Prosecution Insights
Prosecution Insights
Technology area: Biotechnology & Pharmaceuticals
122 pending office actions • 59 art units • 103 examiners • 0 of 122 (0%) have an AI response strategy ready • 113 patents granted in the last 365 days
President and Fellows of Harvard College currently has 1 pending office action in the Biotechnology & Pharmaceuticals technology area. This action is handled by a distinct examiner, BUTTICE, AUDREY L, within a distinct art unit. The busiest examiner pending count of 1 matches the total number of pending office actions. With a distinct examiner and a distinct art unit, the current prosecution is concentrated on a single biotechnology matter.
BUTTICE, AUDREY L is the sole official responsible for reviewing this pending action. This structure means the outcome of the current filing depends on the assessment of a single examiner. The involvement of a distinct art unit suggests that the pending technology falls into a specific area within the biotechnology field. This interaction between the applicant and BUTTICE, AUDREY L defines the current prosecution landscape for the company. The count of examiners and art units for this pending matter limits the communication channel but also concentrates the prosecution outcome on the interpretation of an official. BUTTICE, AUDREY L is the busiest examiner for this pending office action.
Based on the USPTO statutory response window for each pending office action. 37 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.
Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 37 of the docket's apps have a known mailing date.
Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.
| Bucket | Cases |
|---|---|
| §101 + other | 9 (7%) |
| §103 only | 27 (22%) |
| §102 only | 1 (1%) |
| §112 only | 9 (7%) |
| Double-patenting only | 4 (3%) |
| Double-patenting + other | 22 (18%) |
| Multi-statute (no §101) | 48 (39%) |
| No statute on record | 2 (2%) |
How the docket's pending cases split across USPTO tech-center bands.
Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.
| Examiner | Apps on this docket | Allow rate | Interview lift |
|---|---|---|---|
| POHNERT, STEVEN C | 5 | 12.5% | +18.2% |
| QIAN, CELINE X | 4 | 47.5% | +17.2% |
| GROOMS, TIFFANY NICOLE | 3 | 57.8% | +46.3% |
| HALVORSON, MARK | 3 | 47.9% | +20.7% |
| BRETZ, COREY LANE | 2 | 0.0% | +0.0% |
| PETTITT, JOHN F | 2 | 25.9% | +21.6% |
| JOHNSON, KARA D | 2 | 69.3% | +25.1% |
| DHAR, MATASHA | 2 | 43.5% | +44.8% |
| NELSON, HUNTER JARED | 2 | 38.7% | +24.5% |
| ALLEN, SARAH ELIZABETH | 2 | 58.6% | +50.0% |
Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 18055024 | Multiplex End-Tagging Amplification of Nucleic Acids | WILDER, CYNTHIA B | 202d overdue |
| 18210213 | METHODS OF DETECTING SIGNATURES OF DISEASE OR CONDITIONS IN BODILY FLUIDS | SWITZER, JULIET CAROLINE | 119d overdue |
| 17289889 | NUCLEIC ACID-BASED BARCODING | POHNERT, STEVEN C | 110d overdue |
| 18028183 | PRIME EDITING GUIDE RNAS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | ALLEN, SARAH ELIZABETH | 78d overdue |
| 18033754 | TRANSCRIPTOMICS WITH ELECTROPHYSIOLOGICAL RECORDING | TURPIN, ZACHARY MARK | 28d overdue |
| 18382626 | CD47 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE OCULAR DISEASES | WESTON, ALYSSA G | 16d overdue |
