Prosecution Insights
Last updated: October 04, 2026
Application No. 18/682,841

METHOD FOR THE REMOVAL OF ACRYLAMIDE FROM FOODS AND STIMULANTS

Non-Final OA §103§112
Filed
Feb 09, 2024
Priority
Aug 12, 2021 — EU PCT/EP2021/072477 +1 more
Examiner
KERSHAW, KELLY P
Art Unit
1791
Tech Center
1700 — Chemical & Materials Engineering
Assignee
C-Lecta GmbH
OA Round
2 (Non-Final)
18%
Grant Probability
At Risk
2-3
OA Rounds
9m
Est. Remaining
34%
With Interview

Examiner Intelligence

Grants only 18% of cases
18%
Career Allowance Rate
39 granted / 220 resolved
-47.3% vs TC avg
Strong +16% interview lift
Without
With
+16.0%
Interview Lift
resolved cases with interview
Typical timeline
3y 5m
Avg Prosecution
64 currently pending
Career history
292
Total Applications
across all art units

Statute-Specific Performance

§101
1.8%
-38.2% vs TC avg
§103
47.9%
+7.9% vs TC avg
§102
17.3%
-22.7% vs TC avg
§112
22.0%
-18.0% vs TC avg
Black line = Tech Center average estimate • Based on career data from 220 resolved cases

