Prosecution Insights
Prosecution Insights
Technology area: Biotechnology & Pharmaceuticals
119 pending office actions • 50 art units • 102 examiners • 0 of 119 (0%) have an AI response strategy ready • 113 patents granted in the last 365 days
President and Fellows of Harvard College currently has 1 pending office action in the Biotechnology & Pharmaceuticals technology area. This action is handled by a distinct examiner, BUTTICE, AUDREY L, within a distinct art unit. The busiest examiner pending count of 1 matches the total number of pending office actions. With a distinct examiner and a distinct art unit, the current prosecution is concentrated on a single biotechnology matter.
BUTTICE, AUDREY L is the sole official responsible for reviewing this pending action. This structure means the outcome of the current filing depends on the assessment of a single examiner. The involvement of a distinct art unit suggests that the pending technology falls into a specific area within the biotechnology field. This interaction between the applicant and BUTTICE, AUDREY L defines the current prosecution landscape for the company. The count of examiners and art units for this pending matter limits the communication channel but also concentrates the prosecution outcome on the interpretation of an official. BUTTICE, AUDREY L is the busiest examiner for this pending office action.
Based on the USPTO statutory response window for each pending office action. 39 of the docket's apps have a known mailing date; the rest are excluded from the tile counts.
Every pending office action with a known statutory deadline, placed on a days-until-due axis. Dots left of Today are overdue; the further right, the more runway. Cases that share a deadline window stack vertically. 39 of the docket's apps have a known mailing date.
Difficulty is derived from the rejection statutes on the most recent pending office action. §101-driven and multi-statute cases are graded Hard; §112-only and obviousness-type double-patenting cases are graded Easy; everything else is Medium. "Unknown" means we have not yet parsed a statute for that office action.
| Bucket | Cases |
|---|---|
| §101 + other | 6 (5%) |
| §103 only | 26 (22%) |
| §102 only | 1 (1%) |
| §112 only | 9 (8%) |
| Double-patenting only | 4 (3%) |
| Double-patenting + other | 22 (18%) |
| Multi-statute (no §101) | 49 (41%) |
| No statute on record | 2 (2%) |
How the docket's pending cases split across USPTO tech-center bands.
Manual office-action response work runs about 10 hours per case. The time-saved bands below show what IP Author's prosecution pipeline typically delivers — a conservative 20% on the low end, 35% in the middle, 50% on the high end.
| Examiner | Apps on this docket | Allow rate | Interview lift |
|---|---|---|---|
| POHNERT, STEVEN C | 4 | 12.4% | +18.5% |
| QIAN, CELINE X | 4 | 47.6% | +16.9% |
| GROOMS, TIFFANY NICOLE | 3 | 57.8% | +46.3% |
| HALVORSON, MARK | 3 | 47.9% | +20.7% |
| QIAN, SHIZHI | 2 | 61.8% | +47.9% |
| BRETZ, COREY LANE | 2 | 0.0% | +0.0% |
| PETTITT, JOHN F | 2 | 26.0% | +21.8% |
| JOHNSON, KARA D | 2 | 69.5% | +24.6% |
| DHAR, MATASHA | 2 | 43.3% | +45.7% |
| NELSON, HUNTER JARED | 2 | 38.7% | +24.5% |
Multi-statute / §101-driven matters, or cases in front of an examiner with an allow rate under 30%. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 18055024 | Multiplex End-Tagging Amplification of Nucleic Acids | WILDER, CYNTHIA B | 202d overdue |
| 18210213 | METHODS OF DETECTING SIGNATURES OF DISEASE OR CONDITIONS IN BODILY FLUIDS | SWITZER, JULIET CAROLINE | 119d overdue |
| 17289889 | NUCLEIC ACID-BASED BARCODING | POHNERT, STEVEN C | 110d overdue |
| 18028183 | PRIME EDITING GUIDE RNAS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | ALLEN, SARAH ELIZABETH | 78d overdue |
| 18033754 | TRANSCRIPTOMICS WITH ELECTROPHYSIOLOGICAL RECORDING | TURPIN, ZACHARY MARK | 28d overdue |
| 18382626 | CD47 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE OCULAR DISEASES | WESTON, ALYSSA G | 16d overdue |
| 17996846 | ISOTHERMAL METHODS, COMPOSITIONS, KITS, AND SYSTEMS FOR DETECTING NUCLEIC ACIDS | CHUNDURU, SURYAPRABHA | 9d overdue |
| 18162118 | Oligonucleotide Paints | FLINDERS, JEREMY C | 4d overdue |
Cases in front of an examiner whose interview lift is 10 percentage points or more — i.e. interviewed cases historically resolve more favorably than non-interviewed ones. The top 8 ordered by deadline are shown.