| 17996846 | ISOTHERMAL METHODS, COMPOSITIONS, KITS, AND SYSTEMS FOR DETECTING NUCLEIC ACIDS | CHUNDURU, SURYAPRABHA | 9d overdue |
| 18162118 | Oligonucleotide Paints | FLINDERS, JEREMY C | 4d overdue |
Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 17289889 | NUCLEIC ACID-BASED BARCODING | POHNERT, STEVEN C | 110d overdue |
| 17923886 | WAVELENGTH TUNABLE METASURFACE BASED EXTERNAL CAVITY LASER | NELSON, HUNTER JARED | 89d overdue |
| 18028183 | PRIME EDITING GUIDE RNAS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | ALLEN, SARAH ELIZABETH | 78d overdue |
| 16989119 | Large Gene Excision and Insertion | GROOMS, TIFFANY NICOLE | 73d overdue |
| 18204903 | WAVELENGTH TUNABLE METASURFACE BASED EXTERNAL CAVITY LASER | NELSON, HUNTER JARED | 46d |
| 18826883 | METHODS, COMPOSITIONS AND SYSTEMS FOR SOLID-STATE BAROCALORIC APPLICATIONS | PETTITT, JOHN F | — |
| 18844272 | MULTIPLEX FLUORESCENT CELLULAR AND TISSUE IMAGING WITH DNA ENCODED THERMAL CHANNELS AND USES THEREOF | POHNERT, STEVEN C | — |
| 18742930 | SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME | JOHNSON, KARA D | — |
| Art Unit | Apps |
|---|---|
| 1632 | 8 |
| 1637 | 8 |
| 1683 | 7 |
| 2872 | 4 |
| 1638 | 4 |
| 1636 | 4 |
| 1646 | 4 |
| 1634 | 3 |
| 1635 | 3 |
| 1653 | 3 |
| App # | Title | Examiner | Art Unit | Statutes | Status | Due in | AI | Filed |
|---|---|---|---|---|---|---|---|---|
| 19361681 | METHODS AND COMPOSITIONS FOR PRODUCING GRANULOSA-LIKE CELLS | CONNORS, ALEXANDRA F | 1634 | §103§112DPOther | Final Rejection | 13d | Pending | Oct 17, 2025 |
| 19273187 | IMMERSED ROTARY JET SPINNING DEVICES (IRJS) AND USES THEREOF | LEYSON, JOSEPH S | 1744 | §112DP | Non-Final OA | — | Pending | Jul 18, 2025 |
| 19109166 | Particle Alpha Radiation Sampler | KEFAYATI, SOORENA | 2884 | §103§112 | Non-Final OA | — | Pending | Mar 06, 2025 |
| 19057629 | SYSTEMS AND METHODS FOR PERFORMING MEDICAL TASKS USING A MEDICAL ARTIFICIAL INTELLIGENCE SYSTEM | ILAGAN, VINCENT CAESAR | 3686 | §101§102§103 | Non-Final OA | 79d | Pending | Feb 19, 2025 |
| 19045994 | NANOSENSOR METHODS AND APPARATUSES FOR DETERMINATION OF ANALYTES | GIERE, REBECCA M | 1677 | §103DP | Non-Final OA | — | Pending | Feb 05, 2025 |
| 18878627 | NANOOPTICS WITH HIGH REFRACTIVE INDEX APERTURES | JONES, JENNIFER ANN | 2872 | §103 | Non-Final OA | — | Pending | Dec 23, 2024 |
| 18869604 | TOUGH ADHESION WITH A TOUGH GEL AND CHITOSAN BRIDGING POLYMER | HOLLOMAN, NANNETTE | 1612 | §103 | Non-Final OA | — | Pending | Nov 26, 2024 |
| 18949619 | CELLS LACKING B2M SURFACE EXPRESSION AND METHODS FOR ALLOGENEIC ADMINISTRATION OF SUCH CELLS | SINGH, ANOOP KUMAR | 1632 | §103§112 | Non-Final OA | 34d | Pending | Nov 15, 2024 |
| 18940299 | ELECTRONIC CIRCUITS FOR ANALYZING ELECTROGENIC CELLS AND RELATED METHODS | QIAN, SHIZHI | 1795 | §103 | Non-Final OA | — | Pending | Nov 07, 2024 |
| 18858608 | METHODS AND COMPOSITIONS FOR PRODUCING MICROGLIA | JOHNSON, ALLISON MARIE | 1638 | §102§103§112 | Non-Final OA | — | Pending | Oct 21, 2024 |
| 18910120 | FOCUSED ROTARY JET SPINNING DEVICES AND METHODS OF USE THEREOF | LUK, EMMANUEL S | 1744 | DP | Final Rejection | 5d | Pending | Oct 09, 2024 |
| 18907463 | ARBITRARY POLARIZATION-SWITCHABLE METASURFACES | BOOHER, ADAM W | 2872 | §102§103 | Non-Final OA | — | Pending | Oct 04, 2024 |
| 18853224 | IMMUNE MODULATORY AGENTS | CHANDRAKUMAR, NIZAL S | 1625 | §112 | Non-Final OA | — | Pending | Oct 01, 2024 |