Office Action

§103 §112
DETAILED ACTION The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Status of the Application Receipt of the Response and Amendment after Non-Final Office Action filed 04/20/2026 is acknowledged. Applicant has overcome the following rejections by virtue of the amendment: (1) the objections to the specification have been withdrawn; and (2) the 35 U.S.C. §112(b) rejections of claims 6-8 and 11-18 have been withdrawn. The status of the claims upon entry of the present amendment stands as follows: Pending claims: 1-18 Withdrawn claims: None Previously cancelled claims: None Newly cancelled claims: None Amended claims: 4, 6-8, 11-12, 13, 15-16 New claims: None Claims currently under consideration: 1-18 Currently rejected claims: 1-18 Allowed claims: None Claim Objections Claim 1 is objected to because of the following informalities: in claim 1(iv) line 2, delete “with”. Appropriate correction is required. Claim Rejections - 35 USC § 103 The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. This application currently names joint inventors. In considering patentability of the claims the examiner presumes that the subject matter of the various claims was commonly owned as of the effective filing date of the claimed invention(s) absent any evidence to the contrary. Applicant is advised of the obligation under 37 CFR 1.56 to point out the inventor and effective filing dates of each claim that was not commonly owned as of the effective filing date of the later invention in order for the examiner to consider the applicability of 35 U.S.C. 102(b)(2)(C) for any potential 35 U.S.C. 102(a)(2) prior art against the later invention. Claims 1-7, 9, 12, and 17-18 are rejected under 35 U.S.C. 103 as being unpatentable over Ordóñez (WO 2021/123163; previously cited) in view of Bedade (Bedade et al., “Chitosan coated calcium alginate beads for covalent immobilization of acrylamidase: Process parameters and removal of acrylamide from coffee”, 2019, Food Chemistry, 275, pages 95-104; previously cited). Regarding claim 1, Ordóñez teaches a method for removing acrylamide from an aqueous preparation (corresponding to low aromatic aqueous coffee extract having a first acrylamide content) to produce a final product having a reduced acrylamide content (corresponding to a low aromatic aqueous coffee extract having an acrylamide content lower than the first acrylamide content) (page 3, line 28 – page 4, line 45). Ordóñez teaches that the method comprises: (i) providing an aqueous preparation containing acrylamide and other components (corresponding to components such as organic acids) as a starting product for the production of a final product with a reduced acrylamide content (page 8, lines 34-35; page 15, lines 5-7). Ordóñez teaches that the method then comprises: (ii) dividing the aqueous preparation into two material streams to obtain a retentate (R1) and a permeate (P1), wherein R1 contains other components (K1), and wherein the P1 contains acrylamide (page 13, line 24-25; page 14, lines 22-32). Ordóñez teaches that the permeate is combined with a high aromatic aqueous coffee extract to provide a liquid coffee concentrate (page 8, lines 22-25). Ordóñez does not teach steps (iii)-(v) of the presently claimed method. However, Bedade teaches a method for converting acrylamide from an aqueous preparation (corresponding to coffee) to produce a final product having a reduced acrylamide content (page 100, 2nd column, section 3.7.1 – page 101, 1st column, 1st paragraph). Bedade teaches that the method comprises: contacting the aqueous preparation with an acrylamide-reducing biocatalyst (corresponding to acrylamidase), thereby obtaining an aqueous preparation with a reduced content of acrylamide (page 100, 2nd column, section 3.7.1 – page 101, 1st column, 1st paragraph). Bedade teaches that method may comprise recovering the biocatalyst from the aqueous solution so that the solution does not contain a biocatalyst (page 101, 1st column 2nd paragraph). Bedade also teaches that the method may further comprise further processing the aqueous preparation with the reduced acrylamide content to obtain a final product (corresponding to spray drying to produce instant coffee) (page 102, 1st column, 3rd paragraph). It would have been obvious for a person of ordinary skill in the art before the effective filing date of the present invention to have modified the method of Ordóñez to include contacting the permeate with a biocatalyst as taught by Bedade. Since Ordóñez discloses a method of reducing acrylamide in coffee (page 8, lines 1-2) and Bedade discloses a method of reducing acrylamide in coffee (page 100, 2nd column, section under 3.7.1), combining the steps disclosed by both references to form a single method represents “combining prior art elements according to known methods to yield predictable results”. The method disclosed in each reference merely performs the same function as it does separately and since these references show that the content of acrylamide would be