| App # | Title | Examiner | Due in |
|---|---|---|---|
| 17289889 | NUCLEIC ACID-BASED BARCODING | POHNERT, STEVEN C | 110d overdue |
| 17923886 | WAVELENGTH TUNABLE METASURFACE BASED EXTERNAL CAVITY LASER | NELSON, HUNTER JARED | 89d overdue |
| 16989119 | Large Gene Excision and Insertion | GROOMS, TIFFANY NICOLE | 73d overdue |
| 18569809 | LOCAL SENSING AND CONTROL OF PH FOR PARALLELIZED SYNTHESIS | QIAN, SHIZHI | 58d overdue |
| 18204903 | WAVELENGTH TUNABLE METASURFACE BASED EXTERNAL CAVITY LASER | NELSON, HUNTER JARED | 46d |
| 18940299 | ELECTRONIC CIRCUITS FOR ANALYZING ELECTROGENIC CELLS AND RELATED METHODS | QIAN, SHIZHI | — |
| 18826883 | METHODS, COMPOSITIONS AND SYSTEMS FOR SOLID-STATE BAROCALORIC APPLICATIONS | PETTITT, JOHN F | — |
| 18844272 | MULTIPLEX FLUORESCENT CELLULAR AND TISSUE IMAGING WITH DNA ENCODED THERMAL CHANNELS AND USES THEREOF | POHNERT, STEVEN C | — |
| Art Unit | Apps |
|---|---|
| 1637 | 7 |
| 1636 | 5 |
| 1632 | 4 |
| 1683 | 4 |
| 1646 | 4 |
| 1795 | 3 |
| 1635 | 3 |
| 3785 | 3 |
| 1684 | 3 |
| 1682 | 3 |
| App # | Title | Examiner | Art Unit | Statutes | Status | Due in | AI | Filed |
|---|---|---|---|---|---|---|---|---|
| 19361681 | METHODS AND COMPOSITIONS FOR PRODUCING GRANULOSA-LIKE CELLS | CONNORS, ALEXANDRA F | 1634 | §103§112DPOther | Final Rejection | 13d | Pending | Oct 17, 2025 |
| 19109166 | Particle Alpha Radiation Sampler | KEFAYATI, SOORENA | — | §103§112 | Non-Final OA | — | Pending | Mar 06, 2025 |
| 19057629 | SYSTEMS AND METHODS FOR PERFORMING MEDICAL TASKS USING A MEDICAL ARTIFICIAL INTELLIGENCE SYSTEM | ILAGAN, VINCENT CAESAR | 3686 | §101§102§103 | Non-Final OA | 79d | Pending | Feb 19, 2025 |
| 19045994 | NANOSENSOR METHODS AND APPARATUSES FOR DETERMINATION OF ANALYTES | GIERE, REBECCA M | — | §103DP | Non-Final OA | — | Pending | Feb 05, 2025 |
| 18869604 | TOUGH ADHESION WITH A TOUGH GEL AND CHITOSAN BRIDGING POLYMER | HOLLOMAN, NANNETTE | — | §103 | Non-Final OA | — | Pending | Nov 26, 2024 |
| 18949619 | CELLS LACKING B2M SURFACE EXPRESSION AND METHODS FOR ALLOGENEIC ADMINISTRATION OF SUCH CELLS | SINGH, ANOOP KUMAR | 1632 | §103§112 | Non-Final OA | 34d | Pending | Nov 15, 2024 |
| 18940299 | ELECTRONIC CIRCUITS FOR ANALYZING ELECTROGENIC CELLS AND RELATED METHODS | QIAN, SHIZHI | 1795 | §103 | Non-Final OA | — | Pending | Nov 07, 2024 |
| 18858608 | METHODS AND COMPOSITIONS FOR PRODUCING MICROGLIA | JOHNSON, ALLISON MARIE | — | §102§103§112 | Non-Final OA | — | Pending | Oct 21, 2024 |
| 18910120 | FOCUSED ROTARY JET SPINNING DEVICES AND METHODS OF USE THEREOF | LUK, EMMANUEL S | 1744 | DP | Final Rejection | 5d | Pending | Oct 09, 2024 |
| 18907463 | ARBITRARY POLARIZATION-SWITCHABLE METASURFACES | BOOHER, ADAM W | — | §102§103 | Non-Final OA | — | Pending | Oct 04, 2024 |
| 18853224 | IMMUNE MODULATORY AGENTS | CHANDRAKUMAR, NIZAL S | — | §112 | Non-Final OA | — | Pending | Oct 01, 2024 |
