Prosecution Insights
Last updated: April 19, 2026
Application No. 18/833,541

BIFIDOBACTERIUM BREVE FOR IMPROVING AGING-RELATED COGNITIVE DISORDER AND USE THEREOF

Final Rejection §101§102
Filed
Jul 26, 2024
Examiner
DUFFY, PATRICIA ANN
Art Unit
1645
Tech Center
1600 — Biotechnology & Organic Chemistry
Assignee
Wecare Probiotics Co. Ltd.
OA Round
2 (Final)
52%
Grant Probability
Moderate
3-4
OA Rounds
3y 9m
To Grant
87%
With Interview

Examiner Intelligence

Grants 52% of resolved cases
52%
Career Allow Rate
295 granted / 564 resolved
-7.7% vs TC avg
Strong +35% interview lift
Without
With
+34.7%
Interview Lift
resolved cases with interview
Typical timeline
3y 9m
Avg Prosecution
22 currently pending
Career history
586
Total Applications
across all art units

Statute-Specific Performance

§101
6.0%
-34.0% vs TC avg
§103
23.1%
-16.9% vs TC avg
§102
18.6%
-21.4% vs TC avg
§112
36.3%
-3.7% vs TC avg
Black line = Tech Center average estimate • Based on career data from 564 resolved cases

Office Action

§101 §102
DETAILED ACTION RESPONSE TO AMENDMENT Notice of Pre-AIA or AIA Status The present application, filed on or after March 16, 2013, is being examined under the first inventor to file provisions of the AIA . The amendment filed 2-4-2026 has been entered into the record. Claims 1, 2 and 8-10 have been cancelled. Claims 3-7 and 11-15 are pending and under examination. The text of Title 35 of the U.S. Code not reiterated herein can be found in the previous office action. Rejections Withdrawn The rejection of claims 1-9 and 11 under 35 U.S.C. 112(a) or 35 U.S.C. 112 (pre-AIA ), first paragraph, as failing to comply with the enablement requirement is withdrawn in view of the properly filed deposit declarations. The rejection of claim 11 under 35 U.S.C. 112(b), as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor, or for pre-AIA the applicant regards as the invention is withdrawn in view of the amendment to the claims. The rejection of claim 11 under 35 U.S.C. 101 because the claimed recitation of a use, without setting forth any steps involved in the process, results in an improper definition of a process, 1.e., results in a claim which is not a proper process claim under 35 U.S.C. 101. See for example Ex parte Dunki, 153 USPQ 678 (Bd.App. 1967), Clinical Products, Ltd. v. Brenner, 255 F. Supp. 131, 149 USPQ 475 (D.D.C. 1966) and MPEP 2173.05(q) is withdrawn in view of the amendment to the claim. The rejection of claim(s) 1-7 and 11 rejected under 35 U.S.C. 102(a)(1) and (a)(2) as anticipated by or, in the alternative, under 35 U.S.C. 103 as obvious over Kobayashi et al (WO2017/209156 A1) is withdrawn in view of the amendment to the claims. The rejection of claim(s) 8-9 under 35 U.S.C. 103 as obvious over Kobayashi et al (WO2017/209156 A1) in view of CN112777098B (6-21-2022) is withdrawn in view of the amendment to the claims. Rejections Maintained Claims 3-7 stand rejected under 35 U.S.C. 101 because the claimed invention is directed to non-statutory subject matter. The claim(s) does/do not fall within at least one of the four categories of patent eligible subject matter because they are drawn to a natural product for reasons made of record in the Office Action mailed 11-4-2025. Applicant’s arguments have been carefully considered but are not persuasive. Applicant argues that the combination is synergistic as claimed and therefore meets the criteria for 35 USC 101. This is not persuasive, each of the microorganism are still natural products performing the functions known to the art as described in the first office action on the merits. The combination does not amount more than the judicial exception as the function of each remains the same and the fundamental characteristics of the strains are not altered. Synergy does not change the function or change the naturally occurring characteristics of the claimed bacteria. No new property is demonstrated by the combination that is not present in the individual bacteria. The combination does not transform to become something different. As such, the property of synergy does not provide a markedly different characteristic since the function of the individual strains are the same. For the foregoing reasons, the rejection is maintained. Status of Claims Claims 3-7 stand rejected. Claims 11-15 are allowable. Conclusion THIS ACTION IS MADE FINAL. Applicant is reminded of the extension of time policy as set forth in 37 CFR 1.136(a). A shortened statutory period for reply to this final action is set to expire THREE MONTHS from the mailing date of this action. In the event a first reply is filed within TWO MONTHS of the mailing date of this final action and the advisory action is not mailed until after the end of the THREE-MONTH shortened statutory period, then the shortened statutory period will expire on the date the advisory action is mailed, and any extension fee pursuant to 37 CFR 1.136(a) will be calculated from the mailing date of the advisory action. In no event, however, will the statutory period for reply expire later than SIX MONTHS from the mailing date of this final action. Any inquiry concerning this communication or earlier communications from the examiner should be directed to Patricia Duffy whose telephone number is (571)272-0855. The examiner can normally be reached 8:00 am - 4 pm. Examiner interviews are available via telephone, in-person, and video conferencing using a USPTO supplied web-based collaboration tool. To schedule an interview, applicant is encouraged to use the USPTO Automated Interview Request (AIR) at http://www.uspto.gov/interviewpractice. If attempts to reach the examiner by telephone are unsuccessful, the examiner’s supervisor, Daniel Kolker can be reached at 571-272-3181. The fax phone number for the organization where this application or proceeding is assigned is 571-273-8300. Information regarding the status of published or unpublished applications may be obtained from Patent Center. Unpublished application information in Patent Center is available to registered users. To file and manage patent submissions in Patent Center, visit: https://patentcenter.uspto.gov. Visit https://www.uspto.gov/patents/apply/patent-center for more information about Patent Center and https://www.uspto.gov/patents/docx for information about filing in DOCX format. For additional questions, contact the Electronic Business Center (EBC) at 866-217-9197 (toll-free). If you would like assistance from a USPTO Customer Service Representative, call 800-786-9199 (IN USA OR CANADA) or 571-272-1000. /Patricia Duffy/Primary Examiner, Art Unit 1645
Read full office action

Prosecution Timeline

Jul 26, 2024
Application Filed
Oct 31, 2025
Non-Final Rejection — §101, §102
Feb 04, 2026
Response Filed
Mar 18, 2026
Final Rejection — §101, §102 (current)

Precedent Cases

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Study what changed to get past this examiner. Based on 5 most recent grants.

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Prosecution Projections

3-4
Expected OA Rounds
52%
Grant Probability
87%
With Interview (+34.7%)
3y 9m
Median Time to Grant
Moderate
PTA Risk
Based on 564 resolved cases by this examiner. Grant probability derived from career allow rate.

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