Prosecution Insights
Last updated: April 19, 2026
Application No. 18/702,776

BREATH-POWERED NASAL DEVICES FOR TREATMENT OF TRAUMATIC BRAIN INJURY (TBI), INCLUDING CONCUSSION, AND METHODS

Non-Final OA §101§102§103§DP
Filed
Apr 18, 2024
Examiner
HALL, DEANNA K
Art Unit
3783
Tech Center
3700 — Mechanical Engineering & Manufacturing
Assignee
Oragenics Inc.
OA Round
1 (Non-Final)
76%
Grant Probability
Favorable
1-2
OA Rounds
3y 3m
To Grant
91%
With Interview

Examiner Intelligence

Grants 76% — above average
76%
Career Allow Rate
857 granted / 1130 resolved
+5.8% vs TC avg
Strong +15% interview lift
Without
With
+15.2%
Interview Lift
resolved cases with interview
Typical timeline
3y 3m
Avg Prosecution
62 currently pending
Career history
1192
Total Applications
across all art units

Statute-Specific Performance

§101
0.7%
-39.3% vs TC avg
§103
45.6%
+5.6% vs TC avg
§102
35.3%
-4.7% vs TC avg
§112
11.1%
-28.9% vs TC avg
Black line = Tech Center average estimate • Based on career data from 1130 resolved cases