reduced in the coffee, a skilled practitioner would readily recognize that the results of the combined references were predictable. Therefore, the combination of Ordóñez and Bedade render a step of (iii) bringing P1 into contact with an acrylamide-reducing biocatalyst and obtaining permeate (P2) with a reduced acrylamide content obvious as the biocatalyst of Bedade may be used with the P1 of Ordóñez. The combination of Ordóñez and Bedade also render the claimed P2 not containing a biocatalyst obvious since Bedade discloses that the biocatalyst is removed from the coffee (page 101, 1st column 2nd paragraph). Although the combined references do not explicitly disclose combining P2 with R1 to obtain the aqueous preparation having a reduced content of acrylamide as recited in step (iv) of the claimed method, the combination of Ordóñez and Bedade would render such a step obvious since Ordóñez discloses adding a high aromatic aqueous coffee extract to the permeate to provide a liquid coffee concentrate, wherein the high aromatic aqueous coffee extract contains a high amount of compounds responsible for the flavor of the coffee (page 8, lines 22-25; page 10, lines 4-6). Ordóñez discloses that an additional treatment step such as exposure to enzymes may interfere with the flavor profile of the coffee (page 2, lines 7-28); and that a goal of its invention is to better preserve the aromas of the coffee and to avoid the loss of desirable aromas during the filtration process (page 9, lines 12-15). As such, a skilled practitioner would have readily recognized that (A) P2 being added to R1 or (B) P2 being added to a high aromatic aqueous coffee extract results in a coffee product having reduced acrylamide content while conserving the taste profile of the coffee. Therefore, the addition of R1 to P2 as recited in step (iv) of the claimed method is rendered obvious. The combination of Ordóñez and Bedade also renders step (v) of the claimed method obvious as Bedade discloses that the method may further comprise further processing the aqueous preparation with the reduced acrylamide content to obtain a final product (corresponding to spray drying to produce instant coffee) (page 102, 1st column, 3rd paragraph). Regarding claims 2 and 3, Ordóñez teaches the invention as described above in claim 1, including the separation of the material streams in step (ii) is performed as membrane filtration (page 13, line 24-25; page 14, lines 22-32) as recited in present claims 2 and 3. Ordóñez teaches that the pore size of the membrane may be up to 100 Daltons (page 14, lines 9-13). This pore size falls within the claimed pore size range recited in present claim 3. Regarding claim 4, Ordóñez teaches the invention as described above in claim 3, including the transmembrane pressure is and/or is maintained at up to 3000 kPa (page 15, lines 20-26). This maximum value of 3000 kPa equates to 30 bar so that the transmembrane pressure disclosed by Ordóñez encompasses the claimed range. It would have been obvious to one of ordinary skill in the art to select any portions of the disclosed ranges including the instantly claimed ranges from the ranges disclosed in the prior art references, particularly in view of the fact that; "The normal desire of scientists or artisans to improve upon what is already generally known provides the motivation to determine where in a disclosed set percentage ranges is the optimum combination of percentages" In re Peterson 65 USPQ2d 1379 (CAFC 2003). Also In re Malagari, 182 USPQ 549,533 (CCPA 1974) and MPEP 2144.05.I. Regarding claim 5, Ordóñez teaches the invention as described above in claim 1, including the end product is consumed as a beverage (page 1, lines 17-20). Therefore, the end product is at least for nutrition. Regarding claims 6 and 7, modified Ordóñez teaches the invention as described above in claim 1, including the biocatalyst is an amidase (corresponding to acrylamidase) that is present as a partially purified and immobilized enzyme (Bedade page 96, 2nd column, section 2.3; page 97, 1st column, section 2.6). Regarding claim 9, Ordóñez teaches the invention as described above in claim 1, including producing P1 by dividing the aqueous preparation into two material streams (page 13, line 24-25; page 14, lines 22-32). Bedade rendered obvious the step of adding a biocatalyst to P1 as described in the rejection of claim 1 above, thereby rendering obvious the step of mixing P1 and the biocatalyst (page 100, 2nd column, section 3.7.1 – page 101, 1st column, 1st paragraph). Bedade renders a step of dividing the mixture into two material streams to obtain P2, wherein P2 does not contain the biocatalyst in disclosing recovering the biocatalyst from the aqueous preparation through methods such as filtrating or centrifugation (page 101, 1st column 2nd paragraph). Therefore, the combination of prior art renders present claim 9 obvious. Regarding claim 12, Ordóñez teaches the invention as described above in claim 1, including the step of (ii) dividing the aqueous preparation