Prosecution Insights
Last updated: July 17, 2026
Application No. 18/486,374

DIACYLGLYCEROL KINASE (DGK) ALPHA INHIBITORS AND USES THEREOF

Final Rejection §112§DOUBLEPATENT§DP
Filed
Oct 13, 2023
Priority
Mar 01, 2022 — CN PCT/CN2022/078653 +5 more
Examiner
MOORE, SUSANNA
Art Unit
1624
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Insilico Medicine Ip Limited
OA Round
2 (Final)
68%
Grant Probability
Favorable
3-4
OA Rounds
1m
Est. Remaining
99%
With Interview

Examiner Intelligence

Grants 68% — above average
68%
Career Allowance Rate
849 granted / 1249 resolved
+8.0% vs TC avg
Strong +32% interview lift
Without
With
+31.6%
Interview Lift
resolved cases with interview
Typical timeline
2y 10m
Avg Prosecution
69 currently pending
Career history
1317
Total Applications
across all art units

Statute-Specific Performance

§101
0.4%
-39.6% vs TC avg
§103
24.1%
-15.9% vs TC avg
§102
13.4%
-26.6% vs TC avg
§112
21.1%
-18.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1249 resolved cases

Office Action

§112 §DOUBLEPATENT §DP
DETAILED ACTION Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . This is a Final Office Action. Claims 23-44 are pending and under consideration. Specification The objection to the abstract of the disclosure is withdrawn based on the amendments. Claim Objections Claim 34 is objected to because of the following informalities: the term “or” after C1-C6 alkyl should be removed. Appropriate correction is required. Claim Rejections - 35 USC § 112 The rejection of claims 23-41, 43 and 44 under 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph, as failing to comply with the written description requirement is withdrawn based on the amendments. The following is a quotation of 35 U.S.C. 112(b): (B) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention. The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph: The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention. Claims 23-41, 43 and 44 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor, or for pre-AIA the applicant regards as the invention. With regards to claims 23 and 34, the variable R is found in the definition of R4, but is not defined. Thus, all claims which depend from claims 23 and 34 that do not remedy the deficiency are all rejected. In claim 34, the term “comprising” is vague, see the definition of Ring B. Said claim is a Markush claim and should have closed language. Double Patenting The nonstatutory double patenting rejection is based on a judicially created doctrine grounded in public policy (a policy reflected in the statute) so as to prevent the unjustified or improper timewise extension of the “right to exclude” granted by a patent and to prevent possible harassment by multiple assignees. A nonstatutory double patenting rejection is appropriate where the claims at issue are not identical, but at least one examined application claim is not patentably distinct from the reference claim(s) because the examined application claim is either anticipated by, or would have been obvious over, the reference claim(s). See, e.g., In re Berg, 140 F.3d 1428, 46 USPQ2d 1226 (Fed. Cir. 1998); In re Goodman, 11 F.3d 1046, 29 USPQ2d 2010 (Fed. Cir. 1993); In re Longi, 759 F.2d 887, 225 USPQ 645 (Fed. Cir. 1985); In re Van Ornum, 686 F.2d 937, 214 USPQ 761 (CCPA 1982); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); and In re Thorington, 418 F.2d 528, 163 USPQ 644 (CCPA 1969). A timely filed terminal disclaimer in compliance with 37 CFR 1.321(c) or 1.321(d) may be used to overcome an actual or provisional rejection based on a nonstatutory double patenting ground provided the reference application or patent either is shown to be commonly owned with this application, or claims an invention made as a result of activities undertaken within the scope of a joint research agreement. A terminal disclaimer must be signed in compliance with 37 CFR 1.321(b). The USPTO internet Web site contains terminal disclaimer forms which may be used. Please visit http://www.uspto.gov/forms/. The filing date of the application will determine what form should be used. A web-based eTerminal Disclaimer may be filled out completely online using web-screens. An eTerminal Disclaimer that meets all requirements is auto-processed and approved immediately upon submission. For more information about eTerminal Disclaimers, refer to http://www.uspto.gov/patents/process/file/efs/guidance/eTD-info-I.jsp. Claims 23-44 are rejected on the ground of nonstatutory obviousness-type double patenting as being unpatentable over claims 1-20 of U.S. Patent No. 12077538. Although the conflicting claims are not identical, they are not patentably distinct from each other because the present claims are drawn to compounds of formulas (I), see bottom left formula, compositions thereof, and a method of inhibiting diacylglyerol kinase. PNG media_image1.png 294 172 media_image1.png Greyscale PNG media_image2.png 388 346 media_image2.png Greyscale The claims in the ‘538 patent are drawn to compounds of formula (If), see top right formula, and compositions thereof. The compound in the ‘538 patent are embraced by the present claims. Claim 36 of the present application is drawn to compounds of formula (II), wherein B is a bicyclic ring. The genus found in column 2 of the ‘538 patent teaches the B ring may be monocyclic or bicyclic, see column 2 lines 65-67 and column 3, lines 1-5. Applicant states, “Applicant requests that the rejection be held in abeyance until indication of allowable subject matter by the Office.” Thus, the rejection is maintained. Conclusion Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to SUSANNA MOORE whose telephone number is (571)272-9046. The examiner can normally be reached Monday - Friday, 10:00 am to 7:00 pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Jeffrey Murray can be reached on 571-272-9023. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /SUSANNA MOORE/Primary Examiner, Art Unit 1624
Read full office action

Prosecution Timeline

Oct 13, 2023
Application Filed
Jan 10, 2024
Response after Non-Final Action
Dec 23, 2025
Non-Final Rejection mailed — §112, §DOUBLEPATENT, §DP
Mar 23, 2026
Response Filed
May 12, 2026
Final Rejection mailed — §112, §DOUBLEPATENT, §DP (current)

Precedent Cases

Applications granted by this same examiner with similar technology

Patent 12679851
METHYL-SUBSTITUTED BENZOBISOXAZOLE COMPOUND AND USE THEREOF
3y 7m to grant Granted Jul 14, 2026
Patent 12673944
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4y 1m to grant Granted Jul 07, 2026
Patent 12673970
NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
3y 9m to grant Granted Jul 07, 2026
Patent 12667573
COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
4y 10m to grant Granted Jun 30, 2026
Patent 12655157
NOVEL ACC INHIBITORS
2y 10m to grant Granted Jun 16, 2026
Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
68%
Grant Probability
99%
With Interview (+31.6%)
2y 10m (~1m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 1249 resolved cases by this examiner. Grant probability derived from career allowance rate.

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