Prosecution Insights
Last updated: October 04, 2026

Insilico Medicine Ip Limited

Technology areas: Biotechnology & Pharmaceuticals • Computing & Software

13 pending office actions • 5 art units • 11 examiners • 0 of 13 (0%) have an AI response strategy ready • 4 patents granted in the last 365 days

Analysis

Insilico Medicine Ip Limited currently oversees 13 pending office actions within the Biotechnology & Pharmaceuticals technology area. These actions are distributed across 11 distinct examiners, indicating a high level of individual scrutiny for the portfolio. The prosecution activity is spread through 5 distinct art units, which reflects a range of technical applications within the biotechnology and pharmaceutical sectors.

WILLIS, DOUGLAS M is identified as the busiest examiner, managing 2 pending office actions. This concentration of actions is higher than that of the other distinct examiners in the portfolio, as the remaining pending actions are split among the other examiners. The ratio of 13 actions to 11 examiners suggests that most examiners are handling an individual matter for the company.

The presence of 5 distinct art units alongside the pending office actions shows that the company must coordinate its strategy across multiple specialized divisions. With the distinct examiners involved, the company faces a variety of examination styles within the Biotechnology & Pharmaceuticals area. This distribution requires managing different examiner relationships across the units.

Written from this page's own data; every figure is computed from USPTO records and verified before publication.

Portfolio Summary

13
Total Pending OAs
11
Non-Final OAs
2
Final Rejections
0
Advisory / Quayle

Response Deadline Pressure

Based on the USPTO statutory response window for each pending office action. 3 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.

1
Overdue
0
Due this week
1
Due this month
1
Due in next 60 days
0
Due later

Deadline Fire Line

Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 3 of the docket's apps have a known mailing date.

-30dToday30d60d90d120d
Overdue (1)Due ≤ 30 days (1)Due ≤ 60 days (1)

Case Difficulty Mix

Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.

6
Hard (46%)
5
Medium (38%)
2
Easy (15%)
0
Unknown (0%)

Rejection Statute Mix

BucketCases
§101 + other5 (38%)
§103 only2 (15%)
§112 only1 (8%)
Double-patenting only1 (8%)
Double-patenting + other3 (23%)
Multi-statute (no §101)1 (8%)

Industry Mix

How the docket's pending cases split across USPTO tech-center bands.

4
Life Sciences
31% of docket
2
Information Tech
15% of docket
0
Communications
0% of docket
0
Semiconductors
0% of docket
0
Mechanical / Eng
0% of docket
7
Business / Other
54% of docket

Time-on-OA Estimate

Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.

130 h
Manual time on pending OAs
26 h
Time saved (low, 20%)
46 h
Time saved (mid, 35%)
1.1 wks
FTE-weeks freed (mid)

Top Examiners on this docket

ExaminerApps on this docketAllow rateInterview lift
WILLIS, DOUGLAS M 2 82.4% +19.7%
KALLAL, ROBERT JAMES 2 60.0% +32.4%
DAVIS, BRIAN J 1 84.8% -4.0%
ROBINSON, MIKHAIL O'DONNEL 1 59.2% +42.1%
WHITE, DAWANNA SHAR-DAY 1 62.5% +23.3%
HIBSHMAN, SARAH GRACE 1 38.9% +40.0%
O DELL, DAVID K 1 57.7% +36.0%
SKIBINSKY, ANNA 1 39.0% +29.1%
BRACERO, ANDREW ANGEL 1 92.3% +20.0%
LUO, JAMMY NMN 1 — —

Quick Wins (4)

Cases in front of an examiner with an allow rate of 80%+ where the difficulty is Easy or Medium. The top 4 ordered by deadline are shown.

App #TitleExaminerDue in
17800129 ADVERSARIAL AUTOENCODER ARCHITECTURE FOR METHODS OF GRAPH TO SEQUENCE MODELS BRACERO, ANDREW ANGEL 33d
18928814 BETA-LACTAM DERIVATIVES FOR THE TREATMENT OF DISEASES DAVIS, BRIAN J —
18708686 SMALL MOLECULE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) AND USES THEREOF WILLIS, DOUGLAS M —
18702772 METHIONINE ADENOSYLTRANSFERASE 2a (MAT2A) INHIBITORS AND USES THEREOF WILLIS, DOUGLAS M —

Hard Cases (6)

Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 6 ordered by deadline are shown.