into two material streams, wherein the division of the two streams is carried out using membrane filtration (page 13, line 24-25; page 14, lines 9-11, 22-32). Bedade discloses that the biocatalyst may be separated from the aqueous preparation through filtration in order to produce a retentate containing the biocatalyst (page 101, 1st column 2nd paragraph), thereby also producing P2 with a reduced content of acrylamide and no biocatalyst. Ordóñez discloses membrane filtration as known means of filtration (page 14, lines 9-11). Therefore, the combination of Ordóñez and Bedade renders step (iii) recited in present claim 1 obvious as it would have been obvious to use membrane filtration to produce P2 since membrane filtration is a known method of filtration in the art. Since it would have been obvious to use membrane filtration in steps (ii) and (iii) of the method, it would have been obvious to have used the same membrane, particularly wherein the practitioner had an interest in efficiency, low waste production, and/or cost-saving measures. Therefore, claim 12 is rendered obvious. Regarding claim 17, modified Ordóñez teaches the invention as described above in claim 1, including the biocatalyst completely degraded the acrylamide in the aqueous preparation (Bedade, page 101, 1st column, 1st paragraph; page 102, Fig. 5a). As described above in the rejection of claim 1, although the combined references do not explicitly disclose combining P2 with R1 to obtain the aqueous preparation having a reduced content of acrylamide as recited in step (iv) of the claimed method, the combination of Ordóñez and Bedade would render such a step obvious since Ordóñez discloses adding a high aromatic aqueous coffee extract to the permeate to provide a liquid coffee concentrate, wherein the high aromatic aqueous coffee extract contains a high amount of compounds responsible for the flavor of the coffee (page 8, lines 22-25; page 10, lines 4-6). Ordóñez discloses that an additional treatment step such as exposure to enzymes may interfere with the flavor profile of the coffee (page 2, lines 7-28); and that a goal of its invention is to better preserve the aromas of the coffee and to avoid the loss of desirable aromas during the filtration process (page 9, lines 12-15). As such, a skilled practitioner would have readily recognized that: (A) P2 being added to R1; or (B) P2 being added to a high aromatic aqueous coffee extract results in a coffee product having reduced acrylamide content while conserving the taste profile of the coffee. Therefore, the addition of R1 to P2 as recited in step (iv) of the claimed method is rendered obvious. At least wherein the skilled practitioner added P2 to R1, the resulting aqueous preparation with reduced content of acrylamide obtained in step (iv) may have a reduced acrylamide content of 100%, and thus an acrylamide content of 0 µg/kg, when compared to the aqueous preparation provided in step 1, since Bedade discloses complete degradation of acrylamide (page 101, 1st column, 1st paragraph; page 102, Fig. 5a). These values fall within the range of at least 20 wt.% based on the total weight of the aqueous preparation; and less than 2000 µg/kg based on the dry mass of the preparation recited in present claim 17. Therefore, the combination of Ordóñez and Bedade is considered to render the claim obvious. Regarding claim 18, modified Ordóñez teaches the invention as described above in claim 1, including further processing the aqueous preparation with the reduced acrylamide content of step (iv) by spray drying in step (v) (Bedade, page 102, 1st column, 3rd paragraph). Claim 8 is rejected under 35 U.S.C. 103 as being unpatentable over Ordóñez (WO 2021/123163; previously cited) in view of Bedade (Bedade et al., “Chitosan coated calcium alginate beads for covalent immobilization of acrylamidase: Process parameters and removal of acrylamide from coffee”, 2019, Food Chemistry, 275, pages 95-104; previously cited) as applied to claim 1 above, and further in view of Watabe (JP2006340630A; English translation relied on for citations; previously cited) as evidenced by search results filed 01/07/2026. Regarding claim 8, modified Ordóñez teaches the invention as described above in claim 1, including the biocatalyst is an enzyme in the form of an amidase from Cupriavidus oxalaticus (Bedade, abstract). Purified enzymes and immobilized enzymes are known in the art as demonstrated by at least Bedade (page 96, 2nd column, section 2.3; page 97, 1st column, section 2.6). The prior art does not teach that the enzyme has an amino acid sequence recited by present claim 8. However, Watabe discloses that amidases and their function are known in the art (page 1, line 16); and discloses that several microbial-derived amidases are known and are used in the art (page 1, lines 21-26). Watabe discloses a purified amidase labeled as “SEQ ID NO: 10” (page 2, lines 33-34; page 5, lines 47-52) having 99.8% similarity to the total length of claimed SEQ ID NO: 1 as evidenced by Result 2 of the search