| 18901470 | Methods for Rule-based Genome Design | BRETZ, COREY LANE | 1635 | §102§103§112DP | Non-Final OA | — | Pending | Sep 30, 2024 |
| 18899268 | Multiplexed Genome Editing | WILSON, MICHAEL C | — | §112DP | Non-Final OA | — | Pending | Sep 27, 2024 |
| 18826883 | METHODS, COMPOSITIONS AND SYSTEMS FOR SOLID-STATE BAROCALORIC APPLICATIONS | PETTITT, JOHN F | 3763 | §103§112 | Non-Final OA | — | Pending | Sep 06, 2024 |
| 18844272 | MULTIPLEX FLUORESCENT CELLULAR AND TISSUE IMAGING WITH DNA ENCODED THERMAL CHANNELS AND USES THEREOF | POHNERT, STEVEN C | — | §102§103§112DP | Non-Final OA | — | Pending | Sep 05, 2024 |
| 18839599 | SYSTEMS AND METHODS FOR HIGH-DENSITY LONG-TERM INTRACELLULAR ELECTROPHYSIOLOGY | MINCHELLA, ADAM ZACHARY | 3794 | §102§103 | Non-Final OA | — | Pending | Aug 19, 2024 |
| 18837342 | SUTURABLE CUFF, METHOD OF INTEGRATING A TISSUE CONSTRUCT WITH A HOST ORGAN OR VASCULATURE, AND METHOD OF MAKING A SUTURABLE CUFF | RIVERS, LINDSEY RAE | 3771 | §102§103§112 | Non-Final OA | — | Pending | Aug 09, 2024 |
| 18790038 | COMPOSITIONS AND METHODS FOR REDUCING TACTILE DYSFUNCTION, ANXIETY, AND SOCIAL IMPAIRMENT | AULAKH, CHARANJIT | — | §102 | Non-Final OA | — | Pending | Jul 31, 2024 |
| 18791223 | BASE EDITORS AND USES THEREOF | KIEFER, DALTON EDWARD | 1635 | §102§103§112DP | Non-Final OA | — | Pending | Jul 31, 2024 |
| 18725593 | BICYCLIC INHIBITORS OF NICOTINAMIDE NMETHYLTRANSFERASE, COMPOSITIONS AND USES THEREOF | HEITMEIER, KENDALL NICOLE | — | §102§112 | Non-Final OA | — | Pending | Jun 28, 2024 |
| 18742930 | SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME | JOHNSON, KARA D | — | §103 | Non-Final OA | — | Pending | Jun 13, 2024 |
| 18740453 | DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR HEPATIC TARGETING AND THERAPY | NOBLE, MARCIA STEPHENS | — | §103§112Other | Non-Final OA | — | Pending | Jun 11, 2024 |
| 18715569 | SELF-ASSEMBLING VIRUS-LIKE PARTICLES FOR DELIVERY OF NUCLEIC ACID PROGRAMMABLE FUSION PROTEINS AND METHODS OF MAKING AND USING SAME | MOLOYE, TITILAYO | — | §102§103§112 | Non-Final OA | — | Pending | May 31, 2024 |
| 18672600 | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF OLIGODENDROCYTE PROGENITOR CELLS | JOHNSON, KARA D | — | §102§103§112 | Non-Final OA | — | Pending | May 23, 2024 |
| 18658154 | SYSTEM FOR DETECTING MICRO-NEUROMAS AND METHODS OF USE THEREOF | SIPES, JOHN CURTIS | 2872 | Other | Non-Final OA | — | Pending | May 08, 2024 |
| 18654695 | PROCASPASE-CLEAVING PROTEASES AND USES THEREOF | BOWERS, ERIN M | 1653 | §112 | Non-Final OA | — | Pending | May 03, 2024 |
| 18640031 | METHODS AND COMPOSITIONS FOR INHIBITING OXIDATIVE STRESS | QIAN, CELINE X | 1637 | §112DP | Non-Final OA | — | Pending | Apr 19, 2024 |
| 18639592 | COMPOSITIONS AND METHODS FOR MODULATING HYDROXYLATION OF ACC2 BY PHD3 | NATARAJAN, MEERA | — | §112 | Non-Final OA | — | Pending | Apr 18, 2024 |
| 18628222 | METHODS FOR GENERATION OF PODOCYTES FROM PLURIPOTENT STEM CELLS AND CELLS PRODUCED BY THE SAME | BURKHART, MICHAEL D | — | §103 | Non-Final OA | — | Pending | Apr 05, 2024 |
