DETAILED ACTION
This action is in response to Applicant’s submission dated March 12, 2026, in which Applicant elected the invention of Group I as well as the species of Example 1, both without traverse.
Notice of Pre-AIA or AIA Status
The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA .
Information Disclosure Statement
The references in the IDS dated April 26, 2024 are made of record.
Election/Restriction
Claims 37-40 withdrawn from further consideration pursuant to 37 CFR 1.142(b) as being drawn to a non-elected Groups II and IIII, there being no allowable generic or linking claim. Election was made without traverse in the reply filed on March 12, 2026.
The requirement is still deemed proper and is therefore made FINAL.
Claims 23-36 and 41 are examined. A complete reply to the final rejection must include cancellation of non-elected claims or other appropriate action (37 CFR 1.144) See MPEP § 821.01.
Applicant is reminded that upon the cancellation of claims to a non-elected invention, the inventorship must be amended in compliance with 37 CFR 1.48(b) if one or more of the currently named inventors is no longer an inventor of at least one claim remaining in the application. Any amendment of inventorship must be accompanied by a request under 37 CFR 1.48(b) and by the fee required under 37 CFR 1.17(i).
Claim Rejections - 35 USC § 102
The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action:
A person shall be entitled to a patent unless –
(a)(2) the claimed invention was described in a patent issued under section 151, or in an application for patent published or deemed published under section 122(b), in which the patent or application, as the case may be, names another inventor and was effectively filed before the effective filing date of the claimed invention.
Claims 23-25, 27-30, 36, and 41 are rejected under 35 U.S.C. 102(a)(2) as being anticipated by Reynolds, et al, US 2024/0279239 based on its priority date of April 8, 2020 from application No. 63/007,327. Reynolds, et al. teaches compounds and methods for modulating splicing, which include instant compounds. Specifically, the compound with the structure:
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196
460
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of the reference anticipates the aforementioned claims where R1 is 6-member heterocycloalkyl substituted with two R4 that are cyclopropyl and C4 alkoxy-carbonyl; R2 is halogen (fluoro), R3 is C1 alkyl, and A1 is CH. The references compounds exhibit the same activity as the compounds of the instant claims.
Claim Objections
Claims 26 and 31-35 are objected to as being dependent upon rejected independent claim 23, but would be allowable if rewritten in independent form including all of the limitations of the base claims and any intervening claims.
Conclusion
Any inquiry concerning this communication or earlier communications from the Examiner should be directed to ERICH A LEESER whose telephone number is (571) 272-9932. The Examiner can normally be reached Monday through Friday from 10-6 PST, M-F. PST.
If attempts to reach the Examiner by telephone are unsuccessful, the Examiner’s supervisor, Mr. James Alstrum-Acevedo can be reached at (571) 272-5548. The fax number for the organization where this application is assigned is 571-273-8300.
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/ERICH A LEESER/Primary Examiner, Art Unit 1622
United States Patent and Trademark Office
Tel. No.: (571) 272-9932