results filed 01/07/2026. It would have been obvious for a person of ordinary skill in the art before the effective filing date of the present invention to have modified the amidase from Cupriavidus oxalaticus of modified Ordóñez to be the amidase of Watabe as such a modification represents “[t]he selection of a known material based on its suitability for its intended use supported a prima facie obviousness determination in Sinclair & Carroll Co. v. Interchemical Corp., 325 U.S. 327, 65 USPQ 297 (1945) (Claims to a printing ink comprising a solvent having the vapor pressure characteristics of butyl carbitol so that the ink would not dry at room temperature but would dry quickly upon heating were held invalid over a reference teaching a printing ink made with a different solvent that was nonvolatile at room temperature but highly volatile when heated in view of an article which taught the desired boiling point and vapor pressure characteristics of a solvent for printing inks and a catalog teaching the boiling point and vapor pressure characteristics of butyl carbitol. "Reading a list and selecting a known compound to meet known requirements is no more ingenious than selecting the last piece to put in the last opening in a jig-saw puzzle." 325 U.S. at 335, 65 USPQ at 301.).” MPEP 2144.07. Therefore, claim 8 is rendered obvious. Claims 10-11 and 13-16 are rejected under 35 U.S.C. 103 as being unpatentable over Ordóñez (WO 2021/123163; previously cited) in view of Bedade (Bedade et al., “Chitosan coated calcium alginate beads for covalent immobilization of acrylamidase: Process parameters and removal of acrylamide from coffee”, 2019, Food Chemistry, 275, pages 95-104; previously cited) as applied to claim 1 above, and further in view of Nguyen (Nguyen et al., “An Overview of Techniques in Enzyme Immobilization”, 2017, Appl. Sci. Converg. Technol., 26(6), pages 157-163; previously cited). Regarding claim 10, modified Ordóñez teaches the invention as described above in claim 1, including producing P1 by dividing the aqueous preparation into two material streams (page 13, line 24-25; page 14, lines 22-32). Bedade rendered obvious the step of adding a biocatalyst to P1 as described in the rejection of claim 1 above, thereby rendering obvious the step of bringing P1 into contact with the biocatalyst (page 100, 2nd column, section 3.7.1 – page 101, 1st column, 1st paragraph). Immobilization of enzymes by covalent bonds between the enzyme and a support matrix is known and widely used in the art as demonstrated by at least Bedade (page 95, 1st column, 1st paragraph; page 97, 1st column, section 2.6). The prior art does not teach that P1 is brought into contact with the biocatalyst via the contact surface of a membrane as recited in present claim 10. However, Nguyen discloses that enzyme immobilization by covalent bonds between the enzyme and a support matrix is known and widely used in the art (page 159, 2nd column, 1st paragraph under section 2.2). Nguyen also discloses that membranes are used as a support matrix (page 159, 2nd column, 1st paragraph under section 2.2). It would have been obvious for a person of ordinary skill in the art before the effective filing date of the present invention to have modified the enzyme biocatalyst of modified Ordóñez to be immobilized on a membrane as taught by Nguyen. Since the immobilization of enzymes on a support matrix is widely used in the art and using membranes as the support matrix for the immobilized enzyme is also known and used in the art (Bedade, page 95, 1st column, 1st paragraph; page 97, 1st column, section 2.6; Nguyen, page 159, 2nd column, 1st paragraph under section 2.2), a skilled practitioner would have readily recognized that the enzyme biocatalyst of modified Ordóñez may be immobilized on a membrane, thus allowing P1 to be brought into contact with the biocatalyst via the contact surface of a membrane. Therefore, claim 10 is rendered obvious. Regarding claim 11, modified Ordóñez teaches the invention as described above in claim 10, including producing P1 by dividing the aqueous preparation into two material streams (Ordóñez, page 13, line 24-25; page 14, lines 22-32); and contacting the aqueous preparation with an acrylamide-reducing biocatalyst, thereby obtaining an aqueous preparation with a reduced content of acrylamide (Bedade, page 100, 2nd column, section 3.7.1 – page 101, 1st column, 1st paragraph). The combination of Ordóñez and Bedade were shown to render step (iii) obvious as the biocatalyst of Bedade may be used with the P1 of Ordóñez. As such, the combination of prior art teaches that the method comprises: step (iii-1) of contacting P1 with an acrylamide-reducing biocatalyst and obtaining P2 having a reduced content of acrylamide, wherein P2 comprises the biocatalyst. Bedade further discloses that the biocatalyst may be separated from the aqueous preparation through filtration in order to produce a retentate containing the biocatalyst (page 101, 1st column 2nd paragraph), thereby producing P2 with a