| 18626845 | MULTIPLE EMULSIONS CREATED USING JETTING AND OTHER TECHNIQUES | MCGUIRK, JOHN SCHUYLER | 1798 | DP | Non-Final OA | — | Pending | Apr 04, 2024 |
| 18697559 | IONIC LIQUIDS FOR DRUG DELIVERY | ATKINSON, JOSHUA ALEXANDER | — | §102§103DP | Non-Final OA | — | Pending | Apr 01, 2024 |
| 18616723 | Textile Actuators | RAUBENSTRAW, TYLER ALLEN | 3785 | §103DP | Non-Final OA | — | Pending | Mar 26, 2024 |
| 18605451 | MACHINE LEARNING SYSTEMS AND METHODS FOR DEEP LEARNING OF GENOMIC CONTEXTS | DUNAY, CHRISTOPHER E | — | §112 | Non-Final OA | — | Pending | Mar 14, 2024 |
| 18684449 | LONG-LIVED REDOX-ACTIVE MOLECULES WITH LOW REDOX POTENTIAL | KOROVINA, ANNA | — | §102§103 | Non-Final OA | — | Pending | Feb 16, 2024 |
| 18430757 | THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF | CHANDRA, GYAN | — | §103 | Non-Final OA | — | Pending | Feb 02, 2024 |
| 18410249 | ENHANCERS DRIVING EXPRESSION IN MOTOR NEURONS | JACKSON III, WALTER | 1638 | §102§103§112 | Non-Final OA | — | Pending | Jan 11, 2024 |
| 18410439 | MULTIPLEXED IMAGING USING MERFISH, EXPANSION MICROSCOPY, AND RELATED TECHNOLOGIES | POHNERT, STEVEN C | 1683 | §103§112DP | Non-Final OA | — | Pending | Jan 11, 2024 |
| 18408546 | THERAPEUTIC AGENTS AND THEIR USE FOR TREATING CHRONIC WOUNDS | BECKHARDT, LYNDSEY MARIE | 1613 | §103 | Non-Final OA | 16d overdue | Pending | Jan 09, 2024 |
| 18408498 | RECOMBINANT NUCLEIC ACID MOLECULES AND THEIR USE IN WOUND HEALING | DHAR, MATASHA | 1632 | §102§103§112 | Non-Final OA | — | Pending | Jan 09, 2024 |
| 18577453 | COMPOSITIONS AND METHODS RELATING TO CELLS WITH ADHERED PARTICLES | SAMALA, JAGADISHWAR RAO | — | §102§103 | Non-Final OA | — | Pending | Jan 08, 2024 |
| 18394724 | SMALL-MOLECULE-ACTIVATED GLYCAN MODIFYING ENZYMES AND USES THEREOF | MISHRA, DEEPA | 1657 | §102§103 | Non-Final OA | — | Pending | Dec 22, 2023 |
| 18573422 | REHABILITATION SYSTEMS AND METHODS | RESTAINO, DANIELLE BERNADETTE | — | §103§112 | Non-Final OA | — | Pending | Dec 21, 2023 |
| 18392954 | ANTIBODY MOLECULES TO PG-L1 AND METHODS OF TREATING CANCER AND INFECTIOUS DISEASES | KAUFMAN, CLAIRE M | 1674 | DP | Final Rejection | — | Pending | Dec 21, 2023 |
| 18572654 | METHODS OF DETERMINING RESPONSIVENESS TO CHEMOTHERAPEUTIC COMPOUNDS FOR CANCER THERAPY | ZAHORIK, AMANDA MARY | — | §101§102§103§112 | Non-Final OA | — | Pending | Dec 20, 2023 |
| 18569809 | LOCAL SENSING AND CONTROL OF PH FOR PARALLELIZED SYNTHESIS | QIAN, SHIZHI | 1795 | §103 | Final Rejection | 58d overdue | Pending | Dec 13, 2023 |
| 18289777 | PRINTED COMPOSITION FOR BIOMEDICAL USES | COUGHLIN, DANIEL F | 1619 | §103 | Non-Final OA | — | Pending | Nov 07, 2023 |
| 18559038 | SYSTEMS AND METHODS OF INCOHERENT SPATIAL FREQUENCY FILTERING | TABA, MONICA TERESA | 2878 | §102§103 | Non-Final OA | 33d | Pending | Nov 03, 2023 |