| 18901470 | Methods for Rule-based Genome Design | BRETZ, COREY LANE | 1635 | §102§103§112DP | Non-Final OA | — | Pending | Sep 30, 2024 |
| 18899268 | Multiplexed Genome Editing | WILSON, MICHAEL C | 1638 | §112DP | Non-Final OA | — | Pending | Sep 27, 2024 |
| 18883669 | Compositions For and Methods of Treating Influenza | ZOU, NIANXIANG | 1671 | §101§102§103§112 | Non-Final OA | — | Pending | Sep 12, 2024 |
| 18826883 | METHODS, COMPOSITIONS AND SYSTEMS FOR SOLID-STATE BAROCALORIC APPLICATIONS | PETTITT, JOHN F | 3763 | §103§112 | Non-Final OA | — | Pending | Sep 06, 2024 |
| 18844272 | MULTIPLEX FLUORESCENT CELLULAR AND TISSUE IMAGING WITH DNA ENCODED THERMAL CHANNELS AND USES THEREOF | POHNERT, STEVEN C | 1683 | §102§103§112DP | Non-Final OA | — | Pending | Sep 05, 2024 |
| 18839599 | SYSTEMS AND METHODS FOR HIGH-DENSITY LONG-TERM INTRACELLULAR ELECTROPHYSIOLOGY | MINCHELLA, ADAM ZACHARY | 3794 | §102§103 | Non-Final OA | — | Pending | Aug 19, 2024 |
| 18791223 | BASE EDITORS AND USES THEREOF | KIEFER, DALTON EDWARD | 1635 | §102§103§112DP | Non-Final OA | — | Pending | Jul 31, 2024 |
| 18790038 | COMPOSITIONS AND METHODS FOR REDUCING TACTILE DYSFUNCTION, ANXIETY, AND SOCIAL IMPAIRMENT | AULAKH, CHARANJIT | 1621 | §102 | Non-Final OA | — | Pending | Jul 31, 2024 |
| 18725593 | BICYCLIC INHIBITORS OF NICOTINAMIDE NMETHYLTRANSFERASE, COMPOSITIONS AND USES THEREOF | HEITMEIER, KENDALL NICOLE | 1621 | §102§112 | Non-Final OA | — | Pending | Jun 28, 2024 |
| 18742930 | SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME | JOHNSON, KARA D | 1632 | §103 | Non-Final OA | — | Pending | Jun 13, 2024 |
| 18740453 | DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR HEPATIC TARGETING AND THERAPY | NOBLE, MARCIA STEPHENS | 1632 | §103§112Other | Non-Final OA | — | Pending | Jun 11, 2024 |
| 18680465 | ANTIBODY MOLECULES TO PD-1 AND USES THEREOF | WEIDNER, ADAM M | 1675 | §101§103§112Other | Non-Final OA | — | Pending | May 31, 2024 |
| 18715569 | SELF-ASSEMBLING VIRUS-LIKE PARTICLES FOR DELIVERY OF NUCLEIC ACID PROGRAMMABLE FUSION PROTEINS AND METHODS OF MAKING AND USING SAME | MOLOYE, TITILAYO | 1632 | §102§103§112 | Non-Final OA | — | Pending | May 31, 2024 |
| 18672600 | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF OLIGODENDROCYTE PROGENITOR CELLS | JOHNSON, KARA D | 1632 | §102§103§112 | Non-Final OA | — | Pending | May 23, 2024 |
| 18658154 | SYSTEM FOR DETECTING MICRO-NEUROMAS AND METHODS OF USE THEREOF | SIPES, JOHN CURTIS | 2872 | Other | Non-Final OA | — | Pending | May 08, 2024 |
| 18654695 | PROCASPASE-CLEAVING PROTEASES AND USES THEREOF | BOWERS, ERIN M | 1653 | §112 | Non-Final OA | — | Pending | May 03, 2024 |
| 18640031 | METHODS AND COMPOSITIONS FOR INHIBITING OXIDATIVE STRESS | QIAN, CELINE X | 1637 | §112DP | Non-Final OA | — | Pending | Apr 19, 2024 |
| 18639592 | COMPOSITIONS AND METHODS FOR MODULATING HYDROXYLATION OF ACC2 BY PHD3 | NATARAJAN, MEERA | 1643 | §112 | Non-Final OA | — | Pending | Apr 18, 2024 |
| 18628222 | METHODS FOR GENERATION OF PODOCYTES FROM PLURIPOTENT STEM CELLS AND CELLS PRODUCED BY THE SAME | BURKHART, MICHAEL D | 1638 | §103 | Non-Final OA | — | Pending | Apr 05, 2024 |
| 18626845 | MULTIPLE EMULSIONS CREATED USING JETTING AND OTHER TECHNIQUES | MCGUIRK, JOHN SCHUYLER | 1798 | DP | Non-Final OA | — | Pending | Apr 04, 2024 |