reduced content of acrylamide and no biocatalyst. Ordóñez discloses membrane filtration as known means of filtration (page 14, lines 9-11). Therefore, the combination of Ordóñez and Bedade renders step (iii-2) recited in present claim 11 obvious as it would have been obvious to use membrane filtration to produce P2 since membrane filtrations is known method of filtration in the art. Regarding claims 13 and 14, Ordóñez teaches the invention as described above in claim 11, including the step of (ii) dividing the aqueous preparation into two material streams, wherein the division of the two streams is carried out using membrane filtration (page 13, line 24-25; page 14, lines 9-11, 22-32). Bedade discloses that the biocatalyst may be separated from the aqueous preparation through filtration in order to produce a retentate containing the biocatalyst (page 101, 1st column 2nd paragraph), thereby producing P2 with a reduced content of acrylamide and no biocatalyst. Ordóñez discloses membrane filtration as known means of filtration (page 14, lines 9-11). Therefore, the combination of Ordóñez and Bedade renders step (iii-2) recited in present claim 11 obvious as it would have been obvious to use membrane filtration to produce P2 since membrane filtrations is a known method of filtration in the art. Since it would have been obvious to use membrane filtration in steps (ii) and (iii-2) of the method, it would have been obvious to have used the same membrane, particularly wherein the practitioner had an interest in efficiency, low waste production, and/or cost-saving measures. Therefore, claim 13 is rendered obvious. In using the same membrane for step (ii) and step (iii-2), the pore size of the membrane in step (ii) and the pore size of the membrane of step (iii-2) would be equal to each other. Since the membrane is used to remove the biocatalyst (Bedade, page 101, 1st column 2nd paragraph); and the same membrane is used in steps (ii) and (iii-2), the pore size of the membrane in step (ii) and the pore size of the membrane of step (iii-2) would be smaller than the biocatalyst. Therefore, the combination of prior art renders claim 14 obvious. Regarding claim 15, Ordóñez teaches the invention as described above in claim 11, including that the pore size of M1 may be up to 100 Daltons (page 14, lines 9-13). This pore size falls within the claimed pore size range recited in present claim 15. Regarding claim 16, Ordóñez teaches the invention as described above in claim 11, including the transmembrane pressure of M1 is and/or is maintained at up to 3000 kPa (page 15, lines 20-26). This maximum value of 3000 kPa equates to 30 bar so that the transmembrane pressure disclosed by Ordóñez encompasses the claimed range. The selection of a value within the encompassing range renders the claimed range obvious. MPEP 2144.05.I. Response to Arguments Objections to the Specification: Applicant submitted an abstract and an amended specification to fully address the objections. Therefore, the objections are withdrawn. Claim Rejections – 35 U.S.C. §112(b) of claims 6-8 and 11-16: Applicant amended the claims to fully address the rejections. Therefore, the rejections are withdrawn. Claim Rejections – 35 U.S.C. §103 of claims 1-7, 9, and 11-18 over Ordóñez and Bedade: Applicant’s arguments have been fully considered and are considered unpersuasive. Applicant argued that the Office does not explain why a skilled practitioner would have been motivated to contact a permeate from a separate process (e.g., the process of Ordóñez) to degrade acrylamide before being recombined with the original retentate as presently claimed. Applicant argued that neither Ordóñez nor Bedade provide any rationale which would lead a practitioner to combined the techniques of Ordóñez and Bedade to arrive at the presently claimed invention without hindsight (Applicant’s Remarks, page 8, 1st paragraph under “Ordóñez & Bedade” – page 10, 1st paragraph). However, as described above in the rejections of present claim 1, Ordóñez discloses adding a high aromatic aqueous coffee extract (e.g., R1) to the permeate (e.g., P2) to provide a liquid coffee concentrate, wherein the high aromatic aqueous coffee extract contains a high amount of compounds responsible for the flavor of the coffee (page 8, lines 22-25; page 10, lines 4-6). Ordóñez discloses that an additional treatment step such as exposure to enzymes may interfere with the flavor profile of the coffee (page 2, lines 7-28); and that a goal of its invention is to better preserve the aromas of the coffee and to avoid the loss of desirable aromas during the filtration process (page 9, lines 12-15). As such, a skilled practitioner would have readily recognized that P2 being added to R1 results in a coffee product having reduced acrylamide content while conserving the taste profile of the coffee, thereby achieving the goal of preserving the flavor profile of coffee disclosed by Ordóñez. Therefore, the addition of R1 to P2 as recited in step (iv) of the claimed method is rendered