Last updated: July 17, 2026

Application No. 18/715,578

COMPOSITIONS AND METHODS FOR EFFICIENT IN VIVO DELIVERY

Non-Final OA

Filed

May 31, 2024

Priority

Dec 03, 2021 — provisional 63/285,995 +5 more

Examiner

KONOPKA, CATHERINE ANNE

Art Unit

1635

Tech Center

1600 — Biotechnology & Organic Chemistry

Assignee

President and Fellows of Harvard College

OA Round

1 (Non-Final)

This examiner grants 59% of cases after interview

— +65.0% interview lift. A telephonic interview to clarify the technical implementation could significantly improve the outcome.

Based on 191 resolved cases, 2023–2026

Examiner Intelligence

KONOPKA, CATHERINE ANNE View full profile →

Grants 59% of resolved cases

Career Allowance Rate

112 granted / 191 resolved

-1.4% vs TC avg

Strong +65% interview lift

Without

With

+65.0%

Interview Lift

resolved cases with interview

Typical timeline

3y 10m

Avg Prosecution

67 currently pending

Career history

247

Total Applications

across all art units

Statute-Specific Performance

§101

1.4%

-38.6% vs TC avg

§103

45.6%

+5.6% vs TC avg

§102

4.1%

-35.9% vs TC avg

§112

10.9%

-29.1% vs TC avg

Black line = Tech Center average estimate • Based on career data from 191 resolved cases

Prosecution Timeline

May 31, 2024

Application Filed

Mar 17, 2026

Non-Final Rejection mailed (current)

Precedent Cases

Applications granted by this same examiner with similar technology

17/054,938

Patent 12678517

MIRI26-5P FOR TREATING MOTOR NEURON DISEASES

5y 8m to grant Granted Jul 14, 2026

18/552,549

Patent 12673117

AAV-IDS VECTORS FOR TREATMENT OF MUCOPOLYSACCHARIDOSIS II

2y 9m to grant Granted Jul 07, 2026

17/926,208

Patent 12662663

USE OF A DEFICIENT FUSION PROTEIN FOR NUCLEASE ACTIVITY SO AS TO INDUCE MEIOTIC RECOMBINATIONS

3y 7m to grant Granted Jun 23, 2026

17/633,821

Patent 12630815

ARTIFICIAL GENE AND METHOD FOR MUTATING GENE

4y 3m to grant Granted May 19, 2026

17/430,665

Patent 12622931

COMPOSITIONS AND METHODS FOR TREATING ALPHA-1 ANTITRYPSIN DEFICIENCY

4y 9m to grant Granted May 12, 2026

Study what changed to get past this examiner. Based on 5 most recent grants.

Strategy Recommendation AI-generated — please review before filing

Get a prosecution strategy drawn from examiner precedents, rejection analysis, and claim mapping.

Typically takes 5-10 seconds — AI-generated, attorney review required before filing

Prosecution Projections

1-2

Expected OA Rounds

59%

Grant Probability

99%

With Interview (+65.0%)

3y 10m (~1y 8m remaining)

Median Time to Grant

Low

PTA Risk

Based on 191 resolved cases by this examiner. Grant probability derived from career allowance rate.