| 18501954 | ATOMIC LAYER DEPOSITION PROCESS FOR FABRICATING DIELECTRIC METASURFACES FOR WAVELENGTHS IN THE VISIBLE SPECTRUM | JUNG, JONATHAN Y | 2871 | §103 | Final Rejection | 55d | Pending | Nov 03, 2023 |
| 18382626 | CD47 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE OCULAR DISEASES | WESTON, ALYSSA G | 1633 | §102§103 | Final Rejection | 16d overdue | Pending | Oct 23, 2023 |
| 18286903 | Digital Protein Misfolding Assays | JOHANSEN, PETER N. | 1644 | §102§112 | Non-Final OA | — | Pending | Oct 13, 2023 |
| 18286740 | E3 LIGASE BINDERS AND USES THEREOF | JARRELL, NOBLE E | 1699 | §102§112 | Final Rejection | 28d | Pending | Oct 12, 2023 |
| 18484381 | EDITING OF CCR5 RECEPTOR GENE TO PROTECT AGAINST HIV INFECTION | FOX, ALLISON M | — | §103§112Other | Non-Final OA | — | Pending | Oct 10, 2023 |
| 18285899 | METHODS, COMPOSITIONS AND SYSTEMS FOR SOLID-STATE BAROCALORIC APPLICATIONS | PETTITT, JOHN F | 3763 | §102§103§112 | Non-Final OA | — | Pending | Oct 06, 2023 |
| 18282991 | FLUOROGENIC SENSORS FOR DETECTING ANTIGENS | BLUMEL, BENJAMIN P | 1671 | §102§103§112DP | Non-Final OA | — | Pending | Sep 19, 2023 |
| 18365045 | APPARATUSES FOR CELL MAPPING VIA IMPEDANCE MEASUREMENTS AND METHODS TO OPERATE THE SAME | HE, AMY | 2858 | §103§112Other | Final Rejection | 26d | Pending | Aug 03, 2023 |
| 18274757 | ENGINEERED BACTERIA AND METHODS OF PRODUCING TRIACYLGLYCERIDES | SWIFT, CANDICE LEE | 1657 | §103§112DP | Final Rejection | 71d overdue | Pending | Jul 28, 2023 |
| 18272933 | ENGINEERED NUCLEIC ACIDS TARGETING LONG NONCODING RNA INVOLVED IN PATHOGENIC INFECTION | CHONG, KIMBERLY | 1636 | §112 | Final Rejection | 30d overdue | Pending | Jul 18, 2023 |
| 18269939 | JONES MATRIX HOLOGRAPHY WITH METASURFACES | CHAPEL, DEREK S | 2872 | §102§112 | Non-Final OA | — | Pending | Jun 27, 2023 |
| 18339607 | AUTOCATALYTIC BASE EDITING FOR RNA-RESPONSIVE TRANSLATIONAL CONTROL | SAPKOTA, SURAJ | 1684 | §103 | Non-Final OA | — | Pending | Jun 22, 2023 |
| 18210213 | METHODS OF DETECTING SIGNATURES OF DISEASE OR CONDITIONS IN BODILY FLUIDS | SWITZER, JULIET CAROLINE | 1682 | §102§103 | Final Rejection | 119d overdue | Pending | Jun 15, 2023 |
| 18266423 | NOVEL SCREENING PLATFORM TO IDENTIFY IMMUNE MODULATORY AGENTS | QIAN, CELINE X | 1656 | §101§103§112 | Non-Final OA | — | Pending | Jun 09, 2023 |
| 18266093 | COMPOSITIONS AND METHODS FOR GENE EDITING WITH WOOLLY MAMMOTH ALLELES | O'NEILL, MARISOL ANN | 1633 | §102§103 | Non-Final OA | — | Pending | Jun 08, 2023 |
| 18265523 | SCG2 NEUROPEPTIDES AND USES THEREOF | STEELE, AMBER D | 1658 | §101§103§112 | Final Rejection | 14d | Pending | Jun 06, 2023 |
| 18204903 | WAVELENGTH TUNABLE METASURFACE BASED EXTERNAL CAVITY LASER | NELSON, HUNTER JARED | 2828 | §103§112 | Non-Final OA | 46d | Pending | Jun 01, 2023 |
| 18035619 | SYSTEMS AND METHODS FOR ADVANCING REACTIONS BETWEEN MULTIPLE CHAMBERS OF A TESTING DEVICE | MUI, CHRISTINE T | 3616 | §103 | Non-Final OA | — | Pending | May 05, 2023 |