Office Action

§101 §102 §103 §DP
Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . Claim Objections Claim 1 objected to because of the following informalities: typographical error: “mouse” piece. Appropriate correction is required. (also typographical error in claim 11) Claims 5-6, 8-14, and 16-36 are objected to because of the following informalities: dependency of claims. Examiner makes suggestions to dependency; appropriate correction is required. Claim 5 depend from claim 4 Claim 6 depend from claim 5 Claim 16 depend from claim 15 Claim 17 depend from claim 15 Claim 18 depend from claim 15 Claim 19 depend from claim 18 Claim 20 depend from claim 19 Claim 21 depend from claim 18 Claim 22 depend from claim 15 Claims 23-26, 29-36, dependency unclear Double Patenting A rejection based on double patenting of the “same invention” type finds its support in the language of 35 U.S.C. 101 which states that “whoever invents or discovers any new and useful process... may obtain a patent therefor...” (Emphasis added). Thus, the term “same invention,” in this context, means an invention drawn to identical subject matter. See Miller v. Eagle Mfg. Co., 151 U.S. 186 (1894); In re Vogel, 422 F.2d 438, 164 USPQ 619 (CCPA 1970); In re Ockert, 245 F.2d 467, 114 USPQ 330 (CCPA 1957). A statutory type (35 U.S.C. 101) double patenting rejection can be overcome by canceling or amending the claims that are directed to the same invention so they are no longer coextensive in scope. The filing of a terminal disclaimer cannot overcome a double patenting rejection based upon 35 U.S.C. 101. Claims 1-26, 29-36 are provisionally rejected under 35 U.S.C. 101 as claiming the same invention as that of claims 1-36 of copending Application No. 17/803,705 (reference application). This is a provisional statutory double patenting rejection since the claims directed to the same invention have not in fact been patented. Claim Rejections - 35 USC § 102 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of the appropriate paragraphs of 35 U.S.C. 102 that form the basis for the rejections under this section made in this Office action: A person shall be entitled to a patent unless – (a)(1) the claimed invention was patented, described in a printed publication, or in public use, on sale, or otherwise available to the public before the effective filing date of the claimed invention. Claims 1-7, 15-21 are rejected under 35 U.S.C. 102(a)(1) as being anticipated by Djupesland et al. (US 2008/0289629) (“Djupesland”). Djupesland discloses: a device and method for treating a subject for local or systemic nasal injury, disorder or disease or CNS injury, disorder or disease, who is in need of treatment comprising (Fig. 2e): (a) a mouth piece 19 for blowing a breath into said device by a subject; (b) a nose guard 17 for propelling the drug substance in the nasal cavity of the subject; (c) a flexible convoluted middle section sandwiched between said mouth piece and noseguard (see Fig. 2e); and (d) a dual wall drug dispensing system 53 comprised of a first hollow means into which the drug substance is loaded that generates a first airflow, and a second hollow means that surrounds the first hollow means, so that, when a subject blows air through said mouthpiece and into said device, said first hollow means and said second hollow means in parallel provide a dual airflow comprised of (i) a first airflow expelled from said first hollow means carrying the drug substance, and (ii) a second airflow expelled from the second hollow means to create airflow pressure that surrounds the first expelled airflow, so that the first expelled airflow forms and travels initially in a vertical, somewhat tight and narrow or confined, concentrated plume that drives the concentrated drug substance to the targeted olfactory region for direct diffusion into the brain for the effective treatment. (see Fig. 2e, [0051-0054]) the drug substance is deposited into the superior nasal cavity. (see Fig. 2e, [0051-0054]) the drug substance is distributed into mucosa innervated by the trigeminal nerve. (see Fig. 2e, [0051-0054], [0004]) the CNS injury is brain injury; the brain injury is traumatic brain injury ("TBI") or concussion. [0004] the TBI is mild TBI, moderate TBI or severe TBI Claim Rejections - 35 USC § 103 In the event the determination of the status of the application as subject to AIA 35 U.S.C. 102 and 103 (or as subject to pre-AIA 35 U.S.C. 102 and 103) is incorrect, any correction of the statutory basis (i.e., changing from AIA to pre-AIA ) for the rejection will not be considered a new ground of rejection if the prior art relied upon, and the rationale supporting the rejection, would be the same under either status. The following is a quotation of 35 U.S.C. 103 which forms the basis for all obviousness rejections set forth in this Office action: A patent for a claimed invention may not be obtained, notwithstanding that the claimed invention is not identically disclosed as set forth in section 102, if the differences between the claimed invention and the prior art are such that the claimed invention as a whole would have been obvious before the effective filing date of the claimed invention to a person having ordinary skill in the art to which the claimed invention pertains. Patentability shall not be negated by the manner in which the invention was made. The factual inquiries for establishing a background for determining obviousness under 35 U.S.C. 103 are summarized as follows: 1. Determining the scope and contents of the prior art. 2. Ascertaining the differences between the prior art and the claims at issue. 3. Resolving the level of ordinary skill in the pertinent art. 4. Considering objective evidence present in the application indicating obviousness or nonobviousness. Claims 8-14, 22-26, 29-36 are rejected under 35 U.S.C. 103 as being unpatentable over Djupesland in view of Lichty et al. (US 2014/0248367) (“Lichty”). Djupesland discloses the invention as substantially claimed but does not directly disclose the delivery of ent-19- norprogesterone. Lichty, in the analogous art, teaches the breath-powered nasal delivery of ent-19- norprogesterone to treat traumatic or ischemic CNS injury such as TBI or stroke [0124,0132]. Therefore, it would have been obvious to a person having ordinary skill in the art before the effective filing date of the claimed invention to deliver ent-19- norprogesterone as a commonly used substance to treat a CNS injury. Conclusion Any inquiry concerning this communication or earlier communications from the examiner should be directed to DEANNA K HALL whose telephone number is (571)272-2819. The examiner can normally be reached M-F 9:00am-5:30pm est. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Kevin Sirmons can be reached at 571-272-4965. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /DEANNA K HALL/Primary Examiner, Art Unit 3783
Read full office action

Prosecution Timeline

Apr 18, 2024
Application Filed
Jul 23, 2025
Non-Final Rejection — §101, §102, §103
Jan 26, 2026
Response after Non-Final Action
Jan 26, 2026
Response Filed

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

1-2
Expected OA Rounds
76%
Grant Probability
91%
With Interview (+15.2%)
3y 3m
Median Time to Grant
Low
PTA Risk
Based on 1130 resolved cases by this examiner. Grant probability derived from career allow rate.

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