App #TitleExaminerDue in
17596888 SYNTHETIC BIOLOGICAL CHARACTERISTIC GENERATOR BASED ON REAL BIOLOGICAL DATA SIGNATURES KALLAL, ROBERT JAMES 25d overdue
17911376 RETROSYNTHESIS-RELATED SYNTHETIC ACCESSIBILITY SKIBINSKY, ANNA 21d
18721283 METHOD AND MEDICAMENT FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS HIBSHMAN, SARAH GRACE —
18164160 LOCAL STEPS IN LATENT SPACE AND DESCRIPTORS-BASED MOLECULES FILTERING FOR CONDITIONAL MOLECULAR GENERATION KALLAL, ROBERT JAMES —
17835167 ADVERSARIAL FRAMEWORK FOR MOLECULAR CONFORMATION SPACE MODELING IN INTERNAL COORDINATES LUO, JAMMY NMN —
17479892 METHYLATION DATA SIGNATURES OF AGING AND METHODS OF DETERMINING A METHYLATION AGING CLOCK VANNI, GEORGE STEVEN —

Interview Candidates (10)

Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.

App #TitleExaminerDue in
17596888 SYNTHETIC BIOLOGICAL CHARACTERISTIC GENERATOR BASED ON REAL BIOLOGICAL DATA SIGNATURES KALLAL, ROBERT JAMES 25d overdue
17911376 RETROSYNTHESIS-RELATED SYNTHETIC ACCESSIBILITY SKIBINSKY, ANNA 21d
17800129 ADVERSARIAL AUTOENCODER ARCHITECTURE FOR METHODS OF GRAPH TO SEQUENCE MODELS BRACERO, ANDREW ANGEL 33d
18837846 MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF ROBINSON, MIKHAIL O'DONNEL —
18837847 MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF WHITE, DAWANNA SHAR-DAY —
18721283 METHOD AND MEDICAMENT FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS HIBSHMAN, SARAH GRACE —
18708686 SMALL MOLECULE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) AND USES THEREOF WILLIS, DOUGLAS M —
18704366 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF O DELL, DAVID K —

Top Art Units

Art UnitApps
1686 2
2146 1
1635 1
2126 1
1685 1

Pending Office Actions

App #TitleExaminerArt UnitStatutesStatusDue inAIFiled
18928814 BETA-LACTAM DERIVATIVES FOR THE TREATMENT OF DISEASES DAVIS, BRIAN J — §112DP Non-Final OA — Pending Oct 28, 2024
18837846 MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF ROBINSON, MIKHAIL O'DONNEL — §103 Non-Final OA — Pending Aug 12, 2024
18837847 MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF WHITE, DAWANNA SHAR-DAY — §103DP Non-Final OA — Pending Aug 12, 2024
18721283 METHOD AND MEDICAMENT FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS HIBSHMAN, SARAH GRACE — §102§103§112 Non-Final OA — Pending Jun 18, 2024
18708686 SMALL MOLECULE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) AND USES THEREOF WILLIS, DOUGLAS M — §112Other Non-Final OA — Pending May 09, 2024
18704366 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF O DELL, DAVID K — DP Non-Final OA — Pending Apr 24, 2024
18702772 METHIONINE ADENOSYLTRANSFERASE 2a (MAT2A) INHIBITORS AND USES THEREOF WILLIS, DOUGLAS M — §112DP Non-Final OA — Pending Apr 18, 2024
18164160 LOCAL STEPS IN LATENT SPACE AND DESCRIPTORS-BASED MOLECULES FILTERING FOR CONDITIONAL MOLECULAR GENERATION KALLAL, ROBERT JAMES 2146 §101§103§112 Non-Final OA — Pending Feb 03, 2023
17911376 RETROSYNTHESIS-RELATED SYNTHETIC ACCESSIBILITY SKIBINSKY, ANNA 1635 §101§103 Final Rejection 21d Pending Sep 13, 2022
17800129 ADVERSARIAL AUTOENCODER ARCHITECTURE FOR METHODS OF GRAPH TO SEQUENCE MODELS BRACERO, ANDREW ANGEL 2126 §103 Non-Final OA 33d Pending Aug 16, 2022
17835167 ADVERSARIAL FRAMEWORK FOR MOLECULAR CONFORMATION SPACE MODELING IN INTERNAL COORDINATES LUO, JAMMY NMN 1686 §101§103 Final Rejection — Pending Jun 08, 2022
17596888 SYNTHETIC BIOLOGICAL CHARACTERISTIC GENERATOR BASED ON REAL BIOLOGICAL DATA SIGNATURES KALLAL, ROBERT JAMES 1685 §101§112 Non-Final OA 25d overdue Pending Dec 20, 2021
17479892 METHYLATION DATA SIGNATURES OF AGING AND METHODS OF DETERMINING A METHYLATION AGING CLOCK VANNI, GEORGE STEVEN 1686 §101§112DP Non-Final OA — Pending Sep 20, 2021

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