| 18312492 | FORMULATIONS AND MEDICAL DEVICES FOR MINIMALLY-INVASIVE DEEP TISSUE APPLICATIONS | WHITE, KIA XIONG | 3774 | §102§103§112 | Non-Final OA | 9d | Pending | May 04, 2023 |
| 18310477 | MATRIX IMPRINTING AND CLEARING | POHNERT, STEVEN C | 1683 | §103§112 | Final Rejection | — | Pending | May 01, 2023 |
| 18034756 | PROGRAMMABLE METAMATERIAL AND METHOD OF CONTROLLING MACROSCOPIC PROPERTIES OF A METAMATERIAL | OMORI, MARY I | 1784 | §103 | Non-Final OA | 21d | Pending | May 01, 2023 |
| 18033754 | TRANSCRIPTOMICS WITH ELECTROPHYSIOLOGICAL RECORDING | TURPIN, ZACHARY MARK | 1682 | §103§112 | Final Rejection | 28d overdue | Pending | Apr 25, 2023 |
| 18032105 | WW-DOMAIN-ACTIVATED EXTRACELLULAR VESICLES | SPANGLER, JOSEPH RANKIN | 1656 | §102§103§112Other | Final Rejection | 20d | Pending | Apr 14, 2023 |
| 18029028 | STROKE TREATMENT | MACH, ANDRE | 1615 | §103 | Non-Final OA | — | Pending | Mar 28, 2023 |
| 18191818 | MICROSCOPE-FREE IMAGING | GREENE, CAROLYN LEE | 1681 | §112 | Non-Final OA | — | Pending | Mar 28, 2023 |
| 18028183 | PRIME EDITING GUIDE RNAS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | ALLEN, SARAH ELIZABETH | 1637 | §103§112 | Final Rejection | 78d overdue | Pending | Mar 23, 2023 |
| 18162118 | Oligonucleotide Paints | FLINDERS, JEREMY C | 1684 | §102§112Other | Non-Final OA | 4d overdue | Pending | Jan 31, 2023 |
| 18157848 | Systems and Methods for Processing Spatially Related Sequence Data Received from a Sequencing Device | DARRIGRAND, EMILY ANN | — | §101§103§112 | Non-Final OA | — | Pending | Jan 23, 2023 |
| 18003818 | GAS ANALYSIS THROUGH SNIFFING SEQUENCES | JARRETT, LORE RAMILLANO | 1797 | §102§103 | Non-Final OA | — | Pending | Dec 29, 2022 |
| 18012064 | PROGRAMMABLE ORGANOIDS AND METHODS OF PRODUCING THE SAME VIA ORTHOGONAL DIFFERENTIATION AND BIOPRINTING | DHAR, MATASHA | 1632 | §103§112DP | Final Rejection | — | Pending | Dec 21, 2022 |
| 18010427 | METHODS FOR MODULATING TLR4 SIGNALING | FIEBIG, RUSSELL G | 1655 | §102§103 | Non-Final OA | — | Pending | Dec 14, 2022 |
| 18064738 | METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCES | QIAN, CELINE X | 1637 | §102§103§112DP | Non-Final OA | — | Pending | Dec 12, 2022 |
| 18009534 | RIBOSWITCH MODULES AND METHODS FOR CONTROLLING EUKARYOTIC PROTEIN TRANSLATION | SU-TOBON, QIWEN NMN | 1636 | §102§103§112DPOther | Non-Final OA | — | Pending | Dec 09, 2022 |
| 17926748 | INTERFERON- INDUCING OLIGONUCLEOTIDE DUPLEXES AND METHODS OF USE | ROSSI, JULIA ANNE LORRAIN | 1615 | §112 | Final Rejection | — | Pending | Nov 21, 2022 |
| 18055024 | Multiplex End-Tagging Amplification of Nucleic Acids | WILDER, CYNTHIA B | 1681 | §103§112 | Non-Final OA | 202d overdue | Pending | Nov 14, 2022 |
| 17923886 | WAVELENGTH TUNABLE METASURFACE BASED EXTERNAL CAVITY LASER | NELSON, HUNTER JARED | 2828 | §103 | Final Rejection | 89d overdue | Pending | Nov 07, 2022 |
