greyscale Claim(s) 1, 11 is/are rejected under 35 U.S.C. 102(a)(1) and 35 U.S.C. 102(a)(2) as being anticipated by Hu et al., In situ 3-D mapping of pore structures and hollow grains of interplanetary dustparticles with phase contrast X-ray nanotomography, Meteoritics & Planetary Science 51, Nr 9, 1632-1642 (2016). Regarding claim 1, Hu teaches a nanotweezer comprising: a first electrode (e.g. a metal ore in space); a second electrode (e.g. another metal ore on earth struck by lightning) including a central region (ore) surrounded by a plurality of nanoholes (inside interplanetary dust, see Hu, abstract); a fluidic chamber (e.g. earth’s atmosphere) between the first electrode and the second electrode; and a voltage source (lightning) configured to generate an electric field between the first electrode and the second electrode (natural result of being struck by lightning). Claim 11 is rejected for similar reasons as claim 1. Claim(s) 1-5, 10-14, 20 is/are rejected under 35 U.S.C. 102(a)(1) and 35 U.S.C. 102(a)(2) as being anticipated by Ndukaife (US 20200241177 A1). Regarding claim 1, Ndukaife teaches a nanotweezer comprising: a first electrode (see e.g. fig 3: 322); a second electrode (see e.g. 312) including a central region (region without nanoholes) surrounded by a plurality of nanoholes (see e.g. fig 7, [0040]); a fluidic chamber (see 330) between the first electrode and the second electrode; and a voltage source (see 340) configured to generate an electric field between the first electrode and the second electrode (see e.g. claim 1). Regarding claim 2, Ndukaife teaches the plurality of nanoholes includes a circular array of nanoholes surrounding the central region (see Ndukaife, fig 7). Regarding claim 3, Ndukaife teaches the circular array of nanoholes includes nanoholes arranged in concentric circles around the central region (see Ndukaife, fig 7). Regarding claim 4, Ndukaife teaches the plurality of nanoholes includes a square array of nanoholes surrounding the circular array of nanoholes (see Ndukaife, fig 7). Regarding claim 5, Ndukaife teaches a plasmonic nanocavity (see 313) formed through the central region (see Ndukaife, fig 3); and a light source (see claim 1) configured to illuminate the plasmonic nanocavity with a coherent focused light beam (see laser, e.g. [0037]). Regarding claim 10, Ndukaife teaches the second electrode includes a plurality of central regions (see e.g. between Ndukaife, fig 7: 710) surrounded by a plurality of nanoholes (see fig 7); each central region is surrounded by a first plurality of nanoholes arranged in concentric circles around each central region (see fig 7); and a second plurality of nanoholes is arranged in a square array around the first plurality of nanoholes (see fig 7). Regarding claim 11, Ndukaife teaches a method of operating a nanotweezer including: generating an electric field (see e.g. claim 1) between a first electrode (see e.g. fig 3: 322) and a second electrode (see e.g. 312); wherein the second electrode includes a central region (region without nanoholes) surrounded by a plurality of nanoholes (see e.g. fig 7, [0040]); and wherein a fluidic chamber (see 330) is defined between the first electrode and the second electrode (see fig 3). Regarding claim 12, Ndukaife teaches the plurality of nanoholes includes a circular array of nanoholes surrounding the central region (see Ndukaife, fig 7). Regarding claim 13, Ndukaife teaches the circular array of nanoholes includes nanoholes arranged in concentric circles around the central region (see Ndukaife, fig 7). Regarding claim 14, Ndukaife teaches the plurality of nanoholes includes a square array of nanoholes surrounding the circular array of nanoholes (see Ndukaife, fig 7). Regarding claim 20, Ndukaife teaches the second electrode includes a plurality of central regions (see e.g. between Ndukaife, fig 7: 710) surrounded by a plurality of nanoholes (see fig 7); each central region is surrounded by a first plurality of nanoholes arranged in concentric circles around each central region (see fig 7); and a second plurality of nanoholes is arranged in a square array around the first plurality of nanoholes (see fig 7). Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to James Choi whose telephone number is (571) 272 – 2689. The examiner can normally be reached on 9:30 am – 6:00 pm M-F. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Georgia Epps can be reached on (571) 272 – 2328. The fax phone number for the organization where this application or proceeding is assigned is (571) 273 – 8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /JAMES CHOI/Examiner, Art Unit 2881
Read full office action

Prosecution Timeline

Aug 23, 2023
Application Filed
Jan 26, 2026
Non-Final Rejection — §101, §102, §DP (current)

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
67%
Grant Probability
99%
With Interview (+47.1%)
3y 0m
Median Time to Grant
Low
PTA Risk
Based on 374 resolved cases by this examiner. Grant probability derived from career allow rate.

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