| 18697559 | IONIC LIQUIDS FOR DRUG DELIVERY | ATKINSON, JOSHUA ALEXANDER | 1612 | §102§103DP | Non-Final OA | — | Pending | Apr 01, 2024 |
| 18616723 | Textile Actuators | RAUBENSTRAW, TYLER ALLEN | 3785 | §103DP | Non-Final OA | — | Pending | Mar 26, 2024 |
| 18605451 | MACHINE LEARNING SYSTEMS AND METHODS FOR DEEP LEARNING OF GENOMIC CONTEXTS | DUNAY, CHRISTOPHER E | 2875 | §112 | Non-Final OA | — | Pending | Mar 14, 2024 |
| 18690217 | SYSTEMS AND METHODS FOR CONTROLLING FLUID FLOW BETWEEN MULTIPLE CHAMBERS OF A TESTING DEVICE | BORTOLI, JONATHAN | — | §102§103§112 | Non-Final OA | — | Pending | Mar 07, 2024 |
| 18684449 | LONG-LIVED REDOX-ACTIVE MOLECULES WITH LOW REDOX POTENTIAL | KOROVINA, ANNA | 1729 | §102§103 | Non-Final OA | — | Pending | Feb 16, 2024 |
| 18430757 | THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF | CHANDRA, GYAN | 1674 | §103 | Non-Final OA | — | Pending | Feb 02, 2024 |
| 18410439 | MULTIPLEXED IMAGING USING MERFISH, EXPANSION MICROSCOPY, AND RELATED TECHNOLOGIES | POHNERT, STEVEN C | 1683 | §103§112DP | Non-Final OA | — | Pending | Jan 11, 2024 |
| 18410249 | ENHANCERS DRIVING EXPRESSION IN MOTOR NEURONS | JACKSON III, WALTER | 1638 | §102§103§112 | Non-Final OA | — | Pending | Jan 11, 2024 |
| 18408498 | RECOMBINANT NUCLEIC ACID MOLECULES AND THEIR USE IN WOUND HEALING | DHAR, MATASHA | 1632 | §102§103§112 | Non-Final OA | — | Pending | Jan 09, 2024 |
| 18577453 | COMPOSITIONS AND METHODS RELATING TO CELLS WITH ADHERED PARTICLES | SAMALA, JAGADISHWAR RAO | 1618 | §102§103 | Non-Final OA | — | Pending | Jan 08, 2024 |
| 18394724 | SMALL-MOLECULE-ACTIVATED GLYCAN MODIFYING ENZYMES AND USES THEREOF | MISHRA, DEEPA | 1657 | §102§103 | Non-Final OA | — | Pending | Dec 22, 2023 |
| 18391977 | MATRIX IMPRINTING AND CLEARING | POHNERT, STEVEN C | 1683 | §103DP | Non-Final OA | — | Pending | Dec 21, 2023 |
| 18392954 | ANTIBODY MOLECULES TO PG-L1 AND METHODS OF TREATING CANCER AND INFECTIOUS DISEASES | KAUFMAN, CLAIRE M | 1674 | DP | Final Rejection | — | Pending | Dec 21, 2023 |
| 18572654 | METHODS OF DETERMINING RESPONSIVENESS TO CHEMOTHERAPEUTIC COMPOUNDS FOR CANCER THERAPY | ZAHORIK, AMANDA MARY | 1636 | §101§102§103§112 | Non-Final OA | — | Pending | Dec 20, 2023 |
| 18568085 | SYSTEMS AND METHODS FOR SUGAR-REDUCTION AND/OR FIBER PRODUCTION FOR FOOD AND OTHER APPLICATIONS | LE, EMILY M | 1793 | §102§103 | Non-Final OA | — | Pending | Dec 07, 2023 |
| 18289777 | PRINTED COMPOSITION FOR BIOMEDICAL USES | COUGHLIN, DANIEL F | 1619 | §103 | Non-Final OA | — | Pending | Nov 07, 2023 |
| 18501954 | ATOMIC LAYER DEPOSITION PROCESS FOR FABRICATING DIELECTRIC METASURFACES FOR WAVELENGTHS IN THE VISIBLE SPECTRUM | JUNG, JONATHAN Y | 2871 | §103 | Final Rejection | 55d | Pending | Nov 03, 2023 |
IP Author helps IP teams respond to office actions faster with AI-generated responses, examiner analytics, and prosecution intelligence.
Start Free TrialPresident and Fellows of Harvard College has 122 pending office actions as of October 2026, spread across 59 art units and 103 examiners.
Steven C Pohnert has the most, with 5 of President and Fellows of Harvard College's pending office actions.
Mostly Biotechnology & Pharmaceuticals (USPTO Tech Center 1600), based on where its pending office actions are examined.