| 17996846 | ISOTHERMAL METHODS, COMPOSITIONS, KITS, AND SYSTEMS FOR DETECTING NUCLEIC ACIDS | CHUNDURU, SURYAPRABHA | 1681 | §103§112 | Non-Final OA | 9d overdue | Pending | Oct 21, 2022 |
| 17917109 | TGFß THERAPY FOR OCULAR AND NEURODEGENERATIVE DISEASES | MONTANARI, DAVID A | 1632 | §103 | Non-Final OA | — | Pending | Oct 05, 2022 |
| 17956892 | Method and Apparatus for Volumetric Imaging | GERIDO, DWAN A | 1797 | §103§112 | Non-Final OA | 28d | Pending | Sep 30, 2022 |
| 17797701 | ADENINE BASE EDITORS AND USES THEREOF | EPSTEIN, TODD MATTHEW | 1652 | §102§112DP | Non-Final OA | 11d overdue | Pending | Aug 04, 2022 |
| 17869940 | METHOD AND APPARATUS WITH ARTIFICIAL NETWORK GENERATION AND/OR IMPLEMENTATION CORRESPONDING TO A NATURAL NEURAL NETWORK | GRUSZKA, DANIEL PATRICK | 2121 | §103 | Final Rejection | 33d | Pending | Jul 21, 2022 |
| 17783750 | COMPOSITIONS AND METHODS FOR LIGHT-DIRECTED BIOMOLECULAR BARCODING | CROW, ROBERT THOMAS | 1683 | §103§112 | Final Rejection | — | Pending | Jun 09, 2022 |
| 17779272 | COMPOSITIONS, SETS, AND METHODS RELATED TO TARGET ANALYSIS | BEIL, RANDI LYNN | 1684 | §103§112 | Non-Final OA | — | Pending | May 24, 2022 |
| 17777972 | DEVICE FOR ASSISTING MOTION OF A JOINT | RHEE, KELSEY | 3785 | §103 | Final Rejection | — | Pending | May 18, 2022 |
| 17773145 | FLUID-INFUSED ENCAPSULATION OF WATER-SENSITIVE MATERIALS WITH REPLENISHABLE, MULTISCALE WATER REPELLENCY | YAP, DOUGLAS ANTHONY | 2899 | §103 | Final Rejection | 96d overdue | Pending | Apr 29, 2022 |
| 17771530 | POLYMERIC FIBER MATERIALS FOR THERMAL AND MECHANICAL PROTECTION AND METHODS OF MAKING | IMANI, ELIZABETH MARY COLE | 1789 | §102§103 | Final Rejection | — | Pending | Apr 25, 2022 |
| 17755211 | SENSING DEVICES BASED ON MICRONEEDLE ARRAYS FOR SENSING APPLICATIONS INCLUDING KETONE BODIES MONITORING | WESTFALL, SARAH ANN | 3791 | §103 | Non-Final OA | 60d overdue | Pending | Apr 22, 2022 |
| 17770943 | GENOME-SCALE IMAGING OF THE 3D ORGANIZATION AND TRANSCRIPTIONAL ACTIVITY OF CHROMATIN | TURPIN, ZACHARY MARK | 1682 | §103§112Other | Final Rejection | 4d overdue | Pending | Apr 21, 2022 |
| 17719431 | Methods for Rule-based Genome Design | BRETZ, COREY LANE | 1635 | §102§103§112DP | Non-Final OA | — | Pending | Apr 13, 2022 |
| 17712578 | ASSISTIVE FLEXIBLE SUITS, FLEXIBLE SUIT SYSTEMS, AND METHODS FOR MAKING AND CONTROL THEREOF TO ASSIST HUMAN MOBILITY | ZIEGLER, MATTHEW D | 3785 | §112DP | Non-Final OA | — | Pending | Apr 04, 2022 |
| 17642662 | CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF | STOCKTON, LAURA LYNNE | 1626 | §102§112 | Final Rejection | 16d | Pending | Mar 11, 2022 |
| 17540968 | MODIFIED T CELLS AND METHODS OF MAKING AND USING THE SAME | WEHBE, ANNE MARIE SABRINA | 1634 | §112 | Non-Final OA | — | Pending | Dec 02, 2021 |
| 17293678 | MOLECULES AND METHODS FOR IMPROVED IMMUNODETECTION OF SMALL MOLECULES SUCH AS HISTAMINE | IVICH, FERNANDO NMN | 1678 | §103 | Final Rejection | 7d | Pending | May 13, 2021 |
