DETAILED ACTION
Status of the Claims
1. Claims 1,4-16 and 20-26 are pending.
Claims 6,11-13 and 24-26 are withdrawn.
Election/Restrictions
2. Applicant’s election without traverse of claims 1,4,5,7-10,14-16 and 20-23 in the reply filed on 8/05/2026 is acknowledged.
Claim Rejections - 35 USC § 112
The following is a quotation of 35 U.S.C. 112(b):
(b) CONCLUSION.—The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the inventor or a joint inventor regards as the invention.
The following is a quotation of 35 U.S.C. 112 (pre-AIA ), second paragraph:
The specification shall conclude with one or more claims particularly pointing out and distinctly claiming the subject matter which the applicant regards as his invention.
3. Claims 1,4,5,7-10,14-16 and 20-23 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph, as being indefinite for failing to particularly point out and distinctly claim the subject matter which the inventor or a joint inventor (or for applications subject to pre-AIA 35 U.S.C. 112, the applicant), regards as the invention.
Claim 1 recites the limitation "the data samples" in limitation d. There is insufficient antecedent basis for this limitation in the claim.
Claim 14 recites the limitation "the difference" in line 2. There is insufficient antecedent basis for this limitation in the claim.
Claim 22 recites the limitation "the data samples" in line 1. There is insufficient antecedent basis for this limitation in the claim.
Claim 23 recites the limitation "the redox peak current voltage" in line 2. There is insufficient antecedent basis for this limitation in the claim.
Claims 4,5,7-10,13-16,20 and 21 are rejected under 35 U.S.C. 112(b) or 35 U.S.C. 112 (pre-AIA ), second paragraph for being dependent on claim 1.
Allowable Subject Matter
Claims 1, 4-5, 7-10,14-16 and 20-23 are allowed over the cited prior art.
The following is a statement of reasons for the indication of allowable subject matter: the cited prior art, Plaxco et al. teach method of measuring concentration of target comprised of aptamer based sensor comprised of aptamer modified with methylene blue and upon binding to target, the reporter (methylene blue) increase the rate of electron transfer under applied square wave voltammetry wherein the applied voltage is comprised of stepping the potential from -0.1V to -0.3V and sampling the current every 10 µs [0011] and Fig. 3A).
Plaxco et al. do not teach nor render obvious the limitation reciting a first data sample taken at a time point equivalent to which the change in redox tag current has the largest increase for a given increase in target concentration; a second data sample taken at a time point equivalent to which the change in redox tag current has the largest decrease for the given increase in target concentration; and a third data sample taken at a time point equivalent to which the change in redox tag current has the least change for the given increase in target concentration as recited in claim 1.
Conclusion
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/GURPREET KAUR/
Primary Examiner
Art Unit 1759
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