obvious; and the Office has explained why a skilled practitioner would have been motivated to contact a permeate with reduced acrylamide content from the process of Ordóñez with the original retentate as presently claimed. In response to applicant's argument that the examiner's conclusion of obviousness is based upon improper hindsight reasoning, it must be recognized that any judgment on obviousness is in a sense necessarily a reconstruction based upon hindsight reasoning. But so long as it takes into account only knowledge which was within the level of ordinary skill at the time the claimed invention was made, and does not include knowledge gleaned only from the applicant's disclosure, such a reconstruction is proper. See In re McLaughlin, 443 F.2d 1392, 170 USPQ 209 (CCPA 1971). Applicant then argued that the present application noted that prolonged time at high temperatures required for enzyme activity and enzyme degradation can have a negative effect on the additional components of the aqueous preparation. Applicant argued that merely removing acrylamide using membranes alone such as is described in Ordóñez can lead to product loss and ineffective acrylamide removal (Applicant’s Remarks, page 10, 2nd-3rd paragraphs). However, in response to applicant's argument that the references fail to show certain features of the invention, it is noted that the features upon which applicant relies (i.e., specific time and temperature for enzyme activity and enzyme degradation) are not recited in the rejected claim(s). Although the claims are interpreted in light of the specification, limitations from the specification are not read into the claims. See In re Van Geuns, 988 F.2d 1181, 26 USPQ2d 1057 (Fed. Cir. 1993). In response to Applicant’s assertion that merely removing acrylamide using membranes alone such as is described in Ordóñez can lead to product loss and ineffective acrylamide removal, one cannot show nonobviousness by attacking references individually where the rejections are based on combinations of references. See In re Keller, 642 F.2d 413, 208 USPQ 871 (CCPA 1981); In re Merck & Co., 800 F.2d 1091, 231 USPQ 375 (Fed. Cir. 1986). The claimed process recited in present claim 1 comprising membrane filtration and an acrylamide-reducing biocatalyst is rendered obvious by the combination of Ordóñez and Bedade, not by Ordóñez alone. Since the prior art has been shown to render the present claims obvious and Applicant’s arguments have been shown to be unpersuasive, the rejections of the claims stand as written herein. Claim Rejections – 35 U.S.C. §103 of claim 8 over Ordóñez, Bedade, and Watabe as evidenced by search results filed 01/07/2026; claim 10 over Ordóñez, Bedade, and Nguyen: Applicant’s arguments have been fully considered and are considered unpersuasive. Applicant argued that Watabe and Nguyen do not remedy the deficiencies of Ordóñez and Bedade as described in Applicant’s arguments in relation to claim 1 (Applicant’s Remarks, page 10, 1st paragraph under “Ordóñez, Bedade & Watabe- page 11, 2nd paragraph). However, the combination of Ordóñez and Bedade were shown to render the features of claim 1 obvious as described in the prior art rejections and in the responses to Applicant’s Remarks written above. Watabe and Nguyen are continued to be relied on merely for their teachings regarding the additional features recited in present claims 8 and 10. Since the prior art has been shown to render the present claims obvious and Applicant’s arguments have been shown to be unpersuasive, the rejections of the claims stand as written herein. Conclusion Applicant's amendment necessitated the new ground(s) of rejection presented in this Office action. Accordingly, THIS ACTION IS MADE FINAL. See MPEP § 706.07(a). Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any nonprovisional extension fee (37 CFR 1.17(a)) pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Kelly Kershaw whose telephone number is (571)272-2847. The examiner can normally be reached Monday - Thursday 9:00 am - 4:00 pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Nikki Dees can be reached at (571) 270-3435. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /K.P.K./Examiner, Art Unit 1791 /Nikki H. Dees/Supervisory Patent Examiner, Art Unit 1791
Read full office action

Prosecution Timeline

Feb 09, 2024
Application Filed
Jan 20, 2026
Non-Final Rejection mailed — §103, §112
Apr 20, 2026
Response Filed
Jul 14, 2026
Final Rejection mailed — §103, §112
Sep 09, 2026
Response after Non-Final Action

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1y 10m to grant Granted Aug 05, 2025
Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

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Prosecution Projections

2-3
Expected OA Rounds
18%
Grant Probability
34%
With Interview (+16.0%)
3y 5m (~9m remaining)
Median Time to Grant
Moderate
PTA Risk
Based on 220 resolved cases by this examiner. Grant probability derived from career allowance rate.

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