| 17289889 | NUCLEIC ACID-BASED BARCODING | POHNERT, STEVEN C | 1683 | §103§112 | Final Rejection | 110d overdue | Pending | Apr 29, 2021 |
| 17283728 | ENZYMATIC RNA SYNTHESIS | LEE, HOI YAN NMN | 1693 | §103§112DP | Non-Final OA | — | Pending | Apr 08, 2021 |
| 17201347 | DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING VIRAL COMPONENTS | LEITH, NANCY J | 1636 | §103Other | Non-Final OA | — | Pending | Mar 15, 2021 |
| 17265934 | MODULATING PTPN2 TO INCREASE IMMUNE RESPONSES AND PERTURBING GENE EXPRESSION IN HEMATOPOIETIC STEM CELL LINEAGES | CUNNINGCHEN, KATHLEEN MARY | 1646 | §101§103§112 | Non-Final OA | 12d | Pending | Feb 04, 2021 |
| 16973061 | CRISPR EFFECTOR SYSTEM BASED AMPLIFICATION METHODS, SYSTEMS, AND DIAGNOSTICS | RAMIREZ, DELIA M | 1652 | §103§112 | Non-Final OA | — | Pending | Dec 08, 2020 |
| 17052798 | IN VIVO HOMOLOGY DIRECTED REPAIR IN HEART, SKELETAL MUSCLE, AND MUSCLE STEM CELLS | HUDSON, AMY ROSE | 1636 | §103§112 | Non-Final OA | — | Pending | Nov 03, 2020 |
| 16976047 | EVOLVED CAS9 VARIANTS AND USES THEREOF | QIAN, CELINE X | 1637 | §112 | Non-Final OA | — | Pending | Aug 26, 2020 |
| 16989119 | Large Gene Excision and Insertion | GROOMS, TIFFANY NICOLE | 1637 | §103 | Final Rejection | 73d overdue | Pending | Aug 10, 2020 |
| 16984885 | COMPOSITIONS AND METHODS FOR IDENTIFYING A SINGLE-NUCLEOTIDE VARIANT | REGA, KYLE THOMAS | 1636 | §103§112 | Final Rejection | 34d | Pending | Aug 04, 2020 |
| 16960221 | PROTON COUPLED ELECTROCHEMICAL CO2 CAPTURE SYSTEM | KOLTONOW, ANDREW ROBERT | 1795 | §103§112 | Non-Final OA | — | Pending | Jul 06, 2020 |
| 16851360 | RNA-Guided Transcriptional Regulation | GROOMS, TIFFANY NICOLE | 1637 | §103§112DP | Non-Final OA | — | Pending | Apr 17, 2020 |
| 16756134 | SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING | STEADMAN, DAVID J | 1656 | DP | Non-Final OA | 3d overdue | Pending | Apr 15, 2020 |
| 16626396 | NOVEL TYPE VI CRISPR ORTHOLOGS AND SYSTEMS | HUTSON, RICHARD G | 1652 | Other | Final Rejection | — | Pending | Dec 24, 2019 |
| 16484869 | Method of Making Proteins with Non-Standard Amino Acids | KOROTCHKINA, LIOUBOV G | 1653 | §103§112DP | Non-Final OA | 38d overdue | Pending | Aug 09, 2019 |
| 16339019 | Methods of Crispr Mediated Genome Modulation in V. Natriegens | SHELTON, SYNPHANE LA'SHAWN | 1600 | §103 | Final Rejection | — | Pending | Apr 03, 2019 |
| 14701912 | RNA-Guided Human Genome Engineering | HALVORSON, MARK | 1646 | §103 | Final Rejection | — | Pending | May 01, 2015 |
| 14681510 | RNA-Guided Human Genome Engineering | HALVORSON, MARK | 1646 | §103 | Final Rejection | — | Pending | Apr 08, 2015 |
| 14318933 | RNA-Guided Human Genome Engineering | HALVORSON, MARK | 1646 | §103 | Final Rejection | — | Pending | Jun 30, 2014 |
| 14319530 | RNA-Guided Transcriptional Regulation | GROOMS, TIFFANY NICOLE | 1637 | §103DP | Final Rejection | — | Pending | Jun 30, 2014 |
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